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The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

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Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

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TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

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Transforming growth factor-β induces development of the TH17 lineage

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A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene

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Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

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Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12

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A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism

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Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

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Interleukin-17 Family Members and Inflammation

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Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides

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IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

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Development, cytokine profile and function of human interleukin 17-producing helper T cells

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Reciprocal T H 17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid

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Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid

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TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

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Phenotypic and functional features of human Th17 cells

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Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells

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IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells

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Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17

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Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells

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Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine

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Increased expression of interleukin 17 in inflammatory bowel disease

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The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation

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Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation

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T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

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Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction

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IL-23 is essential for T cell–mediated colitis and promotes inflammation via IL-17 and IL-6

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T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines

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TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology

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TH-17 cells in the circle of immunity and autoimmunity

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STAT3 Regulates Cytokine-mediated Generation of Inflammatory Helper T Cells

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IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge

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Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

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A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12Rβ1 and a Novel Cytokine Receptor Subunit, IL-23R

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The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

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A Large-Scale Genetic Association Study Confirms IL12B and Leads to the Identification of IL23R as Psoriasis-Risk Genes

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A Human Interleukin-12/23 Monoclonal Antibody for the Treatment of Psoriasis

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Distinct Cytokine Patterns Identified from Multiplex Profiles of Murine DSS and TNBS-Induced Colitis

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Human CD25highFoxp3pos regulatory T cells differentiate into IL-17–producing cells

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T Cell-Produced Transforming Growth Factor-β1 Controls T Cell Tolerance and Regulates Th1- and Th17-Cell Differentiation

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Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category

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Human interleukin 17–producing cells originate from a CD161+CD4+ T cell precursor

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IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2–dependent mechanisms with implications for psoriasis pathogenesis

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Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses

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Interleukin-22 but Not Interleukin-17 Provides Protection to Hepatocytes during Acute Liver Inflammation

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Unique CD14+ intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-γ axis

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Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility

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IL-23 plays a key role in Helicobacter hepaticus –induced T cell–dependent colitis

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Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction

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Interleukin-17 is a negative regulator of established allergic asthma

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Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis

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Retinoic Acid Increases Foxp3+ Regulatory T Cells and Inhibits Development of Th17 Cells by Enhancing TGF-β-Driven Smad3 Signaling and Inhibiting IL-6 and IL-23 Receptor Expression

Xiao, S., Jin, H., Korn, T., Liu, S. M., Oukka, M., Lim, B., & Kuchroo, V. K. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.4.2277 · Cited by 537

Stimulation of the Intracellular Bacterial Sensor NOD2 Programs Dendritic Cells to Promote Interleukin-17 Production in Human Memory T Cells

van Beelen, A. J., Zelinkova, Z., Taanman-Kueter, E. W., Muller, F. J., Hommes, D. W., Zaat, S. A. J., Kapsenberg, M. L., & de Jong, E. C. (2007) · Immunity · doi:10.1016/j.immuni.2007.08.013 · Cited by 518

Interactions among the transcription factors Runx1, RORγt and Foxp3 regulate the differentiation of interleukin 17–producing T cells

Zhang, F., Meng, G., & Strober, W. (2008) · Nature Immunology · doi:10.1038/ni.1663 · Cited by 500

Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice

Ogawa, A., Andoh, A., Araki, Y., Bamba, T., & Fujiyama, Y. (2004) · Clinical Immunology · doi:10.1016/j.clim.2003.09.013 · Cited by 495

Interleukin-22, a Member of the IL-10 Subfamily, Induces Inflammatory Responses in Colonic Subepithelial Myofibroblasts

Andoh, A., Zhang, Z., Inatomi, O., Fujino, S., Deguchi, Y., Araki, Y., Tsujikawa, T., Kitoh, K., Kim–Mitsuyama, S., Takayanagi, A., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.06.071 · Cited by 481

Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease

Yamazaki, K., McGovern, D., Ragoussis, J., Paolucci, M., Butler, H., Jewell, D., Cardon, L., Takazoe, M., Tanaka, T., Ichimori, T., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi379 · Cited by 473

