Covid-19: automatic detection from X-ray images utilizing transfer learning with convolutional neural networks
Open accessAbstract
In this study, a dataset of X-ray images from patients with common bacterial pneumonia, confirmed Covid-19 disease, and normal incidents, was utilized for the automatic detection of the Coronavirus disease. The aim of the study is to evaluate the performance of state-of-the-art convolutional neural network architectures proposed over the recent years for medical image classification. Specifically, the procedure called Transfer Learning was adopted. With transfer learning, the detection of various abnormalities in small medical image datasets is an achievable target, often yielding remarkable results. The datasets utilized in this experiment are two. Firstly, a collection of 1427 X-ray images including 224 images with confirmed Covid-19 disease, 700 images with confirmed common bacterial pneumonia, and 504 images of normal conditions. Secondly, a dataset including 224 images with confirmed Covid-19 disease, 714 images with confirmed bacterial and viral pneumonia, and 504 images of normal conditions. The data was collected from the available X-ray images on public medical repositories. The results suggest that Deep Learning with X-ray imaging may extract significant biomarkers related to the Covid-19 disease, while the best accuracy, sensitivity, and specificity obtained is 96.78%, 98.66%, and 96.46% respectively. Since by now, all diagnostic tests show failure rates such as to raise concerns, the probability of incorporating X-rays into the diagnosis of the disease could be assessed by the medical community, based on the findings, while more research to evaluate the X-ray approach from different aspects may be conducted.
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Several convolutional neural network approaches for automatic detection from X-ray images in COVID-19 and pulmonary disease showed excellent performance.
“In the area of COVID-19 and pulmonary disease, several convolutional neural network approaches have been proposed for automatic detection from X-ray images which showed an excellent performance [46, 276–279].”
From Review of deep learning: concepts, CNN architectures, challenges, applications, future directions (2021) · cites this paper as [276]
With the help of artificial intelligence, X-ray images can be used to identify deep layer features which are not visible to the human eyes.
“However, with the help of artificial intelligence, the X-ray images can be used to identify the deep layer features which are not visible to the human eyes [73].”
From Can AI help in screening viral and COVID-19 pneumonia? (2020) · cites this paper as [73]
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Cites
Adam: A Method for Stochastic Optimization
Kingma, D. P., & Ba, J. (2014) · arXiv · doi:10.48550/arxiv.1412.6980 · Cited by 98,946 · see citing works
Very Deep Convolutional Networks for Large-Scale Image Recognition
Simonyan, K., & Zisserman, A. (2014) · arXiv · doi:10.48550/arxiv.1409.1556 · Cited by 74,248 · see citing works
ImageNet Large Scale Visual Recognition Challenge
Russakovsky, O., Deng, J., Su, H., Krause, J., Satheesh, S., Ma, S., Huang, Z., Karpathy, A., Khosla, A., Bernstein, M., et al. (2015) · International Journal of Computer Vision · doi:10.1007/s11263-015-0816-y · Cited by 39,380 · see citing works
Xception: Deep Learning with Depthwise Separable Convolutions
Chollet, F. (2017) · 2017 IEEE Conference on Computer Vision and Pattern Recognition (CVPR) · doi:10.1109/cvpr.2017.195 · Cited by 20,380 · see citing works
