Hematopoietic stem cell: self‐renewal versus differentiation

Stem cells, cancer, and cancer stem cells

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Osteoblastic cells regulate the haematopoietic stem cell niche

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Purification and Characterization of Mouse Hematopoietic Stem Cells

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A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

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Wnt proteins are lipid-modified and can act as stem cell growth factors

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Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow

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A role for Wnt signalling in self-renewal of haematopoietic stem cells

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Long-Term Lymphohematopoietic Reconstitution by a Single CD34-Low/Negative Hematopoietic Stem Cell

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Tie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche

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Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

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Impaired immune and acute-phase responses in interleukin-6-deficient mice

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A Stem Cell Molecular Signature

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Cytological Demonstration of the Clonal Nature of Spleen Colonies Derived from Transplanted Mouse Marrow Cells

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The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function

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Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor

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Differentiation and proliferation of hematopoietic stem cells

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Identification of Flt3+ Lympho-Myeloid Stem Cells Lacking Erythro-Megakaryocytic Potential

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Cell intrinsic alterations underlie hematopoietic stem cell aging

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The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype

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Isolation of a candidate human hematopoietic stem-cell population.

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Abnormal lung development and cleft palate in mice lacking TGF–β3 indicates defects of epithelial–mesenchymal interaction

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Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice

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Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo.

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CD34: structure, biology, and clinical utility [see comments]

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The distribution of colony‐forming cells among spleen colonies

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The aging of hematopoietic stem cells

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Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice

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Flk-2 is a marker in hematopoietic stem cell differentiation: A simple method to isolate long-term stem cells

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Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: Implications for gene therapy

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Upregulation of Flt3 Expression within the Bone Marrow Lin−Sca1+c-kit+ Stem Cell Compartment Is Accompanied by Loss of Self-Renewal Capacity

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Human T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subset

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Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy

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Thrombocytopenia in c-mpl-deficient mice

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TGF-β Receptor Type II Deficiency Results in Defects of Yolk Sac Hematopoiesis and Vasculogenesis

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Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation.

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Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders.

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Decrease of mast cells in W/Wv mice and their increase by bone marrow transplantation

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Identification of a Hierarchy of Multipotent Hematopoietic Progenitors in Human Cord Blood

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Loss of β-Catenin Impairs the Renewal of Normal and CML Stem Cells In Vivo

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Abnormal angiogenesis but intact hematopoietic potential in TGF‐β type I receptor‐deficient mice

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Prospective isolation of human clonogenic common myeloid progenitors

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Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice--evidence for an impaired c-kit kinase in mutant mice.

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Identification of Lin–Sca1+kit+CD34+Flt3– short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients

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Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block

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tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors.

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Dendritic cell potentials of early lymphoid and myeloid progenitors

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Hematopoietic stem cell and multilineage defects generated by constitutive β-catenin activation

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Development of CD8α-Positive Dendritic Cells from a Common Myeloid Progenitor

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Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin

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Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis

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Role of c-mpl in Early Hematopoiesis

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Clonal analysis of hematopoietic stem-cell differentiation in vivo.

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Searching for hematopoietic stem cells: evidence that Thy-1.1lo Lin- Sca-1+ cells are the only stem cells in C57BL/Ka-Thy-1.1 bone marrow.

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β-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis

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Self-renewal of primitive human hematopoietic cells (long-term-culture-initiating cells) in vitro and their expansion in defined medium.

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W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor.

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TGF-β as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation

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Distinct classes of human stem cells that differ in proliferative and self-renewal potential

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Isolation of two early B lymphocyte progenitors from mouse marrow: A committed Pre-Pre-B cell and a clonogenic Thy-1lo hematopoietic stem cell

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Hematopoietic Fingerprints: An Expression Database of Stem Cells and Their Progeny

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Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages

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Lymphoid and myeloid differentiation of single human CD34+, HLA-DR+, CD38- hematopoietic stem cells

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HIV, but not murine leukemia virus, vectors mediate high efficiency gene transfer into freshly isolated G 0 /G 1 human hematopoietic stem cells

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Differential Expression of Novel Potential Regulators in Hematopoietic Stem Cells

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Dysregulated gene expression networks in human acute myelogenous leukemia stem cells

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Extended long-term culture reveals a highly quiescent and primitive human hematopoietic progenitor population

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Transforming growth factor β-induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulation

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Bone marrow stromal cell lines with lymphopoietic activity express high levels of a pre-B neoplasia-associated molecule

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Cytokine Signaling and Hematopoietic Homeostasis Are Disrupted in Lnk-deficient Mice

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Release of early human hematopoietic progenitors from quiescence by antisense transforming growth factor beta 1 or Rb oligonucleotides.

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Molecular Cloning and Characterization of Mouse TIE and TEK Receptor Tyrosine Kinase Genes and Their Expression in Hematopoietic Stem Cells

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Long-term, multilineage hematopoiesis occurs in the combined absence of β-catenin and γ-catenin

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New Evidence Supporting Megakaryocyte-Erythrocyte Potential of Flk2/Flt3+ Multipotent Hematopoietic Progenitors

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Hematopoiesis in mice lacking the entire granulocyte-macrophage colony- stimulating factor/interleukin-3/interleukin-5 functions

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Transforming growth factor beta 1 directly and reversibly inhibits the initial cell divisions of long-term repopulating hematopoietic stem cells

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Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways

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