Self-replicating Semliki Forest virus RNA as recombinant vaccine
Abstract
Recombinant RNA based on the Semliki Forest virus (SFV) replicon was used to express the nucleoprotein of influenza virus in mice. Two strategies were employed to deliver the RNA. In the first, recombinant RNA was packaged into infectious suicide SFV particles which were used directly for immunization. The second approach involved injection of in vitro-synthesized RNA directly into the quadriceps muscle. Both approaches resulted in the generation of humoral responses with high antibody titres. Immunization with suicide particles showed that a strong, class I-restricted cytotoxic T-cell response can be obtained using only 100 infectious units. We conclude that the self-replicative recombinant SFV RNA may be quite useful as a nucleic acid vaccine.
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The idea of using in vitro synthesized saRNA as a preventive vaccine was first proposed by Zhou and colleagues in 1994, using a modified Semliki Forest virus (SFV) replicon to express the nucleoprotein (NP) of the influenza virus.
“The idea of using in vitro synthesized saRNA as a preventive vaccine was first proposed by Zhou and colleagues in 1994, using a modified Semliki Forest virus (SFV) replicon to express the nucleoprotein (NP) of the influenza virus.197”
From Advances in COVID-19 mRNA vaccine development (2022) · cites this paper as [197]
Cites
Current protocols in molecular biology
Sargent, T. (1988) · Analytical Biochemistry · doi:10.1016/0003-2697(88)90147-9 · Cited by 7,281 · see citing works
The Dendritic Cell System and its Role in Immunogenicity
Steinman, R. M. (1991) · Annual Review of Immunology · doi:10.1146/annurev.iy.09.040191.001415 · Cited by 4,659 · see citing works
Heterologous Protection Against Influenza by Injection of DNA Encoding a Viral Protein
Ulmer, J. B., Donnelly, J., Parker, S. E., Rhodes, G. H., Felgner, P. L., Dwarki, V., Gromkowski, S. H., Deck, R. R., DeWitt, C. M., Friedman, A., et al. (1993) · Science · doi:10.1126/science.8456302 · Cited by 2,318 · see citing works
Self-citationTownsend, A. (1986) · Cell · doi:10.1016/0092-8674(86)90019-x · Cited by 1,705 · see citing works
Genetic immunization is a simple method for eliciting an immune response
Tang, D.-C. C., DeVit, M. J., & Johnston, S. A. (1992) · Nature · doi:10.1038/356152a0 · Cited by 1,504 · see citing works
Germain, R. N. (1994) · Cell · doi:10.1016/0092-8674(94)90336-0 · Cited by 1,431 · see citing works
DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations.
Fynan, E. F., Webster, R. G., FULLER, D. H., Haynes, J. R., Santoro, J. C., & Robinson, H. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.24.11478 · Cited by 1,116 · see citing works
The Biochemistry and Cell Biology of Antigen Processing and Presentation
Germain, R. N., & Margulies, D. H. (1993) · Annual Review of Immunology · doi:10.1146/annurev.iy.11.040193.002155 · Cited by 1,017 · see citing works
A New Generation of Animal Cell Expression Vectors Based on the Semliki Forest Virus Replicon
Liljeström, P., & Garoff, H. (1991) · Nature Biotechnology · doi:10.1038/nbt1291-1356 · Cited by 905 · see citing works
Self-citationIsolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cells
Rötzschke, O., Falk, K., Deres, K., Schild, H., Norda, M., Metzger, J. W., Jung, G., & Rammensee, H. (1990) · Nature · doi:10.1038/348252a0 · Cited by 771 · see citing works
Gene inoculation generates immune responses against human immunodeficiency virus type 1.
