A Comparative Study of Suicidality and Its Association with Emotion Regulation Impairment in Large ASD and US Census-Matched Samples
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Evidence suggests increased rates of suicidality in autism spectrum disorder (ASD), but the research has rarely used comparison samples and the role of emotion dysregulation has not been considered. We compared the prevalence of parent-reported suicidality ideation and considered the role of emotion dysregulation in 330 psychiatric inpatient youth with ASD, 1169 community youth with ASD surveyed online, and 1000 youth representative of the US census. The prevalence of suicidal ideation was three and five times higher in the community and inpatient ASD samples, respectively, compared to the general US sample. In the ASD groups, greater emotion dysregulation was associated with suicidal ideation. Implications include consideration of emotion regulation as a potential mechanism and treatment target for suicidality in ASD.
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Emotional dysregulation is related to the development and maintenance of affective and behavioral problems, and particularly to the development and maintenance of anxiety and depression.
“La DRE se ha relacionado con el desarrollo y el mantenimiento de problemas afectivos y conductuales (Cai et al., 2018;Conner et al., 2020) y, particularmente, con el desarrollo y mantenimiento de la ansiedad (Cisler y Olatunji, 2012;White et al., 2014) y la depresión (Schäfer et al., 2017).”
From Ansiedad y trastornos del espectro del autismo: notas para la intervención psicoeducativa (2022) · cites this paper as Conner et al., 2020
The Discussion > Limitations passage says impaired emotion regulation is associated with psychiatric symptoms and problem behaviors in ASD, supporting the clause for which Conner et al. is cited. It does not establish that dysregulation contributes to the development or maintenance of those problems. The sentence cites other sources, not Conner et al., for the specific claims about anxiety and depression; page numbers are unavailable in our copy. (LLM, conf=0.85)
Experimental — accuracy not yet measuredEmotion dysregulation (ED) has been identified as an important risk factor for self-harm and suicidal behaviors in autistic individuals.
“Emotion dysregulation (ED), the difficulty in modulating emotions, has been identified as an important risk factor.”
From Feasibility, Acceptability and Preliminary Efficacy of Dialectical Behavior Therapy for Autistic Adults without Intellectual Disability: A Mixed Methods Study (2022) · cites this paper as Conner et al., 2020
The Discussion reports that emotion-regulation impairment was significantly associated with parent-reported suicidal ideation and behavior in the ASD groups. The Methods measure of behavior includes deliberate self-harm or attempted suicide. However, the paper describes an association, not an established risk factor, and does not assess self-harm separately from suicide attempts. (LLM, conf=0.86)
Experimental — accuracy not yet measuredIn a sample of autistic children and adolescents, greater ED was associated with an increased likelihood of suicidal ideation and attempts.
“Indeed, in a sample of autistic children and adolescents, Conner et al. (2020) reported that greater ED was associated with an increased likelihood of suicidal ideation and attempts.”
From Feasibility, Acceptability and Preliminary Efficacy of Dialectical Behavior Therapy for Autistic Adults without Intellectual Disability: A Mixed Methods Study (2022) · cites this paper as Conner et al., 2020
The Results report that higher emotion-regulation impairment was associated with parent-reported suicidal ideation and with a combined measure of suicidal behaviors or attempts in the ASD groups. The Discussion > Limitations states that the study did not assess suicide attempts separately, so it cannot establish the claimed association with attempts specifically. Page numbers were not provided in our copy. (LLM, conf=0.90)
Experimental — accuracy not yet measuredThere is a growing body of literature suggesting that ED might be a relevant treatment target in autistic individuals, especially those with self-harming behaviors and increased suicidality.
“There is a growing body of literature suggesting that ED might be a relevant treatment target in autistic individuals (Reyes et al., 2019; Conner et al., 2020), especially those with self-harming behaviors and increased suicidality (Moseley et al., 2019; Conner et al., 2020).”
