Depression in adolescents with ASD: a pilot RCT of a group intervention

Santomauro, Damian; Sheffield, Jeanie; Sofronoff, Kate

doi:10.1007/s10803-015-2605-4

Cited by 69Autism Spectrum Disorder ResearchAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesChild and Adolescent Psychosocial and Emotional Development

Depression in adolescents with ASD: a pilot RCT of a group intervention

Santomauro, Damian, Sheffield, Jeanie, Sofronoff, Kate·2016·Journal of Autism and Developmental Disorders

DOI 10.1007/s10803-015-2605-4

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Abstract

Depression is a potentially life threatening affective disorder that is highly prevalent in individuals with autism spectrum disorders (ASD). This study aimed to evaluate the feasibility, acceptability and preliminary efficacy of a cognitive behavioural intervention for depression in adolescents with ASD. Participants were randomly assigned to the intervention group, or wait-list control group. Although recruitment was extremely difficult, attendance was favourable and attrition was low, and participants reported being satisfied with the programme. No significant treatment effect was revealed on the Beck Depression Inventory or Emotion Regulation Questionnaire. However despite the small sample size (n = 20), there was a trending treatment effect measured by the Depression Anxiety Stress Scale: Depression Subscale. Limitations and areas of future research are discussed.

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In a trial of 20 autistic youth (13-18 years old; mean age = 16) randomly assigned to 10 weeks of standard group CBT or waitlist control, there were no treatment effects on depressive symptom severity.
“In the second trial, 20 autistic youth (13–18 years old; mean age = 16) were randomly assigned to 10 weeks of standard group CBT or a waitlist control and results indicated no treatment effects on depressive symptom severity (Santomauro et al., 2016).”
From Community-guided, autism-adapted group cognitive behavioral therapy for depression in autistic youth (CBT-DAY): Preliminary feasibility, acceptability, and efficacy (2024) · cites this paper as Santomauro et al., 2016
Santomauro et al. found a trend towards an effect of group CBT on the DASS depression subscale but no significant effect using the BDI-II in 20 autistic adolescents with depression.
“Santomauro et al. 44 conducted a feasibility crossover randomised controlled trial (RCT) of a group CBT intervention for 20 autistic adolescents with depression, defined as a BDI-II score of > 14. They found a trend towards an effect of treatment on the DASS depression subscale, but no significant effect using the BDI-II, and suggested that larger numbers of participants would be needed to gain”
From Guided self-help for depression in autistic adults: The ADEPT feasibility RCT (2019) · cites this paper as [44]

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Emotion regulation in adolescents and young adults with autism spectrum disorders
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Protocol for a feasibility study and randomised pilot trial of a low-intensity psychological intervention for depression in adults with autism: the Autism Depression Trial (ADEPT)
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Guided self-help for depression in autistic adults: The ADEPT feasibility RCT
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Authors: Santomauro, D., Sheffield, J., & Sofronoff, K.
Affiliations: The University of Queensland (AU)
Corresponding author: Santomauro, Damian
ORCID: Santomauro, Damian
Sheffield, Jeanie
Venue: Journal of Autism and Developmental Disorders
Publisher: Springer Science and Business Media LLC
Published: 2015-09-24
Volume: 46
Issue: 2
Pages: 572-588
ISSN: 0162-3257 (ISSN-L)
1573-3432
DOI: 10.1007/s10803-015-2605-4
OpenAlex: W1818604410
Cited by: 69
References: 63
Citations by year: 2026: 3 · 2025: 7 · 2024: 9 · 2023: 6 · 2022: 4 · 2021: 10 · 2020: 12 · 2019: 5 · 2018: 5 · 2017: 6 · 2016: 2
FWCI: 2.60
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Journal of Autism and Developmental Disorders (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Keywords: depression, autism spectrum disorder, adolescents, cognitive-behavioural intervention, group intervention, feasibility, acceptability, emotion regulation, treatment efficacy
MeSH terms: Autism Spectrum Disorder, Adolescent, Cognition, Depression, Emotions, Female, Humans, Male, Pilot Projects, Psychiatric Status Rating Scales, Psychotherapy, Group, Cognitive Behavioral Therapy, Treatment Outcome, Theory of Mind

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Depression in adolescents with ASD: a pilot RCT of a group intervention

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