Induction of IL-17+ T Cell Trafficking and Development by IFN-γ: Mechanism and Pathological Relevance in Psoriasis

Kryczek, I., Bruce, A. T., Gudjonsson, J. E., Johnston, A., Aphale, A., Vatan, L., Szeliga, W., Wang, Y., Liu, Y., Welling, T. H., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.7.4733 · Cited by 470

Critical role of IL-17 receptor signaling in acute TNBS-induced colitis

Zhang, Z., Zheng, M., Bindas, J., Schwarzenberger, P., & Kolls, J. K. (2006) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000218764.06959.91 · Cited by 465

Monoclonal Anti–Interleukin 23 Reverses Active Colitis in a T Cell–Mediated Model in Mice

Elson, C. O., Cong, Y., Weaver, C. T., Schoeb, T. R., McClanahan, T. K., Fick, R. B., & Kastelein, R. A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.104 · Cited by 453

Cutting Edge: Roles of Toll-Like Receptor 4 and IL-23 in IL-17 Expression in Response to Klebsiella pneumoniae Infection

Happel, K. I., Zheng, M., Young, E., Quinton, L. J., Lockhart, E., Ramsay, A. J., Shellito, J. E., Schurr, J. R., Bagby, G. J., Nelson, S., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.9.4432 · Cited by 449

Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway

Elias, K. M., Laurence, A., Davidson, T. S., Stephens, G., Kanno, Y., Shevach, E. M., & O'Shea, J. J. (2008) · Blood · doi:10.1182/blood-2007-06-096438 · Cited by 448

Mutations in STAT3 and IL12RB1 impair the development of human IL-17–producing T cells

de Beaucoudrey, L., Puel, A., Filipe-Santos, O., Cobat, A., Ghandil, P., Chrabieh, M., Feinberg, J., von Bernuth, H., Samarina, A., Jannière, L., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080321 · Cited by 439

Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease

the Wellcome Trust Case Control Consortium, Fisher, S. A., Tremelling, M., Anderson, C. A., Gwilliam, R., Bumpstead, S., Prescott, N. J., Nimmo, E. R., Massey, D., Berzuini, C., et al. (2008) · Nature Genetics · doi:10.1038/ng.145 · Cited by 424

IL-23 Promotes Maintenance but Not Commitment to the Th17 Lineage

Stritesky, G. L., Yeh, N., & Kaplan, M. H. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.9.5948 · Cited by 417

Interleukin-23 Restrains Regulatory T Cell Activity to Drive T Cell-Dependent Colitis

Izcue, A., Hue, S., Buonocore, S., Arancibia-Cárcamo, C. V., Ahern, P. P., Iwakura, Y., Maloy, K. J., & Powrie, F. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.019 · Cited by 413

IL-12p35-Deficient Mice Are Susceptible to Experimental Autoimmune Encephalomyelitis: Evidence for Redundancy in the IL-12 System in the Induction of Central Nervous System Autoimmune Demyelination

Gran, B., Zhang, G.-X., Yu, S., Li, J., Chen, X.-H., Ventura, E. S., Kamoun, M., & Rostami, A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.12.7104 · Cited by 405

Cutting Edge: NKT Cells Constitutively Express IL-23 Receptor and RORγt and Rapidly Produce IL-17 upon Receptor Ligation in an IL-6-Independent Fashion

Rachitskaya, A. V., Hansen, A. M., Horai, R., Li, Z., Villasmil, R., Luger, D., Nussenblatt, R. B., & Caspi, R. R. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.8.5167 · Cited by 399

IL-25 regulates Th17 function in autoimmune inflammation

Kleinschek, M. A., Owyang, A. M., Joyce-Shaikh, B., Langrish, C. L., Chen, Y., Gorman, D. M., Blumenschein, W. M., McClanahan, T., Brombacher, F., Hurst, S. D., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061738 · Cited by 396

Signal Transducer and Activator of Transcription 3 Is the Dominant Mediator of the Anti-Inflammatory Effects of IL-10 in Human Macrophages

Williams, L., Bradley, L., Smith, A., & Foxwell, B. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.1.567 · Cited by 393

STAT3 deletion during hematopoiesis causes Crohn’s disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity

Welte, T., Zhang, S. S. M., Wang, T., Zhang, Z., Hesslein, D. G. T., Yin, Z., Kano, A., Iwamoto, Y., Li, E., Craft, J. E., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0237137100 · Cited by 381

Human T Cells That Are Able to Produce IL-17 Express the Chemokine Receptor CCR6

Singh, S. P., Zhang, H. H., Foley, J. F., Hedrick, M. N., & Farber, J. M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.1.214 · Cited by 371

Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells

Becker, C., Wirtz, S., Blessing, M., Pirhonen, J., Strand, D., Bechthold, O., Frick, J., Galle, P. R., Autenrieth, I., & Neurath, M. F. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17464 · Cited by 361

Distinct regulation of interleukin‐17 in human T helper lymphocytes

Chen, Z., Tato, C. M., Muul, L., Laurence, A., & O'Shea, J. J. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22866 · Cited by 358

TLR4 Mediates Vaccine-Induced Protective Cellular Immunity to Bordetella pertussis : Role of IL-17-Producing T Cells

Higgins, S. C., Jarnicki, A. G., Lavelle, E. C., & Mills, K. H. G. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.11.7980 · Cited by 353

Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis

Franke, A., Balschun, T., Karlsen, T. H., Hedderich, J., May, S., Lu, T., Schuldt, D., Nikolaus, S., Rosenstiel, P., Krawczak, M., et al. (2008) · Nature Genetics · doi:10.1038/ng.148 · Cited by 352

Both IL-12p70 and IL-23 are synthesized during active Crohnʼs disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody

Fuss, I. J., Becker, C., Yang, Z., Groden, C., Hornung, R. L., Heller, F., Neurath, M. F., Strober, W., & Mannon, P. J. (2006) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000194183.92671.b6 · Cited by 326

STAT3 and NF-κB Signal Pathway Is Required for IL-23-Mediated IL-17 Production in Spontaneous Arthritis Animal Model IL-1 Receptor Antagonist-Deficient Mice

Cho, M.-L., Kang, J.-W., Moon, Y.-M., Nam, H.-J., Jhun, J.-Y., Heo, S.-B., Jin, H.-T., Min, S.-Y., Ju, J.-H., Park, K.-S., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.9.5652 · Cited by 313

Mice Lacking Bioactive IL-12 Can Generate Protective, Antigen-Specific Cellular Responses to Mycobacterial Infection Only if the IL-12 p40 Subunit Is Present

Cooper, A. M., Kipnis, A., Turner, J., Magram, J., Ferrante, J., & Orme, I. M. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.3.1322 · Cited by 304

IL-23-dependent IL-17 production is essential in neutrophil recruitment and activity in mouse lung defense against respiratory Mycoplasma pneumoniae infection

Wu, Q., Martin, R. J., Rino, J. G., Breed, R., Torres, R. M., & Chu, H. W. (2007) · Microbes and Infection · doi:10.1016/j.micinf.2006.10.012 · Cited by 300

Expression, Localization, and Functional Activity of TL1A, a Novel Th1-Polarizing Cytokine in Inflammatory Bowel Disease

Bamias, G., Martin, C., Marini, M., Hoang, S., Mishina, M., Ross, W. G., Sachedina, M. A., Friel, C. M., Mize, J., Bickston, S. J., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.9.4868 · Cited by 299

Ubiquitous Transgenic Expression of the IL-23 Subunit p19 Induces Multiorgan Inflammation, Runting, Infertility, and Premature Death

Wiekowski, M. T., Leach, M. W., Evans, E. W., Sullivan, L., Chen, S.-C., Vassileva, G., Bazan, J. F., Gorman, D. M., Kastelein, R. A., Narula, S., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.12.7563 · Cited by 295

Commensal-dependent expression of IL-25 regulates the IL-23–IL-17 axis in the intestine

Zaph, C., Du, Y., Saenz, S. A., Nair, M. G., Perrigoue, J. G., Taylor, B. C., Troy, A. E., Kobuley, D. E., Kastelein, R. A., Cua, D. J., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080720 · Cited by 293

IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype

Huber, M., Brüstle, A., Reinhard, K., Guralnik, A., Walter, G., Mahiny, A., von Löw, E., & Lohoff, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809077106 · Cited by 282

Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17

Nakae, S., Iwakura, Y., Suto, H., & Galli, S. J. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.1006610 · Cited by 282

Expression of Interleukin-12-Related Cytokine Transcripts in Inflammatory Bowel Disease: Elevated Interleukin-23p19 and Interleukin-27p28 in Crohnʼs Disease But Not in Ulcerative Colitis

Schmidt, C., Giese, T., Ludwig, B., Mueller-Molaian, I., Marth, T., Zeuzem, S., Meuer, S. C., & Stallmach, A. (2005) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200501000-00003 · Cited by 280

Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cells

Gerosa, F., Baldani-Guerra, B., Lyakh, L. A., Batoni, G., Esin, S., Winkler-Pickett, R. T., Consolaro, M. R., De Marchi, M., Giachino, D., Robbiano, A., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071450 · Cited by 280

Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation

Chen, Z., Laurence, A., & O'Shea, J. J. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.10.015 · Cited by 274

Genome-wide gene expression differences in Crohnʼs disease and ulcerative colitis from endoscopic pinch biopsies: Insights into distinctive pathogenesis

Wu, F., Dassopoulos, T., Cope, L., Maitra, A., Brant, S. R., Harris, M. L., Bayless, T. M., Parmigiani, G., & Chakravarti, S. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20110 · Cited by 272

IL-22 Induces Lipopolysaccharide-Binding Protein in Hepatocytes: A Potential Systemic Role of IL-22 in Crohn’s Disease

Wolk, K., Witte, E., Hoffmann, U., Doecke, W.-D., Endesfelder, S., Asadullah, K., Sterry, W., Volk, H.-D., Wittig, B. M., & Sabat, R. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.9.5973 · Cited by 270

Regulation of Gut Inflammation and Th17 Cell Response by Interleukin-21

Fina, D., Sarra, M., Fantini, M. C., Rizzo, A., Caruso, R., Caprioli, F., Stolfi, C., Cardolini, I., Dottori, M., Boirivant, M., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.01.041 · Cited by 265

Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes

Evans, H. G., Suddason, T., Jackson, I., Taams, L. S., & Lord, G. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708426104 · Cited by 255

TL1A (TNFSF15) Regulates the Development of Chronic Colitis by Modulating Both T-Helper 1 and T-Helper 17 Activation

Takedatsu, H., Michelsen, K. S., Wei, B., Landers, C. J., Thomas, L. S., Dhall, D., Braun, J., & Targan, S. R. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.04.037 · Cited by 254

Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice

Kobayashi, M., Kweon, M.-N., Kuwata, H., Schreiber, R. D., Kiyono, H., Takeda, K., & Akira, S. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17085 · Cited by 251

Two-Sided Roles of IL-27: Induction of Th1 Differentiation on Naive CD4+ T Cells versus Suppression of Proinflammatory Cytokine Production Including IL-23-Induced IL-17 on Activated CD4+ T Cells Partially Through STAT3-Dependent Mechanism

Yoshimura, T., Takeda, A., Hamano, S., Miyazaki, Y., Kinjyo, I., Ishibashi, T., Yoshimura, A., & Yoshida, H. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.8.5377 · Cited by 250

Divergent effects of IL‐12 and IL‐23 on the production of IL‐17 by human T cells

Hoeve, M. A., Savage, N. D. L., de Boer, T., Langenberg, D. M. L., de Waal Malefyt, R., Ottenhoff, T. H. M., & Verreck, F. A. W. (2006) · European Journal of Immunology · doi:10.1002/eji.200535239 · Cited by 245

Regulated MIP-3α/CCL20 production by human intestinal epithelium: mechanism for modulating mucosal immunity

Izadpanah, A., Dwinell, M. B., Eckmann, L., Varki, N. M., & Kagnoff, M. F. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.280.4.g710 · Cited by 239

Activation Pattern of Signal Transducers and Activators of Transcription (STAT) Factors in Inflammatory Bowel Diseases

