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Functional bowel disorders with diarrhoea: Clinical guidelines of the United European Gastroenterology and European Society for Neurogastroenterology and Motility

Savarino, Edoardo, Zingone, Fabiana, Barberio, Brigida, Marasco, Giovanni, Akyuz, Filiz, Akpinar, Hale, Barboi, Oana, Bodini, Giorgia, Bor, Serhat, Chiarioni, Giuseppe, Cristian, Gheorghe, Corsetti, Maura, Di Sabatino, Antonio, Dimitriu, Anca Mirela, Drug, Vasile, Dumitrascu, Dan L., Ford, Alexander C., Hauser, Goran, Nakov, Radislav, Patel, Nisha, Pohl, Daniel, Sfarti, Cătălin, Serra, Jordi, Simrén, Magnus, Suciu, Alina, Tack, Jan, Toruner, Murat, Walters, Julian, Cremon, Cesare, Barbara, Giovanni·2022·United European Gastroenterology Journal

DOI 10.1002/ueg2.12259

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Abstract

Irritable bowel syndrome with diarrhoea (IBS‐D) and functional diarrhoea (FDr) are the two major functional bowel disorders characterized by diarrhoea. In spite of their high prevalence, IBS‐D and FDr are associated with major uncertainties, especially regarding their optimal diagnostic work‐up and management. A Delphi consensus was performed with experts from 10 European countries who conducted a literature summary and voting process on 31 statements. Quality of evidence was evaluated using the grading of recommendations, assessment, development, and evaluation criteria. Consensus (defined as >80% agreement) was reached for all the statements. The panel agreed with the potential overlapping of IBS‐D and FDr. In terms of diagnosis, the consensus supports a symptom‐based approach also with the exclusion of alarm symptoms, recommending the evaluation of full blood count, C‐reactive protein, serology for coeliac disease, and faecal calprotectin, and consideration of diagnosing bile acid diarrhoea. Colonoscopy with random biopsies in both the right and left colon is recommended in patients older than 50 years and in presence of alarm features. Regarding treatment, a strong consensus was achieved for the use of a diet low fermentable oligo‐, di‐, monosaccharides and polyols, gut‐directed psychological therapies, rifaximin, loperamide, and eluxadoline. A weak or conditional recommendation was achieved for antispasmodics, probiotics, tryciclic antidepressants, bile acid sequestrants, 5‐hydroxytryptamine‐3 antagonists (i.e. alosetron, ondansetron, or ramosetron). A multinational group of European experts summarized the current state of consensus on the definition, diagnosis, and management of IBS‐D and FDr.

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Pimentel, M., Lembo, A., Chey, W. D., Zakko, S., Ringel, Y., Yu, J., Mareya, S. M., Shaw, A. L., Bortey, E., & Forbes, W. P. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1004409 · Cited by 1,036
European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders
Al-Toma, A., Volta, U., Auricchio, R., Castillejo, G., Sanders, D. S., Cellier, C., Mulder, C. J., & Lundin, K. E. A. (2019) · United European Gastroenterology Journal · doi:10.1177/2050640619844125 · Cited by 1,012 · cited 1×
“Upper gastrointestinal endoscopy with duodenal biopsies should be performed in cases of positive serology in adult patients.(45) Statement 1.”
