AAV Capsid Structure and Cell Interactions

Agbandje-McKenna, Mavis; Kleinschmidt, Jürgen

doi:10.1007/978-1-61779-370-7_3

Cited by 217Virus-based gene therapy researchParvovirus B19 Infection StudiesRNA Interference and Gene Delivery

AAV Capsid Structure and Cell Interactions

Agbandje-McKenna, Mavis, Kleinschmidt, Jürgen·2012·Methods in Molecular Biology

DOI 10.1007/978-1-61779-370-7_3

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Abstract

The Adeno-associated viruses (AAVs) are not associated with any diseases, and their ability to package non-genomic DNA and to transduce different cell/tissue populations has generated significant interest in understanding their basic biology in efforts to improve their utilization for corrective gene delivery. This includes their capsid structure, cellular tropism and interactions for entry, uncoating, replication, DNA packaging, capsid assembly, and antibody neutralization. The human and nonhuman primate AAVs are clustered into serologically distinct genetic clade and serotype groups, which have distinct cellular/tissue tropisms and transduction efficiencies. These properties are highly dependent upon the AAV capsid amino acid sequence, their capsid structure, and their interactions with host cell factors, including cell surface receptors, co-receptors, signaling molecules, proteins involved in host DNA replication, and host-derived antibodies. This chapter reviews the current structural information on AAV capsids and the capsid viral protein regions playing a role in the cellular interactions conferring an infective phenotype, which are then used to annotate the functional regions of the capsid. Based on the current data, the indication is that the AAVs, like other members of the Parvoviridae and other ssDNA viruses that form a T = 1 capsid, have evolved a multifunctional capsid with conserved core regions as is required for efficient capsid trafficking, capsid assembly, and genome packaging. Disparate surface loop structures confer differential receptor recognition and are involved in antibody recognition. The role of structural regions in capsid uncoating remains to be elucidated.

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The unique topology of the AAV capsid confers cellular tropism by differential receptor binding.
“The unique topology of the AAV capsid confers cellular tropism by differential receptor binding.”
From Characterization of a novel adeno-associated viral vector with preferential oligodendrocyte tropism (2016) · cites this paper as [18]
The first step of AAV transduction entails AAV binding to a primary receptor and co-receptor on the cell surface.
“The first step of AAV transduction entails AAV binding to a primary receptor and co-receptor on the cell surface.18”
From Characterization of a novel adeno-associated viral vector with preferential oligodendrocyte tropism (2016) · cites this paper as [18]
AAV capsids have nine variable regions surrounded by conserved regions where the variable regions form loops and clusters on the exterior of the capsid.
“The AAV capsids have nine variable regions surrounded by conserved regions where the variable regions form loops and clusters on the exterior of the capsid.18–19”
From Characterization of a novel adeno-associated viral vector with preferential oligodendrocyte tropism (2016) · cites this paper as [18]
The threefold protrusions are formed from interdigitating loops from two VPs and have the most extensive VP-VP interactions.
“These protrusions are formed from interdigitating loops from two VPs and have the most extensive VP–VP interactions [23,24].”
From Understanding Capsid Assembly and Genome Packaging for Adeno-Associated Viruses (2017) · cites this paper as [24]
The twofold region has the least number of VP-VP interface interactions and represents the thinnest region of the virus capsid shell.
“This region has the least number of VP–VP interface interactions and represents the thinnest region of the virus capsid shell [23,24].”
From Understanding Capsid Assembly and Genome Packaging for Adeno-Associated Viruses (2017) · cites this paper as [24]

Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response
Manno, C. S., Pierce, G. F., Arruda, V. R., Glader, B., Ragni, M., Rasko, J. J. E., Ozelo, M. C., Hoots, K., Blatt, P., Konkle, B., et al. (2006) · Nature Medicine · doi:10.1038/nm1358 · Cited by 2,163 · see citing works
Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy
Gao, G.-P., Alvira, M. R., Wang, L., Calcedo, R., Johnston, J., & Wilson, J. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182412299 · Cited by 1,520 · see citing works
Membrane-Associated Heparan Sulfate Proteoglycan Is a Receptor for Adeno-Associated Virus Type 2 Virions
Summerford, C., & Samulski, R. J. (1998) · Journal of Virology · doi:10.1128/jvi.72.2.1438-1445.1998 · Cited by 1,409 · see citing works
Clades of Adeno-Associated Viruses Are Widely Disseminated in Human Tissues
Gao, G., Vandenberghe, L. H., Alvira, M. R., Lu, Y., Calcedo, R., Zhou, X., & Wilson, J. M. (2004) · Journal of Virology · doi:10.1128/jvi.78.12.6381-6388.2004 · Cited by 1,070 · see citing works
Effect of genome size on AAV vector packaging
Wu, Z., Yang, H., & Colosi, P. (2010) · Molecular Therapy · doi:10.1038/mt.2009.255 · Cited by 1,025 · see citing works
Real-Time Single-Molecule Imaging of the Infection Pathway of an Adeno-Associated Virus
Seisenberger, G., Ried, M. U., Endreß, T., Büning, H., Hallek, M. J., & Bräuchle, C. (2001) · Science · doi:10.1126/science.1064103 · Cited by 819 · see citing works
Cross-Packaging of a Single Adeno-Associated Virus (AAV) Type 2 Vector Genome into Multiple AAV Serotypes Enables Transduction with Broad Specificity
Rabinowitz, J. E., Rolling, F., Li, C., Conrath, H., Xiao, W., Xiao, X., & Samulski, R. J. (2002) · Journal of Virology · doi:10.1128/jvi.76.2.791-801.2002 · Cited by 762 · see citing works
Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors
Ferrari, F. K., Samulski, T., Shenk, T., & Samulski, R. J. (1996) · Journal of Virology · doi:10.1128/jvi.70.5.3227-3234.1996 · Cited by 761 · see citing works
αVβ5 integrin: a co-receptor for adeno-associated virus type 2 infection
Summerford, C., Bartlett, J. S., & Samulski, R. J. (1999) · Nature Medicine · doi:10.1038/4768 · Cited by 711 · see citing works
The atomic structure of adeno-associated virus (AAV-2), a vector for human gene therapy
Xie, Q., Bu, W., Bhatia, S., Hare, J., Somasundaram, T., Azzi, A., & Chapman, M. S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162250899 · Cited by 612 · see citing works
Quantitative analysis of the packaging capacity of recombinant adeno-associated virus
Dong, J.-Y., Fan, P.-D., & Frizzell, R. A. (1996) · Human Gene Therapy · doi:10.1089/hum.1996.7.17-2101 · Cited by 583 · see citing works
Next generation of adeno-associated virus 2 vectors: Point mutations in tyrosines lead to high-efficiency transduction at lower doses
Zhong, L., Li, B., Mah, C. S., Govindasamy, L., Agbandje-McKenna, M., Cooper, M., Herzog, R. W., Zolotukhin, I., Warrington, K. H., Weigel-Van Aken, K. A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802866105 · Cited by 558 · see citing works
Self-citation
Transduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesis
Fisher, K. J., Gao, G. P., Weitzman, M. D., DeMatteo, R. P., Burda, J. F., & Wilson, J. M. (1996) · Journal of Virology · doi:10.1128/jvi.70.1.520-532.1996 · Cited by 546 · see citing works
Infectious entry pathway of adeno-associated virus and adeno-associated virus vectors
Bartlett, J. S., Wilcher, R., & Samulski, R. J. (2000) · Journal of Virology · doi:10.1128/jvi.74.6.2777-2785.2000 · Cited by 532 · see citing works
A Viral Phospholipase A2 Is Required for Parvovirus Infectivity
Zádori, Z., Szelei, J., Lacoste, M.-C., Li, Y., Gariépy, S., Raymond, P., Allaire, M., Nabi, I. R., & Tijssen, P. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00031-4 · Cited by 518 · see citing works
The Three-Dimensional Structure of Canine Parvovirus and Its Functional Implications
Tsao, J., Chapman, M. S., Agbandje, M., Keller, W., Smith, K., Wu, H., Luo, M., Smith, T. J., Rossmann, M. G., Compans, R. W., et al. (1991) · Science · doi:10.1126/science.2006420 · Cited by 512 · see citing works
Use of adeno-associated virus as a mammalian DNA cloning vector: transduction of neomycin resistance into mammalian tissue culture cells.
Hermonat, P. L., & Muzyczka, N. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.20.6466 · Cited by 480 · see citing works
The AAV origin binding protein Rep68 is an ATP-dependent site-specific endonuclease with DNA helicase activity
Im, D., & Muzyczka, N. (1990) · Cell · doi:10.1016/0092-8674(90)90526-k · Cited by 466 · see citing works
Integration of Adeno-Associated Virus (AAV) and Recombinant AAV Vectors
McCarty, D. M., Young, S. M., & Samulski, R. J. (2004) · Annual Review of Genetics · doi:10.1146/annurev.genet.37.110801.143717 · Cited by 450 · see citing works
A recombinant plasmid from which an infectious adeno-associated virus genome can be excised in vitro and its use to study viral replication
Samulski, R. J., Chang, L., & Shenk, T. E. (1987) · Journal of Virology · doi:10.1128/jvi.61.10.3096-3101.1987 · Cited by 449 · see citing works
The 37/67-Kilodalton Laminin Receptor Is a Receptor for Adeno-Associated Virus Serotypes 8, 2, 3, and 9
Akache, B., Grimm, D., Pandey, K., Yant, S. R., Xu, H., & Kay, M. A. (2006) · Journal of Virology · doi:10.1128/jvi.00878-06 · Cited by 430 · see citing works
Adeno-Associated Virus Serotype 4 (AAV4) and AAV5 Both Require Sialic Acid Binding for Hemagglutination and Efficient Transduction but Differ in Sialic Acid Linkage Specificity
Kaludov, N. K., Brown, K. E., Walters, R. W., Zabner, J., & Chiorini, J. A. (2001) · Journal of Virology · doi:10.1128/jvi.75.15.6884-6893.2001 · Cited by 428 · see citing works
Packaging Capacity of Adeno-Associated Virus Serotypes: Impact of Larger Genomes on Infectivity and Postentry Steps
Grieger, J. C., & Samulski, R. J. (2005) · Journal of Virology · doi:10.1128/jvi.79.15.9933-9944.2005 · Cited by 419 · see citing works
Endosomal processing limits gene transfer to polarized airway epithelia by adeno-associated virus
Duan, D., Yue, Y., Yan, Z., Yang, J., & Engelhardt, J. F. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8317 · Cited by 391 · see citing works
Mutational Analysis of the Adeno-Associated Virus Type 2 (AAV2) Capsid Gene and Construction of AAV2 Vectors with Altered Tropism
Wu, P., Xiao, W. S., Conlon, T. J., Hughes, J. A., Agbandje‐McKenna, M., Ferkol, T. W., Flotte, T. R., & Muzyczka, N. (2000) · Journal of Virology · doi:10.1128/jvi.74.18.8635-8647.2000 · Cited by 390 · see citing works
Self-citation
Identification of a heparin-binding motif on adeno-associated virus type 2 capsids
Kern, A., Schmidt, K., Leder, C., Müller, O. J., Wobus, C. E., Bettinger, K., Von der Lieth, C. W., King, J. A., & Kleinschmidt, J. A. (2003) · Journal of Virology · doi:10.1128/jvi.77.20.11072-11081.2003 · Cited by 380 · see citing works
Self-citation
Identification of amino acid residues in the capsid proteins of adeno-associated virus type 2 that contribute to heparan sulfate proteoglycan binding
Opie, S. R., Warrington, Agbandje-McKenna, M., Zolotukhin, S., & Muzyczka, N. (2003) · Journal of Virology · doi:10.1128/jvi.77.12.6995-7006.2003 · Cited by 364 · see citing works
Self-citation
Binding of Adeno-associated Virus Type 5 to 2,3-Linked Sialic Acid Is Required for Gene Transfer
Walters, R. W., Yi, S. M. P., Keshavjee, S. H., Brown, K. E., Welsh, M. J., Chiorini, J. A., & Zabner, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101559200 · Cited by 360 · see citing works
Rapid Uncoating of Vector Genomes Is the Key toEfficient Liver Transduction with Pseudotyped Adeno-Associated VirusVectors
Thomas, C. E., Storm, T. A., Huang, Z., & Kay, M. A. (2004) · Journal of Virology · doi:10.1128/jvi.78.6.3110-3122.2004 · Cited by 358 · see citing works
Identification of PDGFR as a receptor for AAV-5 transduction
