Cited by 415Luminescence and Fluorescent MaterialsMolecular Sensors and Ion DetectionOptical Imaging and Spectroscopy Techniques

Flavylium Polymethine Fluorophores for Near‐ and Shortwave Infrared Imaging

Cosco, Emily D., Caram, Justin R., Bruns, Oliver T., Franke, Daniel, Day, Rachael A., Farr, Erik P., Bawendi, Moungi G., Sletten, Ellen M.·2017·Angewandte Chemie International Edition

Abstract

Bright fluorophores in the near‐infrared and shortwave infrared (SWIR) regions of the electromagnetic spectrum are essential for optical imaging in vivo. In this work, we utilized a 7‐dimethylamino flavylium heterocycle to construct a panel of novel red‐shifted polymethine dyes, with emission wavelengths from 680 to 1045 nm. Photophysical characterization revealed that the 1‐ and 3‐methine dyes display enhanced photostability and the 5‐ and 7‐methine dyes exhibit exceptional brightness for their respective spectral regions. A micelle formulation of the 7‐methine facilitated SWIR imaging in mice. This report presents the first polymethine dye designed and synthesized for SWIR in vivo imaging.

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Crossref · 10.1002/anie.201706974

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Authors
Cosco, E. D., Caram, J. R., Bruns, O. T., Franke, D., Day, R. A., Farr, E. P., Bawendi, M. G., & Sletten, E. M.
Affiliations
  • University of California, Los Angeles (US)
  • Massachusetts Institute of Technology (US)
  • Department of Chemistry Massachusetts Institute of Technology Cambridge MA 02139 USA
Corresponding author
Sletten, Ellen M.
Venue
Angewandte Chemie International Edition
Publisher
Wiley
Published
2017-09-14
Volume
56
Issue
42
Pages
13126-13129
ISSN
  • 1433-7851 (ISSN-L)
  • 1521-3773
OpenAlex
W2801493974
Cited by
415
References
33
Citations by year
2026: 30 · 2025: 43 · 2024: 49 · 2023: 46 · 2022: 54 · 2021: 66 · 2020: 61 · 2019: 39 · 2018: 25 · 2017: 2
FWCI
14.65
Type
journal article
Language
en
Open access
closed
Locations
  • Angewandte Chemie International Edition (publishedVersion)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
  • OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
Funders
  • U.S. Department of Energy (DE-SC0001088)
  • National Institute for Health Research (5-P41-EB015871-29)
  • University of California, Los Angeles
  • Boehringer Ingelheim Fonds
  • National Science Foundation (CHE-1048804, DGE-1144087)
Topics
  • Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
  • Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
Keywords
polymethine dyes, short-wave infrared imaging, near-infrared imaging, in vivo optical imaging, photostability, photophysical characterization

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