Background
Global prevalence of irritable bowel syndrome according to Rome III or IV criteria: a systematic review and meta-analysis
Oka, P., Parr, H., Barberio, B., Black, C. J., Savarino, E. V., & Ford, A. C. (2020) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(20)30217-x · Cited by 882
Self-citation
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Pinto-Sanchez, M. I., Hall, G. B., Ghajar, K., Nardelli, A., Bolino, C., Lau, J. T., Martin, F.-P., Cominetti, O., Welsh, C., Rieder, A., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.05.003 · Cited by 821
Self-citation
Eradication of Small Intestinal Bacterial Overgrowth Reduces Symptoms of Irritable Bowel Syndrome
Pimentel, M., Chow, E. J., & Lin, H. C. (2000) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.03368.x · Cited by 780
Gut Microbiota in Patients With Irritable Bowel Syndrome—A Systematic Review
Pittayanon, R., Lau, J. T., Yuan, Y., Leontiadis, G. I., Tse, F., Surette, M., & Moayyedi, P. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.03.049 · Cited by 719
Self-Reported Food-Related Gastrointestinal Symptoms in IBS Are Common and Associated With More Severe Symptoms and Reduced Quality of Life
Böhn, L., Störsrud, S., Törnblom, H., Bengtsson, U., & Simrén, M. (2013) · American Journal of Gastroenterology · doi:10.1038/ajg.2013.105 · Cited by 655
Self-citation
Anxiety and depression comorbidities in irritable bowel syndrome (IBS): a systematic review and meta-analysis
Fond, G., Loundou, A., Hamdani, N., Boukouaci, W., Dargel, A., Oliveira, J., Roger, M., Tamouza, R., Leboyer, M., & Boyer, L. (2014) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-014-0502-z · Cited by 647
Small intestinal bacterial overgrowth syndrome
Bures, J. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i24.2978 · Cited by 620
Systematic review with meta‐analysis: the efficacy of prebiotics, probiotics, synbiotics and antibiotics in irritable bowel syndrome
Ford, A. C., Harris, L. A., Lacy, B. E., Quigley, E. M. M., & Moayyedi, P. (2018) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15001 · Cited by 619
Self-citation
Cognitive-behavioral therapy versus education and desipramine versus placebo for moderate to severe functional bowel disorders 1 1This study was registered with ClinicalTrials.gov (trial registry no. NCT00006157).
Drossman, D. A., Toner, B. B., Whitehead, W. E., Diamant, N. E., Dalton, C. B., Duncan, S., Emmott, S., Proffitt, V., Akman, D., Frusciante, K., et al. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00669-3 · Cited by 614
Biopsychosocial Aspects of Functional Gastrointestinal Disorders: How Central and Environmental Processes Contribute to the Development and Expression of Functional Gastrointestinal Disorders
Van Oudenhove, L., Levy, R. L., Crowell, M. D., Drossman, D. A., Halpert, A. D., Keefer, L., Lackner, J. M., Murphy, T. B., & Naliboff, B. D. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.027 · Cited by 512 · cited 1×
“Summary of evidence: The prevalence of psychiatric illnesses in IBS patients is controversial, but IBS consulters often complain of psychological and somatoform symptoms.(13) Van Tilburg et al.”
Background
Prevalence, Risk Factors, and Outcomes of Irritable Bowel Syndrome After Infectious Enteritis: A Systematic Review and Meta-analysis
Klem, F., Wadhwa, A., Prokop, L. J., Sundt, W. J., Farrugia, G., Camilleri, M., Singh, S., & Grover, M. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.12.039 · Cited by 474
Effect of Antidepressants and Psychological Therapies in Irritable Bowel Syndrome: An Updated Systematic Review and Meta-Analysis
Ford, A. C., Lacy, B. E., Harris, L. A., Quigley, E. M. M., & Moayyedi, P. (2019) · American Journal of Gastroenterology · doi:10.1038/s41395-018-0222-5 · Cited by 467 · cited 5×
“83).(200) A more recent systematic review with network meta‐analysis aimed to compare and”
BackgroundMethodInfluentialSelf-citation
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Mars, R. A. T., Yang, Y., Ward, T., Houtti, M., Priya, S., Lekatz, H. R., Tang, X., Sun, Z., Kalari, K. R., Korem, T., et al. (2020) · Cell · doi:10.1016/j.cell.2020.08.007 · Cited by 456 · cited 1×
“Overall there is substantial heterogeneity among available studies regarding a link between specific microbiota alterations and IBS subtypes and symptom patterns,(108) even though more recent studies suggest an association with IBS symptom severity(109) and specific subtypes when using a longitudinal multi‐ omics appr…”