MobileNets: Efficient Convolutional Neural Networks for Mobile Vision Applications
Howard, A. G., Zhu, M., Chen, B., Kalenichenko, D., Wang, W., Weyand, T., Andreetto, M., & Adam, H. (2017) · arXiv · doi:10.48550/arxiv.1704.04861 · Cited by 19,015 · see citing works
(2010) · International Conference on Machine Learning · Cited by 13,995 · see citing works
Pathological findings of COVID-19 associated with acute respiratory distress syndrome
Xu, Z., Shi, L., Wang, Y., Zhang, J., Huang, L., Zhang, C., Liu, S., Zhao, P., Liu, H., Zhu, L., et al. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30076-x · Cited by 8,545 · see citing works
Improving neural networks by preventing co-adaptation of feature detectors
Hinton, G. E., Srivastava, N., Krizhevsky, A., Sutskever, I., & Salakhutdinov, R. R. (2012) · arXiv · doi:10.48550/arxiv.1207.0580 · Cited by 6,382 · see citing works
Weiss, K., Khoshgoftaar, T. M., & Wang, D. (2016) · Journal of Big Data · doi:10.1186/s40537-016-0043-6 · Cited by 6,260 · see citing works
Identifying Medical Diagnoses and Treatable Diseases by Image-Based Deep Learning
Kermany, D. S., Goldbaum, M., Cai, W., Valentim, C. C. S., Liang, H., Baxter, S. L., McKeown, A., Yang, G., Wu, X., Yan, F., et al. (2018) · Cell · doi:10.1016/j.cell.2018.02.010 · Cited by 4,842 · see citing works
Inception-v4, Inception-ResNet and the Impact of Residual Connections on Learning
Szegedy, C., Ioffe, S., Vanhoucke, V., & Alemi, A. (2017) · Proceedings of the AAAI Conference on Artificial Intelligence · doi:10.1609/aaai.v31i1.11231 · Cited by 4,636 · see citing works
Deep Learning: Methods and Applications
Deng, L., & Yu, D. (2014) · Foundations and Trends® in Signal Processing · doi:10.1561/2000000039 · Cited by 3,480 · see citing works
Hawkins, D. M. (2004) · Journal of Chemical Information and Computer Sciences · doi:10.1021/ci0342472 · Cited by 2,522 · see citing works
Deep Learning: Methods and Applications
Deng, L. (2014) · now publishers, Inc. eBooks · doi:10.1561/9781601988157 · Cited by 1,785 · see citing works
Greenspan, H. K., van Ginneken, B., & Summers, R. M. (2016) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2016.2553401 · Cited by 1,704 · see citing works
COVID-19 Image Data CollectionPreprint
Cohen, J., Morrison, P., & Dao, L. (2020) · arXiv (Cornell University) · doi:10.48550/arxiv.2003.11597 · Cited by 722 · see citing works
What makes ImageNet good for transfer learning?Preprint
Huh, M., Agrawal, P., & Efros, A. A. (2016) · arXiv (Cornell University) · doi:10.48550/arxiv.1608.08614 · Cited by 591 · see citing works
ImageNet Large Scale Visual Recognition Challenge
Russakovsky, O., Deng, J., Su, H., Krause, J., Satheesh, S., Ma, S., Huang, Z., Karpathy, A., Khosla, A., Bernstein, M., et al. (2014) · arXiv · doi:10.48550/arxiv.1409.0575 · Cited by 567 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Review of deep learning: concepts, CNN architectures, challenges, applications, future directions
Alzubaidi, L., Zhang, J., Humaidi, A. J., Al-Dujaili, A., Duan, Y., Al-Shamma, O., Santamaría, J., Fadhel, M. A., Al-Amidie, M., & Farhan, L. (2021) · Journal of Big Data · doi:10.1186/s40537-021-00444-8 · Cited by 7,906 · see citing works
Wynants, L., Van Calster, B., Bonten, M. M., Collins, G. S., Debray, T. P., De Vos, M., Haller, M. C., Heinze, G., Moons, K. G., Riley, R. D., et al. (2020) · doi:10.1101/2020.03.24.20041020 · Cited by 3,070 · see citing works
Can AI help in screening viral and COVID-19 pneumonia?