Wang, B., Ugen, K. E., Srikantan, V., Agadjanyan, M. G., Dang, K., Refaeli, Y., Sato, A. I., Boyer, J., Williams, W. V., & Weiner, D. B. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.9.4156 · Cited by 655 · see citing works
Induction of virus‐specific cytotoxic T lymphocytes <i>in vivo</i> by liposome‐entrapped mRNA
Martinon, F., Krishnan, S., Lenzen, G., Magné, R., Gomard, E., Guillet, J., Lévy, J., & Meulien, P. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230749 · Cited by 473 · see citing works
Liljeström, P., Lusa, S., Huylebroeck, D., & Garoff, H. (1991) · Journal of Virology · doi:10.1128/jvi.65.8.4107-4113.1991 · Cited by 452 · see citing works
Self-citationXiang, Z., Spitalnik, S. L., Tran, M., Wunner, W. H., Cheng, J., & Ertl, H. C. J. (1994) · Virology · doi:10.1006/viro.1994.1105 · Cited by 390 · see citing works
Bovine herpesvirus 1: immune responses in mice and cattle injected with plasmid DNA
Cox, G. J., Zamb, T. J., & Babiuk, L. A. (1993) · Journal of Virology · doi:10.1128/jvi.67.9.5664-5667.1993 · Cited by 342 · see citing works
Semliki Forest Virus Expression System: Production of Conditionally Infectious Recombinant Particles
Berglund, P., Sjöberg, M., Garoff, H., Atkins, G. J., Sheahan, B. J., & Liljeström, P. (1993) · Nature Biotechnology · doi:10.1038/nbt0893-916 · Cited by 289 · see citing works
Self-citationSprent, J. (1994) · Cell · doi:10.1016/0092-8674(94)90338-7 · Cited by 278 · see citing works
Hahn, C. S., Hahn, Y. S., Braciale, T. J., & Rice, C. M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.7.2679 · Cited by 226 · see citing works
Liljeström, P., & Garoff, H. (1991) · Journal of Virology · doi:10.1128/jvi.65.1.147-154.1991 · Cited by 219 · see citing works
Self-citationSpike protein-nucleocapsid interactions drive the budding of alphaviruses
Suomalainen, M., Liljeström, P., & Garoff, H. (1992) · Journal of Virology · doi:10.1128/jvi.66.8.4737-4747.1992 · Cited by 182 · see citing works
Self-citationSalminen, A., Wahlberg, J. M., Lobigs, M., Liljeström, P., & Garoff, H. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.116.2.349 · Cited by 154 · see citing works
Self-citationLiljeström, P. (1994) · Current Opinion in Biotechnology · doi:10.1016/0958-1669(94)90063-9 · Cited by 101 · see citing works
Self-citationPeptide Binding to Major Histocompatibility Complex Molecules
Barber, L. D., & Parham, P. R. (1993) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.09.110193.001115 · Cited by 101 · see citing works
Garoff, H., Huylebroeck, D., Robinson, A., Tillman, U., & Liljeström, P. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.111.3.867 · Cited by 72 · see citing works
Self-citationMembrane protein lateral interactions control Semliki Forest virus budding.
Ekström, M., Liljeström, P., & Garoff, H. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06354.x · Cited by 63 · see citing works
Self-citationInfectious enveloped RNA virus antigenic chimeras.
London, S., Schmaljohn, A. L., Dalrymple, J. M., & Rice, C. M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.1.207 · Cited by 62 · see citing works
Glasgow, G. M., Sheahan, B. J., Atkins, G. J., Wahlberg, J. M., Salminen, A., & Lilieström, P. (1991) · Virology · doi:10.1016/0042-6822(91)90545-m · Cited by 55 · see citing works
Expression of Proteins Using Semliki Forest Virus Vectors
Liljeström, P., & Garoff, H. (1995) · Current Protocols in Molecular Biology · doi:10.1002/0471142727.mb1620s29 · Cited by 55 · see citing works
Self-citationIn vivo primary induction of virus-specific CTL by immunization with 9-mer synthetic peptides
Zhou, X., Berg, L., Abdel‐Motal, U. M., & Jondal, M. (1992) · Journal of Immunological Methods · doi:10.1016/0022-1759(92)90322-k · Cited by 53 · see citing works
Self-citationGlasgow, G. M., Killen, H. M., Liljeström, P., Sheahan, B. J., & Atkins, G. J. (1994) · Journal of General Virology · doi:10.1099/0022-1317-75-3-663 · Cited by 34 · see citing works
Self-citationCharacterization of humoral immunity after DNA injection.