Pasquale, G. D., Davidson, B. L., Stein, C. S., Martins, I., Scudiero, D., Monks, A., & Chiorini, J. A. (2003) · Nature Medicine · doi:10.1038/nm929 · Cited by 355 · see citing works
The VP1 capsid protein of adeno-associated virus type 2 is carrying a phospholipase A2 domain required for virus infectivity
Girod, A., Wobus, C. E., Zádori, Z., Ried, M., Leike, K., Tijssen, P., Kleinschmidt, J. A., & Hallek, M. (2002) · Journal of General Virology · doi:10.1099/0022-1317-83-5-973 · Cited by 354 · see citing works
Self-citation
Adeno-associated virus general transduction vectors: analysis of proviral structures
McLaughlin, S. K., Collis, P., Hermonat, P. L., & Muzyczka, N. (1988) · Journal of Virology · doi:10.1128/jvi.62.6.1963-1973.1988 · Cited by 348 · see citing works
DNA helicase‐mediated packaging of adeno‐associated virus type 2 genomes into preformed capsids
King, J. A., Dubielzig, R., Grimm, D., & Kleinschmidt, J. A. (2001) · The EMBO Journal · doi:10.1093/emboj/20.12.3282 · Cited by 338 · see citing works
Self-citation
α2,3 and α2,6 N-Linked Sialic Acids Facilitate Efficient Binding and Transduction by Adeno-Associated Virus Types 1 and 6
Wu, Z., Miller, E. B., Agbandje‐McKenna, M., & Samulski, R. J. (2006) · Journal of Virology · doi:10.1128/jvi.00895-06 · Cited by 327 · see citing works
Self-citation
Rescue of adeno-associated virus from recombinant plasmids: Gene correction within the terminal repeats of AAV
Samulski, R. J., Srivastava, A., Berns, K. I., & Muzyczka, N. (1983) · Cell · doi:10.1016/0092-8674(83)90342-2 · Cited by 297 · see citing works
Serotype-dependent packaging of large genes in adeno-associated viral vectors results in effective gene delivery in mice
Allocca, M., Doria, M., Petrillo, M., Colella, P., Garcia-Hoyos, M., Gibbs, D., Kim, S. R., Maguire, A., Rex, T. S., Di Vicino, U., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34316 · Cited by 292 · see citing works
Intracellular trafficking of adeno-associated virus vectors: routing to the late endosomal compartment and proteasome degradation
Douar, A.-M., Poulard, K., Stockholm, D., & Danos, O. (2001) · Journal of Virology · doi:10.1128/jvi.75.4.1824-1833.2001 · Cited by 282 · see citing works
Terminal N-Linked Galactose Is the Primary Receptor for Adeno-associated Virus 9
Shen, S., Bryant, K. D., Brown, S. M., Randell, S. H., & Asokan, A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.210922 · Cited by 281 · see citing works
Adeno-Associated Virus Type 2 Capsids with Externalized VP1/VP2 Trafficking Domains Are Generated prior to Passage through the Cytoplasm and Are Maintained until Uncoating Occurs in the Nucleus
Sonntag, F., Bleker, S., Leuchs, B., Fischer, R., & Kleinschmidt, J. A. (2006) · Journal of Virology · doi:10.1128/jvi.01056-06 · Cited by 277 · see citing works
Self-citation
Monoclonal Antibodies against the Adeno-Associated Virus Type 2 (AAV-2) Capsid: Epitope Mapping and Identification of Capsid Domains Involved in AAV-2–Cell Interaction and Neutralization of AAV-2 Infection
Wobus, C. E., Hügle-Dörr, B., Girod, A., Petersen, G., Hallek, M., & Kleinschmidt, J. A. (2000) · Journal of Virology · doi:10.1128/jvi.74.19.9281-9293.2000 · Cited by 273 · see citing works
Self-citation
Endocytosis and Nuclear Trafficking of Adeno-Associated Virus Type 2 Are Controlled by Rac1 and Phosphatidylinositol-3 Kinase Activation
Şanlıoğlu, S., Benson, P. K., Yang, J., Atkinson, E. M., Reynolds, T. C., & Engelhardt, J. F. (2000) · Journal of Virology · doi:10.1128/jvi.74.19.9184-9196.2000 · Cited by 269 · see citing works
Structure of Adeno-Associated Virus Serotype 8, a Gene Therapy Vector
Nam, H.-J., Lane, M. D., Padron, E., Gurda, B. L., McKENNA, R. V., Kohlbrenner, E., Aslanidi, G., Byrne, B. J., Muzyczka, N., Zolotukhin, S., et al. (2007) · Journal of Virology · doi:10.1128/jvi.01304-07 · Cited by 256 · see citing works
Self-citation
Epitope Mapping of Human Anti-Adeno-Associated Virus Type 2 Neutralizing Antibodies: Implications for Gene Therapy and Virus Structure
Moskalenko, M., Chen, L., van Roey, M., Donahue, B. A., Snyder, R. O., McArthur, J. G., & Patel, S. D. (2000) · Journal of Virology · doi:10.1128/jvi.74.4.1761-1766.2000 · Cited by 253 · see citing works
Intracellular trafficking of adeno-associated viral vectors
Ding, W., Zhang, L., Yan, Z., & Engelhardt, J. F. (2005) · Gene Therapy · doi:10.1038/sj.gt.3302527 · Cited by 251 · see citing works
Hepatocyte Growth Factor Receptor Is a Coreceptor for Adeno-Associated Virus Type 2 Infection
Kashiwakura, Y., Tamayose, K., Iwabuchi, K., Hirai, Y., Shimada, T., Matsumoto, K., Nakamura, T., Watanabe, M., Oshimi, K., & Daida, H. (2005) · Journal of Virology · doi:10.1128/jvi.79.1.609-614.2005 · Cited by 246 · see citing works
Two novel adeno-associated viruses from cynomolgus monkey: pseudotyping characterization of capsid protein
Mori, S., Wang, L., Takeuchi, T., & Kanda, T. (2004) · Virology · doi:10.1016/j.virol.2004.10.012 · Cited by 240 · see citing works
Single Amino Acid Changes Can Influence Titer, Heparin Binding, and Tissue Tropism in Different Adeno-Associated Virus Serotypes
Wu, Z., Asokan, A., Grieger, J. C., Lakshmanan Govindasamy, A., Agbandje‐McKenna, M., & Samulski, R. J. (2006) · Journal of Virology · doi:10.1128/jvi.01288-06 · Cited by 239 · see citing works
Self-citation
Tyrosine-phosphorylation of AAV2 vectors and its consequences on viral intracellular trafficking and transgene expression
Zhong, L., Li, B., Jayandharan, G., Mah, C. S., Govindasamy, L., Agbandje-McKenna, M., Herzog, R. W., Weigel-Van Aken, K. A., Hobbs, J. A., Zolotukhin, S., et al. (2008) · Virology · doi:10.1016/j.virol.2008.08.027 · Cited by 232 · see citing works
Self-citation
Characterization of Genome Integrity for Oversized Recombinant AAV Vector
Dong, B., Nakai, H., & Xiao, W. (2010) · Molecular Therapy · doi:10.1038/mt.2009.258 · Cited by 230 · see citing works
Quantification of adeno-associated virus particles and empty capsids by optical density measurement
Sommer, J. Ü. M., Smith, P. H., Parthasarathy, S., Isaacs, J., Vijay, S., Kieran, J., Powell, S. K., McClelland, A., & Wright, J. F. (2003) · Molecular Therapy · doi:10.1016/s1525-0016(02)00019-9 · Cited by 230 · see citing works
Adeno-associated virus 2 co-receptors?-first reply
Qing, K., Hansen, J. J., & Srivastava, A. (1999) · Nature Medicine · doi:10.1038/8526 · Cited by 227 · see citing works
Ubiquitination of both adeno-associated virus type 2 and 5 capsid proteins affects the transduction efficiency of recombinant vectors
Yan, Z., Zak, R., Luxton, G. W. G., Ritchie, T. C., Bantel-Schaal, U., & Engelhardt, J. F. (2002) · Journal of Virology · doi:10.1128/jvi.76.5.2043-2053.2002 · Cited by 222 · see citing works
Subcellular compartmentalization of adeno-associated virus type 2 assembly
Wistuba, A., Kern, A., Weger, S., Grimm, D., & Kleinschmidt, J. A. (1997) · Journal of Virology · doi:10.1128/jvi.71.2.1341-1352.1997 · Cited by 219 · see citing works
Self-citation
Functional implications of the structure of the murine parvovirus, minute virus of mice
Agbandje-McKenna, M., Llamas-Saiz, A. L., Wang, F., Tattersall, P., & Rossmann, M. G. (1998) · Structure · doi:10.1016/s0969-2126(98)00137-3 · Cited by 218 · see citing works
Self-citation
Adeno-Associated Virus Type 2 VP2 Capsid Protein Is Nonessential and Can Tolerate Large Peptide Insertions at Its N Terminus
Warrington, K. H., Gorbatyuk, O. S., Harrison, J. K., Opie, S. R., Zolotukhin, S., & Muzyczka, N. (2004) · Journal of Virology · doi:10.1128/jvi.78.12.6595-6609.2004 · Cited by 205 · see citing works
Structurally mapping the diverse phenotype of adeno-associated virus serotype 4
Govindasamy, L., Padron, E., McKenna, R., Muzyczka, N., Kaludov, N., Chiorini, J. A., & Agbandje-McKenna, M. (2006) · Journal of Virology · doi:10.1128/jvi.01536-06 · Cited by 205 · see citing works
Self-citation
The structure of human parvovirus B19
Kaufmann, B., Simpson, A. A., & Rossmann, M. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402992101 · Cited by 204 · see citing works
Hybrid Vectors Based on Adeno-Associated Virus Serotypes 2 and 5 for Muscle-Directed Gene Transfer
Hildinger, M., Auricchio, A., Gao, G., Wang, L., Chirmule, N. B., & Wilson, J. M. (2001) · Journal of Virology · doi:10.1128/jvi.75.13.6199-6203.2001 · Cited by 204 · see citing works
Mutations on the External Surfaces of Adeno-AssociatedVirus Type 2 Capsids That Affect Transduction andNeutralization
Lochrie, M. A., Tatsuno, G. P., Christie, B., McDonnell, J. W., Zhou, S., Surosky, R., Pierce, G. F., & Colosi, P. (2006) · Journal of Virology · doi:10.1128/jvi.80.2.821-834.2006 · Cited by 201 · see citing works
Mutational analysis of narrow pores at the fivefold symmetry axes of adeno-associated virus type 2 capsids reveals a dual role in genome packaging and activation of phospholipase A2 activity
Bleker, S., Sonntag, F., & Kleinschmidt, J. A. (2005) · Journal of Virology · doi:10.1128/jvi.79.4.2528-2540.2005 · Cited by 200 · see citing works
Self-citation
A conformational change in the adeno-associated virus type 2 capsid leads to the exposure of hidden VP1 N termini
Kronenberg, S., Böttcher, B., von der Lieth, C. W., Bleker, S., & Kleinschmidt, J. A. (2005) · Journal of Virology · doi:10.1128/jvi.79.9.5296-5303.2005 · Cited by 198 · see citing works
Self-citation
Titration of AAV-2 particles via a novel capsid ELISA: packaging of genomes can limit production of recombinant AAV-2
Grimm, D., Kern, A., Pawlita, M., Ferrari, F. K., Samulski, R. J., & Kleinschmidt, J. A. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300946 · Cited by 195 · see citing works
Self-citation
The AAV9 receptor and its modification to improve in vivo lung gene transfer in mice
Bell, C. L., Vandenberghe, L. H., Bell, P., Limberis, M. P., Gao, G.-P., Van Vliet, K., Agbandje-McKenna, M., & Wilson, J. M. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57367 · Cited by 190 · see citing works
Self-citation
Parvoviral virions deploy a capsid-tethered lipolytic enzyme to breach the endosomal membrane during cell entry
Farr, G. A., Zhang, L., & Tattersall, P. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508477102 · Cited by 188 · see citing works
Dynamin Is Required for Recombinant Adeno-Associated Virus Type 2 Infection
Duan, D., Li, Q., Kao, A. W., Yue, Y., Pessin, J. E., & Engelhardt, J. F. (1999) · Journal of Virology · doi:10.1128/jvi.73.12.10371-10376.1999 · Cited by 186 · see citing works
Adeno-Associated Virus Type 2 Contains an Integrin α5β1 Binding Domain Essential for Viral Cell Entry
Asokan, A., Hamra, J. B., Govindasamy, L., Agbandje-McKenna, M., & Samulski, R. J. (2006) · Journal of Virology · doi:10.1128/jvi.00843-06 · Cited by 183 · see citing works
Self-citation
Immunity to adeno-associated virus vectors in animals and humans: a continued challenge
Zaiss, A. K., & Muruve, D. A. (2008) · Gene Therapy · doi:10.1038/gt.2008.54 · Cited by 179 · see citing works
Separate basic region motifs within the adeno-associated virus capsid proteins are essential for infectivity and assembly
Grieger, J. C., Snowdy, S., & Samulski, R. J. (2006) · Journal of Virology · doi:10.1128/jvi.02723-05 · Cited by 172 · see citing works
Cross-Dressing the Virion: the Transcapsidation of Adeno-Associated Virus Serotypes Functionally Defines Subgroups
Rabinowitz, J. E., Bowles, D. E., Faust, S. M., Ledford, J. G., Cunningham, S. E., & Samulski, R. J. (2004) · Journal of Virology · doi:10.1128/jvi.78.9.4421-4432.2004 · Cited by 172 · see citing works
Polarity Influences the Efficiency of Recombinant Adenoassociated Virus Infection in Differentiated Airway Epithelia
Duan, D., Yue, Y., Yan, Z., McCray, P. B., & Engelhardt, J. F. (1998) · Human Gene Therapy · doi:10.1089/hum.1998.9.18-2761 · Cited by 171 · see citing works
Insertional Mutagenesis of the Adeno-Associated Virus Type 2 (AAV2) Capsid Gene and Generation of AAV2 Vectors Targeted to Alternative Cell-Surface Receptors
Shi, W., Arnold, G. S., & Bartlett, J. S. (2001) · Human Gene Therapy · doi:10.1089/104303401750476212 · Cited by 167 · see citing works
Evidence for the Failure of Adeno-associated Virus Serotype 5 to Package a Viral Genome ≥8.2 kb