From Feasibility, Acceptability and Preliminary Efficacy of Dialectical Behavior Therapy for Autistic Adults without Intellectual Disability: A Mixed Methods Study (2022) · cites this paper as Conner et al., 2020
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Weiner, L., Costache, M. E., Bemmouna, D., Rabot, J., Weibel, S., Dubreucq, M., Dubreucq, J., & Coutelle, R. (2023) · Women s Health · doi:10.1177/17455057231174763 · Cited by 29 · see citing works
Bemmouna, D., Lagzouli, A., & Weiner, L. (2023) · Molecular Autism · doi:10.1186/s13229-023-00580-3 · Cited by 26 · see citing works
Beck, K. B., MacKenzie, K. T., Kumar, T., Breitenfeldt, K. E., Chang, J. C., Conner, C. M., Mandell, D. L., White, S. W., & Mazefsky, C. A. (2024) · Autism in Adulthood · doi:10.1089/aut.2023.0214 · Cited by 40 · see citing works
Self-citationEmotion dysregulation in autism: Severity and correlates in early childhood
Northrup, J. B., Hartman, A. G., MacKenzie, K. T., Sivathasan, S., Eldeeb, S. M., & Mazefsky, C. A. (2024) · Autism Research · doi:10.1002/aur.3264 · Cited by 23 · see citing works
Self-citationDu, G., Guo, Y., & Xu, W. (2024) · BMC Psychology · doi:10.1186/s40359-024-02045-5 · Cited by 22 · see citing works
Bemmouna, D., & Weiner, L. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1238116 · Cited by 20 · see citing works
McQuaid, G. A., Sadowski, L. Y., Lee, N., & Wallace, G. L. (2023) · Autism in Adulthood · doi:10.1089/aut.2022.0121 · Cited by 22 · see citing works
Shaffer, R. C., Reisinger, D. L., Schmitt, L., Lamy, M., Dominick, K. C., Smith, E. G., Coffman, M. C., & Esbensen, A. J. (2022) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2022.06.020 · Cited by 20 · see citing works
Self-citationMcMaughan, D. J., Imanpour, S., Mulcahy, A. C., Jones, J. L., & Criss, M. M. (2023) · Autism · doi:10.1177/13623613221143592 · Cited by 20 · see citing works
Wang, L., Cui, Q., Liu, J., & Zou, H. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.707181 · Cited by 16 · see citing works
Beck, K. B., Northrup, J. B., Breitenfeldt, K. E., Porton, S., Day, T. N., MacKenzie, K. T., Conner, C. M., & Mazefsky, C. A. (2021) · Autism · doi:10.1177/13623613211061936 · Cited by 21 · see citing works
Self-citationReisinger, D. L., Goodwin, M. S., Horn, P. S., Schmitt, L., Coffman, M. C., & Shaffer, R. C. (2024) · Scientific Reports · doi:10.1038/s41598-024-66084-z · Cited by 16 · see citing works
Self-citationCharacterizing difficulties with emotion regulation in toddlers with autism spectrum disorder
Day, T. N., Mazefsky, C. A., & Wetherby, A. M. (2022) · Research in Autism · doi:10.1016/j.rasd.2022.101992 · Cited by 16 · see citing works
Self-citationCompassion focused therapy for self-stigma and shame in autism: a single case pre-experimental study
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Kirby, A. V., Conner, C. M., & Mazefsky, C. A. (2024) · Autism Research · doi:10.1002/aur.3120 · Cited by 16 · see citing works
Self-citationDay, T. N., Mazefsky, C. A., Yu, L., Zeglen, K. N., Neece, C. L., & Pilkonis, P. A. (2023) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2023.04.021 · Cited by 15 · see citing works
Self-citationCleary, M. L., West, S., McLean, L., Hunt, G. E., Hungerford, C. L., & Kornhaber, R. A. (2022) · Issues in Mental Health Nursing · doi:10.1080/01612840.2022.2132329 · Cited by 12 · see citing works
Lifetime stressor exposure is related to suicidality in autistic adults: A multinational study
Moseley, R. L., Hedley, D., Turner‐Cobb, J. M., Uljarević, M., Bury, S. M., Shields, G. S., Trollor, J. N., Stokes, M. A., & Slavich, G. M. (2024) · Autism · doi:10.1177/13623613241299872 · Cited by 12 · see citing works
Two Halves of the Same Whole: A Framework to Integrate Autism and Mental Health Services
Cleary, M., West, S., Mclean, L., Kornhaber, R., & Hungerford, C. (2022) · Issues in Mental Health Nursing · doi:10.1080/01612840.2022.2126570 · Cited by 12 · see citing works
Cook, M. L., Tomaszewski, B. R., Lamarche, E., Bowman, K. L., Klein, C. B., Stahl, S., & Klinger, L. G. (2024) · Autism · doi:10.1177/13623613241227983 · Cited by 12 · see citing works
Dialectical Behavior Therapy in Autism
Weiner, L., Bemmouna, D., Costache, M. E., & Martz, É. (2025) · Current Psychiatry Reports · doi:10.1007/s11920-025-01596-7 · Cited by 10 · see citing works
The role of intellectual disability and emotional regulation in the autism–depression relationship
Sáez‐Suanes, G. P., García-Villamisar, D. A., & Armentia, A. D. P. (2023) · Autism · doi:10.1177/13623613231161881 · Cited by 10 · see citing works
Gillies-Walker, L., Ramzan, N., Rankin, J., Nimbley, E., & Gillespie‐Smith, K. (2022) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-021-05392-z · Cited by 9 · see citing works
Correlates of quality of life in autistic individuals
MacKenzie, K. T., Theodat, A., Beck, K. B., Conner, C. M., Mazefsky, C. A., & Eack, S. M. (2024) · Research in Autism · doi:10.1016/j.rasd.2024.102401 · Cited by 11 · see citing works
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Cervantes, P. E., Gibbons, R. D., Palinkas, L. A., Conlon, G. R., & Horwitz, S. M. (2024) · Journal of Developmental and Physical Disabilities · doi:10.1007/s10882-024-09963-7 · Cited by 6 · see citing works