Rhodes, G. H., Abai, A. M., Margalith, M., Kuwahara-Rundell, A., Morrow, J., Parker, S. E., & Dwarki, V. (1994) · PubMed · Cited by 25 · see citing works
Self-citation
Flagged first, then by citations
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Cited by
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mRNA-based therapeutics--developing a new class of drugs
Sahin, U., Karikó, K., & Türeci, Ö. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4278 · Cited by 2,474 · see citing works
SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses
Turner, J. S., O’Halloran, J. A., Kalaidina, E., Kim, W., Schmitz, A. J., Zhou, J. Q., Lei, T., Thapa, M., Chen, R. E., Case, J. B., et al. (2021) · Nature · doi:10.1038/s41586-021-03738-2 · Cited by 831 · see citing works
Advances in mRNA Vaccines for Infectious Diseases
Zhang, C., Maruggi, G., Shan, H., & Li, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00594 · Cited by 680 · see citing works
Advances in COVID-19 mRNA vaccine development
Fang, E., Liu, X., Li, M., Zhang, Z., Song, L., Zhu, B., Wu, X., Liu, J., Zhao, D., & Li, Y. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00950-y · Cited by 601 · see citing works
mRNA as a Transformative Technology for Vaccine Development to Control Infectious Diseases
Maruggi, G., Zhang, C., Li, J., Ulmer, J. B., & Yu, D. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.01.020 · Cited by 507 · see citing works
Vogel, A. B., Lambert, L., Kinnear, E., Busse, D., Erbar, S., Reuter, K. C., Wicke, L., Perkovic, M., Beissert, T., Haas, H., et al. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2017.11.017 · Cited by 501 · see citing works
Self-amplifying RNA vaccines for infectious diseases
Bloom, K., van den Berg, F., & Arbuthnot, P. (2021) · Gene Therapy · doi:10.1038/s41434-020-00204-y · Cited by 487 · see citing works
Pushko, P., Parker, M., Ludwig, G. V., Davis, N., Johnston, R. E., & Smith, J. (1997) · Virology · doi:10.1006/viro.1997.8878 · Cited by 444 · see citing works
DNA and RNA-based vaccines: principles, progress and prospects
Leitner, W. W., Han, Y., & Restifo, N. P. (1999) · Vaccine · doi:10.1016/s0264-410x(99)00271-6 · Cited by 401 · see citing works
Tailoring mRNA Vaccine to Balance Innate/Adaptive Immune Response
Linares-Fernández, S., Lacroix, C., Exposito, J.-Y., & Verrier, B. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.10.002 · Cited by 376 · see citing works
Three decades of messenger RNA vaccine development
Verbeke, R., Lentacker, I., De Smedt, S. C., & Dewitte, H. (2019) · Nano Today · doi:10.1016/j.nantod.2019.100766 · Cited by 342 · see citing works
Alphavirus-based DNA vaccine breaks immunological tolerance by activating innate antiviral pathways
Leitner, W. W., Hwang, L. N., DeVeer, M., Zhou, A., Silverman, R. H., Williams, B. R. G., Dubensky, T. W., Han, Y., & Restifo, N. P. (2002) · Nature Medicine · doi:10.1038/nm813 · Cited by 269 · see citing works
Erasmus, J. H., Khandhar, A. P., O’Connor, M. A., Walls, A. C., Hemann, E. A., Murapa, P., Archer, J., Leventhal, S., Fuller, J. T., Lewis, T. B., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.abc9396 · Cited by 241 · see citing works
Self-citationAlphavirus-based expression vectors: strategies and applications.
Frolov, I. V., Hoffman, T. A., Prágai, B. M., Dryga, S. A., Huang, H. V., Schlesinger, S., & Rice, C. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11371 · Cited by 238 · see citing works
Enhancing immune responses using suicidal DNA vaccines
Berglund, P., Smerdou, C., Fleeton, M. N., Tubulekas, L., & Liljeström, P. (1998) · Nature Biotechnology · doi:10.1038/nbt0698-562 · Cited by 229 · see citing works
Self-citationNanomedicines to Deliver mRNA: State of the Art and Future Perspectives