Lai, Y., Yue, Y., & Duan, D. (2010) · Molecular Therapy · doi:10.1038/mt.2009.256 · Cited by 166 · see citing works
Mutagenesis of an AUG codon in the adeno-associated virus rep gene: Effects on viral DNA replication
Chejanovsky, N., & Carter, B. J. (1989) · Virology · doi:10.1016/0042-6822(89)90227-4 · Cited by 165 · see citing works
Adeno-Associated Virus Type 12 (AAV12): a Novel AAV Serotype with Sialic Acid- and Heparan Sulfate Proteoglycan-Independent Transduction Activity
Schmidt, M., Voutetakis, A., Afione, S. A., Zheng, C., Mandikian, D., & Chiorini, J. A. (2007) · Journal of Virology · doi:10.1128/jvi.02012-07 · Cited by 162 · see citing works
Identification of linear DNA sequences that specifically bind the adeno-associated virus Rep protein
McCarty, D. M., Pereira, D. J., Zolotukhin, I., Zhou, X., Ryan, J. H., & Muzyczka, N. (1994) · Journal of Virology · doi:10.1128/jvi.68.8.4988-4997.1994 · Cited by 161 · see citing works
In vitro resolution of covalently joined AAV chromosome ends
Snyder, R. O., Samulski, R. J., & Muzyczka, N. (1990) · Cell · doi:10.1016/0092-8674(90)90720-y · Cited by 161 · see citing works
Electron cryo‐microscopy and image reconstruction of adeno‐associated virus type 2 empty capsids
Kronenberg, S., Kleinschmidt, J. A., & Böttcher, B. (2001) · The EMBO Reports · doi:10.1093/embo-reports/kve234 · Cited by 161 · see citing works
Self-citation
Generation and characterization of chimeric recombinant AAV vectors
Hauck, B., Chen, L., & Xiao, W. (2003) · Molecular Therapy · doi:10.1016/s1525-0016(03)00012-1 · Cited by 160 · see citing works
Enhancement of Adeno-Associated Virus Infection by Mobilizing Capsids into and Out of the Nucleolus
Johnson, J. S., & Samulski, R. J. (2008) · Journal of Virology · doi:10.1128/jvi.02309-08 · Cited by 158 · see citing works
The VP1 N-Terminal Sequence of Canine Parvovirus Affects Nuclear Transport of Capsids and Efficient Cell Infection
Vihinen‐Ranta, M., Wang, D., Weichert, W. S., & Parrish, C. R. (2002) · Journal of Virology · doi:10.1128/jvi.76.4.1884-1891.2002 · Cited by 154 · see citing works
A novel 165-base-pair terminal repeat sequence is the sole cis requirement for the adeno-associated virus life cycle
Xiao, X., Xiao, W., Li, J., & Samulski, R. J. (1997) · Journal of Virology · doi:10.1128/jvi.71.2.941-948.1997 · Cited by 154 · see citing works
Green Fluorescent Protein-Tagged Adeno-Associated Virus Particles Allow the Study of Cytosolic and Nuclear Trafficking
Lux, K., Goerlitz, N., Schlemminger, S., Perabò, L., Goldnau, D., Endell, J., Leike, K., Kofler, D. M., Finke, S., Hallek, M. J., et al. (2005) · Journal of Virology · doi:10.1128/jvi.79.18.11776-11787.2005 · Cited by 153 · see citing works
Impaired Intracellular Trafficking of Adeno-Associated Virus Type 2 Vectors Limits Efficient Transduction of Murine Fibroblasts
Hansen, J. J., Qing, K., Kwon, H., Mah, C. S., & Srivastava, A. (2000) · Journal of Virology · doi:10.1128/jvi.74.2.992-996.2000 · Cited by 147 · see citing works
Intermediates of adeno-associated virus type 2 assembly: identification of soluble complexes containing Rep and Cap proteins
Wistuba, A., Weger, S., Kern, A., & Kleinschmidt, J. A. (1995) · Journal of Virology · doi:10.1128/jvi.69.9.5311-5319.1995 · Cited by 147 · see citing works
Self-citation
A Dual Role of EGFR Protein Tyrosine Kinase Signaling in Ubiquitination of AAV2 Capsids and Viral Second-strand DNA Synthesis
Li, Z., Zhao, W., Wu, J., Li, B., Zolotukhin, S., Lakshmanan Govindasamy, A., Agbandje‐McKenna, M., & Srivastava, A. (2007) · Molecular Therapy · doi:10.1038/sj.mt.6300170 · Cited by 146 · see citing works
Self-citation
Structural Characterization of the Dual Glycan Binding Adeno-Associated Virus Serotype 6
Ng, R., Lakshmanan Govindasamy, A., Gurda, B. L., McKENNA, R. V., Kozyreva, O. G., Samulski, R. J., Parent, K. N., Baker, T. S., & Agbandje‐McKenna, M. (2010) · Journal of Virology · doi:10.1128/jvi.01235-10 · Cited by 143 · see citing works
Self-citation
Features of the adeno-associated virus origin involved in substrate recognition by the viral Rep protein
Snyder, R. O., Im, D., Ni, T., Xiao, X., Samulski, R. J., & Muzyczka, N. (1993) · Journal of Virology · doi:10.1128/jvi.67.10.6096-6104.1993 · Cited by 142 · see citing works
Recruitment of wild-type and recombinant adeno-associated virus into adenovirus replication centers
Weitzman, M. D., Fisher, K. J., & Wilson, J. M. (1996) · Journal of Virology · doi:10.1128/jvi.70.3.1845-1854.1996 · Cited by 140 · see citing works
Distinct Classes of Proteasome-Modulating Agents Cooperatively Augment Recombinant Adeno-Associated Virus Type 2 and Type 5-Mediated Transduction from the Apical Surfaces of Human Airway Epithelia
Yan, Z., Zak, R., Zhang, Y., Ding, W., Godwin, S., Munson, K., Peluso, R., & Engelhardt, J. F. (2004) · Journal of Virology · doi:10.1128/jvi.78.6.2863-2874.2004 · Cited by 138 · see citing works
Adenovirus-Facilitated Nuclear Translocation of Adeno-Associated Virus Type 2
Xiao, W. S., Warrington, K. H., Hearing, P., Hughes, J. A., & Muzyczka, N. (2002) · Journal of Virology · doi:10.1128/jvi.76.22.11505-11517.2002 · Cited by 137 · see citing works
Insertional Mutagenesis of AAV2 Capsid and the Production of Recombinant Virus
Rabinowitz, J. E., Xiao, W., & Samulski, R. J. (1999) · Virology · doi:10.1006/viro.1999.0045 · Cited by 136 · see citing works
Canine Parvovirus Capsid Structure, Analyzed at 2.9 Å Resolution
Xie, Q., & Chapman, M. S. (1996) · Journal of Molecular Biology · doi:10.1006/jmbi.1996.0657 · Cited by 134 · see citing works
The Mre11/Rad50/Nbs1 complex limits adeno-associated virus transduction and replication
Schwartz, R. A., Palacios, J. A., Cassell, G. D., Adam, S., Giacca, M., & Weitzman, M. D. (2007) · Journal of Virology · doi:10.1128/jvi.01523-07 · Cited by 130 · see citing works
Adeno-associated virus type 2-mediated gene transfer: altered endocytic processing enhances transduction efficiency in murine fibroblasts
Hansen, J., Qing, K., & Srivastava, A. (2001) · Journal of Virology · doi:10.1128/jvi.75.9.4080-4090.2001 · Cited by 129 · see citing works
Endocytosis of Adeno-Associated Virus Type 5 Leads to Accumulation of Virus Particles in the Golgi Compartment
Bantel‐Schaal, U., Hub, B., & Kartenbeck, J. (2002) · Journal of Virology · doi:10.1128/jvi.76.5.2340-2349.2002 · Cited by 127 · see citing works
Intrinsic phospholipase A2 activity of adeno-associated virus is involved in endosomal escape of incoming particles
Stahnke, S., Lux, K., Uhrig, S., Kreppel, F., Hösel, M., Coutelle, O., Ogris, M., Hallek, M. J., & Büning, H. (2010) · Virology · doi:10.1016/j.virol.2010.09.025 · Cited by 126 · see citing works
Adeno-associated virus-2 and its primary cellular receptor—Cryo-EM structure of a heparin complex
O’Donnell, J., Taylor, K. A., & Chapman, M. S. (2009) · Virology · doi:10.1016/j.virol.2008.11.037 · Cited by 126 · see citing works
Adeno-Associated Virus Type 2-Mediated Gene Transfer: Role of Cellular FKBP52 Protein in Transgene Expression
Qing, K., Hansen, J., Weigel-Kelley, K. A., Tan, M., Zhou, S., & Srivastava, A. (2001) · Journal of Virology · doi:10.1128/jvi.75.19.8968-8976.2001 · Cited by 126 · see citing works
Characterization of Tissue Tropism Determinants of Adeno-Associated Virus Type 1
Hauck, B., & Xiao, W. (2003) · Journal of Virology · doi:10.1128/jvi.77.4.2768-2774.2003 · Cited by 124 · see citing works
Controlled Conformational Transitions in the MVM Virion Expose the VP1 N-Terminus and Viral Genome without Particle Disassembly
Cotmore, S. F., D’Abramo, A., Ticknor, C. M., & Tattersall, P. J. (1999) · Virology · doi:10.1006/viro.1998.9520 · Cited by 121 · see citing works
Adeno-Associated Virus Type 2-Mediated Gene Transfer: Correlation of Tyrosine Phosphorylation of the Cellular Single-Stranded D Sequence-Binding Protein with Transgene Expression in Human Cells In Vitro and Murine Tissues In Vivo
Qing, K., Khuntirat, B., Mah, C. S., Kube, D. M., Wang, X.-S., Ponnazhagan, S., Zhou, S., Dwarki, V., Yöder, M. C., & Srivastava, A. (1998) · Journal of Virology · doi:10.1128/jvi.72.2.1593-1599.1998 · Cited by 121 · see citing works
Sequence requirements for binding of Rep68 to the adeno-associated virus terminal repeats
Ryan, J. H., Zolotukhin, S., & Muzyczka, N. (1996) · Journal of Virology · doi:10.1128/jvi.70.3.1542-1553.1996 · Cited by 119 · see citing works
Role of tyrosine phosphorylation of a cellular protein in adeno-associated virus 2-mediated transgene expression
Qing, K., Wang, X.-S., Kube, D. M., Ponnazhagan, S., Bajpai, A., & Srivastava, A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.10879 · Cited by 118 · see citing works
Release of canine parvovirus from endocytic vesicles
Suikkanen, S., Antila, M., Jaatinen, A., Vihinen-Ranta, M., & Vuento, M. (2003) · Virology · doi:10.1016/j.virol.2003.08.031 · Cited by 115 · see citing works
Structure of Adeno-Associated Virus Serotype 5
Walters, R. W., Agbandje-McKenna, M., Bowman, V. D., Moninger, T. O., Olson, N. H., Seiler, M., Chiorini, J. A., Baker, T. S., & Zabner, J. (2004) · Journal of Virology · doi:10.1128/jvi.78.7.3361-3371.2004 · Cited by 114 · see citing works
Self-citation
Low pH-Dependent Endosomal Processing of the Incoming Parvovirus Minute Virus of Mice Virion Leads to Externalization of the VP1 N-Terminal Sequence (N-VP1), N-VP2 Cleavage, and Uncoating of the Full-Length Genome
Mani, B., Baltzer, C., Valle, N., Almendral, J. M., Kempf, C., & Ros, C. (2005) · Journal of Virology · doi:10.1128/jvi.80.2.1015-1024.2006 · Cited by 113 · see citing works
Combinations of Two Capsid Regions Controlling Canine Host Range Determine Canine Transferrin Receptor Binding by Canine and Feline Parvoviruses
Hueffer, K., Lakshmanan Govindasamy, A., Agbandje‐McKenna, M., & Parrish, C. R. (2003) · Journal of Virology · doi:10.1128/jvi.77.18.10099-10105.2003 · Cited by 111 · see citing works
Self-citation
Cell-Type-Specific Characteristics Modulate the Transduction Efficiency of Adeno-Associated Virus Type 2 and Restrain Infection of Endothelial Cells
Pajusola, K., Gruchała, M., Joch, H., Lüscher, T. F., Ylä‐Herttuala, S., & Büeler, H. (2002) · Journal of Virology · doi:10.1128/jvi.76.22.11530-11540.2002 · Cited by 111 · see citing works
Heparin binding induces conformational changes in Adeno-associated virus serotype 2
Levy, H. C., Bowman, V. D., Govindasamy, L., McKenna, R., Nash, K., Warrington, K., Chen, W., Muzyczka, N., Yan, X., Baker, T. S., et al. (2009) · Journal of Structural Biology · doi:10.1016/j.jsb.2008.12.002 · Cited by 110 · see citing works
Self-citation
Assembly of viruslike particles by recombinant structural proteins of adeno-associated virus type 2 in insect cells
Ruffing, M., Zentgraf, H., & Kleinschmidt, J. A. (1992) · Journal of Virology · doi:10.1128/jvi.66.12.6922-6930.1992 · Cited by 109 · see citing works
Self-citation
Structure of Adeno-Associated Virus Type 4
Padron, E., Bowman, V. D., Kaludov, N. K., Lakshmanan Govindasamy, A., Levy, H. C., Nick, P., McKENNA, R. V., Muzyczka, N., Chiorini, J. A., Baker, T. S., et al. (2005) · Journal of Virology · doi:10.1128/jvi.79.8.5047-5058.2005 · Cited by 108 · see citing works
Self-citation
Replication of adeno-associated virus DNA
Senapathy, P., Tratschin, J.-D., & Carter, B. J. (1984) · Journal of Molecular Biology · doi:10.1016/0022-2836(84)90303-6 · Cited by 107 · see citing works
Identification of a DNA-binding domain in the amino terminus of adeno-associated virus Rep proteins
Owens, R. A., Weitzman, M. D., Kyöstió, S. R., & Carter, B. J. (1993) · Journal of Virology · doi:10.1128/jvi.67.2.997-1005.1993 · Cited by 107 · see citing works
Assembly of adeno-associated virus
Myers, M. W., & Carter, B. J. (1980) · Virology · doi:10.1016/0042-6822(80)90071-9 · Cited by 107 · see citing works
The structure of adeno-associated virus serotype 3B (AAV-3B): Insights into receptor binding and immune evasion
Lerch, T. F., Xie, Q., & Chapman, M. S. (2010) · Virology · doi:10.1016/j.virol.2010.03.027 · Cited by 107 · see citing works
Cryo-electron microscopy studies of empty capsids of human parvovirus B19 complexed with its cellular receptor.
