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Oncogenes and signal transduction

Cantley, Lewis C, Auger, Kurt R, Carpenter, Christopher, Duckworth, Brian, Graziani, Andrea, Kapeller, Rosana, Soltoff, Stephen·1991·Cell

DOI 10.1016/0092-8674(91)90639-g

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The neurofibromatosis type 1 gene encodes a protein related to GAP
Xu, G., O'Connell, P., Viskochil, D., Cawthon, R., Robertson, M., Culver, M., Dunn, D., Stevens, J., Gesteland, R., White, R., et al. (1990) · Cell · doi:10.1016/0092-8674(90)90024-9 · Cited by 1,095

Show all 1 references

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.
Hibi, M., Lin, A., Smeal, T., Minden, A., & Karin, M. (1993) · Genes & Development · doi:10.1101/gad.7.11.2135 · Cited by 1,886
Molecular Genetics of Colorectal Cancer
Fearon, E. R. (2011) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130235 · Cited by 1,805
Signal transduction from the extracellular matrix.
Juliano, R. L., & Haskill, S. (1993) · The Journal of cell biology · doi:10.1083/jcb.120.3.577 · Cited by 1,683
Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein
Sun, X. J., Rothenberg, P., Kahn, C. R., Backer, J. M., Araki, E., Wilden, P. A., Cahill, D. A., Goldstein, B. J., & White, M. F. (1991) · Nature · doi:10.1038/352073a0 · Cited by 1,574
Regulation of translation initiation by FRAP/mTOR
Gingras, A.-C., Raught, B., & Sonenberg, N. (2001) · Genes & Development · doi:10.1101/gad.887201 · Cited by 1,545
RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
Sabatini, D. M., Erdjument-Bromage, H., Lui, M., Tempst, P., & Snyder, S. H. (1994) · Cell · doi:10.1016/0092-8674(94)90570-3 · Cited by 1,509
The trk Proto-Oncogene Product: a Signal Transducing Receptor for Nerve Growth Factor
Kaplan, D. R., Hempstead, B. L., Martin-Zanca, D., Chao, M. V., & Parada, L. F. (1991) · Science · doi:10.1126/science.1850549 · Cited by 1,379
Modular binding domains in signal transduction proteins
Cohen, G. B., Ren, R., & Baltimore, D. (1995) · Cell · doi:10.1016/0092-8674(95)90406-9 · Cited by 951
A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages
Araki, N., Johnson, M. T., & Swanson, J. A. (1996) · The Journal of cell biology · doi:10.1083/jcb.135.5.1249 · Cited by 949
“Nonetheless, a number of cellular processes require PI 3-kinase activity, including mitogenesis (6), membrane ruffling (18, 36), fluid-phase pinocytosis (3, 8), the respiratory burst (2, 22), and lysosomal enzyme sorting (5, 10, 25).”
Background
A Specific Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase
Fry, D. W., Kraker, A. J., McMichael, A., Ambroso, L. A., Nelson, J. M., Leopold, W. R., Connors, R. W., & Bridges, A. J. (1994) · Science · doi:10.1126/science.8066447 · Cited by 806
Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73
Smeal, T., Binetruy, B., Mercola, D. A., Birrer, M., & Karin, M. (1991) · Nature · doi:10.1038/354494a0 · Cited by 789
RAS Interaction with PI3K: More Than Just Another Effector Pathway
Castellano, E., & Downward, J. (2011) · Genes & Cancer · doi:10.1177/1947601911408079 · Cited by 762
Phosphatidylinositol 3-Kinase Encoded by Yeast VPS 34 Gene Essential for Protein Sorting
Schu, P. V., Takegawa, K., Fry, M. J., Stack, J. H., Waterfield, M. D., & Emr, S. D. (1993) · Science · doi:10.1126/science.8385367 · Cited by 778
Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene
Shultz, L. D., Schweitzer, P. A., Rajan, T. V., Yi, T., Ihle, J. N., Matthews, R. J., Thomas, M. L., & Beier, D. R. (1993) · Cell · doi:10.1016/0092-8674(93)90369-2 · Cited by 581
Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth
Xia, P., Aiello, L. P., Ishii, H., Jiang, Z. Y., Park, D. J., Robinson, G. S., Takagi, H., Newsome, W. P., Jirousek, M. R., & King, G. L. (1996) · Journal of Clinical Investigation · doi:10.1172/jci119006 · Cited by 566
Mutation of the PIK3CA oncogene in human cancers
Karakas, B., Bachman, K. E., & Park, B. H. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6602970 · Cited by 505
Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase
Jacobs, D., Glossip, D., Xing, H., Muslin, A. J., & Kornfeld, K. (1999) · Genes & Development · doi:10.1101/gad.13.2.163 · Cited by 439