Mudter, J., Weigmann, B., Bartsch, B., Kiesslich, R., Strand, D., Galle, P. R., Lehr, H. A., Schmidt, J., & Neurath, M. F. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.40615.x · Cited by 230

IL-23 Enhances the Inflammatory Cell Response in Cryptococcus neoformans Infection and Induces a Cytokine Pattern Distinct from IL-12

Kleinschek, M. A., Muller, U., Brodie, S. J., Stenzel, W., Kohler, G., Blumenschein, W. M., Straubinger, R. K., McClanahan, T., Kastelein, R. A., & Alber, G. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.2.1098 · Cited by 227

Cutting Edge: IL-23 Cross-Regulates IL-12 Production in T Cell-Dependent Experimental Colitis

Becker, C., Dornhoff, H., Neufert, C., Fantini, M. C., Wirtz, S., Huebner, S., Nikolaev, A., Lehr, H.-A., Murphy, A. J., Valenzuela, D. M., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.5.2760 · Cited by 227

Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease

Lohr, J., Knoechel, B., Wang, J. J., Villarino, A. V., & Abbas, A. K. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061341 · Cited by 224

TL1A–DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease

Pappu, B. P., Borodovsky, A., Zheng, T. S., Yang, X., Wu, P., Dong, X., Weng, S., Browning, B., Scott, M. L., Ma, L., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071364 · Cited by 218

Dendritic cells mediate the induction of polyfunctional human IL17-producing cells (Th17-1 cells) enriched in the bone marrow of patients with myeloma

Dhodapkar, K. M., Barbuto, S., Matthews, P., Kukreja, A., Mazumder, A., Vesole, D., Jagannath, S., & Dhodapkar, M. V. (2008) · Blood · doi:10.1182/blood-2008-03-143222 · Cited by 216

CCR6-deficient mice have impaired leukocyte homeostasis and altered contact hypersensitivity and delayed-type hypersensitivity responses

Varona, R., Villares, R., Carramolino, L., Goya, Í., Zaballos, Á., Gutiérrez, J., Torres, M., Martínez-A., C., & Márquez, G. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11297 · Cited by 216

Abnormally Differentiated Subsets of Intestinal Macrophage Play a Key Role in Th1-Dominant Chronic Colitis through Excess Production of IL-12 and IL-23 in Response to Bacteria

Kamada, N., Hisamatsu, T., Okamoto, S., Sato, T., Matsuoka, K., Arai, K., Nakai, T., Hasegawa, A., Inoue, N., Watanabe, N., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.10.6900 · Cited by 215

Compromised Humoral and Delayed-Type Hypersensitivity Responses in IL-23-Deficient Mice

Ghilardi, N., Kljavin, N., Chen, Q., Lucas, S., Gurney, A. L., & de Sauvage, F. J. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.5.2827 · Cited by 206

Simvastatin Inhibits IL-17 Secretion by Targeting Multiple IL-17-Regulatory Cytokines and by Inhibiting the Expression of IL-17 Transcription Factor RORC in CD4+ Lymphocytes

Zhang, X., Jin, J., Peng, X., Ramgolam, V. S., & Markovic-Plese, S. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.10.6988 · Cited by 201

Molecular Mechanisms of Cytokine and Chemokine Release from Eosinophils Activated by IL-17A, IL-17F, and IL-23: Implication for Th17 Lymphocytes-Mediated Allergic Inflammation

Cheung, P. F. Y., Wong, C. K., & Lam, C. W. K. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.8.5625 · Cited by 200

Constitutive STAT3 Activation in Intestinal T Cells from Patients with Crohn's Disease

Lovato, P., Brender, C., Agnholt, J., Kelsen, J., Kaltoft, K., Svejgaard, A., Eriksen, K. W., Woetmann, A., & Ødum, N. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207999200 · Cited by 199

Functional assay for human CD4+CD25+ Treg cells reveals an age‐dependent loss of suppressive activity

Tsaknaridis, L., Spencer, L., Culbertson, N., Hicks, K., LaTocha, D., Chou, Y. K., Whitham, R. H., Bakke, A., Jones, R. E., Offner, H., et al. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10766 · Cited by 197

