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Prevalence of Depression–PTSD Comorbidity: Implications for Clinical Practice Guidelines and Primary Care-based Interventions
Open accessAbstract
Background Compared to those with depression alone, depressed patients with posttraumatic stress disorder (PTSD) experience more severe psychiatric symptomatology and factors that complicate treatment. Objective To estimate PTSD prevalence among depressed military veteran primary care patients and compare demographic/illness characteristics of PTSD screen-positive depressed patients (MDD-PTSD+) to those with depression alone (MDD). Design Cross-sectional comparison of MDD patients versus MDD-PTSD+ patients. Participants Six hundred seventy-seven randomly sampled depressed patients with at least 1 primary care visit in the previous 12 months. Participants composed the baseline sample of a group randomized trial of collaborative care for depression in 10 VA primary care practices in 5 states. Measurements The Patient Health Questionnaire-9 assessed MDD. Probable PTSD was defined as a Primary Care PTSD Screen > or = 3. Regression-based techniques compared MDD and MDD-PTSD+ patients on demographic/illness characteristics. Results Thirty-six percent of depressed patients screened positive for PTSD. Adjusting for sociodemographic differences and physical illness comorbidity, MDD-PTSD+ patients reported more severe depression (P < .001), lower social support (P < .001), more frequent outpatient health care visits (P < .001), and were more likely to report suicidal ideation (P < .001) than MDD patients. No differences were observed in alcohol consumption, self-reported general health, and physical illness comorbidity. Conclusions PTSD is more common among depressed primary care patients than previously thought. Comorbid PTSD among depressed patients is associated with increased illness burden, poorer prognosis, and delayed response to depression treatment. Providers should consider recommending psychotherapeutic interventions for depressed patients with PTSD.
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“The comorbidity between PTSD and depression is supported by many studies (Bleich et al., 1997; Campbell et al., 2007; O’Donnell et al., 2014), so we assume that depression-related rumination is positively associated with PTSD.”
From Coexistence and different determinants of posttraumatic stress disorder and posttraumatic growth among Chinese survivors after earthquake: role of resilience and rumination (2015) · cites this paper as Campbell et al., 2007
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Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
The PHQ-9: Validity of a brief depression severity measure
Kroenke, K., Spitzer, R. L., & Williams, J. B. W. (2001) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.2001.016009606.x · Cited by 44,910
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2022) · doi:10.1176/appi.books.9780890425787 · Cited by 23,476
Posttraumatic Stress Disorder in the National Comorbidity Survey
Kessler, R. C. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950240066012 · Cited by 10,379
Sherbourne, C. D., & Stewart, A. L. (1991) · Social Science & Medicine · doi:10.1016/0277-9536(91)90150-b · Cited by 6,643
Bush, K. (1998) · Archives of Internal Medicine · doi:10.1001/archinte.158.16.1789 · Cited by 6,196
Combat Duty in Iraq and Afghanistan, Mental Health Problems, and Barriers to Care
Hoge, C. W., Castro, C. A., Messer, S. C., McGurk, D., Cotting, D. I., & Koffman, R. L. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040603 · Cited by 4,778
Hoge, C. W., Auchterlonie, J. L., & Milliken, C. S. (2006) · JAMA · doi:10.1001/jama.295.9.1023 · Cited by 2,027
A Multidimensional Meta-Analysis of Psychotherapy for PTSD
Bradley, R., Greene, J., Russ, E., Dutra, L., & Westen, D. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.2.214 · Cited by 1,938
Norris, F. H. (1992) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.60.3.409 · Cited by 1,527
Research works printed but not linked: 3
- American Psychiatric Association Workgroup on Major Depressive Disorder. Practice guideline for the treatment of patients with major depressive disorder, 2nd edition. Washington: 2000; American Psychiatric Publishing, Inc. Website: http://www.psych.org/psych_pract/treatg/pg/Depression2e.book.cfm .
- Hankin CS, Spiro III A, Miller DR, Kazis L. Mental disorders and mental health treatment among US Department of Veterans Affairs outpatients: the Veterans Health Study. Am J Psychiatry. 1999;156:1924–30. · DOI · Paper page
- Office of Quality and Performance. FY2005 VA Performance Measurement System Technical Manual. Washington, DC: Department of Veterans Affairs, Veterans Health Administration; 2005.
Cited by
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Quantifying Mental Health Signals in Twitter
Coppersmith, G., Dredze, M., & Harman, C. (2014) · Proceedings of the Workshop on Computational Linguistics and Clinical Psychology: From Linguistic Signal to Clinical Reality · doi:10.3115/v1/w14-3207 · Cited by 722
“…as it is in line with known patterns of comorbidity: major depressive disorder, PTSD, and bipolar all have observed comorbidity (Brady et al., 2000; Campbell et al., 2007; McElroy et al., 2001) while SAD is currently considered a specifier of major depressive disorder or bipolar disorder (American…”
BackgroundFlory, J. D., & Yehuda, R. (2015) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2015.17.2/jflory · Cited by 629
Cook, N., Ayers, S., & Horsch, A. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.07.045 · Cited by 481
Forecasting the onset and course of mental illness with Twitter data
Reece, A. G., Reagan, A. J., Lix, K. L. M., Dodds, P. S., Danforth, C. M., & Langer, E. J. (2017) · Scientific Reports · doi:10.1038/s41598-017-12961-9 · Cited by 401
Panagioti, M., Gooding, P. A., & Tarrier, N. (2012) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2012.02.009 · Cited by 280
“Two studies [1,20] were excluded because they reported the same data in more recent articles [21,22].”
