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The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Encapsulation of Nano‐Bortezomib in Apoptotic Stem Cell‐Derived Vesicles for the Treatment of Multiple Myeloma

Cao, Zeyuan, Li, Peiyi, Li, Yuzhen, Zhang, Manjin, Hao, Meng, Li, Wenwen, Mao, Xueli, Mo, Lijie, Yang, Chuan, Ding, Xin, Yang, Yi Yan, Yuan, Peiyan, Shi, Songtao, Kou, Xiaoxing·2023·Small
DOI 10.1002/smll.202301748
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Abstract

Extracellular vesicles (EVs) are lipid bilayer nanovesicles released from living or apoptotic cells that can transport DNA, RNA, protein, and lipid cargo. EVs play critical roles in cell–cell communication and tissue homeostasis, and have numerous therapeutic uses including serving as carriers for nanodrug delivery. There are multiple ways to load EVs with nanodrugs, such as electroporation, extrusion, and ultrasound. However, these approaches may have limited drug‐loading rates, poor EV membrane stability, and high cost for large‐scale production. Here, it is shown that apoptotic mesenchymal stem cells (MSCs) can encapsulate exogenously added nanoparticles into apoptotic vesicles (apoVs) with a high loading efficiency. When nano‐bortezomib is incorporated into apoVs in culture‐expanded apoptotic MSCs, nano‐bortezomib‐apoVs show a synergistic combination effect of bortezomib and apoVs to ameliorate multiple myeloma (MM) in a mouse model, along with significantly reduced side effects of nano‐bortezomib. Moreover, it is shown that Rab7 regulates the nanoparticle encapsulation efficiency in apoptotic MSCs and that activation of Rab7 can increase nanoparticle‐apoV production. In this study, a previously unknown mechanism to naturally synthesize nano‐bortezomib‐apoVs to improve MM therapy is revealed.

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Research works printed but not linked: 71

  1. 10.1038/nrm.2017.125 · DOI · Paper page
  2. 10.3389/fimmu.2018.01486 · DOI · Paper page
  3. 10.1186/s13287-018-0774-8 · DOI
  4. 10.7150/thno.21072 · DOI
  5. 10.1186/s13045-018-0680-7 · DOI
  6. 10.1038/s41422-018-0070-2 · DOI · Paper page
  7. 10.1126/scitranslmed.aai8524 · DOI
  8. 10.1096/fj.202002777RR · DOI
  9. 10.1016/j.stem.2018.05.004 · DOI · Paper page
  10. 10.1038/s41392-022-00932-0 · DOI · Paper page
  11. 10.1186/s13045-021-01037-x · DOI · Paper page
  12. 10.1186/s13045-021-01141-y · DOI
  13. 10.1126/scisignal.3145re8 · DOI
  14. 10.1146/annurev.genet.41.110306.130244 · DOI
  15. 10.1038/nrneph.2017.98 · DOI
  16. 10.1007/s00018-011-0689-3 · DOI
  17. 10.1016/j.ccell.2018.05.012 · DOI
  18. 10.1038/s12276-019-0362-8 · DOI
  19. 10.1073/pnas.1811432115 · DOI
  20. 10.1080/20013078.2019.1608786 · DOI
  21. 10.1002/jev2.12240 · DOI
  22. 10.1021/acsnano.1c03517 · DOI · Paper page
  23. 10.1002/smll.202200306 · DOI · Paper page
  24. 10.1002/jev2.12109 · DOI · Paper page
  25. 10.1182/blood.2020010452 · DOI
  26. 10.1158/0008-5472.CAN-19-2714 · DOI
  27. 10.1002/ajh.26590 · DOI · Paper page
  28. 10.1182/blood-2014-09-568915 · DOI · Paper page
  29. 10.1016/S1470-2045(10)70206-0 · DOI
  30. 10.1016/S1470-2045(20)30452-6 · DOI · Paper page
  31. 10.1093/jnen/nlx043 · DOI
  32. 10.1007/s10439-020-02659-x · DOI
  33. 10.1038/bjc.1972.33 · DOI
  34. 10.1038/cr.2017.133 · DOI
  35. 10.1038/nchem.1012 · DOI
  36. 10.1038/s41467-018-03325-6 · DOI
  37. 10.1002/advs.202001374 · DOI
  38. 10.1021/acsami.7b14319 · DOI
  39. 10.7150/thno.37097 · DOI
  40. 10.1182/blood-2005-09-3870 · DOI
  41. 10.1038/sj.leu.2403823 · DOI
  42. 10.1016/S0025-6196(12)61350-0 · DOI
  43. 10.1182/blood.V81.3.767.767 · DOI
  44. 10.1038/s41467-021-21525-5 · DOI
  45. 10.3389/fimmu.2014.00538 · DOI
  46. 10.1242/jcs.01370 · DOI
  47. 10.1080/15548627.2021.1946739 · DOI
  48. 10.1007/s00418-022-02072-6 · DOI
  49. 10.1038/s41565-021-00931-2 · DOI · Paper page
  50. 10.1016/j.jconrel.2020.03.039 · DOI
  51. 10.1038/s41467-019-11718-4 · DOI · Paper page
  52. 10.1002/jev2.12030 · DOI
  53. 10.1007/s12010-018-2813-4 · DOI
  54. 10.1016/j.jconrel.2014.11.029 · DOI
  55. 10.1016/j.ijpharm.2019.118802 · DOI
  56. 10.1002/sctm.19-0202 · DOI
  57. 10.1002/stem.2575 · DOI · Paper page
  58. 10.1016/bs.ircmb.2015.07.009 · DOI
  59. 10.3390/cimb44080236 · DOI
  60. 10.1038/sj.onc.1204436 · DOI
  61. 10.1046/j.1471-4159.1997.68041679.x · DOI
  62. 10.1096/fasebj.14.5.729 · DOI
  63. 10.1038/nrc.2016.108 · DOI · Paper page
  64. 10.1038/s41563-021-01047-7 · DOI
  65. 10.1016/j.jconrel.2016.01.009 · DOI
  66. 10.1016/j.addr.2020.04.004 · DOI
  67. 10.1038/ncomms8439 · DOI
  68. 10.1038/nature25486 · DOI
  69. 10.1016/j.tcb.2018.06.007 · DOI
  70. Leblanc R., 2002, Cancer Res., 62, 4996
  71. 10.1016/j.ijbiomac.2019.09.013 · DOI

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Metadata

Authors
Cao, Z., Li, P., Li, Y., Zhang, M., Hao, M., Li, W., Mao, X., Mo, L., Yang, C., Ding, X., Yang, Y. Y., Yuan, P., Shi, S., & Kou, X.
Venue
Small
Publisher
Wiley
Published
2023-06-06
Volume
19
Issue
40
ISSN
  • 1613-6810
  • 1613-6829
DOI
10.1002/smll.202301748
Cited by
40
References
7
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Funders
  • National Natural Science Foundation of China (82170924, 52072418)
  • Agency for Science, Technology and Research

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