Cited by 223Thyroid Disorders and TreatmentsThyroid and Parathyroid SurgeryThyroid Cancer Diagnosis and Treatment

The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.

Conditions and drugs interfering with thyroxine absorption

Liwanpo, Llanyee, Hershman, Jerome M.·2009·Best Practice & Research Clinical Endocrinology & Metabolism

DOI 10.1016/j.beem.2009.06.006

Open this paper in CoChat — free account

Abstract

Food, dietary fibre and espresso coffee interfere with the absorption of levothyroxine. Malabsorptive disorders reported to affect the absorption of levothyroxine include coeliac disease, inflammatory bowel disease, lactose intolerance as well as Helicobacter pylori (H. pylori) infection and atrophic gastritis. Many commonly used drugs, such as bile acid sequestrants, ferrous sulphate, sucralfate, calcium carbonate, aluminium-containing antacids, phosphate binders, raloxifene and proton-pump inhibitors, have also been shown to interfere with the absorption of levothyroxine.

Integrity signals

Registry

Crossref · 10.1016/j.beem.2009.06.006

Cites

46 of 46 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Thyroxine in Goiter, Helicobacter pylori Infection, and Chronic Gastritis
Centanni, M., Gargano, L., Canettieri, G., Viceconti, N., Franchi, A., Fave, G. D., & Annibale, B. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa043903 · Cited by 329
Ferrous sulfate reduces thyroxine efficacy in patients with hypothyroidism
Campbell, N. R. C., Hasinoff, B. B., Stalts, H., Rao, B., & Wong, N. C. W. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-117-12-1010 · Cited by 231
Simultaneous Measurement of Thyroxine and Triiodothyronine Peripheral Turnover Kinetics in Man
Nicoloff, J. T., LOW, J. C., Dussault, J. H., & Fisher, D. A. (1972) · Journal of Clinical Investigation · doi:10.1172/jci106835 · Cited by 221
Effect of calcium carbonate on the absorption of levothyroxine
Singh, N. (2000) · JAMA · doi:10.1001/jama.283.21.2822 · Cited by 219
Altered intestinal absorption of L-thyroxine caused by coffee
Benvenga, S., Bartolone, L., Pappalardo, M. A., Russo, A., Lapa, D., Giorgianni, G., Saraceno, G., & Trimarchi, F. (2008) · Thyroid · doi:10.1089/thy.2007.0222 · Cited by 191
Delayed Intestinal Absorption of Levothyroxine
BENVENGA, S., BARTOLONE, L., SQUADRITO, S., GIUDICE, F. L., & TRIMARCHI, F. (1995) · Thyroid · doi:10.1089/thy.1995.5.249 · Cited by 156
Aspects of the absorption of oral L-thyroxine in normal man
Wenzel, K. W., & Kirschsieper, H. E. (1977) · Metabolism · doi:10.1016/0026-0495(77)90121-4 · Cited by 151
The influence of cholestyramine on thyroxine absorption
Northcutt, R. C. (1969) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1969.03160100047012 · Cited by 144
Evidence for a clinically important adverse effect of fiber-enriched diet on the bioavailability of levothyroxine in adult hypothyroid patients.
Liel, Y., Harman-Boehm, I., & Shany, S. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.2.8636317 · Cited by 129
Effect of Proton Pump Inhibitors on Serum Thyroid-Stimulating Hormone Level in Euthyroid Patients Treated with Levothyroxine for Hypothyroidism
Sachmechi, I., Reich, D. M., Aninyei, M., Wibowo, F., Gupta, G., & Kim, P. J. (2007) · Endocrine Practice · doi:10.4158/ep.13.4.345 · Cited by 112