ResultPhilip, N. S., Barredo, J., Wout‐Frank, M. V. ‘., Tyrka, A. R., Price, L. H., & Carpenter, L. L. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.07.021 · Cited by 263
Wells, T. S., LeardMann, C. A., Fortuna, S. O., Smith, B., Smith, T. C., Ryan, M. A. K., Boyko, E. J., Blazer, D. G., & for the Millennium Cohort Study Team (2009) · American Journal of Public Health · doi:10.2105/ajph.2008.155432 · Cited by 248
“Further research to unravel this comorbidity is paramount as comorbid PTSD and depression have been reported to increase dysfunction,(63,64) health care utilization,(65) and the risk for suicide.(65,68) Data from the Millennium Cohort Study have contributed to the understanding of PTSD among US military populations.”
BackgroundSijbrandij, M., Kunovski, I., & Cuijpers, P. (2016) · Depression and Anxiety · doi:10.1002/da.22533 · Cited by 213
“The most prevalent mental health problems include posttraumatic stress disorder (PTSD) and depression.[2, 3] PTSD is a debilitating condition, which is associated with reduced quality of life, impaired social and occupational functioning, and considerable personal and societal costs.”
BackgroundLisieski, M. J., Eagle, A. L., Conti, A. C., Liberzon, I., & Perrine, S. A. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00196 · Cited by 233
Post-traumatic stress disorder and suicidal behavior: A narrative review
Panagioti, M., Gooding, P., & Tarrier, N. (2009) · Clinical Psychology Review · doi:10.1016/j.cpr.2009.05.001 · Cited by 267
“Consistent with this, a recent study by Campbell, and co-workers found that suicidal ideation was significantly more likely to be prevalent among depressed patients with comorbid PTSD than in depressed patients without co-morbid PTSD (Campbell et al., 2007).”
BackgroundResultSerova, L. I., Tillinger, A., Alaluf, L. G., Lauková, M., Keegan, K., & Sabban, E. L. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.01.040 · Cited by 197
Nichter, B., Norman, S. B., Haller, M. M., & Pietrzak, R. H. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.06.072 · Cited by 164
Substance Use Disorders in the U.S. Armed Forces
Institute of Medicine (2013) · National Academies Press eBooks · doi:10.17226/13441 · Cited by 156
Post-traumatic stress disorder screening test performance in civilian primary care
Freedy, J. R., Steenkamp, M. M., Magruder, K. M., Yeager, D. E., Zoller, J. S., Hueston, W. J., & Carek, P. J. (2010) · Family Practice · doi:10.1093/fampra/cmq049 · Cited by 160
Rohleder, N., Wolf, J. M., & Wolf, O. T. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.12.003 · Cited by 150
“A limitation of the model is the comorbidity between MDD and PTSD (e.g. Campbell et al., 2007).”
BackgroundMethodAutomatic behavior descriptors for psychological disorder analysis
Scherer, S., Stratou, G., Mahmoud, M., Boberg, J., Gratch, J., Rizzo, A., & Morency, L.-P. (2013) · 2013 10th IEEE International Conference and Workshops on Automatic Face and Gesture Recognition (FG) · doi:10.1109/fg.2013.6553789 · Cited by 147
“and several findings in the literature that confirmed these co-morbidities [8], [23], we decided to combine the three measures using factor analysis to that of general distress.”
MethodBowers, M. E., & Ressler, K. J. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.008 · Cited by 155
“Use of SSRIs in PTSD stems from the observed efficacy of SSRIs for depression and the high incidence of depression comorbid with anxiety and PTSD (8).”
Music therapy for posttraumatic stress in adults: A theoretical review.
Landis-Shack, N., Heinz, A. J., & Bonn-Miller, M. O. (2017) · Psychomusicology: Music, Mind, and Brain · doi:10.1037/pmu0000192 · Cited by 144
“…traumaexposed individuals still experience residual posttraumatic stress symptoms that negatively impact their quality of life (Thomas et al., 2010) and increased risk for other mental health conditions such as depression and problematic substance use (Campbell et al., 2007; Thomas et al., 2010).”
BackgroundMethodInfluentialSupport for the mutual maintenance of pain and post-traumatic stress disorder symptoms
Liedl, A., O'Donnell, M. L., Creamer, M., Silove, D. M., McFARLANE, A. C., Knaevelsrud, C., & Bryant, R. A. (2009) · Psychological Medicine · doi:10.1017/s0033291709991310 · Cited by 144
“The high co-morbidity of depression and pain (e.g. Bair et al. 2003 ; Beesdo et al. 2009), depression and PTSD (e.g. Campbell et al. 2007) and depression with both disorders (e.g. Roth et al. 2008) is well substantiated.”