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Staudacher, H. M., Lomer, M. C. E., Farquharson, F. M., Louis, P., Fava, F., Franciosi, E., Scholz, M., Tuohy, K. M., Lindsay, J. O., Irving, P. M., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.06.010 · Cited by 430
Association of adult coeliac disease with irritable bowel syndrome: a case-control study in patients fulfilling ROME II criteria referred to secondary care
Sanders, D. S., Carter, M. J., Hurlstone, D. P., Pearce, A., Ward, A. M., McAlindon, M. E., & Lobo, A. J. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06581-3 · Cited by 390
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Dionne, J., Ford, A. C., Yuan, Y., Chey, W. D., Lacy, B. E., Saito, Y. A., Quigley, E. M. M., & Moayyedi, P. (2018) · American Journal of Gastroenterology · doi:10.1038/s41395-018-0195-4 · Cited by 379
Self-citation
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Lembo, A. J., Lacy, B. E., Zuckerman, M. J., Schey, R., Dove, L. S., Andrae, D. A., Davenport, J. M., McIntyre, G., Lopez, R., Turner, L., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1505180 · Cited by 334 · cited 4×
“The most common adverse events with eluxadoline were nausea, constipation, and abdominal pain.(207) However, a more serious side”
BackgroundMethodInfluential
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Arasaradnam, R. P., Brown, S., Forbes, A., Fox, M. R., Hungin, P., Kelman, L., Major, G., O’Connor, M., Sanders, D. S., Sinha, R., et al. (2018) · Gut · doi:10.1136/gutjnl-2017-315909 · Cited by 332
Self-citation
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Lembo, A., Pimentel, M., Rao, S. S., Schoenfeld, P., Cash, B., Weinstock, L. B., Paterson, C., Bortey, E., & Forbes, W. P. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.08.003 · Cited by 310
The Prevalence and Impact of Overlapping Rome IV-Diagnosed Functional Gastrointestinal Disorders on Somatization, Quality of Life, and Healthcare Utilization: A Cross-Sectional General Population Study in Three Countries
Aziz, I., Palsson, O. S., Törnblom, H., Sperber, A. D., Whitehead, W. E., & Simrén, M. (2018) · American Journal of Gastroenterology · doi:10.1038/ajg.2017.421 · Cited by 218
Self-citation
Systematic review with meta‐analysis: the prevalence of bile acid malabsorption in the irritable bowel syndrome with diarrhoea
Slattery, S. A., Niaz, O., Aziz, Q., Ford, A. C., & Farmer, A. D. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13227 · Cited by 214
Self-citation
The immune system in irritable bowel syndrome
Barbara, G., Cremon, C., Carini, G., Bellacosa, L., Zecchi, L., Giorgio, R. D., Corinaldesi, R., & Stanghellini, V. (2011) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2011.17.4.349 · Cited by 211 · cited 1×
“different factors, such as genetic predisposition, impaired mucosal permeability, dysbiosis, stress, and atopy.(156) There are several small”
BackgroundSelf-citation
Influence of antidepressants on whole gut and orocaecal transit times in health and irritable bowel syndrome
GORARD, D. A., LIBBY, G. W., & FARTHING, M. J. G. (1994) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.1994.tb00273.x · Cited by 211
Heat-inactivated Bifidobacterium bifidum MIMBb75 (SYN-HI-001) in the treatment of irritable bowel syndrome: a multicentre, randomised, double-blind, placebo-controlled clinical trial
Andresen, V., Gschossmann, J., & Layer, P. (2020) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(20)30056-x · Cited by 206
Assessing telephone-delivered cognitive–behavioural therapy (CBT) and web-delivered CBT versus treatment as usual in irritable bowel syndrome (ACTIB): a multicentre randomised trial
Everitt, H. A., Landau, S., O’Reilly, G., Sibelli, A., Hughes, S., Windgassen, S., Holland, R., Little, P., McCrone, P., Bishop, F., et al. (2019) · Gut · doi:10.1136/gutjnl-2018-317805 · Cited by 198
Systematic review with meta‐analysis: efficacy of faecal microbiota transplantation for the treatment of irritable bowel syndrome
Ianiro, G., Eusebi, L. H., Black, C. J., Gasbarrini, A., Cammarota, G., & Ford, A. C. (2019) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15330 · Cited by 188
Self-citation
Colonic Transit Time and IBS Symptoms: What's the Link?
