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Dysfunction of the neurovascular unit in ischemic stroke and neurodegenerative diseases: An aging effect
Open accessAbstract
Current understanding on the mechanisms of brain injury and neurodegeneration highlights an appreciation of multicellular interactions within the neurovascular unit (NVU), which include the evolution of blood-brain barrier (BBB) damage, neuronal cell death or degeneration, glial reaction, and immune cell infiltration. Aging is an important factor that influences the integrity of the NVU. The age-related physiological or pathological changes in the cellular components of the NVU have been shown to increase the vulnerability of the NVU to ischemia/reperfusion injury or neurodegeneration, and to result in deteriorated brain damage. This review describes the impacts of aging on each NVU component and discusses the mechanisms by which aging increases NVU sensitivity to stroke and neurodegenerative diseases. Prophylactic or therapeutic perspectives that may delay or diminish aging and thus prevent the incidence of these neurological disorders will also be reviewed.
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“Pathological dysfunction of the neurovascular unit has emerged as an important element in neurodegenerative diseases, in which neuronal cell death, glial cell activation, blood-brain barrier (BBB) disruption, and penetration of peripheral immune cells may ensue with disease progression (Baker and Petersen, 2018; Cai e…”
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Metadata
- Authors
- Cai, W., Zhang, K., Li, P., Zhu, L., Xu, J., Yang, B., Hu, X., Lu, Z., & Chen, J.
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 34
- Pages
- 77-87
- ISSN
- 1568-1637 (ISSN-L)
- OpenAlex
- W2529479402
- Cited by
- 285
- References
- 28
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- green
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