BackgroundAerobic exercise reduces symptoms of posttraumatic stress disorder: a randomized controlled trial
Fetzner, M. G., & Asmundson, G. J. G. (2015) · Cognitive Behaviour Therapy · doi:10.1080/16506073.2014.916745 · Cited by 139
“Depressive symptoms were tracked in the current study given the high comorbidity between PTSD and depression (Campbell et al., 2007) and previous literature outlining the therapeutic effects of aerobic exercise for depressive disorders (Blumenthal et al., 2007).”
BackgroundBlashill, A. J., Perry, N., & Safren, S. A. (2011) · Current HIV/AIDS Reports · doi:10.1007/s11904-011-0089-1 · Cited by 147
“PTSD is a condition that can be comorbid with depression [28], and is also relatively common amongst HIV-infected individuals.”
BackgroundMental Health Care For Iraq And Afghanistan War Veterans
Burnam, M. A., Meredith, L. S., Tanielian, T., & Jaycox, L. H. (2009) · Health Affairs · doi:10.1377/hlthaff.28.3.771 · Cited by 127
“It operates 877 hospitals and clinics and, within these, nearly 200 specialized outpatient and day treatment programs for PTSD, as well as inpatient units dedicated to PTSD. Care for depression within the VHA is delivered largely within the primary care outpatient setting.10 All veterans with combat service after 11 N…”
InfluentialScherer, S. J., Lucas, G., Gratch, J. S., Rizzo, A., & Morency, L. (2015) · IEEE Transactions on Affective Computing · doi:10.1109/taffc.2015.2440264 · Cited by 127
“This fnding is aligned with prior work reporting high comorbidity between PTSD as well as suicidality and depression [21], [75].”
BackgroundResultPrevalence and predictors of PTSD among a college sample
Cusack, S. E., Hicks, T. A., Bourdon, J., Sheerin, C. M., Overstreet, C. M., Kendler, K. S., Dick, D. M., & Amstadter, A. B. (2019) · Journal of American College Health · doi:10.1080/07448481.2018.1462824 · Cited by 157
“use disorders, anxiety disorders, and suicidal ideation.(19,20,21) The use of longitudinal data to further examine these relationships will contribute to a more comprehensive understanding of how PTE exposure and”
BackgroundWidge, A. S., Ellard, K. K., Paulk, A. C., Basu, I., Yousefi, A., Zorowitz, S., Gilmour, A., Afzal, A., Deckersbach, T., Cash, S. S., et al. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2016.07.021 · Cited by 118
“That dysregulation is also commonly seen in MDD (Rive et al., 2013; Heller et al., 2013), and the two disorders are often comorbid (Regier et al., 2013; Bleich et al., 1997; Campbell et al., 2007).”
Automatic audiovisual behavior descriptors for psychological disorder analysis
Scherer, S. J., Stratou, G., Lucas, G., Mahmoud, M., Boberg, J., Gratch, J. S., Rizzo, A., & Morency, L. (2014) · Image and Vision Computing · doi:10.1016/j.imavis.2014.06.001 · Cited by 125
“Based on this analysis, and several findings in theliterature that confirmed these co-morbidities [52,42], we decided to combine the three measures using principal component analysis to that of general distress.”
MethodMental Health Characteristics of Sexual Minority Veterans
Cochran, B. N., Balsam, K. F., Flentje, A., Malte, C., & Simpson, T. L. (2013) · Journal of Homosexuality · doi:10.1080/00918369.2013.744932 · Cited by 124
“Comorbidity, or presence of multiple diagnoses, is also quite common, with one study finding that 36% of depressed patients receiving care through the Veterans Affairs (VA) system also screened positive for PTSD (Campbell et al., 2007).”
BackgroundDepression subtyping based on evolutionary psychiatry: Proximate mechanisms and ultimate functions
Rantala, M. J., Luoto, S., Krams, I. A., & Karlsson, H. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.10.012 · Cited by 125
Wahbeh, H., Svalina, M. N., & Oken, B. S. (2014) · Open Medicine Journal · doi:10.2174/1874220301401010066 · Cited by 116
Rubenstein, L. V., Chaney, E. F., Ober, S. K., Felker, B. L., Sherman, S. E., Lanto, A. B., & Vivell, S. (2010) · Families Systems & Health · doi:10.1037/a0020302 · Cited by 116
“, 2004); posttraumatic stress disorder (PTSD) using the PTSD Check List (PCL) (Campbell et al., 2007); past history of bipolar disorder or use of mood stabilizers; and dysthymia from the 1 International Diagnostic Instrument (CIDI) short form (Composite International Diagnostic Interview (CIDI) Core Version 2.”