Törnblom, H., Van Oudenhove, L., Sadik, R., Abrahamsson, H., Tack, J., & Simrén, M. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2012.5 · Cited by 185
Self-citation
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Chey, W. D., Nojkov, B., Rubenstein, J. H., Dobhan, R. R., Greenson, J. K., & Cash, B. D. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.55 · Cited by 175
Colonic immune cells in irritable bowel syndrome: A systematic review and meta‐analysis
Bashashati, M., Moossavi, S., Cremon, C., Barbaro, M. R., Moraveji, S., Talmon, G., Rezaei, N., Hughes, P. A., Bian, Z. X., Choi, C. H., et al. (2018) · Neurogastroenterology & Motility · doi:10.1111/nmo.13192 · Cited by 175
Self-citation
Screening for Celiac Disease in Irritable Bowel Syndrome: An Updated Systematic Review and Meta-analysis
Irvine, A. J., Chey, W. D., & Ford, A. C. (2017) · American Journal of Gastroenterology · doi:10.1038/ajg.2016.466 · Cited by 172 · cited 2×
“Serologic tests for coeliac disease, including immunoglobulin A (IgA) tissue transglutaminase and quantitative IgA levels, should be performed in patients with DGBI with diarrhoea, particularly if they fail initial therapy.(1,34) The medical literature clearly indicates an”
BackgroundSelf-citation
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Black, C. J., Yuan, Y., Selinger, C. P., Camilleri, M., Quigley, E. M. M., Moayyedi, P., & Ford, A. C. (2020) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(19)30324-3 · Cited by 171
Self-citation
Development and Validation of a Biomarker for Diarrhea-Predominant Irritable Bowel Syndrome in Human Subjects
Pimentel, M., Morales, W., Rezaie, A., Marsh, E., Lembo, A., Mirocha, J., Leffler, D. A., Marsh, Z., Weitsman, S., Chua, K. S., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0126438 · Cited by 148
Efficacy and Safety of Peppermint Oil in a Randomized, Double-Blind Trial of Patients With Irritable Bowel Syndrome
Weerts, Z. Z. R. M., Masclee, A. A. M., Witteman, B. J. M., Clemens, C. H. M., Winkens, B., Brouwers, J. R. B. J., Frijlink, H. W., Muris, J. W. M., De Wit, N. J., Essers, B. A. B., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.08.026 · Cited by 137
Self-citation
Cumulative Effects of Psychologic Distress, Visceral Hypersensitivity, and Abnormal Transit on Patient-reported Outcomes in Irritable Bowel Syndrome
Simrén, M., Törnblom, H., Palsson, O. S., Van Oudenhove, L., Whitehead, W. E., & Tack, J. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.04.019 · Cited by 131
Self-citation
The effect of Clostridium butyricum on symptoms and fecal microbiota in diarrhea-dominant irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial
Sun, Y.-Y., Li, M., Li, Y.-Y., Li, L.-X., Zhai, W.-Z., Wang, P., Yang, X.-X., Gu, X., Song, L.-J., Li, Z., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-21241-z · Cited by 126 · cited 1×
“Of these, four studies were performed in more than 100 patients.(151,152) In particular: (1) a study performed in 313 Rome IV IBS patients showed that specific probiotics improved”
Background
Lactobacillus acidophilus DDS-1 and Bifidobacterium lactis UABla-12 Improve Abdominal Pain Severity and Symptomology in Irritable Bowel Syndrome: Randomized Controlled Trial
Martoni, C. J., Srivastava, S., & Leyer, G. J. (2020) · Nutrients · doi:10.3390/nu12020363 · Cited by 123