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Experiences of the step-out technique in emotion-focused therapy for clients with autistic process
Robinson, A., & Kalawski, J. P. (2022) · Person-Centered & Experiential Psychotherapies · doi:10.1080/14779757.2022.2115941 · Cited by 5 · see citing works
Mazefsky, C. A., Conner, C. M., Siegle, G. J., Scott, L. N., Bylsma, L. M., Beck, K. B., Antezana, L., Hu, X., Cohen, A. D., Borue, X., et al. (2025) · Autism in Adulthood · doi:10.1177/25739581251393807 · Cited by 6 · see citing works
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Self-citationExecutive Functions and Emotional Regulation in Autism Spectrum Disorder: Clinical Implications
Guazzo, G. M., & Ginolfi, C. (2025) · European Journal of Medical and Health Research · doi:10.59324/ejmhr.2025.3(2).18 · Cited by 6 · see citing works
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Exploring self-harm risk vulnerabilities in autism using the ‘thinking patterns profiling model’
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Correlates of Deliberate Self-Harm in Youth With Autism and/or Intellectual Disability
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Mood Alternations on the Autistic Spectrum
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Ansiedad y trastornos del espectro del autismo: notas para la intervención psicoeducativa
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“La DRE se ha relacionado con el desarrollo y el mantenimiento de problemas afectivos y conductuales (Cai et al., 2018; Conner et al., 2020) y, particularmente, con el desarrollo y mantenimiento de la ansiedad (Cisler y Olatunji, 2012; White et al., 2014) y la depresión (Schäfer et al., 2017).”
BackgroundMorris, A. M., Lynch, S., Kasdin, R. G., Hill, I., Shah, S., Shanker, P., Becker, T. D., Staudenmaier, P. J., Leong, A. W., Martin, D., et al. (2025) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-025-06898-6 · Cited by 1 · see citing works
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Neurodiversity‐Affirming Emotion‐Focused Group Therapy: An Exploratory Outcome Study
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Kang, S., Burkett, K., Sarawgi, S., Ruberg, J., Paustian, J., Reisinger, D. L., Schmitt, L. M., & Shaffer, R. C. (2026) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2026.105317 · Cited by 1 · see citing works
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Review of Dejian Mind-Body Intervention Used to Children with Autism Spectrum Disorder
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Psychiatric Inpatient Treatment for Youth with Autism Spectrum Disorder
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Self-citationIzotova, A., Stänicke, L. I., Mars, B., Stene‐Larsen, K., Hannigan, L. J., Øyen, A., Ask, H., Smith, G. D., Reneflot, A., Havdahl, A., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-7235784/v1
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A Systematic Review of the Risk and Protective Factors for Suicide in Autism Spectrum Disorder
Tubío-Fungueiriño, M., Cruz, S., Zubizarreta, S. C.-P., Pozo-Rodríguez, M., Amaia Hervas, G., Carracedo, Á., & Fernández-Prieto, M. (2026) · The Spanish Journal of Psychology · doi:10.1017/sjp.2026.10034
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Self-citationEmotion Regulation Difficulties in Autism‐ PTSD Co‐Occurrence
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La thérapie comportementale dialectique
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Funcionamiento ejecutivo y comportamiento suicida: una revisión sistemática
Sánchez, O. A., & Jorquera-Zapata, L. (2026) · doi:10.21501/9786287765375.4
- Authors
- Conner, C. M., Golt, J., Righi, G., Shaffer, R., Siegel, M., & Mazefsky, C. A.
- Affiliations
- University of Pittsburgh (US)
- Brown University (US)
- Cincinnati Children's Hospital Medical Center (US)
- Tufts University (US)
- Corresponding author
- Mazefsky, Carla A.
- Venue
- Journal of Autism and Developmental Disorders
- Published
- 2020-01-14
- Volume
- 50
- Issue
- 10
- Pages
- 3545-3560
- ISSN
- 0162-3257 (ISSN-L)
- 1573-3432
- PMC
- PMC7893480
- OpenAlex
- W3000587089
- Cited by
- 77
- References
- 80
- Citations by year
- 2026: 10 · 2025: 18 · 2024: 18 · 2023: 11 · 2022: 11 · 2021: 7 · 2020: 2
- FWCI
- 3.09
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Autism and Developmental Disorders (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01 HD079512)
- Simons Foundation Autism Research Initiative (296318)
- Nancy Lurie Marks Family Foundation
- Ritvo-Slifka Award for Innovation in Autism Research
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Keywords
- autism spectrum disorder, suicidality, suicidal ideation, emotional dysregulation, emotion regulation, youth, psychiatric inpatients, prevalence, U.S. Census
- MeSH terms
- Autism Spectrum Disorder, Emotional Regulation, Adolescent, Child, Emotions, Female, Humans, Male, Surveys and Questionnaires, Suicide, United States, Prevalence, Censuses, Suicidal Ideation
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