MethodInfluentialSelf-citationTheory of mind performance in women with posttraumatic stress disorder related to childhood abuse
Nazarov, A., Frewen, P., Parlar, M., Oremus, C., MacQueen, G., McKinnon, M., & Lanius, R. (2014) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12142 · Cited by 111
Delahanty, D. L., Gabert-Quillen, C., Ostrowski, S. A., Nugent, N. R., Fischer, B., Morris, A., Pitman, R. K., Bon, J., & Fallon, W. (2013) · CNS Spectrums · doi:10.1017/s1092852913000096 · Cited by 115
Nichter, B., Norman, S. B., Haller, M. M., & Pietrzak, R. H. (2019) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2019.109744 · Cited by 115
Schulze, L., Schulze, A., Renneberg, B., Schmahl, C., & Niedtfeld, I. (2019) · Biological Psychiatry: Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2018.11.004 · Cited by 102
Dennis, E. L., Disner, S. G., Fani, N., Salminen, L. E., Logue, M. W., Clarke‐Rubright, E. K., Haswell, C. C., Averill, C. L., Baugh, L. A., Bomyea, J. A., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0631-x · Cited by 116
Post‐traumatic stress disorder and risk of dementia among members of a health care delivery system
Flatt, J. D., Gilsanz, P., Quesenberry, C. P., Albers, K. B., & Whitmer, R. A. (2017) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2017.04.014 · Cited by 105
“For example, depression is associated with a 2- to 3-fold increased risk of dementia [18,19]; and comorbid depression among individuals with PTSD is very common, with estimates of co-occurrence ranging from 30% to 50% [20,21].”
BackgroundZhou, X., & Wu, X. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.12.076 · Cited by 102
Health Care Utilization and Its Costs for Depressed Veterans With and Without Comorbid PTSD Symptoms
Chan, D., Cheadle, A. D., Reiber, G. E., Unützer, J., & Chaney, E. F. (2009) · Psychiatric Services · doi:10.1176/ps.2009.60.12.1612 · Cited by 103
Self-citationPharmacotherapy for posttraumatic stress disorder: Review with clinical applications
Jeffreys, M., Capehart, B. P., & Friedman, M. J. (2012) · The Journal of Rehabilitation Research and Development · doi:10.1682/jrrd.2011.09.0183 · Cited by 104
Targeting opioid dysregulation in depression for the development of novel therapeutics
Browne, C. A., & Lucki, I. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.04.009 · Cited by 100
Neuropeptide Y (NPY) and posttraumatic stress disorder (PTSD): A translational update
Schmeltzer, S. N., Herman, J. P., & Sah, R. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.06.020 · Cited by 100
“Significant comorbidity is observed between depression and PTSD, with about 36–43% of traumatized subjects expressing comorbid PTSD and depressive symptomology (Campbell et al., 2007; Stein and Kennedy, 2001).”
Structural brain abnormalities common to posttraumatic stress disorder and depression
Kroes, M. C. W., Rugg, M. D., Whalley, M. G., & Brewin, C. R. (2011) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.100077 · Cited by 97
“This overlap is hard to interpret since PTSD and depression have a number of symptoms in common and are frequently comorbid.(4) For example, in one study, reduced hippocampal size was found only in depressed individuals if they also reported early childhood trauma, but two-thirds of this group had comorbid PTSD.”
Sabri, B., Bolyard, R., McFadgion, A. L., Stockman, J. K., Lucea, M. B., Callwood, G. B., Coverston, C. R., & Campbell, J. C. (2013) · Social Work in Health Care · doi:10.1080/00981389.2012.745461 · Cited by 89
“Co-occurrence of PTSD and depression increases illness burden, delays response to treatment of one type of problem, and impairs women’s ability to fully utilize personal and social resources (Campbell et al., 2006; Gorde, Helfrich, & Finalyson, 2004; Green et al., 2006; Sullivan & Bybee, 1999).”
BackgroundChaney, E. F., Rubenstein, L. V., Liu, C., Yano, E. M., Bolkan, C. R., Lee, M., Simon, B. F., Lanto, A. B., Felker, B. L., & Uman, J. E. (2011) · Implementation Science · doi:10.1186/1748-5908-6-121 · Cited by 88
“Campbell DG, et al: Prevalence of depression-PTSD comorbidity: implications for clinical practice guidelines and primary care-based interventions.”
BackgroundSelf-citationAndersen, J. P., Wade, M. J., Possemato, K., & Ouimette, P. C. (2010) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181d969a1 · Cited by 89
Trauma, depression, and comorbid PTSD/depression in a community sample of Latina immigrants.
Kaltman, S. I., Green, B. L., Méte, M., Shara, N. M., & Miranda, J. M. (2010) · Psychological Trauma Theory Research Practice and Policy · doi:10.1037/a0018952 · Cited by 87
Puetz, T. W., Youngstedt, S. D., & Herring, M. P. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126529 · Cited by 92
“For example, higher depressive symptom severity was found among patients with PTSD and comorbid panic disorder compared to patients without the comorbidity [45].”
Post-traumatic stress disorder, depression, and health-related quality of life in OEF/OIF veterans
Pittman, J. O. E., Goldsmith, A. A., Lemmer, J. A., Kilmer, M. T., & Baker, D. G. (2011) · Quality of Life Research · doi:10.1007/s11136-011-9918-3 · Cited by 85
“negative effects on health status [6], understanding that the unique impact of PTSD and depression is important.”
