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Cortical Variability in the Sensory-Evoked Response in Autism
Open accessAbstract
Previous findings have shown that individuals with autism spectrum disorder (ASD) evince greater intra-individual variability (IIV) in their sensory-evoked fMRI responses compared to typical control participants. We explore the robustness of this finding with a new sample of high-functioning adults with autism. Participants were presented with visual, somatosensory and auditory stimuli in the scanner whilst they completed a one-back task. While ASD and control participants were statistically indistinguishable with respect to behavioral responses, the new ASD group exhibited greater IIV relative to controls. We also show that the IIV was equivalent across hemispheres and remained stable over the duration of the experiment. This suggests that greater cortical IIV may be a replicable characteristic of sensory systems in autism.
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“individuals with ASD exhibit increased inter-trial variability in visual evoked potentials (Haigh et al., 2014)”
From Behavioral, Perceptual, and Neural Alterations in Sensory and Multisensory Function in Autism Spectrum Disorder (2015) · cites this paper as Haigh et al., 2014
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Metadata
- Authors
- Haigh, S. M., Heeger, D. J., Dinstein, I., Minshew, N., & Behrmann, M.
- Affiliations
- University of Pittsburgh (US)
- New York University (US)
- Ben-Gurion University of the Negev (IL)
- Carnegie Mellon University (US)
- Corresponding author
- Haigh, Sarah M.
- Venue
- Journal of Autism and Developmental Disorders
- Published
- 2014-10-19
- Volume
- 45
- Issue
- 5
- Pages
- 1176-1190
- ISSN
- 0162-3257 (ISSN-L)
- 1573-3432
- PMC
- PMC5201125
- OpenAlex
- W2038592273
- Cited by
- 113
- References
- 67
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 10 · 2023: 4 · 2022: 10 · 2021: 17 · 2020: 14 · 2019: 12 · 2018: 6 · 2017: 9 · 2016: 12 · 2015: 8
- FWCI
- 5.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Autism and Developmental Disorders (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Simons Foundation
- University of Pittsburgh
- National Eye Institute (P30EY013079)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P50HD055748, HD 055748)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- autism spectrum disorder, within-person variability, sensory evoked potentials, high-functioning adults, hemispheric symmetry, visual stimuli, somatosensory stimuli, auditory stimuli, one-back task, neural response variability
- MeSH terms
- Adult, Autistic Disorder, Cerebral Cortex, Evoked Potentials, Somatosensory, Female, Humans, Magnetic Resonance Imaging, Male, Young Adult, Functional Neuroimaging
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