Maintenance of long-term potentiation in hippocampal mossy fiber-CA3 pathway requires fine-tuned MMP-9 proteolytic activity
Abstract
Mechanisms of synaptic plasticity involve proteolytic activity mediated by a complex system of proteases, including members of metalloproteinase (MMP) family. In particular, MMP-9 is critical in LTP maintenance in the Schaffer collateral-CA1 pathway and in the acquisition of hippocampus-dependent memory. Recent studies from this laboratory revealed that in the mossy fiber-CA3 (MF-CA3) projection, where LTP induction and expression are largely presynaptic, MMPs blockade disrupts LTP maintenance and that LTP induction is associated with increased MMP-9 expression. Here we used acute brain slices from MMP-9 knock-out mice and transgenic rats overexpressing MMP-9 to determine how manipulations in endogenous MMP-9 affect LTP in the MF-CA3 projection. Both types of transgenic models showed a normal basal synaptic transmission and short-term plasticity. Interestingly, the maintenance of LTP induced in slices from knock-out mice and overexpressing rats was nearly abolished. However, in the presence of active MMP-9, a gradual fEPSP autopotentiation was observed and tetanization evoked a marked LTP in knock-out mice. Additionally, in MMP-9-treated slices from wild-type mice, fEPSP autopotentiation also occurred and partially occluded LTP. This indicates that exogenous protease can restore LTP in null mice whereas in the wild-type, MMP-9 excess impairs LTP. We expected that LTP maintenance in transgenic rats could be re-established by a partial MMP blockade but non-saturating concentrations of MMP inhibitor were ineffective. In conclusion, we demonstrate that LTP maintenance in MF-CA3 pathway requires fine-tuned MMP-9 activity and raises the possibility that altered MMP-9 level might be detrimental for cognitive processes as observed in some neuropathologies.
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Enhanced neural activity in the hippocampus increases the active form of MMP9 into the perisynaptic space.
“Enhanced neural activity in the hippocampus increases the active form of MMP9 into the perisynaptic space (Bozdagi et al., 2007; Nagy et al., 2006; Wiera et al., 2013).”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Wiera et al., 2013
MMP9 is involved in hippocampal synaptic plasticity.
“One of the most widely studied MMPs in the adult hippocampus, MMP9, is involved in hippocampal synaptic plasticity.”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Wiera et al., 2013
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- Authors
- Wiera, G., Wozniak, G., Bajor, M., Kaczmarek, L., & Mozrzymas, J. W.
- Affiliations
- University of Wrocław (PL)
- Instytut Biologii Doświadczalnej im. Marcelego Nenckiego (PL)
- Wroclaw Medical University (PL)
- Corresponding author
- Wiera, Grzegorz
- Venue
- Hippocampus
- Publisher
- Wiley
- Published
- 2013-04-05
- Volume
- 23
- Issue
- 6
- Pages
- 529-543
- ISSN
- 1050-9631 (ISSN-L)
- 1098-1063
- OpenAlex
- W2052724410
- Cited by
- 57
- References
- 52
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 1 · 2019: 5 · 2018: 4 · 2017: 7 · 2016: 7 · 2015: 10 · 2014: 5 · 2013: 2
- FWCI
- 3.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hippocampus (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Keywords
- long-term potentiation, LTP maintenance, MMP-9, metalloproteinases, synaptic plasticity, presynaptic plasticity, tetanic potentiation, MMP-9 knockout mice, proteolytic activity
- MeSH terms
- Animals, Enzyme Activation, Male, Mice, Inbred C57BL, Neural Pathways, Organ Culture Techniques, Rats, Wistar, Long-Term Potentiation, Mice, Knockout, Mossy Fibers, Hippocampal, Matrix Metalloproteinase 9, Mice, Rats, Rats, Transgenic, CA3 Region, Hippocampal, Proteolysis
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