BackgroundStecker, T. A., Fortney, J. C., Owen, R. R., McGovern, M. P., & Williams, S. (2010) · Psychosomatics · doi:10.1176/appi.psy.51.6.503 · Cited by 83
for the Millennium Cohort Study Team, Armenta, R. F., Walter, K. H., Geronimo-Hara, T. R., Porter, B., Stander, V. A., & LeardMann, C. A. (2019) · BMC Psychiatry · doi:10.1186/s12888-019-2375-1 · Cited by 94
Zandvakili, A., Philip, N. S., Jones, S. R., Tyrka, A. R., Greenberg, B. D., & Carpenter, L. L. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.03.077 · Cited by 86
“Their symptoms overlap, and they are notably comorbid: up to half of those with PTSD also have MDD (Campbell et al., 2007; Franklin and Zimmerman, 2001).”
BackgroundHeld, P., Klassen, B. J., Brennan, M. B., & Zalta, A. K. (2018) · Cognitive and Behavioral Practice · doi:10.1016/j.cbpra.2017.09.003 · Cited by 82
“Depressive Symptoms—Because depression is highly comorbid with PTSD, especially in veteran populations (Campbell et al., 2007), veterans were also assessed weekly with the Patient Health Questionnaire-9 (PHQ-9; Kroenke, Spitzer, & Williams, 2001), a reliable and valid self-report measure of depressive symptom severity.”
MethodChiu, S., Niles, J. K., Webber, M. P., Zeig-Owens, R., Gustave, J., Lee, R., Rizzotto, L., Kelly, K. J., Cohen, H. W., & Prezant, D. J. (2011) · Public Health Reports · doi:10.1177/003335491112600211 · Cited by 81
“2 Alternative explanations for the observed comorbidity include: (1) both conditions are reactions to traumatic events,7 (2) depression is a reaction to severe or prolonged PTSD,8 and (3) symptom overlap between these conditions accounts for the appearance of their co-occurrence.”
BackgroundAhmadpanah, M., Sabzeiee, P., Hosseini, S. M., Torabian, S., Haghighi, M., Jahangard, L., Bajoghli, H., Holsboer‐Trachsler, E., & Brand, S. (2014) · Neuropsychobiology · doi:10.1159/000362243 · Cited by 80
Maguen, S., Cohen, B. E., Cohen, G. H., Madden, E., Bertenthal, D., & Seal, K. H. (2012) · Journal of Women s Health · doi:10.1089/jwh.2011.3113 · Cited by 80
Darcet, F., Gardier, A. M., Gaillard, R., David, D. J. P., & Guilloux, J. (2016) · Pharmaceuticals · doi:10.3390/ph9010009 · Cited by 85
“Although PTSD confers specific significant psychiatric disturbances and functional impairments, depression and PTSD are commonly co-morbid diseases.”
BackgroundInfluentialSchnurr, P. P., Friedman, M. J., Oxman, T. E., Dietrich, A. J., Smith, M. W., Shiner, B. R., Forshay, E., Gui, J., & Thurston, V. (2012) · Journal of General Internal Medicine · doi:10.1007/s11606-012-2166-6 · Cited by 77
Automatic Nonverbal Behavior Indicators of Depression and PTSD: Exploring Gender Differences
Stratou, G., Scherer, S. J., Gratch, J. S., & Morency, L. (2013) · International Conference on Affective Computing and Intelligent Interaction and workshops · doi:10.1109/acii.2013.31 · Cited by 77
The Impact of Specific and Complex Trauma on the Mental Health of Homeless Youth
Wong, C. F., Clark, L. F., & Marlotte, L. (2014) · Journal of Interpersonal Violence · doi:10.1177/0886260514556770 · Cited by 95
“Studies should also consider how complex traumatic experiences may lead to the development of complex mental health symptoms, particularly the comorbidity between depression and PTSD (Campbell et al., 2007).”
BackgroundDavidson, C. L., Babson, K. A., Bonn‐Miller, M. O., Souter, T., & Vannoy, S. (2013) · Suicide and Life-Threatening Behavior · doi:10.1111/sltb.12014 · Cited by 71
“Indeed, although some studies suggest that PTSD is a risk factor for suicide only in the context of co-occurring depression (Campbell et al., 2007; Oquendo et al., 2003; Zivin et al., 2007), the preponderance of evidence seems to point to PTSD as an important independent risk factor for suicide…”
BackgroundMDMA Impairs Both the Encoding and Retrieval of Emotional Recollections
Doss, M. K., Weafer, J. J., Gallo, D. A., & de Wit, H. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.171 · Cited by 77
Relations among social support, PTSD symptoms, and substance use in veterans.
Grös, D. F., Flanagan, J. C., Korte, K. J., Mills, A. C., Brady, K. T., & Back, S. E. (2016) · Psychology of Addictive Behaviors · doi:10.1037/adb0000205 · Cited by 72
“Individuals with PTSD and cooccurring SUD are more likely than individuals without SUD to have numerous health and psychosocial complications and lower social support has been documented in those with PTSD and co-occurring disorders than individuals with a single diagnosis (Campbell et al., 2007).”
