Circadian rhythm of firing rate recorded from single cells in the rat suprachiasmatic brain slice

Green, Daniel J.; Gillette, Rhanor

doi:10.1016/0006-8993(82)90361-4

Cited by 503Circadian rhythm and melatoninSleep and Wakefulness ResearchSleep and Work-Related Fatigue

Circadian rhythm of firing rate recorded from single cells in the rat suprachiasmatic brain slice

Green, Daniel J., Gillette, Rhanor·1982·Brain Research

DOI 10.1016/0006-8993(82)90361-4

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The suprachiasmatic nuclei express a robust circadian rhythm of electrophysiologic activity even when isolated from the rest of the brain.
“The SCN express a robust circadian rhythm of electrophysiologic activity, even when isolated from the rest of the brain (3,4).”
From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [4]

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“…approach used by Dan Green and Rhanor Gillette most resembles the way in which this method is now used in that SCN slices were maintained in vitro for several hours and rhythmicity in the firing rate of the population was detected by sampling many single units over time (Green and Gillette, 1982).”
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Mechanism of Spontaneous Firing in Dorsomedial Suprachiasmatic Nucleus Neurons
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“When isolated and cultured in vitro, the SCN maintains a robust near 24 h rhythm of neuronal firing (Green & Gillette 1982), further reflecting the endogenous nature of the rhythmicity.”
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Suprachiasmatic Nucleus Organization
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“SCN cells in culture maintain a circadian rhythm (Green and Gillette, 1982; Groos and Hendriks, 1982; Shibata et al., 1982).”
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Circadian Rhythm Sleep Disorders
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Do the suprachiasmatic nuclei oscillate in old rats as they do in young ones?
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“Furthermore, circadian rhythms in neural firing rate persist in isolated SCN tissue maintained in culture (Green and Gillette, 1982), demonstrating that input from extra-SCN brain sites is not necessary for circadian rhythms in this nucleus.”
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Melatonin binding sites in the central nervous system
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“Further evidence that clock function is contained within the SCN comes from studies demonstrating that circadian rhythms in neural firing rate persist in isolated SCN tissue maintained in culture (Green and Gillette, 1982; Groos and Hendriks, 1982; Shibata et al., 1982).”
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Retinal Circadian Clocks and Control of Retinal Physiology
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“Furthermore, it was found that sustained circadian oscillations in vitro—formerly measured only for the SCN (Green and Gillette, 1982; Groos and Hendriks, 1982; Earnest and Sladek, 1986), the pineal gland of nonmammalian vertebrates (Deguchi, 1979; Falcon et al.”
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“Likewise, circadian rhythms in neural firing rate persist in isolated SCN tissue maintained in culture (Groos and Hendriks, 1982; Green and Gillette, 1982; Shibata et al., 1982).”
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“Neurons in the suprachiasmatic nucleus (SCN) of the hypothalamus, the site of the mammalian circadian pacemaker (Rusak and Zucker, 1979; Green and Gillette, 1982; Rusak and Groos, 1982; Inouye and Kawamura, 1982), respond to light patterns that are spatially and temporally relatively…”
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Effects of Nocturnal Light on (Clock) Gene Expression in Peripheral Organs: A Role for the Autonomic Innervation of the Liver
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“1980) and in vitro (Green and Gillette 1982; Newman and Hospod 1986; Earnest and Sladek 1986), and they receive direct retinal input which is sufficient to mediate entrainment by the external light/dark cycle (Moore and Klein 1974; Moore and Lenn 1972).”
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Circadian rhythmic changes of neuronal activity in the suprachiasmatic nucleus of the rat hypothalamic slice.
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Electrophysiology of the Suprachiasmatic Nucleus: Single-Unit Recording
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Development of the circadian rhythm of neuronal activity in suprachiasmatic nucleus of rat hypothalamic slices
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Authors: Green, D. J., & Gillette, R.
Affiliations: University of Illinois Urbana-Champaign (US)
ORCID: Green, Daniel J.
Gillette, Rhanor
Venue: Brain Research
Publisher: Elsevier BV
Published: 1982-08
Volume: 245
Issue: 1
Pages: 198-200
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/0006-8993(82)90361-4
OpenAlex: W2083497067
Cited by: 503
References: 10
Citations by year: 2025: 1 · 2024: 4 · 2023: 7 · 2022: 12 · 2021: 13 · 2020: 10 · 2019: 11 · 2018: 9 · 2017: 8 · 2016: 10 · 2015: 12 · 2014: 10 · 2013: 15 · 2012: 14
FWCI: 7.40
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords: circadian rhythm, suprachiasmatic nucleus, neuronal firing rate, single-unit recording, brain slices, light-dark cycle, rats, circadian pacemaker
MeSH terms: Action Potentials, Animals, Circadian Rhythm, Female, Hypothalamus, Anterior, Rats, In Vitro Techniques

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Circadian rhythm of firing rate recorded from single cells in the rat suprachiasmatic brain slice

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