Chipman, P. R., Agbandje‐McKenna, M., Kajigaya, S., Brown, K. E., Young, N. S., Baker, T. S., & Rossmann, M. G. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.15.7502 · Cited by 106 · see citing works
Self-citation
Cellular Proteins Required for Adeno-Associated Virus DNA Replication in the Absence of Adenovirus Coinfection
Ni, T.-H., McDonald, W. F., Zolotukhin, I., Melendy, T., Waga, S., Stillman, B., & Muzyczka, N. (1998) · Journal of Virology · doi:10.1128/jvi.72.4.2777-2787.1998 · Cited by 106 · see citing works
Adeno-Associated Virus Type 2 Protein Interactions: Formation of Pre-Encapsidation Complexes
Dubielzig, R., King, J., Weger, S., Kern, A., & Kleinschmidt, J. A. (1999) · Journal of Virology · doi:10.1128/jvi.73.11.8989-8998.1999 · Cited by 105 · see citing works
Self-citation
Rescue and replication of adeno-associated virus type 2 as well as vector DNA sequences from recombinant plasmids containing deletions in the viral inverted terminal repeats: Selective encapsidation of viral genomes in progeny virions
Wang, X. S., Ponnazhagan, S., & Srivastava, A. (1996) · Journal of Virology · doi:10.1128/jvi.70.3.1668-1677.1996 · Cited by 104 · see citing works
Efficient Transduction of Vascular Endothelial Cells with Recombinant Adeno-Associated Virus Serotype 1 and 5 Vectors
Chen, S., Kapturczak, M., Loiler, S., Zolotukhin, S., Glushakova, O. Y., Madsen, K., Samulski, R. J., Hauswirth, W. W., Campbell‐Thompson, M., Berns, K. I., et al. (2005) · Human Gene Therapy · doi:10.1089/hum.2005.16.235 · Cited by 102 · see citing works
Sequence requirements for stable binding and function of Rep68 on the adeno-associated virus type 2 inverted terminal repeats
Chiorini, J. A., Wiener, S. M., Owens, R. A., Kyöstió, S. R., Kotin, R. M., & Safer, B. (1994) · Journal of Virology · doi:10.1128/jvi.68.11.7448-7457.1994 · Cited by 101 · see citing works
rAAV2 traffics through both the late and the recycling endosomes in a dose-dependent fashion
Ding, W., Zhang, L. N., Yeaman, C. A., & Engelhardt, J. F. (2006) · Molecular Therapy · doi:10.1016/j.ymthe.2005.12.002 · Cited by 99 · see citing works
Molecular Characterization of Adeno-Associated Viruses Infecting Children
Chen, C., Jensen, R. L., Schnepp, B. C., Connell, M. J., SHELL, R. D., Sferra, T. J., Bartlett, J. S., Clark, K. R., & Johnson, P. R. (2005) · Journal of Virology · doi:10.1128/jvi.79.23.14781-14792.2005 · Cited by 99 · see citing works
The packaging capacity of adeno‐associated virus (AAV) and the potential for <i>wild‐type‐plus</i> AAV gene therapy vectors
Hermonat, P. L., Quirk, J. G., Bishop, B. M., & Han, L. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00311-6 · Cited by 98 · see citing works
Intracellular Viral Processing, Not Single-Stranded DNA Accumulation, Is Crucial for Recombinant Adeno-Associated Virus Transduction
Hauck, B., Zhao, W., High, K. A., & Xiao, W. (2004) · Journal of Virology · doi:10.1128/jvi.78.24.13678-13686.2004 · Cited by 98 · see citing works
Asymmetric binding of transferrin receptor to parvovirus capsids
Hafenstein, S. L., Palermo, L. M., Kostyuchenko, V. A., Xiao, C., Morais, M. C., Nelson, C. D. S., Bowman, V. D., Battisti, A. J., Chipman, P. R., Parrish, C. R., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701574104 · Cited by 96 · see citing works
Infection of Purified Nuclei by Adeno-associated Virus 2
Hansen, J. J., Qing, K., & Srivastava, A. (2001) · Molecular Therapy · doi:10.1006/mthe.2001.0457 · Cited by 95 · see citing works
Structures of Host Range-Controlling Regions of the Capsids of Canine and Feline Parvoviruses and Mutants
Lakshmanan Govindasamy, A., Hueffer, K., Parrish, C. R., & Agbandje‐McKenna, M. (2003) · Journal of Virology · doi:10.1128/jvi.77.22.12211-12221.2003 · Cited by 95 · see citing works
Self-citation
Detection of intact rAAV particles up to 6 years after successful gene transfer in the retina of dogs and primates
Stieger, K., Schroeder, J., Provost, N., Mendes-Madeira, A., Belbellaa, B., Meur, G. L., Weber, M., Deschamps, J.-Y., Lorenz, B., Moullier, P., et al. (2009) · Molecular Therapy · doi:10.1038/mt.2008.283 · Cited by 88 · see citing works
A 110-kDa Nuclear Shuttle Protein, Nucleolin, Specifically Binds to Adeno-Associated Virus Type 2 (AAV-2) Capsid
Qiu, J., & Brown, K. E. (1999) · Virology · doi:10.1006/viro.1999.9664 · Cited by 86 · see citing works
Structural Determinants of Tissue Tropism and In Vivo Pathogenicity for the Parvovirus Minute Virus of Mice
Kontou, M., Lakshmanan Govindasamy, A., Nam, H.-J., Bryant, N. D., Llamas-Saiz, A. L., Foces‐Foces, C., Hernando, E., Rubio, M., McKENNA, R. V., Almendral, J. M., et al. (2005) · Journal of Virology · doi:10.1128/jvi.79.17.10931-10943.2005 · Cited by 85 · see citing works
Self-citation
A Two-hybrid Screen Identifies Cathepsins B and L as Uncoating Factors for Adeno-associated Virus 2 and 8
Akache, B., Grimm, D., Shen, X., Fuess, S., Yant, S. R., Glazer, D. S., Park, J., & Kay, M. A. (2007) · Molecular Therapy · doi:10.1038/sj.mt.6300053 · Cited by 85 · see citing works
Processing of recombinant AAV genomes occurs in specific nuclear structures that overlap with foci of DNA-damage-response proteins
Cervelli, T., Palacios, J. A., Zentilin, L., Mano, M., Schwartz, R. A., Weitzman, M. D., & Giacca, M. (2008) · Journal of Cell Science · doi:10.1242/jcs.003632 · Cited by 84 · see citing works
Surface-exposed adeno-associated virus Vp1-NLS capsid fusion protein rescues infectivity of noninfectious wild-type Vp2/Vp3 and Vp3-only capsids but not that of fivefold pore mutant virions
Grieger, J. C., Johnson, J. S., Gurda-Whitaker, B., Agbandje-McKenna, M., & Samulski, R. J. (2007) · Journal of Virology · doi:10.1128/jvi.00580-07 · Cited by 83 · see citing works
Self-citation
Role of the Adenovirus DNA-Binding Protein in In Vitro Adeno-Associated Virus DNA Replication
Ward, P., Dean, F. B., O’Donnell, M. E., & Berns, K. I. (1998) · Journal of Virology · doi:10.1128/jvi.72.1.420-427.1998 · Cited by 83 · see citing works
Biochemical Characterization of Adeno-Associated Virus Rep68 DNA Helicase and ATPase Activities
Zhou, X., Zolotukhin, I., Im, D., & Muzyczka, N. (1999) · Journal of Virology · doi:10.1128/jvi.73.2.1580-1590.1999 · Cited by 80 · see citing works
Host-Selected Amino Acid Changes at the Sialic Acid Binding Pocket of the Parvovirus Capsid Modulate Cell Binding Affinity and Determine Virulence
López-Bueno, A., Rubio, M., Bryant, N. D., McKENNA, R. V., Agbandje‐McKenna, M., & Almendral, J. M. (2006) · Journal of Virology · doi:10.1128/jvi.80.3.1563-1573.2006 · Cited by 79 · see citing works
Self-citation
Impact of Capsid Conformation and Rep-Capsid Interactions on Adeno-Associated Virus Type 2 Genome Packaging
Bleker, S., Pawlita, M., & Kleinschmidt, J. A. (2006) · Journal of Virology · doi:10.1128/jvi.80.2.810-820.2006 · Cited by 75 · see citing works
Self-citation
Development of AAV serotype-specific ELISAs using novel monoclonal antibodies
Kuck, D., Kern, A., & Kleinschmidt, J. A. (2007) · Journal of Virological Methods · doi:10.1016/j.jviromet.2006.10.005 · Cited by 74 · see citing works
Self-citation
Molecular Characterization of the Heparin-Dependent Transduction Domain on the Capsid of a Novel Adeno-Associated Virus Isolate, AAV(VR-942)
Schmidt, M., Lakshmanan Govindasamy, A., Afione, S. A., Kaludov, N., Agbandje‐McKenna, M., & Chiorini, J. A. (2008) · Journal of Virology · doi:10.1128/jvi.00672-08 · Cited by 74 · see citing works
Self-citation
Second-Strand Genome Conversion of Adeno-Associated Virus Type 2 (AAV-2) and AAV-5 Is Not Rate Limiting following Apical Infection of Polarized Human Airway Epithelia
Ding, W., Yan, Z., Žák, R., Saavedra, M. T., Rodman, D. M., & Engelhardt, J. F. (2003) · Journal of Virology · doi:10.1128/jvi.77.13.7361-7366.2003 · Cited by 72 · see citing works
Viral Transport of DNA Damage That Mimics a Stalled Replication Fork
Jurvansuu, J., Raj, K., Stasiak, A., & Beard, P. (2004) · Journal of Virology · doi:10.1128/jvi.79.1.569-580.2005 · Cited by 71 · see citing works
VP2 Cleavage and the Leucine Ring at the Base of the Fivefold Cylinder Control pH-Dependent Externalization of both the VP1 N Terminus and the Genome of Minute Virus of Mice
Farr, G. A., Cotmore, S. F., & Tattersall, P. J. (2005) · Journal of Virology · doi:10.1128/jvi.80.1.161-171.2006 · Cited by 71 · see citing works
Nuclear Transport of the Major Capsid Protein Is Essential for Adeno-Associated Virus Capsid Formation
Hoque, M., Ishizu, K., Matsumoto, A., Han, S., Arisaka, F., Takayama, M., Suzuki, K., Kenzo, K. A. T. O., Kanda, T., Watanabe, H., et al. (1999) · Journal of Virology · doi:10.1128/jvi.73.9.7912-7915.1999 · Cited by 70 · see citing works
Role of cellular FKBP52 protein in intracellular trafficking of recombinant adeno-associated virus 2 vectors
Zhao, W., Li, Z., Wu, J., Chen, L., Qing, K., Weigel-Kelley, K. A., Larsen, S. H., Shou, W., Warrington, K. H., & Srivastava, A. (2006) · Virology · doi:10.1016/j.virol.2006.04.042 · Cited by 69 · see citing works
Adeno-associated virus (AAV)-7 and -8 poorly transduce vascular endothelial cells and are sensitive to proteasomal degradation
Denby, L., Nicklin, S., & Baker, A. H. (2005) · Gene Therapy · doi:10.1038/sj.gt.3302564 · Cited by 69 · see citing works
Colocalization of adeno-associated virus Rep and capsid proteins in the nuclei of infected cells
Hunter, L. A., & Samulski, R. J. (1992) · Journal of Virology · doi:10.1128/jvi.66.1.317-324.1992 · Cited by 68 · see citing works
Complete In Vitro Reconstitution of Adeno-Associated Virus DNA Replication Requires the Minichromosome Maintenance Complex Proteins
Nash, K. R., Chen, W., & Muzyczka, N. (2007) · Journal of Virology · doi:10.1128/jvi.01968-07 · Cited by 68 · see citing works
A Common Mechanism for Cytoplasmic Dynein-Dependent Microtubule Binding Shared among Adeno-Associated Virus and Adenovirus Serotypes
Kelkar, S., De, B. P., Gao, G., Wilson, J. M., Crystal, R. G., & Leopold, P. L. (2006) · Journal of Virology · doi:10.1128/jvi.00481-06 · Cited by 67 · see citing works
A conserved leucine that constricts the pore through the capsid fivefold cylinder plays a central role in parvoviral infection
Farr, G. A., & Tattersall, P. J. (2004) · Virology · doi:10.1016/j.virol.2004.03.006 · Cited by 67 · see citing works
The Rep Protein of Adeno-Associated Virus Type 2 Interacts with Single-Stranded DNA-Binding Proteins That Enhance Viral Replication
Stracker, T. H., Cassell, G. D., Ward, P., Loo, Y., van Breukelen, B., Carrington-Lawrence, S. D., Hamatake, R. K., van der Vliet, P. C., Weller, S. K., Melendy, T., et al. (2003) · Journal of Virology · doi:10.1128/jvi.78.1.441-453.2004 · Cited by 67 · see citing works
Adeno-associated virus interactions with B23/Nucleophosmin: Identification of sub-nucleolar virion regions
Bevington, J. M., Needham, P. G., Verrill, K. C., Collaco, R. F., Basrur, V., & Trempe, J. P. (2007) · Virology · doi:10.1016/j.virol.2006.07.050 · Cited by 65 · see citing works
Parvoviral nuclear import: bypassing the host nuclear-transport machinery
Cohen, S., Behzad, A. R., Carroll, J. B., & Panté, N. (2006) · Journal of General Virology · doi:10.1099/vir.0.82232-0 · Cited by 65 · see citing works
Adeno-Associated Virus Type 2-Mediated Gene Transfer: Role of Cellular T-Cell Protein Tyrosine Phosphatase in Transgene Expression in Established Cell Lines In Vitro and Transgenic Mice In Vivo
Qing, K., Li, W., Li, Z., Tan, M., Hansen, J. J., Weigel-Kelley, K. A., Chen, L., Yöder, M. C., & Srivastava, A. (2003) · Journal of Virology · doi:10.1128/jvi.77.4.2741-2746.2003 · Cited by 64 · see citing works
In Vitro Packaging of Adeno-Associated Virus DNA
Zhou, X., & Muzyczka, N. (1998) · Journal of Virology · doi:10.1128/jvi.72.4.3241-3247.1998 · Cited by 63 · see citing works
Adeno-associated virus type 2 DNA replication in vivo: Mutation analyses of the D sequence in viral inverted terminal repeats
Wang, X. S., Qing, K., Ponnazhagan, S., & Srivastava, A. (1997) · Journal of Virology · doi:10.1128/jvi.71.4.3077-3082.1997 · Cited by 61 · see citing works
Parvovirus uncoating in vitro reveals a mechanism of DNA release without capsid disassembly and striking differences in encapsidated DNA stability