Cognitive behavioural therapy for irritable bowel syndrome: 24-month follow-up of participants in the ACTIB randomised trial
Everitt, H. A., Landau, S., O'Reilly, G., Sibelli, A., Hughes, S., Windgassen, S., Holland, R., Little, P., McCrone, P., Bishop, F. L., et al. (2019) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(19)30243-2 · Cited by 116
Quantifying bile acid malabsorption helps predict response and tailor sequestrant therapy
Orekoya, O., McLaughlin, J., Leitao, E., Johns, W., Lal, S., & Paine, P. (2015) · Clinical Medicine · doi:10.7861/clinmedicine.15-3-252 · Cited by 74
The role of diet in irritable bowel syndrome: implications for dietary advice
Rej, A., Aziz, I., Tornblom, H., Sanders, D. S., & Simrén, M. (2019) · Journal of Internal Medicine · doi:10.1111/joim.12966 · Cited by 61
Self-citation
Double-blind placebo-controlled study of mesalamine in post-infective irritable bowel syndrome – a pilot study
Tuteja, A. K., Fang, J. C., Al-Suqi, M., Stoddard, G. J., & Hale, D. C. (2012) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2012.694903 · Cited by 41
Bimodal Release Ondansetron Improves Stool Consistency and Symptomatology in Diarrhea-Predominant Irritable Bowel Syndrome: A Randomized, Double-Blind, Trial
Plasse, T. F., Barton, G., Davidson, E., Abramson, D., Kalfus, I., Fathi, R., Raday, G., & Harris, M. S. (2020) · American Journal of Gastroenterology · doi:10.14309/ajg.0000000000000727 · Cited by 40
The clinical potential of ramosetron in the treatment of irritable bowel syndrome with diarrhea (IBS-D)
Min, Y. W., & Rhee, P.-L. (2015) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x15572580 · Cited by 30

Research works printed but not linked: 183

10.1053/j.gastro.2016.02.031 · DOI · Paper page
10.1016/s0140‐6736(20)32115‐2 · DOI · Paper page
10.14309/ajg.0000000000000946 · DOI
10.1053/j.gastro.2020.04.014 · DOI · Paper page
10.1108/14777260310469319 · DOI
10.1111/apt.12573 · DOI · Paper page
10.1016/j.cgh.2019.08.020 · DOI
10.1016/j.cgh.2016.07.028 · DOI
10.1016/j.cgh.2019.08.062 · DOI
10.1016/j.jpsychores.2013.03.004 · DOI
10.1016/j.jpsychores.2019.109821 · DOI
10.1016/j.pain.2007.08.029 · DOI
10.1007/s10620‐018‐5352‐5 · DOI
10.1038/ajg.2013.410 · DOI
10.1016/j.cgh.2019.03.046 · DOI
10.1053/j.gastro.2016.02.009 · DOI
10.1053/j.gastro.2009.04.054 · DOI
10.1111/ijcp.12018 · DOI
10.1016/j.cgh.2013.07.020 · DOI
10.1016/j.jamda.2019.03.033 · DOI · Paper page
10.1053/j.gastro.2013.10.062 · DOI
10.1016/j.cgh.2019.05.040 · DOI
10.14309/ctg.0000000000000060 · DOI
10.1016/s0140‐6736(82)92413‐8 · DOI
Johanson J, 1996, Epidemiology of fecal incontinence: the silent affliction ‐ PubMed, Am J Gastroenterol, 91, 33
10.3122/jabfm.2018.05.180045 · DOI
10.1016/j.cgh.2012.12.038 · DOI
10.1038/ajg.2015.6 · DOI · Paper page
10.1136/gutjnl‐2019‐319281 · DOI
10.1053/j.gastro.2011.06.084 · DOI
10.1111/nmo.12799 · DOI
10.1111/j.1572‐0241.2002.07027.x · DOI
10.1053/j.gastro.2004.03.012 · DOI
10.1001/archinternmed.2009.22 · DOI
10.1053/j.gastro.2019.06.014 · DOI · Paper page
10.1016/j.dld.2017.06.010 · DOI
10.1038/ajg.2010.47 · DOI
Tolliver B, Evaluation of patients who meet clinical criteria for irritable bowel syndrome ‐ PubMed, Am J Gastroenterol, 89, 176
10.1111/j.1572‐0241.2004.30223.x · DOI