Simblett, S. K., Birch, J., Matcham, F., Yágüez, L., & Morris, R. G. (2017) · JMIR Mental Health · doi:10.2196/mental.5558 · Cited by 74
“Other mental health problems such as poor anger control, drug and alcohol problems, and depression can develop alongside symptoms of PTSD, which can delay access to treatment and increase the burden of illness for individuals [1,2].”
BackgroundPilot randomized controlled trial of exercise training for older veterans with PTSD
Hall, K. S. M., Morey, M. C., Bosworth, H. B., Beckham, J. C., Pebole, M. M., Sloane, R. J., & Pieper, C. F. (2019) · Journal of Behavioral Medicine · doi:10.1007/s10865-019-00073-w · Cited by 81
Wu, X., Zhou, X., Wu, Y., & An, Y. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.01335 · Cited by 71
“Posttraumatic stress disorder (PTSD) is the most common negative outcome after traumatic events (Campbell et al., 2007; Bal, 2008; Wang et al., 2012).”
BackgroundWu, K., Zhang, Y., Liu, Z., Zhou, P., & Wei, C. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.01043 · Cited by 76
“…between PTSD and Frontiers in Psychology | www.frontiersin.org 2 August 2015 | Volume 6 | Article 1043 depression is supported by many studies (Bleich et al., 1997; Campbell et al., 2007; O’Donnell et al., 2014), so we assume that depression-related rumination is positively associated with”
BackgroundAssociation of Posttraumatic Stress and Depressive Symptoms With Mortality in Women
Roberts, A. L., Kubzansky, L. D., Chibnik, L. B., Rimm, E. B., & Koenen, K. C. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.27935 · Cited by 72
“3 (43-64) years at study baseline in 2008.”
BackgroundHoogsteder, L. M., Thije, L. T., Schippers, E. E., & Stams, G. J. J. M. (2021) · International Journal of Offender Therapy and Comparative Criminology · doi:10.1177/0306624x211010290 · Cited by 79
“These developmental areas often relate to internalizing behavior problems, such as mood disorder symptoms, anxiety symptoms, or a negative self-image (Campbell et al., 2007; Green et al., 2010; McLaughlin et al., 2012).”
BackgroundPosttraumatic stress disorder and depressive symptoms: Joined or independent sequelae of trauma?
Dekel, S., Solomon, Z., Horesh, D., & Ein‐Dor, T. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.03.003 · Cited by 67
Carpenter, L. L., Conelea, C. A., Tyrka, A. R., Welch, E. S., Greenberg, B. D., Price, L. H., Niedzwiecki, M. J., Yip, A. G., Barnes, J. L., & Philip, N. S. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.04.009 · Cited by 62
“Patients with comorbid MDD and PTSD symptoms have poorer treatment outcomes for both pharmacotherapy and psychotherapy (Holtzheimer et al., 2005; Campbell et al., 2007) and as such are well represented among those with treatment-resistant major depression referred for rTMS therapy.”
Influence of Multiple Traumatic Event Types on Mental Health Outcomes: Does Count Matter?
Gerber, M. M., Frankfurt, S. B., Contractor, A. A., Oudshoorn, K., Dranger, P., & Brown, L. A. (2018) · Journal of Psychopathology and Behavioral Assessment · doi:10.1007/s10862-018-9682-6 · Cited by 62
“2011), negative cognitive appraisals (Whiting and Bryant 2007), and physiological changes (Campbell et al. 2007; Cicerone and Fraser 1999) including interruptions in neurological development (Heim et al.”
BackgroundZammit, S., Lewis, C., Dawson, S., Colley, H., McCann, H. M., Piekarski, A., Rockliff, H., & Bisson, J. I. (2018) · The British Journal of Psychiatry · doi:10.1192/bjp.2017.8 · Cited by 61
Kirkpatrick, M. G., Goldenson, N. I., Kapadia, N., Kahler, C. W., de Wit, H., Swift, R. M., McGeary, J. E., Sussman, S. Y., & Leventhal, A. M. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4091-y · Cited by 59
“Anxiety-related general distress is implicated in forms of anxiety that are highly comorbid with depression, such as generalized anxiety and PTSD (Campbell et al. 2007; Rector et al. 2007).”
Brignone, E., Fargo, J. D., Blais, R. K., Carter, M. E., Samore, M. H., & Gundlapalli, A. V. (2017) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2016.11.015 · Cited by 59
Bryan, C. J., Clemans, T. A., Hernandez, A. M., & Rudd, M. D. (2013) · Journal of Head Trauma Rehabilitation · doi:10.1097/htr.0b013e31826c73cc · Cited by 76
The Mental Health Needs of Military Service Members and Veterans
Lazar, S. G. (2014) · Psychodynamic Psychiatry · doi:10.1521/pdps.2014.42.3.459 · Cited by 62
Investigation of telomere length and psychological stress in rape victims
Malan‐Müller, S., Hemmings, S. M. J., Kidd, M., Martin, L. I., & Seedat, S. (2011) · Depression and Anxiety · doi:10.1002/da.20903 · Cited by 61
“[36] Data from other countries suggest strong associations between rape and MDD, PTSD, and other anxiety disorders.[37,38] Coid et al.”
