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βA4 deposits are constant in the brain of the oldest old: An immunocytochemical study of 20 french centenarians
Abstract
beta A4 deposits occur in the brain of some individuals over 50 years of age. It could be a part of the aging process or indicate a disease found frequently in the elderly. To address this question, beta A4 immunocytochemistry was performed on the brain of 15 nondemented and 5 demented centenarians, some of whom were affected by Alzheimer's disease. We found beta A4 deposits in the parahippocampal and the superior temporal gyri of all the cases, whatever the clinical state. The hippocampus was frequently spared. The lesion density was not correlated with the severity of the mental deterioration. The constant deposition of beta A4 protein in the brain of very old people indicates that this process does not spare a large proportion of this population. This result favors beta A4 accumulation in the brain being an ineluctable age-related process.
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“Autopsy studies reveal at the time of death, brains from cognitively normal individuals frequently contain plaques [77, 234-237].”
From The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives (2014) · cites this paper as [236]
In the citing paper
“Also, since most young individuals will develop Aβ deposits if they live long enough [9, 54, 79], almost the entire population that doesn’t already have AD is on their way to developing AD [3].”
From Brain aging, Alzheimer's disease, and mitochondria (2011) · cites this paper as [79]
In the citing paper
“Brain histology surveys suggest that brains from individuals surviving to age 85 and beyond have at least some degree of plaque and tangle pathology [9, 54, 79].”
From Brain aging, Alzheimer's disease, and mitochondria (2011) · cites this paper as [79]
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Metadata
- Authors
- Delaère, P., He, Y., Fayet, G., Duyckaerts, C., & Hauw, J.-J.
- Affiliations
- Inserm (FR)
- Corresponding author
- Delaère, Pia
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 1993-03
- Volume
- 14
- Issue
- 2
- Pages
- 191-194
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W1974729491
- Cited by
- 149
- References
- 38
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 3
- FWCI
- 7.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Association France Alzheimer
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- amyloid-beta, centenarians, brain aging, Alzheimer's disease, dementia, parahippocampal gyrus, superior temporal gyrus, hippocampus, lesion density, immunocytochemistry
- MeSH terms
- Aged, Aged, 80 and over, Brain, Brain Chemistry, Dementia, Female, France, Hippocampus, Humans, Immunohistochemistry, Male, Temporal Lobe, Amyloid beta-Peptides, Neurofibrillary Tangles
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