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Cited by 316Neural and Behavioral Psychology StudiesMemory and Neural MechanismsNeurotransmitter Receptor Influence on Behavior

Amygdala-prefrontal cortical circuitry regulates effort based decision making

Floresco, S. B., Ghods-Sharifi, S.·2006·Cerebral Cortex
DOI 10.1093/cercor/bhj143
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Abstract

The basolateral amygdala (BLA) and the anterior cingulate cortex (ACC) region of the prefrontal cortex form an interconnected neural circuit that may mediate certain types of decision-making processes. The present study assessed the role of this pathway in effort-based decision making using a cost-benefit T-maze task. Rats were given a choice of obtaining a high reward by climbing a 30-cm barrier in 1 arm (4 pellets; high-reward [HR] arm) or a small reward in the other arm with no barrier (2 pellets; low-reward [LR] arm). In Experiment 1, bilateral inactivation of the BLA via infusion of bupivacaine impaired decision making, reducing the preference for the HR arm. This effect was not due to spatial or motor deficits because BLA inactivation did not alter behavior when the amount of effort required to obtain either reward was equalized by placing a 2nd barrier in the LR arm. In Experiment 2, disconnection between the BLA and ACC, entailing a unilateral BLA inactivation combined with a contralateral ACC inactivation also impaired decision making. These data suggest that the serial transfer of information between the BLA and ACC guides response selection when evaluating the value of an expected outcome relative to the costs of performing a particular action.

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  • Amygdala and ACC inactivations caused changes to behaviour during a cognitive effort task that were different from those in physical effort tasks.

    “Specifically, amygdala and ACC inactivations caused changes to behaviour during a cognitive effort task [27] that were different to those in physical effort tasks [2, 25, 26].”

    From Neurocomputational mechanisms underlying subjective valuation of effort costs (2017) · cites this paper as [25]

  • dACC/dmPFC neurons signal the net value of rewards associated with effort.

    “In addition, single-unit studies have shown that dACC/dmPFC neurons signal the net value of rewards associated with effort, and the necessity of this region in cost–benefit valuation has been demonstrated by lesion studies that report that inactivation of medial prefrontal cortex impairs an animal’s ability to overcome effort costs [15, 16, 25, 48, 55].”

    From Neurocomputational mechanisms underlying subjective valuation of effort costs (2017) · cites this paper as [25]

  • Inactivation of medial prefrontal cortex impairs an animal's ability to overcome effort costs.

    “In addition, single-unit studies have shown that dACC/dmPFC neurons signal the net value of rewards associated with effort, and the necessity of this region in cost–benefit valuation has been demonstrated by lesion studies that report that inactivation of medial prefrontal cortex impairs an animal’s ability to overcome effort costs [15, 16, 25, 48, 55].”

    From Neurocomputational mechanisms underlying subjective valuation of effort costs (2017) · cites this paper as [25]

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Research works printed but not linked: 2

  1. Caterall WA, Mackie K. 1996. Local anesthetics. In: Hardman JG, Limbard LE, Molinoff PB, Rudden RW, Gillman A, editors. Goodman and Gillman's the pharmacological basis of experimental therapeutics. 9th ed. New York: McGraw-Hill. p 321--347.
  2. Robbins TW, Everitt BJ. 1992. Amygdala-ventral striatal interactions and reward related processes. In: Aggleton JP, editor. The amygdala: neurobiological aspects of emotions, memory and mental dysfunc- tion. New York: Wiley-Liss Inc. p 401--429.

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Authors
Floresco, S. B., & Ghods-Sharifi, S.
Affiliations
University of British Columbia (CA)
ORCID
Floresco, S. B.
Venue
Cerebral Cortex
Publisher
Oxford University Press (OUP)
Published
2006-02-22
Volume
17
Issue
2
Pages
251-260
ISSN
  • 1047-3211 (ISSN-L)
  • 1460-2199
DOI
10.1093/cercor/bhj143
OpenAlex
W2157302628
Cited by
316
References
65
Citations by year
2026: 6 · 2025: 9 · 2024: 10 · 2023: 6 · 2022: 12 · 2021: 19 · 2020: 11 · 2019: 14 · 2018: 18 · 2017: 16 · 2016: 33 · 2015: 17 · 2014: 16 · 2013: 20 · 2012: 12
FWCI
8.10
Type
journal article
Language
en
Open access
closed
Locations
  • Cerebral Cortex (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
effort-based decision making, basolateral amygdala, anterior cingulate cortex, cost-benefit decision making, T-maze task, response selection, rats
MeSH terms
Adaptation, Physiological, Amygdala, Animals, Choice Behavior, Conditioning, Operant, Decision Making, Physical Exertion, Neural Pathways, Reward, Task Performance and Analysis, Prefrontal Cortex, Maze Learning, Rats, Long-Evans, Rats

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