Chowdhury, M. E. H., Rahman, T., Khandakar, A., Mazhar, R., Kadir, M. A., Mahbub, Z. B., Islam, K. R., Khan, M. S., Iqbal, A., Emadi, N. A., et al. (2020) · IEEE Access · doi:10.1109/access.2020.3010287 · Cited by 1,913 · see citing works
Rahimzadeh, M., & Attar, A. (2020) · Informatics in Medicine Unlocked · doi:10.1016/j.imu.2020.100360 · Cited by 695 · see citing works
Machine-learning-based disease diagnosis: a comprehensive review
Ahsan, M. M., Luna, S. A., & Siddique, Z. (2022) · Healthcare · doi:10.3390/healthcare10030541 · Cited by 603 · see citing works
Mahmud, T., Rahman, M. A., & Fattah, S. A. (2020) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2020.103869 · Cited by 525 · see citing works
AI4COVID-19: AI enabled preliminary diagnosis for COVID-19 from cough samples via an app
Imran, A., Posokhova, I., Qureshi, H. N., Masood, U., Riaz, M. S., Ali, K., John, C. N., Hussain, M. I., & Nabeel, M. (2020) · Informatics in Medicine Unlocked · doi:10.1016/j.imu.2020.100378 · Cited by 621 · see citing works
Heidari, M., Mirniaharikandehei, S., Khuzani, A. Z., Danala, G., Qiu, Y., & Zheng, B. (2020) · International Journal of Medical Informatics · doi:10.1016/j.ijmedinf.2020.104284 · Cited by 423 · see citing works
Pham, Q.-V., Nguyen, D. C., Huynh-The, T., Hwang, W.-J., & Pathirana, P. N. (2020) · IEEE Access · doi:10.1109/access.2020.3009328 · Cited by 413 · see citing works
Viral pneumonia screening on chest X-rays using confidence-aware anomaly detection
Zhang, J., Xie, Y., Pang, G., Liao, Z., Verjans, J., Li, W., Sun, Z., He, J., Li, Y., Shen, C., et al. (2021) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2020.3040950 · Cited by 389 · see citing works
Toraman, S., Alakus, T. B., & Turkoglu, I. (2020) · Chaos, Solitons & Fractals · doi:10.1016/j.chaos.2020.110122 · Cited by 327 · see citing works
Nour, M., Cömert, Z., & Polat, K. (2020) · Applied Soft Computing · doi:10.1016/j.asoc.2020.106580 · Cited by 316 · see citing works
Shorfuzzaman, M., & Hossain, M. S. (2021) · Pattern Recognition · doi:10.1016/j.patcog.2020.107700 · Cited by 217 · see citing works
Applications of artificial intelligence in battling against covid-19: A literature review
Tayarani N., M.-H. (2021) · Chaos, Solitons & Fractals · doi:10.1016/j.chaos.2020.110338 · Cited by 210 · see citing works
Unveiling COVID-19 from CHEST X-ray with deep learning: A hurdles race with small data
Tartaglione, E., Barbano, C. A., Berzovini, C., Calandri, M., & Grangetto, M. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17186933 · Cited by 211 · see citing works
Celard, P., Iglesias, E. L., Sorribes-Fdez, J. M., Romero, R., Vieira, A. S., & Borrajo, L. (2023) · Neural Computing and Applications · doi:10.1007/s00521-022-07953-4 · Cited by 188 · see citing works
COVID-19 image classification using deep learning: Advances, challenges and opportunities
Aggarwal, P., Mishra, N. K., Fatimah, B., Singh, P., Gupta, A., & Joshi, S. D. (2022) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2022.105350 · Cited by 168 · see citing works
A survey on deep transfer learning to edge computing for mitigating the COVID-19 pandemic
Sufian, A., Ghosh, A., Sadiq, A. S., & Smarandache, F. (2020) · Journal of Systems Architecture · doi:10.1016/j.sysarc.2020.101830 · Cited by 156 · see citing works
Lu, S., Zhu, Z., Gorriz, J. M., Wang, S., & Zhang, Y. (2022) · International Journal of Intelligent Systems · doi:10.1002/int.22686 · Cited by 151 · see citing works