Flagged first, then by citations

Show all 45 references

Sorted by citations

2013 ETA Guideline: Management of Subclinical Hypothyroidism
Pearce, S. H. S., Brabant, G., Duntas, L. H., Monzani, F., Peeters, R. P., Razvi, S., & Wemeau, J.-L. (2013) · European Thyroid Journal · doi:10.1159/000356507 · Cited by 877
Soy, Soy Foods and Their Role in Vegetarian Diets
Rizzo, G., & Baroni, L. (2018) · Nutrients · doi:10.3390/nu10010043 · Cited by 536
Pitfalls in the measurement and interpretation of thyroid function tests
Koulouri, O., Moran, C., Halsall, D., Chatterjee, K., & Gurnell, M. (2013) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2013.10.003 · Cited by 282
Treatment with thyroid hormone
Biondi, B., & Wartofsky, L. (2014) · Endocrine Reviews · doi:10.1210/er.2013-1083 · Cited by 259
Overt and Subclinical Hypothyroidism
Khandelwal, D., & Tandon, N. (2011) · Drugs · doi:10.2165/11598070-000000000-00000 · Cited by 204
A review of the pharmacokinetics of levothyroxine for the treatment of hypothyroidism
Colucci, P., Yue, C. S., Ducharme, M., Benvenga, S., Principal Scientist, L. A. C. I., Principal Scientist, L. A. C. I. A. P. C., President and CEO, L. A. C. I., & Professor of Medicine, D. (2010) · European Endocrinology · doi:10.17925/ee.2013.09.01.40 · Cited by 167
Gastrointestinal malabsorption of thyroxine
Virili, C., Antonelli, A., Santaguida, M. G., Benvenga, S., & Centanni, M. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00168 · Cited by 164
Drugs affecting thyroid function
Barbesino, G. (2010) · Thyroid · doi:10.1089/thy.2010.1635 · Cited by 146
Factors Affecting Gastrointestinal Absorption of Levothyroxine: A Review
Skelin, M., Lucijanić, T., Amidžić Klarić, D., Rešić, A., Bakula, M., Liberati-Čizmek, A.-M., Gharib, H., & Rahelić, D. (2017) · Clinical Therapeutics · doi:10.1016/j.clinthera.2017.01.005 · Cited by 133
The Role of Soy in Vegetarian Diets
Messina, M. J., & Messina, V. (2010) · Nutrients · doi:10.3390/nu2080855 · Cited by 137
Insights Gained from 20 Years of Soy Research ,
Messina, M. J. (2010) · Journal of Nutrition · doi:10.3945/jn.110.124107 · Cited by 122
Atypical celiac disease as cause of increased need for thyroxine: a systematic study
Virili, C., Bassotti, G., Santaguida, M. G., Iuorio, R., Del Duca, S. C., Mercuri, V., Picarelli, A., Gargiulo, P., Gargano, L., & Centanni, M. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1851 · Cited by 114
Diagnosis and management of treatment-refractory hypothyroidism: an expert consensus report
Centanni, M., Benvenga, S., & Sachmechi, I. (2017) · Journal of Endocrinological Investigation · doi:10.1007/s40618-017-0706-y · Cited by 113
“The ingestion of one or more of these at, or close to, the time of levothyroxine dosing can significantly change the dose requirement in individual patients, especially when done regularly [49].”
Background
Thyroid hormone therapy for hypothyroidism
Biondi, B., & Cooper, D. S. (2019) · Endocrine · doi:10.1007/s12020-019-02023-7 · Cited by 112
Levothyroxine Dose Adjustment to Optimise Therapy Throughout a Patient’s Lifetime
Duntas, L. H., & Jonklaas, J. (2019) · Advances in Therapy · doi:10.1007/s12325-019-01078-2 · Cited by 99
The administration of l -thyroxine as soft gel capsule or liquid solution
Vita, R., Fallahi, P., Antonelli, A., & Benvenga, S. (2014) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.918101 · Cited by 93
A novel formulation of L-thyroxine (L-T4) reduces the problem of L-T4 malabsorption by coffee observed with traditional tablet formulations
Vita, R., Saraceno, G., Trimarchi, F., & Benvenga, S. (2013) · Endocrine · doi:10.1007/s12020-012-9772-2 · Cited by 91
