The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Dietary advanced glycation end products modify gut microbial composition and partially increase colon permeability in rats
Abstract
Scope: The adverse impacts of dietary advanced glycation end products (AGEs) on health are currently of interest. These compounds are inevitably formed during thermal food processing and make foods less digestible because of protein cross‐linking. This study examined not only whether dietary AGEs alter cecal microbiota and their metabolites but also their effects on colon permeability. Methods and results: Sprague–Dawley rats were exposed to a high‐AGEs diet (AGEs content was increased by heating food at 125°C/3 h) for 6, 12, or 18 weeks. Cecal microbiota was analyzed by 16S rDNA gene sequencing. Colon permeability was assessed through histopathology, immunohistochemistry and endotoxin testing. Microbial metabolites (e.g. ammonia and short‐chain fatty acids (SCFAs)) were also measured. AGEs treatment reduced the diversity and richness of the microbiota, especially saccharolytic bacteria such as Ruminococcaceae and Alloprevotella, which can produce SCFAs, whereas some putatively harmful bacteria (Desulfovibrio and Bacteroides) were increased. Protein fermentation was enhanced, supported by elevated ammonia and branched‐chain fatty acid levels (p < 0.05). Additionally, the colonocytes structure changed and the expression of tight junction proteins in colon were decreased. Conclusion: Dietary AGEs detrimentally modulate gut microbial ecology and may partially increase colon permeability, which can adversely impact host health.
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“Elevated accumulation of AGEs can enhance gut barrier dysfunction, intestinal permeability, and bacterial translocation by stimulating the production and release of proinflammatory cytokines, potentially toxic metabolites and bacterial products, as well as causing intestinal epithelial cell damage, contributing to systemic endotoxemia, inflammation, and multiorgan injury98.”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [98]
In the citing paper
“The intestinal microbiota produces deglycating enzymes to digest AGEs, which are utilized for energy production.”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [98]
In the citing paper
“AGEs can modify gut microbiota composition by triggering the growth of particular microbiomes, resulting in the loss of microbial diversity and an increased possibility of intestinal leakiness98,99.”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [98]
In the citing paper
“As a result of this mechanism, unabsorbed AGEs may play a role in modulating the composition and number of intestinal microflora98.”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [98]
Citations
Cites
Reeves, P. G., Nielsen, F. H., & Fahey, G. C., Jr. (1993) · Journal of Nutrition · doi:10.1093/jn/123.11.1939 · Cited by 8,751
De Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., Collini, S., Pieraccini, G., & Lionetti, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005963107 · Cited by 5,579
Gut microbiota, metabolites and host immunity
Rooks, M. G., & Garrett, W. S. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.42 · Cited by 3,409
Origins and evolution of the Western diet: health implications for the 21st century1,2
Cordain, L., Eaton, S. B., Sebastian, A., Mann, N., Lindeberg, S., Watkins, B. A., O’Keefe, J. H., & Brand-Miller, J. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn.81.2.341 · Cited by 2,397
Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk
Zhu, W., Gregory, J. C., Org, E., Buffa, J. A., Gupta, N., Wang, Z., Li, L., Fu, X., Wu, Y., Mehrabian, M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.02.011 · Cited by 1,968
Intestinal homeostasis and its breakdown in inflammatory bowel disease
Maloy, K. J., & Powrie, F. M. (2011) · Nature · doi:10.1038/nature10208 · Cited by 1,911
Understanding RAGE, the receptor for advanced glycation end products
Bierhaus, A., Humpert, P. M., Morcos, M., Wendt, T., Chavakis, T., Arnold, B., Stern, D. M., & Nawroth, P. P. (2005) · Journal of Molecular Medicine · doi:10.1007/s00109-005-0688-7 · Cited by 1,297
Advanced glycation end products in foods and a practical guide to their reduction in the diet
Uribarri, J., Woodruff, S., Goodman, S., Cai, W., Chen, X., Pyzik, R., Yong, A., Striker, G. E., & Vlassara, H. (2010) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2010.03.018 · Cited by 1,289
