The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Skin photoplethysmography — a review
Abstract
The photoplethysmograph has been used for over 50 years but there are still misconceptions in how and what is the information obtained. A photoplethysmograph signal from any site on the skin can be separated into an oscillating (a.c.) and a steady-state (d.c.) component, their amplitudes dependent upon the structure and flow in the vascular bed. Many simple applications are available: pulse counters, using the a.c. component, skin colour and haemoglobin saturation meters, using the d.c. component. The d.c. component of the photoplethysmograph signal is a function of the blood flux beneath the device. A good emitter for use in a photoplethysmograph of skin blood flow is one in the frequency range 600-700 nm and the best signal for a.c. analysis is obtained from the finger pulp. The frequency range of the electronic circuitry should be from 0.01 to 15 Hz, then all the information in the signal can be extracted about the autonomic nervous system control of the cardiovascular system, particularly between 0.01 and 2 Hz. Comparative studies may be drawn between similar skin sites on a subject or between subjects if the afferent inputs to the brain stem are controlled or driven at a known frequency. These afferents, inputs, will modulate the efferents, outputs, which generate variations in the a.c. component of the detected photoplethysmograph signal.
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“Without this type of real-time, in-sensor processing (IR_Non in Fig. 6D), robust operation would be impossible: PPG signals would quickly drift outside of the narrow operating range of the ADC as a result of patient-to-patient variations in skin pigmentation and unavoidable, time-dependent fluctuations in optical scattering that result from micromotions relative to underlying blood vessels and sub”
From Binodal, wireless epidermal electronic systems with in-sensor analytics for neonatal intensive care (2019) · cites this paper as [28]
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“Photoplethysmography (PPG) is a non-invasive optical technique mostly used for measuring changes in skin blood flow (Challoner 1979; Kamal et al. 1989).”
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“Photoplethysmography (PPG) is mostly used for skin blood flow monitoring (Challoner, 1979; Kamal et al., 1989).”
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“The PPG signal is complex and has several components which can be classified as either low frequency (LF) or high frequency (HF) (Kamal et al 1989).”
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“Conversely, the DC component (commonly used for venous evaluation) of the signal varies slowly and reflects variations in the total blood volume of the examined tissue [19].”
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“PPG signals reflect changes in blood flow and can provide valuable information about the cardiovascular system, including the presence of irregular heart rhythms like AF [40].”
BackgroundLimitations of Oximetry to Measure Heart Rate Variability Measures
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“It has mostly been suggested that the AC component is related to pulsatile volume changes due to varying lumen of the vessel [6, 16, 23, 24].”
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“The pulsatile component of the photoplethysmograph signal re¯ects changes in the calibre of cutaneous arterioles and thus mirrors changes in cutaneous blood ¯ow (Hertzman et al., 1946; Drummond and Lance, 1981; Kamal et al., 1989).”
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“Unfortunately, the PPG signal is highly sensitive to noise-corruption, especially due to motion (Allen 2007, Kamal et al 1989, Abdallah and Bolz 2011).”
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“The light emitted from the diode is reflected (or transmitted) through the tissues and the arteries and arterioles and then detected by the photodetector [40].”
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“Provided that the degree of vasoconstriction is constant, PI may estimate stroke volume and cardiac output (17, 23).”
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“Another method involves the use of a photoplethysmography (PPG) sensor [11]–[15]; until recently, this was one of the most actively studied methods for tracking physiological information.”
MethodLin, Q., Song, S., Wegberg, R. V., Sijbers, W., Biswas, D., Konijnenburg, M., Vanhoof, C., Tavernier, F., & van Helleputte, N. (2021) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2021.3130470 · Cited by 30
“Such an AC component represents microvascular blood volume change within each heartbeat [7].”
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Technologies for non-invasive physiological sensing: Status, challenges, and future horizons
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Remote Photoplethysmography for Heart Rate and Blood Oxygenation Measurement: A Review
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“These vitals can also be monitored with contact-based pulse oximetry [23], [24], [25], discussed next.”
A Method for Respiration Rate Detection in Wrist PPG Signal Using Holo-Hilbert Spectrum
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Experimental evaluation of two new sensors for respiratory rate monitoring
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Non-contact Reflection Photoplethysmography towards Effective Human Physiological Monitoring
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A New Probe for Ankle Systolic Pressure Measurement Using Photoplethysmography (PPG)
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Ambiguity of mapping the relative phase of blood pulsations
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Non-invasive Measurement of Blood Components
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Advances in PPG Sensors Data Acquisition With Light-to-Digital Converters: A Review
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“…variability of a PPG signal: temperature fluctuations [29], LED placement (reflection mode or transmission mode) [30], [31], skin pigmentation and composition, arterial diameter, concentration and direction of oxygenated and deoxygenated hemoglobin [32], [33], [34], and site of measurement [35].”
BackgroundUsing imaging photoplethysmography for heart rate estimation in non-human primates
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Photoplethysmography for non-invasivein vivomeasurement of bone hemodynamics
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LED Based Sensor System for Non-Invasive Measurement of the Hemoglobin Concentration in Human Blood
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“[5] According to the assumption that red blood cells are mainly filled with water, the absorption coefficient of blood is similar to a solution consisting HHb, HbO2 and water (H2O) and the absorption of HHb and Hb02 is indistinguishable to the absorption of H2O above 1200nm, it is necessary to select a wavelength valu…”
BackgroundDevelopment of a new analgesic index using nasal photoplethysmography
Choi, B., Park, C., Lee, Y. H., Shin, H., Lee, S. H., Jeong, S., Noh, G., & Lee, B. (2018) · Anaesthesia · doi:10.1111/anae.14327 · Cited by 27
“The AC component reflects variations in the blood volume below the sensor; the DC component represents the optical character of the underlying tissue and venous blood content [28, 29].”
Background
Metadata
- Authors
- Kamal, A. A. R., Harness, J. B., Irving, G., & Mearns, A. J.
- Affiliations
- University of Bradford (GB)
- Corresponding author
- Harness, J.B.
- Venue
- Computer Methods and Programs in Biomedicine
- Publisher
- Elsevier BV
- Published
- 1989-04
- Volume
- 28
- Issue
- 4
- Pages
- 257-269
- ISSN
- 0169-2607 (ISSN-L)
- OpenAlex
- W2054173774
- Cited by
- 328
- References
- 56
- Citations by year
- 2026: 1 · 2025: 13 · 2024: 16 · 2023: 21 · 2022: 31 · 2021: 15 · 2020: 19 · 2019: 26 · 2018: 15 · 2017: 22 · 2016: 14 · 2015: 17 · 2014: 13 · 2013: 8 · 2012: 12
- FWCI
- 0.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Computer Methods and Programs in Biomedicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Non-Invasive Vital Sign Monitoring
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- photoplethysmography, skin blood flow, pulse counting, hemoglobin oxygen saturation, finger pulp, vascular bed
- MeSH terms
- Equipment Design, Humans, Monitoring, Physiologic, Plethysmography, Regional Blood Flow, Skin
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