Predicting Developmental Status from 12 to 24 Months in Infants at Risk for Autism Spectrum Disorder: A Preliminary Report
Open accessAbstract
The study examined whether performance profiles on individual items of the Toddler Module of the Autism Diagnostic Observation Schedule at 12 months are associated with developmental status at 24 months in infants at high and low risk for developing Autism Spectrum Disorder (ASD). A nonparametric decision-tree learning algorithm identified sets of 12-month predictors of developmental status at 24 months. Results suggest that identification of infants who are likely to exhibit symptoms of ASD at 24 months is complicated by variable patterns of symptom emergence. Fine-grained analyses linking specific profiles of strengths and deficits with specific patterns of symptom emergence will be necessary for further refinement of screening and diagnostic instruments for ASD in infancy.
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Previous studies have used the strategy of contrasting ASD with no ASD outcome collapsed across risk group.
“Several previous studies have also used the strategy of contrasting ASD with no ASD outcome collapsed across risk group [11, 67–72].”
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- Authors
- Macari, S. L., Campbell, D., Gengoux, G. W., Saulnier, C. A., Klin, A. J., & Chawarska, K.
- Affiliations
- Yale University (US)
- Emory University (US)
- Corresponding author
- Macari, Suzanne L.
- Venue
- Journal of Autism and Developmental Disorders
- Published
- 2012-04-07
- Volume
- 42
- Issue
- 12
- Pages
- 2636-2647
- ISSN
- 0162-3257 (ISSN-L)
- 1573-3432
- PMC
- PMC3565427
- OpenAlex
- W2030278404
- Cited by
- 116
- References
- 57
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 1 · 2022: 5 · 2021: 4 · 2020: 43 · 2019: 3 · 2018: 15 · 2017: 11 · 2016: 9 · 2015: 4 · 2014: 10 · 2013: 7
- FWCI
- 3.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Autism and Developmental Disorders (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Simons Foundation
- National Institute of Mental Health (R01MH087554)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD003008)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Social Sciences › Psychology › Developmental and Educational Psychology › Child and Animal Learning Development
- Keywords
- autism spectrum disorder, Autism Diagnostic Observation Schedule, early screening, decision tree induction
- MeSH terms
- Algorithms, Child Development, Child Development Disorders, Pervasive, Child, Preschool, Female, Humans, Infant, Male, Predictive Value of Tests, Prospective Studies, Risk Factors
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