BackgroundAutomatic nonverbal behavior indicators of depression and PTSD: the effect of gender
Stratou, G., Scherer, S. J., Gratch, J. S., & Morency, L. (2014) · Journal on Multimodal User Interfaces · doi:10.1007/s12193-014-0161-4 · Cited by 57
“Others argue that it is highly meaningful to differentially distinguish between these conditions and recommend distinct treatments depending on whether one or both conditions are present [42].”
BackgroundFarhood, L., Fares, S. A., Sabbagh, R., & Hamady, C. (2016) · European Journal of Psychotraumatology · doi:10.3402/ejpt.v7.31509 · Cited by 56
“Patients who exhibited this comorbidity often showed exacerbated symptoms, thereby corroborating the increasingly complex necessitation for treatment (Campbell et al., 2007).”
BackgroundBruijniks, S. J. E., DeRubeis, R. J., Hollon, S. D., & Huibers, M. J. H. (2019) · Clinical Psychological Science · doi:10.1177/2167702619830391 · Cited by 57
Paparrigopoulos, T. J., Melissaki, A., Tzavellas, E., Karaiskos, D., Ilias, Ι., & Kokras, N. (2013) · International Journal of Psychiatry in Clinical Practice · doi:10.3109/13651501.2013.855793 · Cited by 52
“Indeed, the co-occurrence of PTSD and depression, as revealed in the present study, is in agreement with previous observations advocating the high co-morbidity between these two conditions (Ginzburg 2006; Campbell et al. 2007).”
ResultCo-Occurrence of Major Depressive Episode and Posttraumatic Stress Disorder Among Survivors of War
Nexhmedin Morina, B., Ajduković, D., Bogić, M., Frančišković, T., Kučukalić, A., Lečić‐Toševski, D., Morina, L., Popovski, M., & Priebe, S. (2013) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.12m07844 · Cited by 56
Jain, S., Ortigo, K. M., Gimeno, J., Baldor, D. A., Weiss, B. J., & Cloître, M. (2020) · Journal of Traumatic Stress · doi:10.1002/jts.22523 · Cited by 56
Brancu, M., Thompson, N. L., Beckham, J. C., Green, K. T., Calhoun, P. S., Elbogen, E. B., Robbins, A. T., Fairbank, J. A., & Wagner, H. R. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.02.025 · Cited by 50
“Considering comorbidity in veterans is associated with lower social support (Campbell et al., 2007) and increased distress and impairment (Ikin et al.”
BackgroundMartin, C. E., Vujanovic, A. A., Paulus, D. J., Bartlett, B., Gallagher, M. W., & Tran, J. K. (2017) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2017.01.002 · Cited by 49
A Snapshot of Mental Health and Wellness of Engineering Students Across the Western United States
Danowitz, A., & Beddoes, K. (2020) · IEEE Frontiers in Education Conference (FIE) · doi:10.1109/fie44824.2020.9273885 · Cited by 49
“studies have indicated a high-comorbidity of these conditions [26].”
BackgroundDual Use of VA and Non-VA Services Among Primary Care Patients with Depression
Liu, C., Bolkan, C. R., Chan, D., Yano, E. M., Rubenstein, L. V., & Chaney, E. F. (2008) · Journal of General Internal Medicine · doi:10.1007/s11606-008-0867-7 · Cited by 49
Self-citationSu, T., Zhang, L., Chung, M., Chen, Y.-S., Bi, Y.-M., Chou, Y.-H., Barker, J. L., Barrett, J. E., Maric, D., Li, X. X., et al. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.03.010 · Cited by 49
Kothgassner, O. D., Pellegrini, M., Goreis, A., Giordano, V., Edobor, J., Fischer, S., Plener, P. L., & Huscsava, M. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105168 · Cited by 49
Post-traumatic stress disorder as a comorbidity: impact on disease outcomes
Cavalcanti-Ribeiro, P., Andrade-Nascimento, M., Morais-de-Jesus, M., de Medeiros, G. M., Daltro-Oliveira, R., conceição, J. O., Rocha, M. F. V., Miranda‐Scippa, Â., Koenen, K. C., & Quarantini, L. C. (2012) · Expert Review of Neurotherapeutics · doi:10.1586/ern.12.77 · Cited by 48
A Dynamic Model of Post-Traumatic Stress Disorder for Military Personnel and Veterans
Ghaffarzadegan, N., Ebrahimvandi, A., & Jalali, M. S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161405 · Cited by 55
“PTSD is highly comorbid with other psychological effects or mental illnesses that can occur following trauma, including depression [7, 8], anger and violence [3], guilt and shame [9, 10], substance abuse [11, 12], and suicidality [13].”