Ros, C., Baltzer, C., Mani, B., & Kempf, C. (2005) · Virology · doi:10.1016/j.virol.2005.09.030 · Cited by 60 · see citing works
Proteasome Inhibition Enhances AAV-Mediated Transgene Expression in Human Synoviocytes in Vitro and in Vivo
Jennings, K., Miyamae, T., Traister, R. S., Marinov, A. D., Katakura, S., Sowders, D. P., Trapnell, B. C., Wilson, J. M., Gao, G., & Hirsch, R. (2004) · Molecular Therapy · doi:10.1016/j.ymthe.2004.10.020 · Cited by 59 · see citing works
Impaired Nuclear Transport and Uncoating Limit Recombinant Adeno-Associated Virus 2 Vector-Mediated Transduction of Primary Murine Hematopoietic Cells
Li, Z., Li, W., Yang, Z., Qing, K., Tan, M., Hansen, J. J., Li, Y., Chen, L., Chan, R. J., Bischof, D., et al. (2004) · Human Gene Therapy · doi:10.1089/hum.2004.15.1207 · Cited by 59 · see citing works
Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 1
Miller, E. B., Gurda, B. L., Lakshmanan Govindasamy, A., McKENNA, R. V., Zolotukhin, S., Muzyczka, N., & Agbandje‐McKenna, M. (2006) · Acta Crystallographica Section F Structural Biology and Crystallization Communications · doi:10.1107/s1744309106048184 · Cited by 58 · see citing works
Self-citation
Optimised helper virus-free production of high-quality adeno-associated virus vectors
Drittanti, L., Jenny, C., Poulard, K., Samba, A., Manceau, P., Soria, N., Vincent, N., Danos, O., & Vega, M. T. (2001) · The Journal of Gene Medicine · doi:10.1002/1521-2254(2000)9999:9999 · Cited by 56 · see citing works
The Adeno-Associated Virus Rep78 Protein Is Covalently Linked to Viral DNA in a Preformed Virion
Prasad, K.-M. R., & Trempe, J. P. (1995) · Virology · doi:10.1006/viro.1995.0045 · Cited by 55 · see citing works
Scalable production of adeno‐associated virus type 2 vectors via suspension transfection
Park, J. Y., Lim, B., Lee, K., Kim, Y. K., & Jo, E. (2006) · Biotechnology and Bioengineering · doi:10.1002/bit.20776 · Cited by 55 · see citing works
Assembly of adeno-associated virus type 2 capsids in vitro.
Steinbach, S., Kleinschmidt, J. A., Wistuba, A., & Bock, T. (1997) · Journal of General Virology · doi:10.1099/0022-1317-78-6-1453 · Cited by 52 · see citing works
Self-citation
Residues within the B′ Motif Are Critical for DNA Binding by the Superfamily 3 Helicase Rep40 of Adeno-associated Virus Type 2
Yoon-Robarts, M., Blouin, A. G., Bleker, S., Kleinschmidt, J. A., Aggarwal, A. K., Escalante, C. R., & Linden, R. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403900200 · Cited by 52 · see citing works
Self-citation
Pushing the envelope: microinjection of Minute virus of mice into Xenopus oocytes causes damage to the nuclear envelope
Cohen, S., & Panté, N. (2005) · Journal of General Virology · doi:10.1099/vir.0.80967-0 · Cited by 52 · see citing works
Surface Loop Dynamics in Adeno-Associated Virus Capsid Assembly
DiPrimio, N., Asokan, A., Lakshmanan Govindasamy, A., Agbandje‐McKenna, M., & Samulski, R. J. (2008) · Journal of Virology · doi:10.1128/jvi.02721-07 · Cited by 49 · see citing works
Self-citation
Integrin αVβ5 Is Not Involved in Adeno-Associated Virus Type 2 (AAV2) Infection
Qiu, J.-M., & Brown, K. (1999) · Virology · doi:10.1006/viro.1999.0010 · Cited by 48 · see citing works
Correlating structure with function in the viral capsid
Agbandje‐McKenna, M., & Chapman, M. S. (2005) · CRC Press eBooks · doi:10.1201/b13393-14 · Cited by 48 · see citing works
Self-citation
Production, purification, crystallization and preliminary X-ray structural studies of adeno-associated virus serotype 5
DiMattia, M. A., Lakshmanan Govindasamy, A., Levy, H. C., Gurda, B. L., Kalina, A., Kohlbrenner, E., Chiorini, J. A., McKENNA, R. V., Muzyczka, N., Zolotukhin, S., et al. (2005) · Acta Crystallographica Section F Structural Biology and Crystallization Communications · doi:10.1107/s1744309105028514 · Cited by 42 · see citing works
Self-citation
Adeno-associated virus of a single-polarity DNA genome is capable of transduction in vivo
Zhou, X., Zeng, X., Fan, Z., Li, C., McCown, T., Samulski, R. J., & Xiao, X. (2008) · Molecular Therapy · doi:10.1038/sj.mt.6300397 · Cited by 41 · see citing works
Single-polarity Recombinant Adeno-associated Virus 2 Vector-mediated Transgene Expression In Vitro and In Vivo: Mechanism of Transduction
Li, Z., Zhou, X., Li, Y., Qing, K., Xiao, X., Samulski, R. J., & Srivastava, A. (2007) · Molecular Therapy · doi:10.1038/sj.mt.6300376 · Cited by 41 · see citing works
Differential internalization and nuclear uncoating of self-complementary adeno-associated virus pseudotype vectors as determinants of cardiac cell transduction
Sipo, I., Fechner, H., Pinkert, S., Suckau, L., Wang, X., Weger, S., & Poller, W. C. (2007) · Gene Therapy · doi:10.1038/sj.gt.3302987 · Cited by 40 · see citing works
Adeno-associated virus replication. The effect of L-canavanine or a helper virus mutation on accumulation of viral capsids and progeny single-stranded DNA.
Myers, M. W., & Carter, B. J. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70007-6 · Cited by 38 · see citing works
A combination of mutations enhances the neurotropism of AAV-2
Xu, J., Ma, C., Bass, C. E., & Terwilliger, E. F. (2005) · Virology · doi:10.1016/j.virol.2005.06.051 · Cited by 38 · see citing works
Adeno-associated virus type 5 exploits two different entry pathways in human embryo fibroblasts
Bantel‐Schaal, U., Braspenning‐Wesch, I., & Kartenbeck, J. (2009) · Journal of General Virology · doi:10.1099/vir.0.005595-0 · Cited by 37 · see citing works
Pathways of Removal of Free DNA Vector Ends in Normal and DNA-PKcs–Deficient SCID Mouse Hepatocytes Transduced with rAAV Vectors
Nakai, H., Storm, T. A., Fuess, S., & Kay, M. (2003) · Human Gene Therapy · doi:10.1089/104303403765701169 · Cited by 35 · see citing works
Effect of inhibition of dynein function and microtubule-altering drugs on AAV2 transduction
Hirosue, S., Senn, K., Clément, N., Nonnenmacher, M. E., Gigout, L. I., Linden, R. M., & Weber, T. (2007) · Virology · doi:10.1016/j.virol.2007.05.009 · Cited by 34 · see citing works
Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 9
Mitchell, M., Nam, H.-J., Carter, A., McCall, A. L., Rence, C., Bennett, A. D., Gurda, B. L., McKENNA, R. V., Porter, M., Sakai, Y., et al. (2009) · Acta Crystallographica Section F Structural Biology and Crystallization Communications · doi:10.1107/s1744309109021460 · Cited by 29 · see citing works
Self-citation
Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 4
Kaludov, N. K., Padron, E., Lakshmanan Govindasamy, A., McKENNA, R. V., Chiorini, J. A., & Agbandje‐McKenna, M. (2003) · Virology · doi:10.1016/s0042-6822(02)00037-5 · Cited by 28 · see citing works
Self-citation
Double strand interaction is the predominant pathway for intermolecular recombination of adeno-associated viral genomes.
Yue, Y., & Duan, D. (2003) · Virology · doi:10.1016/s0042-6822(03)00432-x · Cited by 27 · see citing works
Production, purification, crystallization and preliminary X-ray analysis of adeno-associated virus serotype 8
Lane, M. D., Nam, H.-J., Padron, E., Gurda, B. L., Kohlbrenner, E., Aslanidi, G., Byrne, B. J., McKENNA, R. V., Muzyczka, N., Zolotukhin, S., et al. (2005) · Acta Crystallographica Section F Structural Biology and Crystallization Communications · doi:10.1107/s1744309105014132 · Cited by 25 · see citing works
Self-citation
Conformational Changes in Adeno-Associated Virus Type 1 Induced by Genome Packaging
Gerlach, B., Kleinschmidt, J. A., & Böttcher, B. (2011) · Journal of Molecular Biology · doi:10.1016/j.jmb.2011.03.062 · Cited by 24 · see citing works
Self-citation
Crystallization and preliminary X-ray structural studies of adeno-associated virus serotype 6
Xie, Q., Ongley, H. M., Hare, J. T., & Chapman, M. S. (2008) · Acta Crystallographica Section F Structural Biology and Crystallization Communications · doi:10.1107/s1744309108033290 · Cited by 21 · see citing works
Characterization of the Rep78/Adeno-Associated Virus Complex
Prasad, K. M. R., Zhou, C., & Trempe, J. P. (1997) · Virology · doi:10.1006/viro.1996.8431 · Cited by 21 · see citing works
High-throughput Screening and Biophysical Interrogation of Hepatotropic AAV
Murphy, S. L., Bhagwat, A. S., Edmonson, S. A., Zhou, S., & High, K. A. (2008) · Molecular Therapy · doi:10.1038/mt.2008.210 · Cited by 20 · see citing works
Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 7
Quesada, O., Gurda, B. L., Lakshmanan Govindasamy, A., McKENNA, R. V., Kohlbrenner, E., Aslanidi, G., Zolotukhin, S., Muzyczka, N., & Agbandje‐McKenna, M. (2007) · Acta Crystallographica Section F Structural Biology and Crystallization Communications · doi:10.1107/s1744309107060289 · Cited by 20 · see citing works
Self-citation
Twinned crystals of adeno-associated virus serotype 3b prove suitable for structural studies
Lerch, T. F., Xie, Q., Ongley, H. M., Hare, J. T., & Chapman, M. S. (2009) · Acta Crystallographica Section F Structural Biology and Crystallization Communications · doi:10.1107/s1744309109000372 · Cited by 19 · see citing works
A Comparative Analysis of the Structural Architecture of ssDNA Viruses
Bennett, A. D., McKENNA, R. V., & Agbandje‐McKenna, M. (2008) · Computational and Mathematical Methods in Medicine · doi:10.1080/17486700802168247 · Cited by 18 · see citing works
Self-citation
cis Effects in Adeno-Associated Virus Type 2 Replication
Ward, P., Clément, N., & Linden, R. M. (2007) · Journal of Virology · doi:10.1128/jvi.00630-07 · Cited by 17 · see citing works
Adeno-associated Virus 2-Mediated Transduction and Erythroid Lineage-Specific Expression in Human Hematopoietic Progenitor Cells
Srivastava, A., Wang, X.-S., Ponnazhagan, S., Zhou, S. Z., & Yöder, M. C. (1996) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-80207-2_7 · Cited by 15 · see citing works
7 Adeno-associated Viral VectorsPreprint
Samulski, R. J., Sally, M., & Muzyczka, N. (1999) · Cold Spring Harbor Monograph Archive · doi:10.1101/087969528.36.131 · Cited by 5 · see citing works

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Adeno-associated virus vector as a platform for gene therapy delivery
Wang, D., Tai, P. W. L., & Gao, G. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0012-9 · Cited by 2,444 · see citing works
Adeno-Associated Virus (AAV) as a Vector for Gene Therapy
Naso, M. F., Tomkowicz, B., Perry, W. L., & Strohl, W. R. (2017) · BioDrugs · doi:10.1007/s40259-017-0234-5 · Cited by 1,362 · see citing works
AAV vectors: The Rubik’s cube of human gene therapy
Pupo, A., Fernández, A., Low, S. H., François, A., Suárez-Amarán, L., & Samulski, R. J. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.09.015 · Cited by 361 · see citing works
Adeno-Associated Virus at 50: A Golden Anniversary of Discovery, Research, and Gene Therapy Success—A Personal Perspective
Hastie, E. L., & Samulski, R. J. (2015) · Human Gene Therapy · doi:10.1089/hum.2015.025 · Cited by 284 · see citing works
Structural insight into the unique properties of adeno-associated virus serotype 9
DiMattia, M. A., Nam, H.-J., Van Vliet, K., Mitchell, M., Bennett, A., Gurda, B. L., McKenna, R., Olson, N. H., Sinkovits, R. S., Potter, M., et al. (2012) · Journal of Virology · doi:10.1128/jvi.07232-11 · Cited by 219 · see citing works
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Structure and Dynamics of Adeno-Associated Virus Serotype 1 VP1-Unique N-Terminal Domain and Its Role in Capsid Trafficking
Venkatakrishnan, B., Yarbrough, J., Domsic, J. F., Bennett, A. D., Bothner, B. B., Kozyreva, O. G., Samulski, R. J., Muzyczka, N., McKENNA, R. V., & Agbandje‐McKenna, M. (2013) · Journal of Virology · doi:10.1128/jvi.02524-12 · Cited by 225 · see citing works
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Adeno-associated virus capsid assembly is divergent and stochastic
Wörner, T. P., Bennett, A. D., Habka, S., Snijder, J., Friese, O. V., Powers, T. W., Agbandje‐McKenna, M., & Heck, A. J. R. (2021) · Nature Communications · doi:10.1038/s41467-021-21935-5 · Cited by 221 · see citing works
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AAV-based in vivo gene therapy for neurological disorders
Ling, Q., Herstine, J. A., Bradbury, A. M., & Gray, S. J. (2023) · Nature Reviews Drug Discovery · doi:10.1038/s41573-023-00766-7 · Cited by 206 · see citing works
“synthesis 148,149 .”