10.1016/s1473‐3099(15)00349‐7 · DOI
10.1152/ajpgi.00144.2015 · DOI
10.1016/j.mimet.2016.08.017 · DOI
Rodrigo L, 2007, Fecal calprotectin, Rev Esp Enferm Dig, 12, 683
10.1136/bmj.c3369 · DOI
10.1111/j.1365‐2036.2006.02956.x · DOI · Paper page
10.1371/journal.pone.0106478 · DOI
10.1186/1471‐230x‐12‐55 · DOI
10.3109/00365521.2015.1007079 · DOI
Neugut A, 1993, Diagnostic yield of colorectal neoplasia with colonoscopy for abdominal pain, change in bowel habits, and rectal bleeding, Am J Gastroenterol, 88, 1179
10.1007/s00535‐012‐0573‐4 · DOI
10.1177/2050640620951905 · DOI · Paper page
10.1371/journal.pone.0066088 · DOI
10.1097/meg.0b013e328058ed76 · DOI
10.1111/apt.13573 · DOI
10.1053/j.gastro.2011.02.003 · DOI
10.1111/j.1365‐2036.2012.05166.x · DOI
10.1038/ajg.2014.431 · DOI
10.1016/j.ejim.2008.04.018 · DOI
10.1016/j.mehy.2012.05.038 · DOI
10.5946/ce.2018.055 · DOI
10.1055/s‐0034‐1391855 · DOI · Paper page
10.1136/gut.42.3.421 · DOI
10.1111/j.1365‐2982.2009.01442.x · DOI · Paper page
10.1097/mcg.0000000000001047 · DOI
10.1136/gut.35.2.203 · DOI
10.1111/nmo.13357 · DOI
10.1136/gutjnl‐2019‐318404 · DOI · Paper page
10.1016/s2468‐1253(17)30154‐1 · DOI
10.1093/jcag/gwy071 · DOI · Paper page
10.1097/00004836‐199607000‐00005 · DOI
Vernia P, 1995, Lactose malabsorption and irritable bowel syndrome. Effect of a long‐term lactose‐free diet ‐ PubMed, Ital J Gastroenterol, 27, 117
10.1097/00042737‐200103000‐00001 · DOI
10.1007/bf01299809 · DOI
10.1097/00042737‐199610000‐00015 · DOI
10.1016/j.cgh.2007.04.008 · DOI
10.1159/000489877 · DOI
10.1097/mcg.0b013e3181eed6bf · DOI
10.1111/nmo.14150 · DOI
10.5009/gnl16126 · DOI
10.1016/j.cgh.2009.07.026 · DOI
10.1136/bmjgast‐2016‐000116 · DOI
10.1053/j.gastro.2018.11.069 · DOI
10.1111/j.1365‐2036.2009.04081.x · DOI · Paper page
10.1136/gutjnl‐2015‐309889 · DOI
10.1136/gutjnl‐2020‐322519 · DOI · Paper page
10.1111/1751‐2980.12969 · DOI
10.1053/j.gastro.2019.07.004 · DOI
10.1053/j.gastro.2020.06.090 · DOI
10.1038/ajg.2017.46 · DOI · Paper page
10.14309/ajg.0000000000000504 · DOI
10.14309/ajg.0000000000000444 · DOI
10.1038/s41467‐019‐09964‐7 · DOI
10.1053/j.gastro.2016.09.049 · DOI · Paper page
10.1016/j.cell.2020.10.040 · DOI
10.1136/gutjnl‐2020‐321466 · DOI
10.1111/j.1365‐2036.2004.02267.x · DOI
10.1186/s12906‐018‐2409‐0 · DOI · Paper page
10.1136/bmj.38545.505764.06 · DOI
10.1111/j.1365‐2982.2011.01771.x · DOI
10.3748/wjg.v16.i5.547 · DOI
10.1111/j.1365‐2036.2011.04730.x · DOI
10.1177/1756283x16681708 · DOI
10.1136/bmj.a2313 · DOI · Paper page
10.1016/j.cgh.2015.01.015 · DOI
10.1046/j.1365‐2036.2002.01277.x · DOI
10.1038/ajg.2014.187 · DOI
10.1111/j.1365‐2036.2009.04216.x · DOI
10.3109/00365528709091004 · DOI
10.3109/00365528709091003 · DOI
10.1097/md.0000000000024361 · DOI
10.1007/bf01296258 · DOI
10.1038/ajg.2017.72 · DOI
10.7861/clinmed.2020‐1046 · DOI
Dumitrascu D, 2004, The effect of two antidiarrhoeal drugs on the psychosocial adjustment to illness in chronic functional diarrhoea, Rom J Intern Med, 42, 191
10.1111/j.1440‐1746.2007.04895.x · DOI
10.1186/s12876‐015‐0386‐z · DOI
10.1177/2050640619862721 · DOI
10.1080/00365520212495 · DOI
10.1016/0005‐2787(67)90147‐5 · DOI
10.3920/bm2019.0171 · DOI
10.1124/jpet.107.121913 · DOI
10.14309/ctg.0000000000000144 · DOI
10.1007/s10620‐017‐4598‐7 · DOI
10.1111/apt.12735 · DOI · Paper page
