Persistent depressive symptomatology and inflammation: To what extent do health behaviours and weight control mediate this relationship?

Hamer, Mark; Molloy, Gerard J.; de Oliveira, Cesar; Demakakos, Panayotes

doi:10.1016/j.bbi.2009.01.005

Cited by 82Tryptophan and brain disordersAdipokines, Inflammation, and Metabolic DiseasesHealth disparities and outcomes

Persistent depressive symptomatology and inflammation: To what extent do health behaviours and weight control mediate this relationship?

Hamer, Mark, Molloy, Gerard J., de Oliveira, Cesar, Demakakos, Panayotes·2009·Brain, Behavior, and Immunity

DOI 10.1016/j.bbi.2009.01.005

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Abstract

We examined if persistent depressive symptoms are associated with markers of inflammation (C-Reactive Protein-CRP) and coagulation (fibrinogen), and if this association can be partly explained by weight control and behavioural risk factors (smoking, alcohol, physical activity). The study sample included 3609 men and women (aged 60.5+/-9.2 years) from The English Longitudinal Study of Ageing, a prospective study of community dwelling older adults. Depressive symptoms (using the 8-item CES-D scale), health behaviours (smoking, alcohol, physical activity), body weight, and central adiposity were assessed at baseline and 2 years follow up. CRP and fibrinogen were assessed at follow up. At baseline 12.7% of the sample reported elevated depressive symptomatology, which persisted in 6.1% of participants at follow up. Baseline CES-D score was associated with CRP (beta=.035, SE=.0066) and fibrinogen (beta=.023, SE=.0060) measured 2 years later. Using simple mediation analysis we observed both a direct association of depressive symptoms on CRP (beta=.013, SE=.0066) and indirect mediating effects through behavioural risk factors (beta for total indirect effect beta=.022, SE=.0023). For fibrinogen there were no direct effects of depression, and the association was entirely explained through indirect mediating effects of health behaviours. The presence of recurrent elevated depressive symptomatology at both time points was more strongly associated with CRP and fibrinogen. In summary, the association between depressive symptoms and low grade inflammation can be partly explained by behavioural risk factors. The presence of persistent depression appears to be associated with the greatest risk of elevated inflammation.

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Poor sleep has pro-inflammatory effects in humans.
“both of these factors have also been shown to have pro-inflammatory effects in humans 110,111 .”
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Smoking has pro-inflammatory effects in humans.
“both of these factors have also been shown to have pro-inflammatory effects in humans 110,111 .”
From A meta-review of "lifestyle psychiatry": the role of exercise, smoking, diet and sleep in the prevention and treatment of mental disorders (2020) · cites this paper as [111]

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Authors: Hamer, M., Molloy, G. J., de Oliveira, C., & Demakakos, P.
Affiliations: University College London (GB)
Corresponding author: Hamer, Mark
ORCID: Hamer, Mark
Molloy, Gerard J.
Demakakos, Panayotes
Venue: Brain, Behavior, and Immunity
Publisher: Elsevier BV
Published: 2009-05
Volume: 23
Issue: 4
Pages: 413-418
ISSN: 0889-1591 (ISSN-L)
DOI: 10.1016/j.bbi.2009.01.005
OpenAlex: W2080690713
Cited by: 82
References: 44
Citations by year: 2024: 2 · 2023: 1 · 2022: 2 · 2020: 7 · 2019: 2 · 2018: 6 · 2017: 7 · 2016: 4 · 2015: 5 · 2014: 11 · 2013: 9 · 2012: 9
FWCI: 2.84
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Brain Behavior and Immunity (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: British Heart Foundation
National Institute on Aging (2R01AG7644-01A1, R01AG017644)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Social Sciences › Health › Health disparities and outcomes
Keywords: persistent depressive symptoms, low-grade inflammation, C-reactive protein, fibrinogen, health behavior, smoking, alcohol consumption, physical activity, weight management, abdominal obesity, older adults, mediation analysis, English Longitudinal Study of Ageing
MeSH terms: Age Factors, Body Weight, C-Reactive Protein, Depression, England, Female, Fibrinogen, Humans, Inflammation, Longitudinal Studies, Male, Middle Aged, Motor Activity, Prospective Studies, Smoking, Biomarkers, Health Behavior, Patient Selection, Adiposity

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Persistent depressive symptomatology and inflammation: To what extent do health behaviours and weight control mediate this relationship?

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