Background
Twenty-Five Years of Structural Parvovirology
Mietzsch, M., Pénzes, J. J., & Agbandje-McKenna, M. (2019) · Viruses · doi:10.3390/v11040362 · Cited by 197 · see citing works
“This channel, located at the icosahedral 5-fold axis, connects the inside and outside of the capsid (see below) [38,39,47,73,74].”
BackgroundSelf-citation
Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno‐associated virus capsid and promoter
Cronin, T., Vandenberghe, L. H., Hantz, P., Jüttner, J., Reimann, A., Kacsó, Á., Huckfeldt, R. M., Busskamp, V., Kohler, H., Lagali, P. S., et al. (2014) · EMBO Molecular Medicine · doi:10.15252/emmm.201404077 · Cited by 184 · see citing works
“The amino acid sequences and structural topology of these large outer loops have been reported to facilitate tissue tropism and transduction efficiency (Agbandje-McKenna & Kleinschmidt, 2011).”
Parvoviruses: Small Does Not Mean Simple
Cotmore, S. F., & Tattersall, P. J. (2014) · Annual Review of Virology · doi:10.1146/annurev-virology-031413-085444 · Cited by 173 · see citing works
Defining the Stoichiometry and Cargo Load of Viral and Bacterial Nanoparticles by Orbitrap Mass Spectrometry
Snijder, J., van de Waterbeemd, M., Damoc, E., Denisov, E., Grinfeld, D., Bennett, A., Agbandje-McKenna, M., Makarov, A., & Heck, A. J. R. (2014) · Journal of the American Chemical Society · doi:10.1021/ja502616y · Cited by 168 · see citing works
Self-citation
Comparative Analysis of Adeno-Associated Virus Capsid Stability and Dynamics
Rayaprolu, V., Kruse, S., Kant, R., Venkatakrishnan, B., Movahed, N., Brooke, D. J., Lins, B., Bennett, A. D., Potter, T., McKENNA, R. V., et al. (2013) · Journal of Virology · doi:10.1128/jvi.01415-13 · Cited by 161 · see citing works
“They efficiently replicate in the presence of a helper virus, such as Adenovirus or Herpesvirus (2, 3), and have distinct capsid-governed tissue specificities and strict host ranges (4, 5).”
BackgroundSelf-citation
Biology of adeno-associated viral vectors in the central nervous system
Murlidharan, G., Samulski, R. J., & Asokan, A. (2014) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2014.00076 · Cited by 157 · see citing works
“Different AAV serotypes exhibit a range of properties pertaining to antigenicity, in vivo tropism and receptor interactions based on their capsid structures (Agbandje-McKenna and Kleinschmidt, 2011).”
Background
Resolving Adeno-Associated Viral Particle Diversity With Charge Detection Mass Spectrometry
Pierson, E. E., Keifer, D. Z., Asokan, A., & Jarrold, M. F. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b00883 · Cited by 152 · see citing works
Adeno-Associated Virus Vectors as Therapeutic and Investigational Tools in the Cardiovascular System
Zacchigna, S., Zentilin, L., & Giacca, M. (2014) · Circulation Research · doi:10.1161/circresaha.114.302331 · Cited by 140 · see citing works
Biophysical and Ultrastructural Characterization of Adeno-Associated Virus Capsid Uncoating and Genome Release
Horowitz, E. D., Rahman, K. S., Bower, B. D., Dismuke, D. J., Falvo, M. R., Griffith, J. D., Harvey, S. C., & Asokan, A. (2013) · Journal of Virology · doi:10.1128/jvi.03017-12 · Cited by 139 · see citing works
“The largest VP1 subunit is known to possess a phospholipase A2 domain required for infectivity (4).”
Background
AAV vectors applied to the treatment of CNS disorders: Clinical status and challenges
Kang, L., Jin, S., Wang, J., Lv, Z., Xin, C., Tan, C., Zhao, M., Wang, L., & Liu, J. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.01.067 · Cited by 131 · see citing works
Parvovirus glycan interactions
Huang, L., Halder, S., & Agbandje‐McKenna, M. (2014) · Current Opinion in Virology · doi:10.1016/j.coviro.2014.05.007 · Cited by 136 · see citing works
“These sites, mostly located in VRs, overlap residues reported to affect the transduction properties of the AAVs (Table 1) (reviewed in [22]).”
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Mapping the AAV Capsid Host Antibody Response toward the Development of Second Generation Gene Delivery Vectors
Tseng, Y.-S., & Agbandje‐McKenna, M. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00009 · Cited by 134 · see citing works
“While the AAVs have a sequence similarity that ranges from ~55 to 99%, they are structurally very similar (33).”
BackgroundSelf-citation
Differential Adeno-Associated Virus Serotype-Specific Interaction Patterns with Synthetic Heparins and Other Glycans
Mietzsch, M., Broecker, F., Reinhardt, A., Seeberger, P. H., & Heilbronn, R. (2013) · Journal of Virology · doi:10.1128/jvi.03371-13 · Cited by 128 · see citing works
“Various AAV serotypes of human and primate origin (AAV1 to AAV13) that differ in the structures of their capsids and display variable cell or tissue tropism have been defined (1).”
Background
Capsid antibodies to different adeno-associated virus serotypes bind common regions
Gurda, B. L., DiMattia, M. A., Miller, E. B., Bennett, A., McKenna, R., Weichert, W. S., Nelson, C. D., Chen, W.-J., Muzyczka, N., Olson, N. H., et al. (2013) · Journal of Virology · doi:10.1128/jvi.00622-13 · Cited by 127 · see citing works
Self-citation
Targeting T cell malignancies using CAR-based immunotherapy: challenges and potential solutions
Fleischer, L. C., Spencer, H. T., & Raikar, S. S. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0801-y · Cited by 126 · see citing works
Adeno-Associated Viral Vectors in Neuroscience Research
Haggerty, D. L., Grecco, G. G., Reeves, K. C., & Atwood, B. K. (2019) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2019.11.012 · Cited by 123 · see citing works
“Eleven natural serotypes of AAVs have been identified so far, which have different capsid structures, resulting in differing tropism.(7) AAV tropism can also be further altered by creating recombinant versions of multiple AAV serotypes, a process known as pseudotyping.”
Background
Small But Increasingly Mighty: Latest Advances in AAV Vector Research, Design, and Evolution
Grimm, D., & Büning, H. (2017) · Human Gene Therapy · doi:10.1089/hum.2017.172 · Cited by 111 · see citing works
Glycan Engagement by Viruses: Receptor Switches and Specificity
Stroh, L. J., & Stehle, T. (2014) · Annual Review of Virology · doi:10.1146/annurev-virology-031413-085417 · Cited by 111 · see citing works
Adeno-associated virus 2 bound to its cellular receptor AAVR
Zhang, R., Cao, L., Cui, M., Sun, Z., Hu, M., Zhang, R., Stuart, W. S., Zhao, X., Yang, Z., Li, X., et al. (2019) · Nature Microbiology · doi:10.1038/s41564-018-0356-7 · Cited by 106 · see citing works
Engraftment of a Galactose Receptor Footprint onto Adeno-associated Viral Capsids Improves Transduction Efficiency
Shen, S., Horowitz, E. D., Troupes, A. N., Brown, S. M., Pulicherla, N., Samulski, R. J., Agbandje‐McKenna, M., & Asokan, A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.482380 · Cited by 103 · see citing works
Self-citation
Systemic delivery of adeno-associated viral vectors
Duan, D. (2016) · Current Opinion in Virology · doi:10.1016/j.coviro.2016.07.006 · Cited by 103 · see citing works
Characterization of the Adeno-Associated Virus 1 and 6 Sialic Acid Binding Site
Huang, L.-Y., Patel, A. R., Ng, R., Miller, E. B., Halder, S., McKENNA, R. V., Asokan, A., & Agbandje‐McKenna, M. (2016) · Journal of Virology · doi:10.1128/jvi.00161-16 · Cited by 99 · see citing works
Self-citation
A Precise Chemical Strategy To Alter the Receptor Specificity of the Adeno‐Associated Virus
Kelemen, R. E., Mukherjee, R., Cao, X., Erickson, S. B., Zheng, Y., & Chatterjee, A. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201604067 · Cited by 97 · see citing works
Structural insights into adeno-associated virus serotype 5
Govindasamy, L., DiMattia, M. A., Gurda, B. L., Halder, S., McKenna, R., Chiorini, J. A., Muzyczka, N., Zolotukhin, S., & Agbandje-McKenna, M. (2013) · Journal of Virology · doi:10.1128/jvi.00867-13 · Cited by 95 · see citing works
Self-citation
Characterization of a novel adeno-associated viral vector with preferential oligodendrocyte tropism
Powell, S. K., Khan, N., Parker, C. L., Samulski, R. J., Matsushima, G., Gray, S. J., & McCown, T. J. (2016) · Gene Therapy · doi:10.1038/gt.2016.62 · Cited by 93 · see citing works
Mapping a Neutralizing Epitope onto the Capsid of Adeno-Associated Virus Serotype 8
Gurda, B. L., Raupp, C., Popa-Wagner, R., Naumer, M., Olson, N. H., Ng, R., McKENNA, R. V., Baker, T. S., Kleinschmidt, J. A., & Agbandje‐McKenna, M. (2012) · Journal of Virology · doi:10.1128/jvi.00218-12 · Cited by 93 · see citing works
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Properties of the Adeno-Associated Virus Assembly-Activating Protein
Naumer, M., Sonntag, F., Schmidt, K., Nieto, K., Panke, C., Davey, N. E., Popa-Wagner, R., & Kleinschmidt, J. A. (2012) · Journal of Virology · doi:10.1128/jvi.01675-12 · Cited by 97 · see citing works
“AAV capsid assembly requires the coordinated formation of three types of capsid protein subunit interactions (1, 27).”
BackgroundSelf-citation
Structure of AAV-DJ, a Retargeted Gene Therapy Vector: Cryo-Electron Microscopy at 4.5 Å Resolution
Lerch, T. F., O’Donnell, J., Meyer, N., Xie, Q., Taylor, K. A., Stagg, S. M., & Chapman, M. S. (2012) · Structure · doi:10.1016/j.str.2012.05.004 · Cited by 89 · see citing works
“It is possible that VR-I is a dominant neutralizing epitope, due to proximity to unknown binding sites of one of the co-receptors (Agbandje-McKenna and Kleinschmidt, 2011) or other interactions important to trafficking in specific cells.”
Diversity of environmental single-stranded DNA phages revealed by PCR amplification of the partial major capsid protein
Hopkins, M., Kailasan, S., Cohen, A. L., Roux, S., Tucker, K. P., Shevenell, A., Agbandje‐McKenna, M., & Breitbart, M. (2014) · The ISME Journal · doi:10.1038/ismej.2014.43 · Cited by 86 · see citing works
“…threefold interaction loop, whereas the 30 portion includes three of the eight b-sheets (bF-bG) that comprise the ‘b-barrel’ motif common to all Microviridae (Bull et al., 2000) as well as many other viral families with T¼ 1 capsids (McKenna et al., 1992; Agbandje-McKenna and Kleinschmidt, 2011).”