Gómez-Aguado, I., Rodríguez-Castejón, J., Vicente-Pascual, M., Rodríguez‐Gascón, A., Solinís, M. Á., & del Pozo‐Rodríguez, A. (2020) · Nanomaterials · doi:10.3390/nano10020364 · Cited by 224 · see citing works
Liljeqvist, S., & Ståhl, S. (1999) · Journal of Biotechnology · doi:10.1016/s0168-1656(99)00107-8 · Cited by 214 · see citing works
Davis, N., Caley, I. J., Brown, K. W., Betts, M. R., Irlbeck, D. M., McGrath, K. M., Connell, M. J., Montefiori, D. C., Frelinger, J. A., Swanstrom, R. I., et al. (2000) · Journal of Virology · doi:10.1128/jvi.74.1.371-378.2000 · Cited by 201 · see citing works
Current prospects for mRNA gene delivery
Yamamoto, A., Kormann, M., Rosenecker, J., & Rudolph, C. (2008) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.09.016 · Cited by 193 · see citing works
Sindbis virus DNA-based expression vectors: utility for in vitro and in vivo gene transfer
Dubensky, T. W., Driver, D. A., Polo, J. M., Belli, B., LATHAM, E. M., Ibañez, C. E., Chada, S., Brumm, D., Banks, T. A., Mento, S. J., et al. (1996) · Journal of Virology · doi:10.1128/jvi.70.1.508-519.1996 · Cited by 192 · see citing works
RNA: The new revolution in nucleic acid vaccines
Geall, A. J., Mandl, C. W., & Ulmer, J. B. (2013) · Seminars in Immunology · doi:10.1016/j.smim.2013.05.001 · Cited by 187 · see citing works
Ulmer, J. B., Mason, P. W., Geall, A. J., & Mandl, C. W. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.04.060 · Cited by 183 · see citing works
Brito, L. A., Kommareddy, S., Maione, D., Uematsu, Y., Giovani, C., Scorza, F. B., Otten, G. R., Yu, D. L., Mandl, C. W., Mason, P. W., et al. (2014) · Advances in genetics · doi:10.1016/bs.adgen.2014.10.005 · Cited by 182 · see citing works
Alphavirus vectors and vaccination
Rayner, J. O., Dryga, S. A., & Kamrud, K. I. (2002) · Reviews in Medical Virology · doi:10.1002/rmv.360 · Cited by 181 · see citing works
DNA Immunization against Herpes Simplex Virus: Enhanced Efficacy Using a Sindbis Virus-Based Vector
Hariharan, M. J., Driver, D. A., Townsend, K., Brumm, D., Polo, J. M., Belli, B., Catton, D. J., Hsu, D. S., Mittelstaedt, D., McCormack, J. E., et al. (1998) · Journal of Virology · doi:10.1128/jvi.72.2.950-958.1998 · Cited by 178 · see citing works
Fleeton, M. N., Chen, M., Berglund, P., Rhodes, G., Parker, S. E., Murphy, M., Atkins, G. J., & Liljeström, P. (2001) · The Journal of Infectious Diseases · doi:10.1086/319857 · Cited by 157 · see citing works
Self-citationImmune Responses Induced by mRNA Vaccination in Mice, Monkeys and Humans
Cagigi, A., & Loré, K. (2021) · Vaccines · doi:10.3390/vaccines9010061 · Cited by 153 · see citing works
Pascolo, S. (2004) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.4.8.1285 · Cited by 152 · see citing works
Mossman, S. P., Bex, F., Berglund, P., Arthos, J. A., O'Neil, S. P., Riley, D. M., Maul, D. H., Bruck, C., Momin, P., Burny, A., et al. (1996) · Journal of Virology · doi:10.1128/jvi.70.3.1953-1960.1996 · Cited by 149 · see citing works
Self-citationKhromykh, A. A., Varnavski, A. N., & Westaway, E. G. (1998) · Journal of Virology · doi:10.1128/jvi.72.7.5967-5977.1998 · Cited by 142 · see citing works
Self-replicating alphavirus RNA vaccines
Ljungberg, K., & Liljeström, P. (2014) · Expert Review of Vaccines · doi:10.1586/14760584.2015.965690 · Cited by 137 · see citing works
Self-citationBerglund, P., QUESADA-ROLANDER, M., Putkonen, P., Biberfeld, G., Thorstensson, R., & Liljeström, P. (1997) · AIDS Research and Human Retroviruses · doi:10.1089/aid.1997.13.1487 · Cited by 135 · see citing works
Self-citationDNA Vaccines: Technology and Application as Anti-parasite and Anti-microbial Agents
