Cited by 260Schizophrenia research and treatmentNeural dynamics and brain functionNeuroscience and Neuropharmacology Research

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Alterations of Cortical GABA Neurons and Network Oscillations in Schizophrenia

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Gonzalez-Burgos, Guillermo, Hashimoto, Takanori, Lewis, David A.·2010·Current Psychiatry Reports

DOI 10.1007/s11920-010-0124-8PMC PMC2919752

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Abstract

The hypothesis that alterations of cortical inhibitory gamma-aminobutyric acid (GABA) neurons are a central element in the pathology of schizophrenia has emerged from a series of postmortem studies. How such abnormalities may contribute to the clinical features of schizophrenia has been substantially informed by a convergence with basic neuroscience studies revealing complex details of GABA neuron function in the healthy brain. Importantly, activity of the parvalbumin-containing class of GABA neurons has been linked to the production of cortical network oscillations. Furthermore, growing knowledge supports the concept that gamma band oscillations (30-80 Hz) are an essential mechanism for cortical information transmission and processing. Herein we review recent studies further indicating that inhibition from parvalbumin-positive GABA neurons is necessary to produce gamma oscillations in cortical circuits; provide an update on postmortem studies documenting that deficits in the expression of glutamic acid decarboxylase67, which accounts for most GABA synthesis in the cortex, are widely observed in schizophrenia; and describe studies using novel, noninvasive approaches directly assessing potential relations between alterations in GABA, oscillations, and cognitive function in schizophrenia.

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Wang HX, Gao WJ: Cell type-specific development of NMDA receptors in the interneurons of rat prefrontal cortex. Neuropsychopharmacology 2009, 34:2028–2040. · DOI

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Authors: Gonzalez-Burgos, G., Hashimoto, T., & Lewis, D. A.
Affiliations: Kanazawa University (JP)
University of Pittsburgh (US)
ORCID: Hashimoto, Takanori
Lewis, David A.
Venue: Current Psychiatry Reports
Publisher: Springer Science and Business Media LLC
Published: 2010-06-17
Volume: 12
Issue: 4
Pages: 335-344
ISSN: 1523-3812 (ISSN-L)
1535-1645
DOI: 10.1007/s11920-010-0124-8
PMC: PMC2919752
OpenAlex: W2073239561
Cited by: 260
References: 97
Citations by year: 2026: 7 · 2025: 7 · 2024: 10 · 2023: 11 · 2022: 9 · 2021: 10 · 2020: 12 · 2019: 8 · 2018: 9 · 2017: 15 · 2016: 14 · 2015: 21 · 2014: 21 · 2013: 30 · 2012: 29
FWCI: 4.78
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Current Psychiatry Reports (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (P50MH084053, R01MH051234)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: schizophrenia, GABAergic neurons, parvalbumin, gamma oscillations, cortical inhibition, glutamic acid decarboxylase 67, postmortem brain studies, cognitive function
MeSH terms: Biological Clocks, Cerebral Cortex, gamma-Aminobutyric Acid, Humans, Nerve Net, Synaptic Transmission, Neurons, Schizophrenia

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Alterations of Cortical GABA Neurons and Network Oscillations in Schizophrenia

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