BackgroundSelf-citation
Structure of adeno-associated virus-2 in complex with neutralizing monoclonal antibody A20
McCraw, D. M., O’Donnell, J. K., Taylor, K. A., Stagg, S. M., & Chapman, M. S. (2012) · Virology · doi:10.1016/j.virol.2012.05.004 · Cited by 84 · see citing works
“AAV enters cells endosomally, after initial attachment to a heparan sulfate proteoglycan (HSPG) (Summerford and Samulski, 1998), and subsequent binding to one of several possible protein co-receptors (Agbandje-McKenna and Kleinschmidt, 2011).”
Background
Sub-2 Å Ewald curvature corrected structure of an AAV2 capsid variant
Tan, Y. Z., Aiyer, S., Mietzsch, M., Hull, J. A., McKENNA, R. V., Grieger, J. C., Samulski, R. J., Baker, T. S., Agbandje‐McKenna, M., & Lyumkis, D. (2018) · Nature Communications · doi:10.1038/s41467-018-06076-6 · Cited by 84 · see citing works
Self-citation
Divergent engagements between adeno-associated viruses with their cellular receptor AAVR
Zhang, R., Xu, G., Cao, L., Sun, Z., He, Y., Cui, M., Sun, Y., Li, S., Li, H., Qin, L., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11668-x · Cited by 83 · see citing works
Therapeutic applications of genetic code expansion
Huang, Y., & Liu, T. (2018) · Synthetic and Systems Biotechnology · doi:10.1016/j.synbio.2018.09.003 · Cited by 82 · see citing works
“Its icosahedral capsid is made up of three capsid proteins, VP1, VP2, and VP3 [109].”
Background
Adeno-associated virus (AAV) vectors: Rational design strategies for capsid engineering
Lee, E. J., Guenther, C. M., & Suh, J. (2018) · Current Opinion in Biomedical Engineering · doi:10.1016/j.cobme.2018.09.004 · Cited by 83 · see citing works
Understanding Capsid Assembly and Genome Packaging for Adeno-Associated Viruses
Bennett, A., Mietzsch, M., & Agbandje-McKenna, M. (2017) · Future Virology · doi:10.2217/fvl-2017-0011 · Cited by 82 · see citing works
Self-citation
Mapping the Structural Determinants Required for AAVrh.10 Transport across the Blood-Brain Barrier
Albright, B. H., Storey, C. M., Murlidharan, G., Castellanos Rivera, R. M., Berry, G. E., Madigan, V. J., & Asokan, A. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2017.10.017 · Cited by 82 · see citing works
“These diverse phenotypes are determined by capsid structure.(4) The AAV capsid is assembled from 60 viral protein (VP) subunits.”
BackgroundInfluential
Gene therapy for retinal disease
McClements, M. E., & MacLaren, R. E. (2013) · Translational Research · doi:10.1016/j.trsl.2012.12.007 · Cited by 80 · see citing works
“It is thought that receptors on the various cell surfaces are responsible for the serotype tropisms observed.(30) In liver transduction studies, the ability of the host cells to uncoat different serotypes appeared to vary, effecting transduction and subsequent expression.”
Highly Efficient Delivery of Adeno-Associated Viral Vectors to the Primate Retina
Boye, S. L., Alexander, J. J., Witherspoon, C. D., Boye, S. L., Peterson, J. J., Clark, M. E., Sandefer, K. J., Girkin, C. A., Hauswirth, W. W., & Gamlin, P. D. (2016) · Human Gene Therapy · doi:10.1089/hum.2016.085 · Cited by 78 · see citing works
“AAVs use glycans as primary receptors for cellular recognition and internalization, and the hyaluronic acid in Healon is a glycosoaminoglycan (GAG).(53) We therefore preincubated AAV2 with Healon and then performed an in vitro transduction assay in 661W cone-derived photoreceptor cells.”
Method
Current progress and limitations of AAV mediated delivery of protein therapeutic genes and the importance of developing quantitative pharmacokinetic/pharmacodynamic (PK/PD) models
Chowdhury, E. A., Meno‐Tetang, G. M. L., Chang, H. Y., Wu, S., Huang, H. W., Jamier, T., Chandran, J. S., & Shah, D. K. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.01.017 · Cited by 78 · see citing works
Vector Design Tour de Force: Integrating Combinatorial and Rational Approaches to Derive Novel Adeno-associated Virus Variants
Marsic, D., Lakshmanan Govindasamy, A., Currlin, S., Markusic, D. M., Tseng, Y.-S., Herzog, R. W., Agbandje‐McKenna, M., & Zolotukhin, S. (2014) · Molecular Therapy · doi:10.1038/mt.2014.139 · Cited by 73 · see citing works
Self-citation
Proof of concept for AAV2/5-mediated gene therapy in iPSC-derived retinal pigment epithelium of a choroideremia patient
Cereso, N., Pequignot, M. O., Robert, L., Becker, F., De Luca, V., Nabholz, N., Rigau, V., De Vos, J., Hamel, C. P., & Kalatzis, V. (2014) · Molecular Therapy - Methods & Clinical Development · doi:10.1038/mtm.2014.11 · Cited by 72 · see citing works
Adeno-Associated Viruses (AAV) and Host Immunity – A Race Between the Hare and the Hedgehog
Rapti, K., & Grimm, D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.753467 · Cited by 70 · see citing works
“While the three viral capsid proteins VP1-3 share their C-terminal region, it is VP3, the shortest and most abundant of the three, that determines tissue tropism through receptor binding and interaction with factors in the circulation and interstitial tissue, including but not limited to antibodies [(10–12), reviewed…”
Background
The membrane associated accessory protein is an adeno-associated viral egress factor
Elmore, Z. C., Havlik, L. P., Oh, D. K., Anderson, L., Daaboul, G. G., Devlin, G. W., Vincent, H. A., & Asokan, A. (2021) · Nature Communications · doi:10.1038/s41467-021-26485-4 · Cited by 70 · see citing works
Automated Glycan Assembly of Oligo-N-Acetyllactosamine and Keratan Sulfate Probes to Study Virus-Glycan Interactions
Hahm, H. S., Broecker, F., Kawasaki, F., Mietzsch, M., Heilbronn, R., Fukuda, M., & Seeberger, P. H. (2017) · Chem · doi:10.1016/j.chempr.2016.12.004 · Cited by 70 · see citing works
Comparative Analysis of the Capsid Structures of AAVrh.10, AAVrh.39, and AAV8
Mietzsch, M., Barnes, C., Hull, J. A., Chipman, P. R., Xie, J., Bhattacharya, N., Sousa, D. R., McKENNA, R. V., Gao, G., & Agbandje‐McKenna, M. (2019) · Journal of Virology · doi:10.1128/jvi.01769-19 · Cited by 66 · see citing works
“The virions of these viruses are composed of nonenveloped capsids with T 1 icosahedral symmetry and diameters of 260 Å that enclose the ssDNA genome (4).”
BackgroundSelf-citation
Structure of neurotropic adeno-associated virus AAVrh.8
Halder, S., Vliet, K. V., Smith, J. K., Duong, T. T. P., McKENNA, R. V., Wilson, J. M., & Agbandje‐McKenna, M. (2015) · Journal of Structural Biology · doi:10.1016/j.jsb.2015.08.017 · Cited by 62 · see citing works
Self-citation
Glycan Binding Avidity Determines the Systemic Fate of Adeno-Associated Virus Type 9
Shen, S., Bryant, K. D., Sun, J., Brown, S. M., Troupes, A. N., Pulicherla, N., & Asokan, A. (2012) · Journal of Virology · doi:10.1128/jvi.01155-12 · Cited by 62 · see citing works
“In addition, various coreceptors, such as integrins and growth factor receptors, have been implicated in AAV infection in vitro (1, 23).”
Background
Adeno-Associated Virus 2 at 2.8 ang
Lou, Z. Y., & Zhang, R. (2018) · Worldwide Protein Data Bank · doi:10.2210/pdb6ih9/pdb · Cited by 66 · see citing works
Strategies to circumvent humoral immunity to adeno-associated viral vectors
Tse, L. V., Moller-Tank, S., & Asokan, A. (2015) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2015.1035645 · Cited by 61 · see citing works
“Wild-type AAV (wtAAV) was first discovered as a contaminant in adenoviral preparations, but was later ascribed to a unique genus of Dependoparvovirus, belonging to the Parvoviridae family [1-3].”
Background
Evaluation of the expression pattern of rAAV2/1, 2/5, 2/7, 2/8, and 2/9 serotypes with different promoters in the mouse visual cortex
Scheyltjens, I., Laramée, M., den Haute, C. V., Gijsbers, R., Debyser, Z., Baekelandt, V., Vreysen, S., & Arckens, L. (2015) · The Journal of Comparative Neurology · doi:10.1002/cne.23819 · Cited by 56 · see citing works
Relevance of Assembly-Activating Protein for Adeno-associated Virus Vector Production and Capsid Protein Stability in Mammalian and Insect Cells
Große, S., Penaud‐Budloo, M., Herrmann, A.-K., Börner, K., Fakhiri, J., Laketa, V., Krämer, C., Wiedtke, E., Gunkel, M., Ménard, L., et al. (2017) · Journal of Virology · doi:10.1128/jvi.01198-17 · Cited by 59 · see citing works
Coevolution of Adeno-associated Virus Capsid Antigenicity and Tropism through a Structure-Guided Approach
Havlik, L. P., Simon, K. E., Smith, J. K., Klinc, K. A., Tse, L. V., Oh, D. K., Fanous, M. M., Meganck, R. M., Mietzsch, M., Kleinschmidt, J. A., et al. (2020) · Journal of Virology · doi:10.1128/jvi.00976-20 · Cited by 56 · see citing works
“This structural diversity arises primarily from the variable surface loops or regions (VRs) (6).”
BackgroundSelf-citation
Adeno-associated Virus 9 Structural Rearrangements Induced by Endosomal Trafficking pH and Glycan Attachment
Pénzes, J. J., Chipman, P. R., Bhattacharya, N., Zeher, A., Huang, R. K., McKENNA, R. V., & Agbandje‐McKenna, M. (2021) · Journal of Virology · doi:10.1128/jvi.00843-21 · Cited by 55 · see citing works
“The AAV T=1 icosahedral capsid is assembled using 60 subunits of the structural virus proteins (VPs) VP1,22, and 23, in an approximate ratio of 5:5:50 (29, 30).”
BackgroundMethodSelf-citation
Virus-assisted directed evolution of enhanced suppressor tRNAs in mammalian cells
Jewel, D., Kelemen, R. E., Huang, R. L., Zhu, Z., Sundaresh, B., Cao, X., Malley, K., Huang, Z., Pasha, M., Anthony, J. S., et al. (2022) · Nature Methods · doi:10.1038/s41592-022-01706-w · Cited by 54 · see citing works
Parvoviruses: Structure and Infection
Halder, S., Ng, R., & Agbandje‐McKenna, M. (2012) · Future Virology · doi:10.2217/fvl.12.12 · Cited by 53 · see citing works
Self-citation
Next-generation AAV vectors for clinical use: an ever-accelerating race
Weinmann, J., & Grimm, D. (2017) · Virus Genes · doi:10.1007/s11262-017-1502-7 · Cited by 53 · see citing works
Structural Insights into Human Bocaparvoviruses
Mietzsch, M., Kailasan, S., Garrison, J., Ilyas, M., Chipman, P. R., Kantola, K., Janssen, M. E. W., Spear, J. M., Sousa, D. R., McKENNA, R. V., et al. (2017) · Journal of Virology · doi:10.1128/jvi.00261-17 · Cited by 52 · see citing works
“important for antigenic reactivity and infectivity in other parvoviruses and strainspecific antibody recognition for HBoV1 (30, 34, 48).”
BackgroundSelf-citation
Perspective on Adeno-Associated Virus Capsid Modification for Duchenne Muscular Dystrophy Gene Therapy
Nance, M. E., & Duan, D. (2015) · Human Gene Therapy · doi:10.1089/hum.2015.107 · Cited by 50 · see citing works
Precise Photoremovable Perturbation of a Virus–Host Interaction
Erickson, S. B., Mukherjee, R., Kelemen, R. E., Wrobel, C. J. J., Cao, X., & Chatterjee, A. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201700683 · Cited by 51 · see citing works
Characteristics and advantages of adeno-associated virus vector-mediated gene therapy for neurodegenerative diseases
Qu, Y., Liu, Y., Noor, A. F., Tran, J., & Li, R. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.250570 · Cited by 51 · see citing works
Protease-activatable adeno-associated virus vector for gene delivery to damaged heart tissue
Guenther, C. M., Brun, M. J., Bennett, A. D., Ho, M. L., Chen, W., Zhu, B., Lam, M., Yamagami, M., Kwon, S., Bhattacharya, N., et al. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.01.015 · Cited by 46 · see citing works
Self-citation
Development of patient-specific AAV vectors after neutralizing antibody selection for enhanced muscle gene transfer
Li, C., Wu, S., Albright, B., Hirsch, M., Li, W., Tseng, Y.-S., Agbandje-McKenna, M., McPhee, S., Asokan, A., & Samulski, R. J. (2016) · Molecular Therapy · doi:10.1038/mt.2015.134 · Cited by 48 · see citing works
Self-citation
Complex and Dynamic Interactions between Parvovirus Capsids, Transferrin Receptors, and Antibodies Control Cell Infection and Host Range
Callaway, H., Welsch, K., Weichert, W. S., Allison, A. B., Hafenstein, S. L., Huang, K., Iketani, S., & Parrish, C. R. (2018) · Journal of Virology · doi:10.1128/jvi.00460-18 · Cited by 46 · see citing works
High-resolution structural characterization of a new adeno-associated virus serotype 5 antibody epitope toward engineering antibody-resistant recombinant gene delivery vectors
Jose, A., Mietzsch, M., Smith, J. K., Kurian, J., Chipman, P., McKenna, R., Chiorini, J., & Agbandje-McKenna, M. (2019) · Journal of Virology · doi:10.1128/jvi.01394-18 · Cited by 44 · see citing works
“These viruses are composed of nonenveloped capsids with T 1 icosahedral symmetry and a diameter of 260 Å (1).”