Alarcon, J. B., Waine, G. J., & McManus, D. P. (1999) · Advances in Parasitology/Advances in parasitology · doi:10.1016/s0065-308x(08)60152-9 · Cited by 130 · see citing works
Game changers in science and technology - now and beyond
Betz, U. A. K., Arora, L., Assal, R. A., de Azevedo, H. F. Z., Baldwin, J., Becker, M. S., Bostock, S., Cheng, V. W. T., Egle, T., Ferrari, N., et al. (2023) · Technological Forecasting and Social Change · doi:10.1016/j.techfore.2023.122588 · Cited by 146 · see citing works
In vitro-synthesized infectious RNA as an attenuated live vaccine in a flavivirus model
Mandl, C. W., Aberle, J. H., Aberle, S. W., Holzmann, H., Allison, S. L., & Heinz, F. X. (1998) · Nature Medicine · doi:10.1038/4031 · Cited by 124 · see citing works
Caley, I. J., Betts, M. R., Irlbeck, D. M., Davis, N., Swanstrom, R. I., Frelinger, J. A., & Johnston, R. E. (1997) · Journal of Virology · doi:10.1128/jvi.71.4.3031-3038.1997 · Cited by 122 · see citing works
Kallen, K., & Theß, A. (2013) · Therapeutic Advances in Vaccines · doi:10.1177/2051013613508729 · Cited by 120 · see citing works
Berglund, P., Fleeton, M. N., Smerdou, C., & Liljeström, P. (1999) · Vaccine · doi:10.1016/s0264-410x(98)00224-2 · Cited by 117 · see citing works
Self-citationVaccines for Venezuelan equine encephalitis
Paessler, S., & Weaver, S. C. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.07.095 · Cited by 114 · see citing works
Davis, N., Brown, K. W., & Johnston, R. E. (1996) · Journal of Virology · doi:10.1128/jvi.70.6.3781-3787.1996 · Cited by 111 · see citing works
Asselin‐Paturel, C., Lassau, N., Jm, G., Zhang, J., Gay, F., Bex, F., Hallez, S., Leclère, J., PERONNEAU, P., Mami‐Chouaib, F., et al. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300841 · Cited by 107 · see citing works
Immune responses to DNA vaccines
Kowalczyk, D. W., & Ertl, H. C. J. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050330 · Cited by 105 · see citing works
Mucosal adjuvants and delivery systems for protein‐, DNA‐ and RNA‐based vaccines
Vajdy, M., Srivastava, I. K., Polo, J., Donnelly, J., O’Hagan, D. T., & Singh, M. (2004) · Immunology and Cell Biology · doi:10.1111/j.1440-1711.2004.01288.x · Cited by 104 · see citing works
Johanning, F. W., Conry, R. M., LoBuglio, A. F., Wright, M., Sumerel, L. A., Pike, M. J., & Curiel, D. T. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.9.1495 · Cited by 99 · see citing works
Intradermal Electroporation of Naked Replicon RNA Elicits Strong Immune Responses
Johansson, D. X., Ljungberg, K., Kakoulidou, M., & Liljeström, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029732 · Cited by 98 · see citing works
Self-citationThe molecular pathogenesis of Semliki Forest virus: a model virus made useful?
Atkins, G. J., Sheahan, B. J., & Liljeström, P. (1999) · Journal of General Virology · doi:10.1099/0022-1317-80-9-2287 · Cited by 98 · see citing works
Self-citationYamshchikov, V. F., Mishin, V. P., & Cominelli, F. (2001) · Virology · doi:10.1006/viro.2000.0793 · Cited by 97 · see citing works
DNA Vaccines against Human Immunodeficiency Virus Type 1 in the Past Decade
Giri, M. S., Ugen, K. E., & Weiner, D. B. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.2.370-389.2004 · Cited by 95 · see citing works
Moyo, N., Vogel, A. B., Buus, S., Erbar, S., Wee, E. G., Sahin, U., & Hanke, T. (2019) · Molecular Therapy - Methods & Clinical Development · doi:10.1016/j.omtm.2018.10.010 · Cited by 94 · see citing works
Engineering nanoparticle toolkits for mRNA delivery
Sun, B., Wu, W., Narasipura, E. A., Ma, Y., Yu, C., Fenton, O. S., & Song, H. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.115042 · Cited by 93 · see citing works
Enlisting the mRNA Vaccine Platform to Combat Parasitic Infections