Stat3 and Stat4: members of the family of signal transducers and activators of transcription.
Zhong, Z., Wen, Z., & Darnell, J. E. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.4806 · Cited by 397
Activation and Association of Stat3 with Src in v-Src-Transformed Cell Lines
Cao, X., Tay, A., Guy, G. R., & Tan, Y. H. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.4.1595 · Cited by 359
Expression and function of IRS-1 in insulin signal transmission.
Sun, X. J., Miralpeix, M., Myers, M. G., Glasheen, E. M., Backer, J. M., Kahn, C. R., & White, M. F. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41723-1 · Cited by 326
Activation of Phospholipase C-γ by Phosphatidylinositol 3,4,5-Trisphosphate
Bae, Y. S., Cantley, L. G., Chen, C.-S., Kim, S.-R., Kwon, K.-S., & Rhee, S. G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.8.4465 · Cited by 330
Self-citation
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Samuels, Y., & Waldman, T. (2010) · Current Topics in Microbiology and Immunology · doi:10.1007/82_2010_68 · Cited by 291
An essential gene, ESR1, is required for mitotic growth, DNA repair and meiotic recombination Saccharomyces cerevisiae
Kato, R., & Ogawa, H. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.15.3104 · Cited by 218
Phosphorylated Peptides Are Naturally Processed and Presented by Major Histocompatibility Complex Class I Molecules in Vivo
Zarling, A. L., Ficarro, S. B., White, F. M., Shabanowitz, J., Hunt, D. F., & Engelhard, V. H. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.12.1755 · Cited by 213
Involvement of phosphatidylinositol 3-kinase in Fc gamma receptor signaling.
Ninomiya, N., Hazeki, K., Fukui, Y., Seya, T., Okada, T., Hazeki, O., & Ui, M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31707-6 · Cited by 210
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Goruppi, S., Ruaro, E., Varnum, B., & Schneider, C. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.8.4442 · Cited by 191
Cloning and analysis of gene regulation of a novel LPS-inducible cDNA
Lee, C. L., Jenkins, N., Gilbert, D., Copeland, N., & O'Brien, W. (1995) · Immunogenetics · doi:10.1007/bf00172150 · Cited by 165
p53-independent Induction of p21 (WAF1/CIP1), Reduction of Cyclin B1 and G2/M Arrest by the Isoflavone Genistein in Human Prostate Carcinoma Cells
Choi, Y. H., Lee, W. H., Park, K., & Zhang, L. (2000) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.2000.tb00928.x · Cited by 164
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Wisniewski, D., Strife, A., Swendeman, S., Erdjument-Bromage, H., Geromanos, S., Kavanaugh, W. M., Tempst, P., & Clarkson, B. (1999) · Blood · doi:10.1182/blood.v93.8.2707 · Cited by 162
Growth Factor-Induced Tyrosine Phosphorylation of Hrs, a Novel 115-Kilodalton Protein with a Structurally Conserved Putative Zinc Finger Domain
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Elevated c-Src tyrosine kinase activity in premalignant epithelia of ulcerative colitis.
Cartwright, C. A., Coad, C. A., & Egbert, B. M. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117000 · Cited by 134
Insulin receptor substrate-1 gene mutations in NIDDM; implications for the study of polygenic disease
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Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex.
Law, C. L., Sidorenko, S. P., Chandran, K. A., Draves, K. E., Chan, A. C., Weiss, A., Edelhoff, S., Disteche, C. M., & Clark, E. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32717-5 · Cited by 103
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Authors: Cantley, L. C., Auger, K. R., Carpenter, C., Duckworth, B., Graziani, A., Kapeller, R., & Soltoff, S.
Venue: Cell
Publisher: Elsevier BV
Published: 1991-01
Volume: 64
Issue: 2
Pages: 281-302
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(91)90639-g
OpenAlex: W2005529016
Cited by: 2,694
References: 1
FWCI: 159.18
Type: journal article
Language: en
Open access: closed

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Oncogenes and signal transduction

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