Cited by 79Gut microbiota and healthTryptophan and brain disordersGastrointestinal motility and disorders

The microbiome-gut-brain axis: implications for schizophrenia and antipsychotic induced weight gain

Kanji, S., Fonseka, T. M., Marshe, V. S., Sriretnakumar, V., Hahn, M. K., Müller, D. J.·2018·European Archives of Psychiatry and Clinical Neuroscience

Abstract

With the emergence of knowledge implicating the human gut microbiome in the development and regulation of several physiological systems, evidence has accumulated to suggest a role for the gut microbiome in psychiatric conditions and drug response. A complex relationship between the enteric nervous system, the gut microbiota and the central nervous system has been described which allows for the microbiota to influence and respond to a variety of behaviors and psychiatric conditions. Additionally, the use of pharmaceuticals may interact with and alter the microbiota to potentially contribute to adverse effects of the drug. The gut microbiota has been described in several psychiatric disorders including depression and anxiety, but only a few reports have discussed the role of the microbiome in schizophrenia. The following review examines the evidence surrounding the gut microbiota in behavior and psychiatric illness, the role of the microbiota in schizophrenia and the potential for antipsychotics to alter the gut microbiota and promote adverse metabolic events.

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Crossref · 10.1007/s00406-017-0820-z

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53 of 53 references verified0 citation errors · 0 not checkable

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  • The gut microbiota may confer beneficial effects on schizophrenia by regulating the expression of neurotrophic factor receptors and the levels of inflammatory factors and chemokines, thereby alleviating metabolic dysfunction.

    “Notably, the gut microbiota may confer beneficial effects on SZ by regulating the expression of neurotrophic factor receptors and the levels of inflammatory factors and chemokines, thereby alleviating metabolic dysfunction and providing a new direction for obtaining beneficial effects in patients with SZ [20,21].”
  • The vagus nerve is a chief mediator of the bidirectional communication along the gut-brain axis through cholinergic activation of nicotinic receptors.

    “Lastly, the vagus nerve is a chief mediator of the bidirectional communication along the gut-brain axis through cholinergic activation of nicotinic receptors102.”

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Authors
Kanji, S., Fonseka, T. M., Marshe, V. S., Sriretnakumar, V., Hahn, M. K., & Müller, D. J.
Affiliations
  • Centre for Addiction and Mental Health (CA)
  • St. Michael's Hospital (CA)
Corresponding author
Müller, D. J.
Venue
European Archives of Psychiatry and Clinical Neuroscience
Published
2017-06-17
Volume
268
Issue
1
Pages
3-15
ISSN
  • 0003-9373 (ISSN-L)
  • 0940-1334
  • 1433-8491
OpenAlex
W2626393670
Cited by
79
References
53
Citations by year
2026: 2 · 2025: 4 · 2024: 3 · 2023: 9 · 2022: 9 · 2021: 14 · 2020: 15 · 2019: 7 · 2018: 11 · 2017: 5
FWCI
0.97
Type
journal article
Language
en
Open access
closed
Locations
  • European Archives of Psychiatry and Clinical Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
Centre for Addiction and Mental Health Foundation
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
gut microbiota, microbiome-gut-brain axis, schizophrenia, antipsychotic-induced weight gain, mental illness, depression, anxiety, enteric nervous system, adverse drug reactions
MeSH terms
Gastrointestinal Microbiome, Animals, Brain, Humans, Schizophrenia, Antipsychotic Agents, Weight Gain

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