Versteeg, L., Almutairi, M. M., Hotez, P. J., & Pollet, J. B. K. (2019) · Vaccines · doi:10.3390/vaccines7040122 · Cited by 93 · see citing works
Aberle, J. H., Aberle, S. W., Kofler, R. M., & Mandl, C. W. (2005) · Journal of Virology · doi:10.1128/jvi.79.24.15107-15113.2005 · Cited by 91 · see citing works
Lundstrom, K. H. (2014) · Viruses · doi:10.3390/v6062392 · Cited by 91 · see citing works
Rise of the RNA machines – self-amplification in mRNA vaccine design
Comes, J. D. G., Pijlman, G. P., & Hick, T. A. H. (2023) · Trends in Biotechnology · doi:10.1016/j.tibtech.2023.05.007 · Cited by 87 · see citing works
A new generation of vaccines based on alphavirus self-amplifying RNA
Ballesteros-Briones, M. C., Silva-Pilipich, N., Herrador, G., Vanrell, L., & Smerdou, C. (2020) · Current Opinion in Virology · doi:10.1016/j.coviro.2020.08.003 · Cited by 87 · see citing works
Recombinant viruses as vaccines against viral diseases
de Souza, A. P. D., Haut, L. H., Reyes‐Sandoval, A., & Pinto, A. R. (2005) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2005000400004 · Cited by 87 · see citing works
Ward, G. B., Rieder, E. A., & Mason, P. W. (1997) · Journal of Virology · doi:10.1128/jvi.71.10.7442-7447.1997 · Cited by 80 · see citing works
Current view on novel vaccine technologies to combat human infectious diseases
Matić, Z., & Šantak, M. (2021) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-021-11713-0 · Cited by 80 · see citing works
mRNA vaccines: the most recent clinical applications of synthetic mRNA
Kwon, S., Kwon, M., Im, S., Lee, K., & Lee, H. (2022) · Archives of Pharmacal Research · doi:10.1007/s12272-022-01381-7 · Cited by 81 · see citing works
Self-Amplifying RNA Approach for Protein Replacement Therapy
Papukashvili, D., Rcheulishvili, N., Liu, C., Ji, Y., He, Y., & Wang, P. G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232112884 · Cited by 76 · see citing works
Noncytopathic Flavivirus Replicon RNA-Based System for Expression and Delivery of Heterologous Genes
Varnavski, A. N., & Khromykh, A. A. (1999) · Virology · doi:10.1006/viro.1998.9564 · Cited by 74 · see citing works
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Ye, Z., Harmon, J., Ni, W., Li, Y., Wich, D., & Xu, Q. (2023) · ACS Nano · doi:10.1021/acsnano.2c12584 · Cited by 71 · see citing works
Caley, I. J., Betts, M. R., Davis, N., Swanstrom, R. I., Frelinger, J. A., & Johnston, R. E. (1999) · Vaccine · doi:10.1016/s0264-410x(99)00142-5 · Cited by 70 · see citing works
Alphavirus vectors for vaccine production and gene therapy
Lundstrom, K. H. (2003) · Expert Review of Vaccines · doi:10.1586/14760584.2.3.445 · Cited by 67 · see citing works
Fleeton, M. N., Sheahan, B. J., Atkins, G. J., & Liljeström, P. (2000) · Journal of General Virology · doi:10.1099/0022-1317-81-3-749 · Cited by 67 · see citing works
Self-citationAlphavirus expression vectors and their use as recombinant vaccines: a minireview
Tubulekas, I., Berglund, P., Fleeton, M. N., & Liljeström, P. (1997) · Gene · doi:10.1016/s0378-1119(96)00679-8 · Cited by 67 · see citing works
Self-citationFleeton, M. N., Sheahan, B. J., Gould, E. A., Atkins, G. J., & Liljestrm, P. (1999) · Journal of General Virology · doi:10.1099/0022-1317-80-5-1189 · Cited by 64 · see citing works
Self-citationMorris-Downes, M. M., Phenix, K. V., Smyth, J. A., Sheahan, B. J., Liljeqvist, S., MOONEY, D. A., Liljeström, P., Todd, D., & Atkins, G. J. (2001) · Vaccine · doi:10.1016/s0264-410x(00)00428-x · Cited by 60 · see citing works
Self-citationBrand, D., Lemiale, F., Turbica, I., Buzelay, L., BRUNET, S., & Barin, F. (1998) · AIDS Research and Human Retroviruses · doi:10.1089/aid.1998.14.1369 · Cited by 59 · see citing works
Type I Interferons are essential for the efficacy of replicase-based DNA vaccines