BackgroundSelf-citation
Advances in AAV technology for delivering genetically encoded cargo to the nonhuman primate nervous system
Campos, L., Arokiaraj, C. M., Chuapoco, M. R., Chen, X., Goeden, N., Gradinaru, V., & Fox, A. S. (2023) · Current Research in Neurobiology · doi:10.1016/j.crneur.2023.100086 · Cited by 41 · see citing works
Genome-wide RNAi screening identifies host restriction factors critical for in vivo AAV transduction
Mano, M., Ippodrino, R., Zentilin, L., Zacchigna, S., & Giacca, M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1503607112 · Cited by 39 · see citing works
Multiple Roles for Sialylated Glycans in Determining the Cardiopulmonary Tropism of Adeno-Associated Virus 4
Shen, S., Troupes, A. N., Pulicherla, N., & Asokan, A. (2013) · Journal of Virology · doi:10.1128/jvi.02109-13 · Cited by 40 · see citing works
“The surface protrusions and spikes surrounding the 3-fold axes are predominantly composed of the highly dynamic GH loop connecting the G and H strands within the capsid protein subunit (10, 11).”
Background
An Emerging Adeno-Associated Viral Vector Pipeline for Cardiac Gene Therapy
Asokan, A., & Samulski, R. J. (2013) · Human Gene Therapy · doi:10.1089/hum.2013.2515 · Cited by 38 · see citing works
“A summary of current knowledge pertaining to the biology, preclinical studies, and clinical applications of the different AAV serotypes and pertinent literature has been reviewed elsewhere (Agbandje-McKenna and Kleinschmidt, 2011; Mingozzi and High, 2011).”
Background
Engineering AAV receptor footprints for gene therapy
Madigan, V. J., & Asokan, A. (2016) · Current Opinion in Virology · doi:10.1016/j.coviro.2016.05.001 · Cited by 37 · see citing works
AAV-Mediated Gene Delivery to the Liver: Overview of Current Technologies and Methods
Palaschak, B., Herzog, R. W., & Markusic, D. M. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9139-6_20 · Cited by 37 · see citing works
Routes of administration for adeno-associated viruses carrying gene therapies for brain diseases
Zhou, K., Han, J., Wang, Y., Zhang, Y., & Zhu, C. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.988914 · Cited by 38 · see citing works
“However, most rAAVs cannot cross the blood–brain barrier (BBB), and different rAAV stereotypes recognize different cell receptors and thus have different tropisms for distinct tissues and cell types (Agbandje-McKenna and Kleinschmidt, 2011; Wang et al., 2019), which causes difficulties in delivering rAAVs into the bra…”
Background
Structurally Mapping Antigenic Epitopes of Adeno-associated Virus 9: Development of Antibody Escape Variants
Emmanuel, S. N., Smith, J. K., Hsi, J., Tseng, Y.-S., Kaplan, M., Mietzsch, M., Chipman, P. R., Asokan, A., McKenna, R., & Agbandje-McKenna, M. (2021) · Journal of Virology · doi:10.1128/jvi.01251-21 · Cited by 35 · see citing works
“various transduction efficiency in different host tissues (11).”
BackgroundSelf-citation
Limitations of Encapsidation of Recombinant Self-Complementary Adeno-Associated Viral Genomes in Different Serotype Capsids and Their Quantitation
Wang, Y., Ling, C., Song, L., Wang, L., Aslanidi, G., Tan, M., Ling, C., & Srivastava, A. (2012) · Human Gene Therapy Methods · doi:10.1089/hgtb.2012.090 · Cited by 36 · see citing works
“To date, 12 distinct human and nonhuman AAV serotypes (AAV1–12) have been described, and recombinant AAV (rAAV) vectors have been developed (Agbandje-McKenna and Kleinschmidt, 2011).”
Gene manipulation in liver ductal organoids by optimized recombinant adeno-associated virus vectors
Wei, J., Ran, G., Wang, X., Jiang, N., Liang, J., Lin, X., Ling, C., & Zhao, B. T. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.008616 · Cited by 36 · see citing works
Distinct transduction difference between adeno-associated virus type 1 and type 6 vectors in human polarized airway epithelia
Yan, Z., Lei-Butters, D. C. M., Keiser, N. W., & Engelhardt, J. F. (2012) · Gene Therapy · doi:10.1038/gt.2012.46 · Cited by 33 · see citing works
High-Throughput Dissection of AAV–Host Interactions: The Fast and the Curious
Herrmann, A.-K., & Grimm, D. (2018) · Journal of Molecular Biology · doi:10.1016/j.jmb.2018.05.022 · Cited by 33 · see citing works
Parvovirus Capsid-Antibody Complex Structures Reveal Conservation of Antigenic Epitopes Across the Family
Emmanuel, S. N., Mietzsch, M., Tseng, Y.-S., Smith, J. K., & Agbandje‐McKenna, M. (2020) · Viral Immunology · doi:10.1089/vim.2020.0022 · Cited by 33 · see citing works
Self-citation
Adeno-associated virus and lentivirus vectors: a refined toolkit for the central nervous system
Blessing, D., & Déglon, N. (2016) · Current Opinion in Virology · doi:10.1016/j.coviro.2016.08.004 · Cited by 34 · see citing works
“They are responsible for surface topology and determine tropism and specificity [9].”
Background
Nanotherapy for Duchenne muscular dystrophy
Nance, M. E., Hakim, C. H., Yang, N. N., & Duan, D. (2017) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1472 · Cited by 33 · see citing works
Genome DNA leakage of Adeno–Associated virus under freeze–thaw stress
Xu, Y., Jiang, B., Samai, P., Tank, S.-M., Shameem, M., & Liu, D. (2022) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2022.121464 · Cited by 32 · see citing works
Atomic structure of a rationally engineered gene delivery vector, AAV2. 5
Burg, M., Rosebrough, C., Drouin, L. M., Bennett, A., Mietzsch, M., Chipman, P., McKenna, R., Sousa, D., Potter, M., Byrne, B., et al. (2018) · Journal of Structural Biology · doi:10.1016/j.jsb.2018.05.004 · Cited by 30 · see citing works
Self-citation
Computationally guided AAV engineering for enhanced gene delivery
Guo, J., Lin, L. F., Oraskovich, S. V., de Jesús, J. A. R., Listgarten, J., & Schaffer, D. V. (2024) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2024.03.002 · Cited by 30 · see citing works
Gene delivery to rat and human Schwann cells and nerve segments: a comparison of AAV 1–9 and lentiviral vectors
Hoyng, S. A., de Winter, F., Gnavi, S., van Egmond, L., Attwell, C. L., Tannemaat, M. R., Verhaagen, J., & Malessy, M. J. A. (2015) · Gene Therapy · doi:10.1038/gt.2015.47 · Cited by 29 · see citing works
Programmable Assembly of Adeno-Associated Virus–Antibody Composites for Receptor-Mediated Gene Delivery
Zdechlik, A. C., He, Y., Aird, E. J., Gordon, W. R., & Schmidt, D. (2019) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.9b00790 · Cited by 28 · see citing works
Global CNS correction in a large brain model of human alpha-mannosidosis by intravascular gene therapy
Yoon, S. Y., Hunter, J. E., Chawla, S., Clarke, D. L., Molony, C. M., O’Donnell, P. A., Bagel, J. H., Kumar, M., Poptani, H., Vite, C. H., et al. (2020) · Brain · doi:10.1093/brain/awaa161 · Cited by 28 · see citing works
Engineering and In Vitro Selection of a Novel AAV3B Variant with High Hepatocyte Tropism and Reduced Seroreactivity
Biswas, M., Marsic, D., Li, N., Zou, C., González‐Aseguinolaza, G., Zolotukhin, I., Kumar, S. R. P., Rana, J., Butterfield, J. S. S., Kondratov, O., et al. (2020) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2020.09.019 · Cited by 28 · see citing works
“The nature of exposed amino acid residues on the capsid surface largely determines receptor attachment, tissue transduction, and antigenicity.(20) Therefore, the development of engineered AAV vectors designed either by rational modification of specific amino acids (rational mutagenesis) or in vitro/in vivo selection i…”
Background
The Structures and Functions of Parvovirus Capsids and Missing Pieces: the Viral DNA and Its Packaging, Asymmetrical Features, Nonprotein Components, and Receptor or Antibody Binding and Interactions
López-Astacio, R. A., Adu, O. F., Lee, H., Hafenstein, S. L., & Parrish, C. R. (2023) · Journal of Virology · doi:10.1128/jvi.00161-23 · Cited by 27 · see citing works
Viral vector‐based cancer treatment and current clinical applications
Xie, L., Han, Y., Liu, Y., Zhou, Y., Yu, J., von Brunn, A., & Lei, J. (2023) · MedComm – Oncology · doi:10.1002/mog2.55 · Cited by 26 · see citing works
AAV-8 Is More Efficient than AAV-9 in Transducing Neonatal Dog Heart
Pan, X., Yue, Y., Zhang, K., Hakim, C. H., Kodippili, K., McDonald, T., & Duan, D. (2015) · Human Gene Therapy Methods · doi:10.1089/hgtb.2014.128 · Cited by 26 · see citing works
“Future site-directed mutagenesis in these regions will help to pinpoint structural features that are responsible for the superior myocardial transduction by AAV-8 in newborn dogs.(28) It is currently unclear why AAV-9 can effectively transduce rodent heart but not newborn dog heart.”
Machine-learning-guided Directed Evolution for AAV Capsid Engineering
Fu, X., Suo, H., Zhang, J., & Chen, D. (2024) · Current Pharmaceutical Design · doi:10.2174/0113816128286593240226060318 · Cited by 24 · see citing works
Creating an arsenal of Adeno-associated virus (AAV) gene delivery stealth vehicles
Smith, J. K., & Agbandje‐McKenna, M. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1006929 · Cited by 24 · see citing works
Self-citation
Receptor Switching in Newly Evolved Adeno-associated Viruses
Havlik, L. P., Das, A., Mietzsch, M., Oh, D. K., Ark, J., McKENNA, R. V., Agbandje‐McKenna, M., & Asokan, A. (2021) · Journal of Virology · doi:10.1128/jvi.00587-21 · Cited by 24 · see citing works
Self-citation

The amazing AAV capsids: Into the structure-verse
Hsi, J., Mietzsch, M., & McKENNA, R. V. (2025) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2025.101629 · Cited by 8 · see citing works
Biophysical characterization of adeno-associated virus capsid through the viral transduction life cycle
Xiang, Y. S., & Hao, G. G. (2023) · Journal of Genetic Engineering and Biotechnology · doi:10.1186/s43141-023-00518-5 · Cited by 17 · see citing works
Structurally mapping the diverse phenotype of adeno-associated virus serotype 4
Govindasamy, L., Padron, E., McKenna, R., Muzyczka, N., Kaludov, N., Chiorini, J. A., & Agbandje-McKenna, M. (2006) · Journal of Virology · doi:10.1128/jvi.01536-06 · Cited by 205 · see citing works
Self-citation
Structural and cellular biology of adeno-associated virus attachment and entry
Zengel, J. R., & Carette, J. E. (2020) · Advances in virus research · doi:10.1016/bs.aivir.2020.01.002 · Cited by 44 · see citing works
Completion of the AAV Structural Atlas: Serotype Capsid Structures Reveals Clade-Specific Features
Mietzsch, M., Jose, A., Chipman, P. R., Bhattacharya, N., Daneshparvar, N., McKENNA, R. V., & Agbandje‐McKenna, M. (2021) · Viruses · doi:10.3390/v13010101 · Cited by 103 · see citing works
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Authors: Agbandje-McKenna, M., & Kleinschmidt, J.
Affiliations: German Cancer Research Center (DE)
Venue: Methods in Molecular Biology
Publisher: Humana Press
Published: 2011-09-27
Volume: 807
Pages: 47-92
ISSN: 1064-3745 (ISSN-L)
1940-6029
DOI: 10.1007/978-1-61779-370-7_3
OpenAlex: W124314106
Cited by: 215
References: 195
Citations by year: 2026: 12 · 2025: 16 · 2024: 19 · 2023: 19 · 2022: 17 · 2021: 15 · 2020: 13 · 2019: 17 · 2018: 14 · 2017: 11 · 2016: 10 · 2015: 12 · 2014: 16 · 2013: 12 · 2012: 12
FWCI: 32.78
Type: book chapter
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Methods in molecular biology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (R01GM082946)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Health Sciences › Medicine › Infectious Diseases › Parvovirus B19 Infection Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Keywords: adeno-associated virus, capsid structure, capsid assembly, DNA packaging, cell tropism, receptor recognition, capsid uncoating, antibody neutralization, serotypes, gene delivery vectors, host cell interactions
MeSH terms: Dependovirus, Antibody Formation, Capsid, Humans, Models, Molecular, Endosomes, Viral Proteins, Protein Structure, Secondary

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