10.1016/j.amjmed.2011.08.026 · DOI
10.1111/apt.14539 · DOI · Paper page
10.1177/2050640617736478 · DOI
10.1111/nmo.13037 · DOI
10.1590/s0004‐28032013000400012 · DOI
10.1111/j.1365‐2036.2011.04715.x · DOI
10.2147/ceg.s18381 · DOI
10.1136/gutjnl‐2014‐308188 · DOI
10.1136/gutjnl‐2015‐309122 · DOI
10.15171/mejdd.2016.47 · DOI
10.1097/MD.0000000000016297 · DOI
10.1016/s0016‐5085(72)80109‐4 · DOI
10.1136/gut.17.12.965 · DOI
10.1136/gut.28.8.970 · DOI
10.1136/gut.32.9.1004 · DOI
10.1111/apt.12684 · DOI
10.1016/j.clinthera.2009.11.027 · DOI
10.1111/apt.15099 · DOI
10.1111/apt.13193 · DOI
10.1136/gutjnl‐2013‐305965 · DOI
10.1016/j.crohns.2014.05.009 · DOI
10.1097/meg.0000000000000541 · DOI
10.1016/j.cgh.2019.10.031 · DOI
10.1111/j.1365‐2036.2010.04237.x · DOI · Paper page
10.1016/j.nut.2017.07.004 · DOI
Lanenvan AS, 2021, Efficacy of a low‐FODMAP diet in adult irritable bowel syndrome: a systematic review and meta‐analysis, Eur J Nutr, 60, 3505
10.1111/jhn.12385 · DOI · Paper page
10.1111/jgh.14051 · DOI
10.3390/jcm9010125 · DOI
10.3390/nu11071566 · DOI
10.1111/jhn.12530 · DOI
10.1111/jgh.15410 · DOI
10.1111/jgh.15470 · DOI
10.23736/s1121‐421x.18.02518‐7 · DOI
10.1097/mcg.0000000000001445 · DOI
10.1016/j.cgh.2015.12.031 · DOI
10.1053/j.gastro.2013.01.049 · DOI · Paper page
10.1053/j.gastro.2013.04.051 · DOI
10.1053/j.gastro.2017.10.040 · DOI
10.14309/ajg.0000000000001038 · DOI
10.14309/ajg.0000000000001247 · DOI
10.1016/j.cpr.2016.11.001 · DOI
10.1177/2050640619866990 · DOI
10.1136/gutjnl‐2019‐319630 · DOI · Paper page
10.1016/j.cgh.2017.11.025 · DOI
10.14309/ajg.0000000000000327 · DOI
10.1111/j.1365‐2036.2008.03633.x · DOI
10.1007/bf02236848 · DOI
10.1111/j.1365‐2036.2010.04395.x · DOI
10.1016/s0025‐6196(12)60797‐6 · DOI
10.1111/j.1365‐2036.1993.tb00131.x · DOI
10.1046/j.1365‐2036.1996.30172000.x · DOI
10.1136/gutjnl‐2013‐305989 · DOI · Paper page
10.1186/s13063‐019‐3562‐6 · DOI
10.1111/j.1572‐0241.2006.00459.x · DOI · Paper page
10.1111/nmo.14279 · DOI
10.1016/j.cgh.2021.08.025 · DOI
10.1111/j.1572‐0241.2004.04097.x · DOI · Paper page
10.1136/gutjnl‐2018‐318160 · DOI · Paper page

AGA Clinical Practice Update on GI Manifestations and Autonomic or Immune Dysfunction in Hypermobile Ehlers-Danlos Syndrome: Expert Review
Aziz, Q., Harris, L. A., Goodman, B. P., Simrén, M., & Shin, A. (2025) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2025.02.015 · Cited by 27
Self-citation
Microbiota and enteric nervous system crosstalk in diabetic gastroenteropathy: bridging mechanistic insights to microbiome-based therapies
Tao, W., Yu, Y., Tan, D., Huang, X., Huang, J., Lin, C., & Yu, R. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1603442 · Cited by 9
Plant-Derived Treatments for IBS: Clinical Outcomes, Mechanistic Insights, and Their Position in International Guidelines
Pastras, P., Aggeletopoulou, I., Bali, M., & Triantos, C. (2026) · Nutrients · doi:10.3390/nu18020183 · Cited by 1

See all 146

Authors: Savarino, E., Zingone, F., Barberio, B., Marasco, G., Akyuz, F., Akpinar, H., Barboi, O., Bodini, G., Bor, S., Chiarioni, G., Cristian, G., Corsetti, M., Di Sabatino, A., Dimitriu, A. M., Drug, V., Dumitrascu, D. L., Ford, A. C., Hauser, G., Nakov, R., Patel, N., Pohl, D., Sfarti, C., Serra, J., Simrén, M., Suciu, A., Tack, J., Toruner, M., Walters, J., Cremon, C., & Barbara, G.