Leitner, W. W., Bergmann‐Leitner, E. S., Hwang, L. N., & Restifo, N. P. (2006) · Vaccine · doi:10.1016/j.vaccine.2006.04.059 · Cited by 56 · see citing works
mRNA vaccines contribute to innate and adaptive immunity to enhance immune response in vivo
Cao, Q., Fang, H., & Tian, H. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122628 · Cited by 55 · see citing works
Kimura, T., Leal, J. M., Simpson, A., Warner, N. L., Berube, B. J., Archer, J. F., Park, S., Kurtz, R., Hinkley, T., Nicholes, K., et al. (2023) · Molecular Therapy · doi:10.1016/j.ymthe.2023.06.017 · Cited by 52 · see citing works
Self-citationThe Importance of RNA-Based Vaccines in the Fight against COVID-19: An Overview
Machado, B. A. S., Hodel, K. V. S., Fonseca, L. M. D. S., Mascarenhas, L. A. B., Andrade, L. P. C. D. S., Rocha, V. P. C., Soares, M. B. P., Berglund, P., Duthie, M. S., Reed, S. G., et al. (2021) · Vaccines · doi:10.3390/vaccines9111345 · Cited by 52 · see citing works
Self-citationModified mRNA as a Therapeutic Tool for the Heart
Kaur, K., & Zangi, L. (2020) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-020-07051-4 · Cited by 50 · see citing works
Virus-based vectors for human vaccine applications
Polo, J. M., & Dubensky, T. W. (2002) · Drug Discovery Today · doi:10.1016/s1359-6446(02)02324-3 · Cited by 48 · see citing works
Vignuzzi, M., Gerbaud, S., van der Werf, S., & Escriou, N. (2001) · Journal of General Virology · doi:10.1099/0022-1317-82-7-1737 · Cited by 47 · see citing works
Self-amplifying mRNA-Based Vaccine Technology and Its Mode of Action
Maruggi, G., Ulmer, J. B., Rappuoli, R., & Yu, D. L. (2021) · Current topics in microbiology and immunology · doi:10.1007/82_2021_233 · Cited by 45 · see citing works
Vaccines ‘on demand’: science fiction or a future reality
Ulmer, J. B., Mansoura, M. K., & Geall, A. J. (2015) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2015.996128 · Cited by 45 · see citing works
Nucleic acid vaccines: research tool or commercial reality
Babiuk, L. A., Babiuk, S., Loehr, B. I., & den Hurk, S. V. D. L.-V. (2000) · Veterinary Immunology and Immunopathology · doi:10.1016/s0165-2427(00)00198-7 · Cited by 44 · see citing works
RNA Replicons - A New Approach for Influenza Virus Immunoprophylaxis
Zimmer, G. (2010) · Viruses · doi:10.3390/v2020413 · Cited by 43 · see citing works
Smith, M. L., Corbo, T. A., Bernales, J., Lindbo, J. A., Pogue, G. P., Palmer, K. E., & McCormick, A. A. (2006) · Virology · doi:10.1016/j.virol.2006.08.040 · Cited by 41 · see citing works
Delivery of synthetic mRNAs for tissue regeneration
Steinle, H., Weber, M., Stoppelkamp, S., Große‐Berkenbusch, K., Golombek, S., Weber, M., Çanak-Ipek, T., Trenz, S.-M., Schlensak, C., & Avci‐Adali, M. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.114007 · Cited by 41 · see citing works
Alphaviruses as vectors for gene delivery
Berglund, P., Tubulekas, I., & Liljeström, P. (1996) · Trends in biotechnology · doi:10.1016/0167-7799(96)10019-6 · Cited by 41 · see citing works
Self-citationThe messenger's great message for vaccination
Pascolo, S. (2015) · Expert Review of Vaccines · doi:10.1586/14760584.2015.1000871 · Cited by 40 · see citing works
In Vitro Transcribed RNA-Based Platform Vaccines: Past, Present, and Future
Perenkov, A. D., Sergeeva, A. D., Vedunova, M. V., & Krysko, D. V. (2023) · Vaccines · doi:10.3390/vaccines11101600 · Cited by 40 · see citing works
Vidalin, O., Fournillier, A., Renard, N., Chen, M., Depla, E., Boucreux, D., Brinster, C., Baumert, T. F., Nakano, I., Fukuda, Y., et al. (2000) · Virology · doi:10.1006/viro.2000.0566 · Cited by 39 · see citing works