The influence of diet on the gut microbiota
Scott, K. P., Gratz, S. W., Sheridan, P. O., Flint, H. J., & Duncan, S. H. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2012.10.020 · Cited by 1,052
The role of microbial amino acid metabolism in host metabolism
Neis, E., Dejong, C., & Rensen, S. (2015) · Nutrients · doi:10.3390/nu7042930 · Cited by 920
Microbiota and diabetes: an evolving relationship
Tilg, H., & Moschen, A. R. (2014) · Gut · doi:10.1136/gutjnl-2014-306928 · Cited by 853
Lam, Y. Y., Ha, C. W. Y., Campbell, C. R., Mitchell, A. J., Dinudom, A., Oscarsson, J., Cook, D. I., Hunt, N. H., Caterson, I. D., Holmes, A. J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034233 · Cited by 604
The gut microbiota, obesity and insulin resistance
Shen, J., Obin, M. S., & Zhao, L. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.11.001 · Cited by 599
The human gut microbiome as a screening tool for colorectal cancer
Zackular, J. P., Rogers, M. A. M., Ruffin, M. T., & Schloss, P. D. (2014) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-14-0129 · Cited by 551
Intestinal luminal nitrogen metabolism: Role of the gut microbiota and consequences for the host
Davila, A.-M., Blachier, F., Gotteland, M., Andriamihaja, M., Benetti, P.-H., Sanz, Y., & Tomé, D. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2012.11.005 · Cited by 548
A high-fat diet is associated with endotoxemia that originates from the gut
Pendyala, S., Walker, J. M., & Holt, P. R. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.01.034 · Cited by 546
Microbial pathways in colonic sulfur metabolism and links with health and disease
Carbonero, F., Benefiel, A. C., Alizadeh-Ghamsari, A. H., & Gaskins, H. R. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00448 · Cited by 544
Intestinal barrier: An interface between health and disease
Farhadi, A., Banan, A., Fields, J. Z., & Keshavarzian, A. (2003) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2003.03032.x · Cited by 532
Theriot, C. M., Bowman, A. A., & Young, V. B. (2016) · mSphere · doi:10.1128/msphere.00045-15 · Cited by 481
Intestinal microbiota, diet and health
Power, S. E., O'Toole, P. W., Stanton, C., Ross, R. P., & Fitzgerald, G. F. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114513002560 · Cited by 476
Interaction Between Obesity and the Gut Microbiota: Relevance in Nutrition
Delzenne, N. M., & Cani, P. D. (2011) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-072610-145146 · Cited by 418
Vaziri, N. D., Zhao, Y., & Pahl, M. V. (2015) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfv095 · Cited by 394
Vaziri, N. D., Yuan, J. J., Rahimi, A., Ni, Z., Said, H., & Subramanian, V. S. (2011) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfr624 · Cited by 306
Nε-(carboxymethyl)lysine content of foods commonly consumed in a Western style diet
Hull, G. L. J., Woodside, J. V., Ames, J. M., & Cuskelly, G. J. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.08.055 · Cited by 264
Role of diet in the development of inflammatory bowel disease
Chapman-Kiddell, C., Davies, P. S. W., Gillen, L., & Radford‐Smith, G. L. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20968 · Cited by 254
Birlouez‐Aragon, I., Saavedra, G., Tessier, F. J., Galinier, A., Ameur, L. A., Lacoste, F., Niamba, C.-N., Alt, N., Somoza, V., & Lecerf, J. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28737 · Cited by 250
Importance of measuring products of non-enzymatic glycation of proteins
Lapolla, A., Traldi, P., & Fedele, D. (2005) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2004.09.007 · Cited by 236
Zhong, Y., NYMAN, M. E., & Fåk, F. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500187 · Cited by 224
The study on the impact of glycated pea proteins on human intestinal bacteria
Swiatecka, D., Narbad, A., Ridgway, K. P., & Kostyra, H. (2011) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2011.01.002 · Cited by 219
Prevention of diabetic nephropathy in mice by a diet low in glycoxidation products
Zheng, F., He, C., Cai, W., Hattori, M., Steffes, M. W., & Vlassara, H. (2002) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.283 · Cited by 207
The family feud: turning off Sp1 by Sp1-like KLF proteins
Lomberk, G. A., & Urrutia, R. A. (2005) · Biochemical Journal · doi:10.1042/bj20051234 · Cited by 204
Faist, V., & Erbersdobler, H. F. (2001) · Annals of Nutrition and Metabolism · doi:10.1159/000046699 · Cited by 192
Metabolism of Maillard reaction products by the human gut microbiota – implications for health