Affiliations: Gastroenterology Unit Department of Surgery, Oncology and Gastroenterology University of Padua Padua Italy
Division of Internal Medicine IRCCS Azienda Ospedaliero‐Universitaria di Bologna Bologna Italy
Department of Gastroenterology İstanbul University İstanbul School of Medicine İstanbul Turkey
Department of Internal Medicine Dokuz Eylül University School of Medicine Izmir Turkey
Department of Gastroenterology ‘Grigore T. Popa’ University of Medicine and Pharmacy Iasi Romania
Gastrointestinal Unit Department of Internal Medicine University of Genoa Genoa Italy
Division of Gastroenterology Ege University School of Medicine Izmir Turkey
Division of Gastroenterology University of Verona Verona Italy
Fundeni Clinical Institute Center of Gastroenterology and Hepatology Carol Davila University of Medicine and Pharmacy Bucharest Romania
National Institute for Health Research Nottingham Biomedical Research Centre Nottingham University Hospitals NHS Trust Nottingham UK
First Department of Internal Medicine IRCCS San Matteo Hospital Foundation University of Pavia Pavia Italy
Center of Gastroenterology and Hepatology Fundeni Clinical Institute University of Medicine and Pharmacy Bucharest Romania
2nd Department of Internal Medicine ‘Iuliu Hatieganu’ University of Medicine and Farmacy Cluj‐Napoca Romania
Leeds Gastroenterology Institute Leeds Teaching Hospitals NHS Trust Leeds UK
Department of Gastroenterology Clinical Hospital Center Rijeka Faculty of Medicine University of Rijeka Rijeka Croatia
Department of Gastroenterology Tsaritsa Yoanna University Hospital Medical University of Sofia Sofia Bulgaria
Imperial College Healthcare NHS Trust Institute of Global Health Innovation St Mary's Hospital Campus London UK
Department of Gastroenterology University Hospital Zurich Zurich Switzerland
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd) Badalona Spain
Sahlgrenska Academy University of Gothenburg Gothenburg Sweden
Translational Research Center for Gastrointestinal Disorders University of Leuven Leuven Belgium
Department of Gastroenterology Ankara University School of Medicine Ankara Turkey
Division of Digestive Diseases Department of Metabolism, Digestion, and Reproduction Faculty of Medicine Imperial College London London UK
ORCID: Savarino, Edoardo
Di Sabatino, Antonio
Toruner, Murat
Cremon, Cesare
Venue: United European Gastroenterology Journal
Publisher: Wiley
Published: 2022-06-13
Volume: 10
Issue: 6
Pages: 556-584
ISSN: 2050-6406
2050-6414
DOI: 10.1002/ueg2.12259
Cited by: 146
References: 44
Language: en
Licence: creativecommons.org/licenses/by-nc-nd/4.0/ (vor)

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Functional bowel disorders with diarrhoea: Clinical guidelines of the United European Gastroenterology and European Society for Neurogastroenterology and Motility

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