Levothyroxine interactions with food and dietary supplements – a systematic review
Wiesner, A., Gajewska, D., & Paśko, P. (2021) · Pharmaceuticals · doi:10.3390/ph14030206 · Cited by 85
TSH normalization in bariatric surgery patients after the switch from L-Thyroxine in tablet to an oral liquid formulation
Fallahi, P., Ferrari, S. M., Camastra, S., Politti, U., Ruffilli, I., Vita, R., Navarra, G., Benvenga, S., & Antonelli, A. (2017) · Obesity Surgery · doi:10.1007/s11695-016-2247-4 · Cited by 81
A double-blind placebo-controlled trial of liquid thyroxine ingested at breakfast: results of the TICO study
Cappelli, C., Pirola, I., Daffini, L., Formenti, A., Iacobello, C., Cristiano, A., Gandossi, E., Agabiti Rosei, E., & Castellano, M. (2016) · Thyroid · doi:10.1089/thy.2015.0422 · Cited by 80
Gastric secretion
Schubert, M. L. (2010) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32833f2010 · Cited by 80
Neither soyfoods nor isoflavones warrant classification as endocrine disruptors: a technical review of the observational and clinical data
Messina, M. J., Mejía, S. B., Cassidy, A., Duncan, A. M., Kurzer, M. S., Nagato, C., Ronis, M. J. J., Rowland, I. R., Sievenpiper, J. L., & Barnes, S. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1895054 · Cited by 79
When thyroid hormone replacement is ineffective?
Benvenga, S. (2013) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0000000000000003 · Cited by 74
Systematic appraisal of lactose intolerance as cause of increased need for oral thyroxine
Cellini, M., Santaguida, M. G., Gatto, I., Virili, C., Del Duca, S. C., Brusca, N., Capriello, S., Gargano, L., & Centanni, M. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1217 · Cited by 72
Liquid and softgel levothyroxine use in clinical practice: state of the art
Virili, C., Trimboli, P., Romanelli, F., & Centanni, M. (2016) · Endocrine · doi:10.1007/s12020-016-1035-1 · Cited by 71
Using Body Mass Index to Predict Optimal Thyroid Dosing after Thyroidectomy
Ojomo, K. A., Schneider, D. F., Reiher, A. E., Lai, N. B., Schaefer, S. C., Chen, H., & Sippel, R. S. (2013) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2012.12.002 · Cited by 69
Drugs that interact with levothyroxine: an observational study from the Thyroid Epidemiology, Audit and Research Study (TEARS)
A. Irving, S., Vadiveloo, T., & Leese, G. P. (2015) · Clinical Endocrinology · doi:10.1111/cen.12559 · Cited by 69
A thyroxine absorption test followed by weekly thyroxine administration: a method to assess non-adherence to treatment
Walker, J. N., Shillo, P., Ibbotson, V, Vincent, A., Karavitaki, N., Weetman, A. P., Wass, J. A. H., & Allahabadia, A. (2013) · European Journal of Endocrinology · doi:10.1530/eje-12-1035 · Cited by 70
Thyroxine softgel capsule in patients with gastric-related T4 malabsorption
Santaguida, M. G., Virili, C., Duca, S. C. D., Cellini, M., Gatto, I., Brusca, N., De Vito, C., Gargano, L., & Centanni, M. (2015) · Endocrine · doi:10.1007/s12020-014-0476-7 · Cited by 68
All disease begins in the gut: Influence of gastrointestinal disorders and surgery on oral drug performance
Hatton, G. B., Madla, C. M., Rabbie, S. C., & Basit, A. W. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.06.054 · Cited by 69
Serum Thyrotropin Levels Following Levothyroxine Administration at Breakfast
Perez, C. L. S., Araki, F. S., Graf, H., & de Carvalho, G. A. (2013) · Thyroid · doi:10.1089/thy.2012.0435 · Cited by 63
Comorbidities, Concomitant Medications, and Diet as Factors Affecting Levothyroxine Therapy: Results of the CONTROL Surveillance Project