Tuohy, K. M., Hinton, D. J. S., Davies, S. J., Crabbe, M. J. C., Gibson, G. R., & Ames, J. M. (2006) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200500126 · Cited by 186
Clarke, R., Dordevic, A. L., Tan, S. M., Ryan, L., & Coughlan, M. T. (2016) · Nutrients · doi:10.3390/nu8030125 · Cited by 186
Bread crust melanoidins as potential prebiotic ingredients
Borrelli, R. C., & Fogliano, V. (2005) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200500011 · Cited by 180
Effect of diet-derived advanced glycation end products on inflammation
Kellow, N. J., & Coughlan, M. T. (2015) · Nutrition Reviews · doi:10.1093/nutrit/nuv030 · Cited by 160
Interference in determination of ammonia with the hypochlorite-alkaline phenol method of Berthelot
Ngo, T. T., Phan, A. P. H., Yam, C. F., & Lenhoff, H. M. (1982) · Analytical Chemistry · doi:10.1021/ac00238a015 · Cited by 159
Mafra, D., Lobo, J. C., Barros, A. F. H., Koppe, L., Vaziri, N. D., & Fouque, D. P. (2014) · Future Microbiology · doi:10.2217/fmb.13.165 · Cited by 159
Ahmed, N., Mirshekar-Syahkal, B., Kennish, L., Karachalias, N., Babaei‐Jadidi, R., & Thornalley, P. J. (2005) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200500008 · Cited by 157
Mills, D., Tuohy, K. M., Booth, J., Buck, M., Crabbe, M. J. C., Gibson, G. R., & Ames, J. M. (2008) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2008.03783.x · Cited by 146
Andriamihaja, M., Davila, A., Eklou-Lawson, M., Petit, N., Delpal, S., Allek, F., Blais, A., Delteil, C., Tomé, D., & Blachier, F. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00149.2010 · Cited by 145
Maillard reaction products modulate gut microbiota composition in adolescents
Seiquer, I., Rubio, L. A., Peinado, M. J., Delgado‐Andrade, C., & Navarro, M. P. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300847 · Cited by 140
Tessier, F. J., Niquet‐Léridon, C., Jacolot, P., Jouquand, C., Génin, M., Schmidt, A., Grossin, N., & Boulanger, É. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600140 · Cited by 132
Stability of Individual Maillard Reaction Products in the Presence of the Human Colonic Microbiota
Hellwig, M., Bunzel, D., Huch, M., Franz, C. M. A. P., Kulling, S. E., & Henle, T. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b01391 · Cited by 130
Zhang, G., Huang, G., Xiao, L., & Mitchell, A. E. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf202515k · Cited by 127
Determination of Nϵ-carboxymethyllysine in milk products by a modified reversed-phase HPLC method
Drusch, S., Faist, V., & Erbersdobler, H. F. (1999) · Food Chemistry · doi:10.1016/s0308-8146(98)00244-1 · Cited by 127
Formation of advanced glycation endproducts in ground beef under pasteurisation conditions
Sun, X., Tang, J., Wang, J., Rasco, B., Lai, K., & Huang, Y. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2014.09.129 · Cited by 124
Self-citationStudy of the urinary and faecal excretion of N ε-carboxymethyllysine in young human volunteers
Delgado‐Andrade, C., Tessier, F. J., Niquet‐Léridon, C., Seiquer, I., & Navarro, M. P. (2011) · Amino Acids · doi:10.1007/s00726-011-1107-8 · Cited by 118
Metabolic transit of early and advanced Maillard products.
Finot, P. A., & Magnenat, E. M. (1981) · PubMed · Cited by 108
Role of interleukin 15 in colitis induced by dextran sulphate sodium in mice
Yoshihara, K., Yajima, T., Kubo, C., & Yoshikai, Y. (2005) · Gut · doi:10.1136/gut.2005.076000 · Cited by 107
van Nuenen, M. H. M. C., Venema, K., van der Woude, C. J., & Kuipers, E. J. (2004) · Digestive Diseases and Sciences · doi:10.1023/b:ddas.0000020508.64440.73 · Cited by 106
Hellwig, M., Matthes, R., Peto, A., Löbner, J., & Henle, T. (2013) · Amino Acids · doi:10.1007/s00726-013-1501-5 · Cited by 105
Schneider, S. M., Girard-Pipau, F., Anty, R., VANDERLINDE, E., Philipsen-Geerling, B. J., Knol, J., Filippi, J., ARAB, K., & Hébuterne, X. (2005) · Clinical Nutrition · doi:10.1016/j.clnu.2005.09.006 · Cited by 97
Kellow, N. J., Coughlan, M. T., Savige, G. S., & Reid, C. M. (2014) · BMC Endocrine Disorders · doi:10.1186/1472-6823-14-55 · Cited by 93
Digestibility of extruded proteins and metabolic transit of N ε -carboxymethyllysine in rats
Alamir, I., Niquet‐Léridon, C., Jacolot, P., Rodriguez, C., Orosco, M., Anton, P. M., & Tessier, F. J. (2012) · Amino Acids · doi:10.1007/s00726-012-1427-3 · Cited by 88
Julio-Pieper, M., Bravo, J. A., Aliaga, E., & Gotteland, M. (2014) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12950 · Cited by 84
Trivedi, P. P., & Jena, G. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.06.019 · Cited by 80