A Review of Recent Advances in Deep Learning Models for Chest Disease Detection Using Radiography
Ait Nasser, A., & Akhloufi, M. A. (2023) · Diagnostics · doi:10.3390/diagnostics13010159 · Cited by 121 · see citing works
A systematic review on AI/ML approaches against COVID-19 outbreak
Dogan, O., Tiwari, S., Jabbar, M. A., & Guggari, S. (2021) · Complex & Intelligent Systems · doi:10.1007/s40747-021-00424-8 · Cited by 87 · see citing works
Deep Ensemble Model for Classification of Novel Coronavirus in Chest X‐Ray Images
Ahmad, F., Farooq, A., & Ghani, M. U. (2021) · Computational Intelligence and Neuroscience · doi:10.1155/2021/8890226 · Cited by 65 · see citing works
Bayoudh, K., Hamdaoui, F., & Mtibaa, A. (2020) · Physical and Engineering Sciences in Medicine · doi:10.1007/s13246-020-00957-1 · Cited by 50 · see citing works
Al-Timemy, A. H., Khushaba, R. N., Mosa, Z. M., & Escudero, J. (2021) · Studies in Systems, Decision and Control · doi:10.1007/978-3-030-69744-0_6 · Cited by 41 · see citing works
Suri, J. S., Agarwal, S., Jena, B., Saxena, S., El-Baz, A., Agarwal, V., Kalra, M. K., Saba, L., Viskovic, K., Fatemi, M., et al. (2024) · IEEE Transactions on Instrumentation and Measurement · doi:10.1109/tim.2022.3174270 · Cited by 38 · see citing works
Pre-training in Medical Data: A Survey
Qiu, Y., Lin, F., Chen, W., & Xu, M. (2023) · Machine Intelligence Research · doi:10.1007/s11633-022-1382-8 · Cited by 30 · see citing works
Trivedi, A., Robinson, C., Blazes, M., Ortiz, A., Desbiens, J., Gupta, S., Dodhia, R., Bhatraju, P. K., Liles, W. C., Kalpathy-Cramer, J., et al. (2022) · PLOS ONE · doi:10.1371/journal.pone.0274098 · Cited by 28 · see citing works
Nguyen, D. C., Ding, M., Pathirana, P. N., Seneviratne, A., & Zomaya, A. Y. (2022) · IEEE Internet of Things Journal · doi:10.1109/jiot.2021.3120998 · Cited by 5 · see citing works
Rami Naidji, M., & Elberrichi, Z. (2024) · International Journal of Computing and Digital Systems · doi:10.12785/ijcds/1501102 · Cited by 4 · see citing works
- Authors
- Apostolopoulos, I. D., & Mpesiana, T. A.
- Affiliations
- University of Patras (GR)
- Corresponding author
- Apostolopoulos, Ioannis D.
- Venue
- Physical and Engineering Sciences in Medicine
- Published
- 2020-04-03
- Volume
- 43
- Issue
- 2
- Pages
- 635-640
- ISSN
- 2662-4729 (ISSN-L)
- 2662-4737
- PMC
- PMC7118364
- OpenAlex
- W3013601031
- Cited by
- 2,338
- References
- 18
- Citations by year
- 2026: 70 · 2025: 106 · 2024: 236 · 2023: 348 · 2022: 544 · 2021: 732 · 2020: 301 · 2012: 1
- FWCI
- 234.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Physical and Engineering Sciences in Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- arXiv (Cornell University) (submittedVersion)
- arXiv (Cornell University)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › COVID-19 diagnosis using AI
- Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiomics and Machine Learning in Medical Imaging
- Keywords
- COVID-19 detection, chest X-ray images, transfer learning, convolutional neural networks, bacterial pneumonia, viral pneumonia, medical image classification
- MeSH terms
- Betacoronavirus, Deep Learning, COVID-19, SARS-CoV-2, Humans, Pneumonia, Viral, Radiographic Image Interpretation, Computer-Assisted, Radiography, Thoracic, Databases, Factual, Neural Networks, Computer, Coronavirus Infections, Pneumonia, Bacterial, Pandemics
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