BackgroundInfluentialRoberts, A. L., Koenen, K. C., Chen, Q., Gilsanz, P., Mason, S. M., Prescott, J., Ratanatharathorn, A. D., Rimm, E. B., Sumner, J. A., Winning, A., et al. (2017) · Depression and Anxiety · doi:10.1002/da.22620 · Cited by 55
“Moreover, as depression and PTSD are highly comorbid (Bleich, Koslowsky, Dolev, & Lerer, 1997; Campbell et al., 2007; Gill, Page, Sharps, & Campbell, 2008), and depression is associated with shorter TL in several (Hartmann, Boehner, Groenen, & Kalb, 2010; Schutte & Malouff, 2015; Simon et al.,…”
Fruchtman-Steinbok, T., Keynan, J. N., Cohen, A., Jaljuli, I., Mermelstein, S., Drori, G., Routledge, E., Krasnoshtein, M., Playle, R., Linden, D. E. J., et al. (2021) · NeuroImage: Clinical · doi:10.1016/j.nicl.2021.102859 · Cited by 42
Bolkan, C. R., Bonner, L. M., Campbell, D. G., Lanto, A., Zivin, K., Chaney, E., & Rubenstein, L. V. (2013) · Psychiatric Services · doi:10.1176/appi.ps.201200160 · Cited by 47
Reduced vowel space is a robust indicator of psychological distress: A cross-corpus analysis
Scherer, S. J., Morency, L., Gratch, J. S., & Pestian, J. P. (2015) · IEEE International Conference on Acoustics Speech and Signal Processing · doi:10.1109/icassp.2015.7178880 · Cited by 47
“Indeed the comorbidity between PTSD as well as suicidality and depression has been previously identified in the literature [31, 32] and the observed strong correlation between conditions has been further discussed in our prior work, where we have identified the more generic condition of psychological distress as a com…”
BackgroundVujanovic, A. A., Rathnayaka, N. S., Amador, C. D., & Schmitz, J. M. (2015) · Behavior Modification · doi:10.1177/0145445515621490 · Cited by 47
“54), consistent with extant literature (e.g., Brady et al., 2000; Campbell et al., 2007).”
ResultSuicidal or Self‐Harming Ideation in Military Personnel Transitioning to Civilian Life
Mansfield, A. J., Bender, R. H., Hourani, L. L., & Larson, G. E. (2011) · Suicide and Life-Threatening Behavior · doi:10.1111/j.1943-278x.2011.00039.x · Cited by 50
Depression in post-traumatic stress disorder
Radell, M. L., Hamza, E. A., & Moustafa, A. A. (2020) · Reviews in the Neurosciences · doi:10.1515/revneuro-2020-0006 · Cited by 47
The Effectiveness of Emotionally Focused Couples Therapy With Veterans With PTSD: A Pilot Study
Weissman, N. J., Batten, S. V., Rheem, K. D., Wiebe, S. A., Pasillas, R. M., Potts, W., Barone, M. D., Brown, C. H., & Dixon, L. B. (2017) · Journal of Couple & Relationship Therapy · doi:10.1080/15332691.2017.1285261 · Cited by 45
“Further, there is evidence that EFT may contribute to a reduction in depressive symptoms (Denton, Wittenborn, & Golden, 2012; Dessaulles, Johnson, & Denton, 2003), a common comorbidity with PTSD (Campbell et al., 2007).”
BackgroundLee, C. J., Wu, H.-F., Chu, M.-C., Chung, Y.-J., Mao, W.-C., Li, C., & Lin, H. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa244 · Cited by 43
Metadata
- Authors
- Campbell, D. G., Felker, B. L., Liu, C.-F., Yano, E. M., Kirchner, J. E., Chan, D., Rubenstein, L. V., & Chaney, E. F.
- Affiliations
- Health Services Research & Development (US)
- University of Washington (US)
- University of California, Los Angeles (US)
- Central Arkansas Veterans Healthcare System (US)
- RAND Corporation (US)
- Corresponding author
- Campbell, Duncan G.
- ORCID
- Venue
- Journal of General Internal Medicine
- Published
- 2007-01-24
- Volume
- 22
- Issue
- 6
- Pages
- 711-718
- ISSN
- 0884-8734 (ISSN-L)
- 1525-1497
- PMC
- PMC2219856
- OpenAlex
- W2030974975
- Cited by
- 458
- References
- 57
- Citations by year
- 2026: 15 · 2025: 24 · 2024: 14 · 2023: 19 · 2022: 25 · 2021: 29 · 2020: 34 · 2019: 39 · 2018: 34 · 2017: 37 · 2016: 36 · 2015: 31 · 2014: 26 · 2013: 30 · 2012: 14
- FWCI
- 10.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of General Internal Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs
- Pfizer
- RAND Corporation
- Health Services Research and Development
- University of Washington
- University of Montana
- University of California, Los Angeles
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Social Sciences › Psychology › Clinical Psychology › Migration, Health and Trauma
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Keywords
- depression, post-traumatic stress disorder, PTSD prevalence, comorbidities, military veterans, primary care, collaborative care, suicidal ideation, social support, PHQ-9, PTSD screening, treatment response
- MeSH terms
- Aged, Cross-Sectional Studies, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Primary Health Care, Stress Disorders, Post-Traumatic, Veterans, Comorbidity, Prevalence, Practice Guidelines as Topic
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