Report of altered urinary oxytocin and AVP excretion in neglected orphans should be reconsidered
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Wismer Fries et al. reported that urinary oxytocin and vasopressin in orphans were affected by early neglect, but their reported levels were nearly a million-fold too high for both peptides, using a method neither sensitive nor selective enough to measure either peptide in urine; the report drew criticism, and the authors later improved their methodology.
“The discrepancy between measurements in unextracted and extracted plasma is two orders of magnitude, but when Wismer Fries et al. reported that urinary excretion of oxytocin and vasopressin in orphans was affected by early neglect, they reported levels that were, for both peptides, nearly a million fold too high, after applying a method that was neither sensitive enough or selective enough to”
From Intranasal Oxytocin: Myths and Delusions (2016) · cites this paper as [73]
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“According to Anderson (121), that discrepancy arose from the limited analytical selectivity of rapid chromatographic separation and the low sensitivity of ultraviolet absorbance detection.”
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- Authors
- Anderson, G. M.
- Affiliations
- Yale University (US)
- Corresponding author
- Anderson, George M.
- ORCID
- Anderson, George M.
- Venue
- Journal of Autism and Developmental Disorders
- Published
- 2006-07-28
- Volume
- 36
- Issue
- 6
- Pages
- 829-830
- ISSN
- 0162-3257 (ISSN-L)
- 1573-3432
- OpenAlex
- W2032639475
- Cited by
- 22
- References
- 17
- Citations by year
- 2021: 1 · 2017: 1 · 2016: 1 · 2015: 3 · 2013: 5 · 2012: 2
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Autism and Developmental Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Safety Research › Child Welfare and Adoption
- Keywords
- vasopressin, biomarkers
- MeSH terms
- Arginine Vasopressin, Child Abuse, Child, Preschool, Chromatography, High Pressure Liquid, Foster Home Care, Humans, Oxytocin, Predictive Value of Tests, Reference Values, Romania, Russia, Spectrophotometry, Ultraviolet
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