IL-23/IL-17 immunity as a hallmark of Crohnʼs disease

Hölttä, V., Klemetti, P., Sipponen, T., Westerholm-Ormio, M., Kociubinski, G., Salo, H., Räsänen, L., Kolho, K.-L., Färkkilä, M., Savilahti, E., et al. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20475 · Cited by 196

Cutting Edge: Opposite Effects of IL-1 and IL-2 on the Regulation of IL-17+ T Cell Pool IL-1 Subverts IL-2-Mediated Suppression

Kryczek, I., Wei, S., Vatan, L., Escara-Wilke, J., Szeliga, W., Keller, E. T., & Zou, W. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.3.1423 · Cited by 187

IL23R Variation Determines Susceptibility But Not Disease Phenotype in Inflammatory Bowel Disease

Tremelling, M., Cummings, F., Fisher, S. A., Mansfield, J., Gwilliam, R., Keniry, A., Nimmo, E. R., Drummond, H., Onnie, C. M., Prescott, N. J., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.02.051 · Cited by 182

Essential role of TNF receptor superfamily 25 (TNFRSF25) in the development of allergic lung inflammation

Fang, L., Adkins, B., Deyev, V., & Podack, E. R. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20072528 · Cited by 178

In Vitro Differentiation of Dendritic Cells in the Presence of Prostaglandin E2 Alters the IL-12/IL-23 Balance and Promotes Differentiation of Th17 Cells

Khayrullina, T., Yen, J.-H., Jing, H., & Ganea, D. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.1.721 · Cited by 170

Role of TL1A and its receptor DR3 in two models of chronic murine ileitis

Bamias, G., Mishina, M., Nyce, M., Ross, W. G., Kollias, G., Rivera-Nieves, J., Pizarro, T. T., & Cominelli, F. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510903103 · Cited by 169

IL-10 Induces IL-10 in Primary Human Monocyte-Derived Macrophages via the Transcription Factor Stat3

Staples, K. J., Smallie, T., Williams, L. M., Foey, A., Burke, B., Foxwell, B. M. J., & Ziegler-Heitbrock, L. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.8.4779 · Cited by 160

Potential role for TL1A, the new TNF-family member and potent costimulator of IFN-γ, in mucosal inflammation

Prehn, J. L., Mehdizadeh, S., Landers, C. J., Luo, X., Cha, S. C., Wei, P., & Targan, S. R. (2004) · Clinical Immunology · doi:10.1016/j.clim.2004.02.007 · Cited by 160

IL-23 up-regulates IL-10 and induces IL-17 synthesis by polyclonally activated naive T cells in human

Vanden Eijnden, S., Goriely, S., De Wit, D., Willems, F., & Goldman, M. (2005) · European Journal of Immunology · doi:10.1002/eji.200425677 · Cited by 148

IL-12– and IL-23–induced T helper cell subsets

Bettelli, E., & Kuchroo, V. K. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20042279 · Cited by 145

T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype

Mathur, A. N. (2006) · Blood · doi:10.1182/blood-2006-04-015016 · Cited by 143

IL-23 receptor (IL-23R) gene protects against pediatric Crohnʼs disease

Dubinsky, M. C., Wang, D., Picornell, Y., Wrobel, I. T., Katzir, L., Quiros, A., Dutridge, D., Wahbeh, G. T., Silber, G. H., Bahar, R., et al. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20126 · Cited by 139

Differential Regulation of Chemokines by IL-17 in Colonic Epithelial Cells

Lee, J. W., Wang, P., Kattah, M. G., Youssef, S., Steinman, L., DeFea, K., & Straus, D. S. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.9.6536 · Cited by 137

Essential Roles of c-Rel in TLR-Induced IL-23 p19 Gene Expression in Dendritic Cells

Carmody, R. J., Ruan, Q., Liou, H., & Chen, Y. H. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.1.186 · Cited by 136

Regulation of IL-17 in Human CCR6+ Effector Memory T Cells

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IL-23 Production by Cosecretion of Endogenous p19 and Transgenic p40 in Keratin 14/p40 Transgenic Mice: Evidence for Enhanced Cutaneous Immunity

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