The role of RAGE in the pathogenesis of intestinal barrier dysfunction after hemorrhagic shock
Raman, K. G., Sappington, P. L., Yang, R., Levy, R. M., Prince, J. M., Liu, S., Watkins, S. C., Schmidt, A. M., Billiar, T. R., & Fink, M. P. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00055.2006 · Cited by 74
Microbiota-host interplay at the gut epithelial level, health and nutrition
Lallès, J. P. (2016) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-016-0123-7 · Cited by 71
Study on fluorescence of Maillard reaction compounds in breakfast cereals
Delgado‐Andrade, C., Rufián‐Henares, J. Á., & Morales, F. J. (2006) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200500249 · Cited by 68
A case of masked toxic adenoma in a patient with non-thyroidal illness
Cho, E. A., Yoon, J. H., Kim, H. K., & Kang, H.-C. (2014) · BMC Endocrine Disorders · doi:10.1186/1472-6823-14-1 · Cited by 63
Colonic protein fermentation and promotion of colon carcinogenesis by thermolyzed casein
Corpet, D. E., Yin, Y., Zhang, X., Rémésy, C., Stamp, D., Medline, A., Thompson, L. U., Bruce, W. R., & Archer, M. C. (1995) · Nutrition and Cancer · doi:10.1080/01635589509514381 · Cited by 57
Zhong, W. H., Li, Q., Sun, Q., Zhang, W., Zhang, J., Sun, X., Yin, X., Zhang, X., & Zhou, Z. (2015) · Journal of Nutrition · doi:10.3945/jn.115.216093 · Cited by 50
Increased intake of Maillard reaction products reduces phosphorous digestibility in male adolescents
Delgado‐Andrade, C., Seiquer, I., Mesías, M., Galdó, G., & Navarro, M. P. (2010) · Nutrition · doi:10.1016/j.nut.2009.10.009 · Cited by 46
Deppe, V. M., Bongaerts, J., O’Connell, T., Maurer, K., & Meinhardt, F. (2011) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-010-3083-4 · Cited by 43
Trivedi, P. P., & Jena, G. (2012) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2012.03.001 · Cited by 34
Heat-treated high-fat diet modifies gut microbiota and metabolic markers in apoe−/− mice
Marungruang, N., Fåk, F., & Tareke, E. (2016) · Nutrition & Metabolism · doi:10.1186/s12986-016-0083-0 · Cited by 28
Shangari, N., Dépeint, F., Furrer, R., Bruce, W. R., Popović, M., Zheng, F., & O’Brien, P. J. (2007) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2007.05.009 · Cited by 27
The impact of glycated pea proteins on bacterial adhesion
Swiatecka, D., Iwan, M., Świa̧tecki, A., Kostyra, H., & Elżbieta, K. (2010) · Food Research International · doi:10.1016/j.foodres.2010.03.003 · Cited by 26
Peptidase Activity of Human Colonic Bacteria
Wallace, R. J., & McKain, N. (1997) · Anaerobe · doi:10.1006/anae.1997.0080 · Cited by 21
Bacterial enzymes that can deglycate glucose- and fructose-modified lysine
Monnier, V. M. (2005) · Biochemical Journal · doi:10.1042/bj20051625 · Cited by 20
Chuang, Y. C., Wu, M., Wu, T.-H., Su, Y.-K., & Lee, Y.-M. (2012) · Journal of Functional Foods · doi:10.1016/j.jff.2012.04.009 · Cited by 7
EFFECT OF HIGH AMYLOSE CORN STARCH ON INTESTINAL FERMENTATION IN RATS
Fa-long, Y. (2007) · Acta Nutrimenta Sinica · Cited by 1
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Metadata
- Authors
- Qu, W., Yuan, X., Zhao, J., Zhang, Y., Hu, J., Wang, J., & Li, J.
- Affiliations
- Northwest A&F University (CN)
- Shaanxi Research Institute of Agricultural Products Processing Technology Xi'an P. R. China
- Corresponding author
- Li, Juxiu
- Venue
- Molecular Nutrition & Food Research
- Publisher
- Wiley
- Published
- 2017-07-31
- Volume
- 61
- Issue
- 10
- ISSN
- 1613-4125 (ISSN-L)
- 1613-4133
- OpenAlex
- W2626757016
- Cited by
- 195
- References
- 73
- Citations by year
- 2026: 12 · 2025: 23 · 2024: 18 · 2023: 26 · 2022: 31 · 2021: 32 · 2020: 19 · 2019: 20 · 2018: 13 · 2017: 1
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Nutrition & Food Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31471579)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- advanced glycation end products, gut microbiota, short-chain fatty acids, protein fermentation, ammonia, tight junction proteins, Ruminococcaceae, Alloprevotella, Desulfovibrio, Bacteroides, thermal food processing
- MeSH terms
- Bacillota, Gastrointestinal Microbiome, Cyanobacteria, Ammonia, Animals, Colon, Diet, DNA, Bacterial, Fatty Acids, Volatile, Fermentation, Male, Permeability, RNA, Ribosomal, 16S, Glycation End Products, Advanced, Rats, Sprague-Dawley, Sequence Analysis, DNA, Proteobacteria, Bacteroidetes, Rats, Verrucomicrobia, Occludin, Zonula Occludens-1 Protein
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