Neuropeptides and the social brain: potential rodent models of autism

Lim, Miranda M.; Bielsky, Isadora F.; Young, Larry J.

doi:10.1016/j.ijdevneu.2004.05.006

Cited by 129Neuroendocrine regulation and behaviorAutism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

Neuropeptides and the social brain: potential rodent models of autism

Lim, Miranda M., Bielsky, Isadora F., Young, Larry J.·2005·International Journal of Developmental Neuroscience

DOI 10.1016/j.ijdevneu.2004.05.006

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Abstract

Conducting basic scientific research on a complex psychiatric disorder, such as autism, is a challenging prospect. It is difficult to dissociate the fundamental neurological and psychological processes that are disturbed in autism and, therefore, it is a challenge to discover accurate and reliable animal models of the disease. Because of their role in animal models of social processing and social bonding, the neuropeptides oxytocin and vasopressin are strong candidates for dysregulation in autism. In this review, we discuss the current animal models which have investigated oxytocin and vasopressin systems in the brain and their effects on social behavior. For example, mice lacking the oxytocin gene have profound deficits in social processing and social recognition, as do rats lacking vasopressin or mice lacking the vasopressin V1a receptor (V1aR). In another rodent model, monogamous prairie voles are highly social and form strong pair bonds with their mates. Pair bonds can be facilitated or disrupted by perturbing the oxytocin and vasopressin systems. Non‐monogamous vole species that do not pair bond have different oxytocin and V1aR distribution patterns in the brain than monogamous vole species. Potential ties from these rodent models to the human autistic condition are then discussed. Given the hallmark disturbances in social function, the study of animal models of social behavior may provide novel therapeutic targets for the treatment of autism.

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The neuropeptide oxytocin (OXT) has been strongly implicated in social behaviors including social recognition, social approach, pair bonding, paternal care and maternal behavior.
“The neuropeptide oxytocin (OXT) has been strongly implicated in social behaviors including social recognition, social approach, pair bonding, paternal care and maternal behavior (Lim et al, 2005;Sala et al, 2011;Winslow and Insel, 2002).”
From Chronic and acute intranasal oxytocin produce divergent social effects in mice (2014) · cites this paper as Lim et al, 2005

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Authors: Lim, M. M., Bielsky, I. F., & Young, L. J.
Affiliations: Emory University (US)
Corresponding author: Lim, Miranda M.
ORCID: Lim, Miranda M.
Young, Larry J.
Venue: International Journal of Developmental Neuroscience
Publisher: Wiley
Published: 2004-07-03
Volume: 23
Issue: 2-3
Pages: 235-243
ISSN: 0736-5748 (ISSN-L)
1873-474X
DOI: 10.1016/j.ijdevneu.2004.05.006
OpenAlex: W2026554384
Cited by: 129
References: 93
Citations by year: 2026: 1 · 2025: 1 · 2023: 3 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 7 · 2018: 6 · 2017: 7 · 2016: 4 · 2015: 5 · 2014: 6 · 2013: 10 · 2012: 6
FWCI: 1.82
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: International Journal of Developmental Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: Yerkes National Primate Research Center, Emory University (RR00165)
Topics: Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords: autism spectrum disorder, neuropeptides, oxytocin, vasopressin, vasopressin V1a receptor, animal models of autism, social behavior, social recognition, pair bonding, Microtus ochrogaster, monogamy, knockout mice, therapeutic target
MeSH terms: Animals, Autistic Disorder, Disease Models, Animal, Humans, Oxytocin, Social Behavior, Vasopressins, Rats

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Neuropeptides and the social brain: potential rodent models of autism

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