Single nigrostriatal dopaminergic neurons form widely spread and highly dense axonal arborizations in the neostriatum
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The axonal arbors of single nigrostriatal dopaminergic neurons were visualized with a viral vector expressing membrane-targeted green fluorescent protein in rat brain. All eight reconstructed tyrosine hydroxylase-positive dopaminergic neurons possessed widely spread and highly dense axonal arborizations in the neostriatum. All of them emitted very little axon collateral arborization outside of the striatum except for tiny arborization in the external pallidum. The striatal axonal bush of each reconstructed dopaminergic neuron covered 0.45-5.7% (mean +/- SD = 2.7 +/- 1.5%) of the total volume of the neostriatum. Furthermore, all the dopaminergic neurons innervated both striosome and matrix compartments of the neostriatum, although each neuron's arborization tended to favor one of these compartments. Our findings demonstrate that individual dopaminergic neurons of the substantia nigra can broadcast a dopamine signal and exert strong influence over a large number of striatal neurons. This divergent signaling should be a key to the function of the nigrostriatal system in dopamine-based learning and suggests that neurodegeneration of individual nigral neurons can affect multiple neurons in the striatum. Thus, these results would also contribute to understanding the clinicopathology of Parkinson's disease and related syndromes.
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Projections of Vip+ dopamine neurons are focal, mapped to the bed nucleus of the stria terminalis and central nucleus of the amygdala, and innervate a smaller target volume than other dopamine neurons.
“The projections of these neurons are peculiar in that they are particularly focal – they have been mapped to the bed nucleus of the stria terminals (BST) and central nucleus of the amygdala [13,20], and appear to innervate a much smaller target volume than other DA neurons (e.g. [49] and [50]).”
From Classification of midbrain dopamine neurons using single-cell gene expression profiling approaches (2020) · cites this paper as [49]
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- Authors
- Matsuda, W., Furuta, T., Nakamura, K. C., Hioki, H., Fujiyama, F., Arai, R., & Kaneko, T.
- Affiliations
- Kyoto University (JP)
- Shiga University of Medical Science (JP)
- Corresponding author
- Kaneko, Takeshi
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2009-01-14
- Volume
- 29
- Issue
- 2
- Pages
- 444-453
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6664950
- OpenAlex
- W2054466443
- Cited by
- 865
- References
- 54
- Citations by year
- 2026: 51 · 2025: 72 · 2024: 59 · 2023: 59 · 2022: 60 · 2021: 69 · 2020: 60 · 2019: 55 · 2018: 50 · 2017: 58 · 2016: 54 · 2015: 50 · 2014: 33 · 2013: 33 · 2012: 36
- FWCI
- 21.09
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (17022020, 18019017, 18500262, 18020013, 18700341, 20700315, 18700342, 16200025, 17650100)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- nigrostriatal dopaminergic neurons, substantia nigra, neostriatum, axonal arborization, striosomes, striatal matrix, axon collaterals, external pallidum, tyrosine hydroxylase, dopamine signaling, Parkinson's disease, single-neuron reconstruction
- MeSH terms
- Animals, Axons, Brain Mapping, Corpus Striatum, Dopamine, Male, Neural Pathways, Neurons, Substantia Nigra, Tyrosine 3-Monooxygenase, Neostriatum, Rats, Wistar, Receptors, Opioid, mu, Statistics, Nonparametric, Green Fluorescent Proteins, Rats
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