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Cited by 421

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

In vivo determination of intra‐myocellular lipids in human muscle by means of localized 1H‐MR‐spectroscopy

Boesch, Chris, Slotboom, Johannes, Hoppeler, Hans, Kreis, Roland·1997·Magnetic Resonance in Medicine
DOI 10.1002/mrm.1910370403
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Abstract

Intra‐myocellular lipids (IMCL) are stored in droplets in the cytoplasm of muscle cells and are an energy storage form readily accessed during long‐term exercise. 1 H‐MR spectroscopy methods are presented for noninvasive determination of IMCL in human muscle. This is based on (a) the separation of two resonances in the lipid‐CH 2‐region, with the one assigned to IMCL being independent of muscle orientation relative to the magnetic field and (b) the fact that IMCL resonances scale along with signal amplitudes of metabolites in the muscle cell (e.g., creatine) when voxel size is increased, while lipid signals of bulk fat show a disproportionate growth. Inter‐individual and intra‐individual reproducibility studies indicate that the error of the method is about 6% and that IMCL levels differ significantly between identical muscles in different subjects, as well as intra‐individually when measured at 1 week intervals. IMCL determinations in a single subject before and after strenuous exercise indicate that lipid stores recover with a t 1/2 of about 1 day.

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Metadata

Authors
Boesch, C., Slotboom, J., Hoppeler, H., & Kreis, R.
Venue
Magnetic Resonance in Medicine
Publisher
Wiley
Published
1997-04
Volume
37
Issue
4
Pages
484-493
ISSN
  • 0740-3194 (ISSN-L)
  • 1522-2594
DOI
10.1002/mrm.1910370403
OpenAlex
W2055407151
Cited by
421
References
1
FWCI
12.85
Type
journal article
Language
en
Open access
closed

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