Self-citationCabrera, A. C., Sáez, D. R., Céspedes, S., Andrews, E. M., & Oñate, A. A. (2009) · Immunobiology · doi:10.1016/j.imbio.2008.11.016 · Cited by 38 · see citing works
DeFrancesco, L. (2017) · Nature Biotechnology · doi:10.1038/nbt.3812 · Cited by 38 · see citing works
Giraud, A., Ataman‐Önal, Y., Battail‐Poirot, N., Piga, N., Brand, D., Mandrand, B., & Verrier, B. (1999) · Journal of Virological Methods · doi:10.1016/s0166-0934(99)00009-9 · Cited by 36 · see citing works
Sindbis virus vectors for expression in animal cells
Huang, H. V. (1996) · Current Opinion in Biotechnology · doi:10.1016/s0958-1669(96)80057-7 · Cited by 36 · see citing works
Alphavirus Vectors: Applications for DNA Vaccine Production and Gene Expression
Lundstrom, K. H. (2000) · Intervirology · doi:10.1159/000053992 · Cited by 35 · see citing works
Recombinant Semliki Forest virus vector exhibits potential for avian virus vaccine development
Phenix, K. V., Wark, K. L., Luke, C. J., Skinner, M. A., Smyth, J. A., Mawhinney, K. A., & Todd, D. (2001) · Vaccine · doi:10.1016/s0264-410x(01)00026-3 · Cited by 34 · see citing works
Alphaviruses as expression vectors
Lundstrom, K. H. (1997) · Current Opinion in Biotechnology · doi:10.1016/s0958-1669(97)80032-8 · Cited by 32 · see citing works
Schoenly, K. A., & Weiner, D. B. (2007) · Journal of Virology · doi:10.1128/jvi.01634-07 · Cited by 32 · see citing works
Immunogenicity of West Nile virus infectious DNA and its noninfectious derivatives
Seregin, A. V., Nistler, R., Borisevich, V., Yamshchikov, G. V., Chaporgina, E., Kwok, C. W., & Yamshchikov, V. F. (2006) · Virology · doi:10.1016/j.virol.2006.07.038 · Cited by 31 · see citing works
Andersson, C., Vasconcelos, N. ‐., Sievertzon, M., Haddad, D. E., Liljeqvist, S., Berglund, P., Liljeström, P., Ahlborg, N., Ståhl, S., & Berzins, K. (2001) · Scandinavian Journal of Immunology · doi:10.1046/j.1365-3083.2001.00951.x · Cited by 30 · see citing works
Self-citationLi, N., Qiu, H., Jian-jun, Z., Li, Y., Wang, M., Lu, B., Han, C.-G., Hou, Q., Wang, Z., Gao, H. J., et al. (2006) · Vaccine · doi:10.1016/j.vaccine.2006.08.020 · Cited by 30 · see citing works
Erasmus, J. H., Khandhar, A. P., Walls, A. C., Hemann, E. A., O’Connor, M. A., Murapa, P., Archer, J. F., Leventhal, S. S., Fuller, J., Lewis, T. B., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.28.121640 · Cited by 30 · see citing works
Self-citationKarlsson, G. B., & Liljeström, P. (2004) · Humana Press eBooks · doi:10.1385/1-59259-650-9:543 · Cited by 29 · see citing works
Self-citationAdvances in saRNA Vaccine Research against Emerging/Re-Emerging Viruses
Liu, Y., Li, Y., & Hu, Q. (2023) · Vaccines · doi:10.3390/vaccines11071142 · Cited by 27 · see citing works
- Authors
- Zhou, X., Berglund, P., Rhodes, G., Parker, S. E., Jondal, M., & Liljeström, P.
- Affiliations
- Karolinska Institutet (SE)
- Vical (United States) (US)
- Corresponding author
- Liljeström, P
- Venue
- Vaccine
- Publisher
- Elsevier BV
- Published
- 1994-12
- Volume
- 12
- Issue
- 16
- Pages
- 1510-1514
- ISSN
- 0264-410X (ISSN-L)
- OpenAlex
- W2006168695
- Cited by
- 193
- References
- 32
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 9 · 2023: 17 · 2022: 10 · 2021: 13 · 2020: 8 · 2019: 6 · 2018: 1 · 2017: 3 · 2015: 3 · 2014: 7 · 2013: 5 · 2012: 4
- FWCI
- 6.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Vaccine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- Semliki Forest virus, nucleic acid vaccines, influenza nucleoprotein, humoral immune response, cytotoxic T lymphocytes, self-replicating RNA
- MeSH terms
- Animals, Mice, Inbred BALB C, RNA, Viral, Semliki forest virus, T-Lymphocytes, Cytotoxic, Transfection, Vaccines, Synthetic, Viral Vaccines, Virus Replication, Mice
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