McMillan, M., Rotenberg, K. S., Vora, K., Sterman, A. B., Thevathasan, L., Ryan, M. F., Mehra, M., & Sandulli, W. (2016) · Drugs in R&D · doi:10.1007/s40268-015-0116-6 · Cited by 64
Levothyroxine therapy: changes of TSH levels by switching patients from tablet to liquid formulation. a systematic review and meta-analysis
Virili, C., Giovanella, L., Fallahi, P., Antonelli, A., Santaguida, M. G., Centanni, M., & Trimboli, P. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00010 · Cited by 61
Associations of Helicobacter pylori Infection and Cytotoxin-Associated Gene A Status with Autoimmune Thyroid Diseases: A Meta-Analysis
Shi, W.-J., Liu, W., Zhou, X., Ye, F., & Zhang, G. (2013) · Thyroid · doi:10.1089/thy.2012.0630 · Cited by 60
How to interpret thyroid function tests
Levy, M. J., Koulouri, O., & Gurnell, M. (2013) · Clinical Medicine · doi:10.7861/clinmedicine.13-3-282 · Cited by 60
Decrease in TSH levels after lactose restriction in Hashimoto's thyroiditis patients with lactose intolerance
Asik, M., Gunes, F., Binnetoglu, E., Eroglu, M., Bozkurt, N., Sen, H., Akbal, E., Bakar, C., Beyazit, Y., & Ukinc, K. (2014) · Endocrine · doi:10.1007/s12020-013-0065-1 · Cited by 58
Shift from levothyroxine tablets to liquid formulation at breakfast improves quality of life of hypothyroid patients
Guglielmi, R., Grimaldi, F., Negro, R., Frasoldati, A., Misischi, I., Graziano, F., Cipri, C., Guastamacchia, E., Triggiani, V., & Papini, E. (2018) · Endocrine, Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530318666180125155348 · Cited by 57
Improved Levothyroxine Pharmacokinetics After Bariatric Surgery
Gkotsina, M., Michalaki, M., Mamali, I., Markantes, G., Sakellaropoulos, G. C., Kalfarentzos, F., Vagenakis, A. G., & Markou, K. B. (2013) · Thyroid · doi:10.1089/thy.2011.0526 · Cited by 57
Probiotics Ingestion Does Not Directly Affect Thyroid Hormonal Parameters in Hypothyroid Patients on Levothyroxine Treatment
Spaggiari, G., Brigante, G., Vincentis, S. D., Cattini, U., Roli, L., Santis, M. C. D., Baraldi, E., Tagliavini, S., Varani, M., Trenti, T., et al. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00316 · Cited by 57
Celiac disease and hypothyroidism
Collins, D., Wilcox, R., Nathan, M., & Zubarik, R. (2012) · The American Journal of Medicine · doi:10.1016/j.amjmed.2011.09.003 · Cited by 54
The economic impact of levothyroxine dose adjustments: the CONTROL HE study
Ernst, F. R., Barr, P., Elmor, R., Sandulli, W., Thevathasan, L., Sterman, A. B., Goldenberg, J., & Vora, K. (2017) · Clinical Drug Investigation · doi:10.1007/s40261-016-0462-3 · Cited by 53
Oral L-thyroxine liquid versus tablet in patients with hypothyroidism without malabsorption: a prospective study
Fallahi, P., Ferrari, S. M., & Antonelli, A. (2016) · Endocrine · doi:10.1007/s12020-015-0836-y · Cited by 53
Helicobacter pyloriinfection and drugs malabsorption
Lahner, E. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i30.10331 · Cited by 53
A new strategy to estimate levothyroxine requirement after total thyroidectomy for benign thyroid disease
Di Donna, V., Santoro, M. G., de Waure, C., Ricciato, M. P., Paragliola, R. M., Pontecorvi, A., & Corsello, S. M. (2014) · Thyroid · doi:10.1089/thy.2014.0111 · Cited by 52
Levothyroxine therapy in gastric malabsorptive disorders
Virili, C., Brusca, N., Capriello, S., & Centanni, M. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.621616 · Cited by 52
Weight Loss and variation of levothyroxine requirements in hypothyroid obese patients after bariatric surgery
Fierabracci, P., Martinelli, S., Tamberi, A., Piaggi, P., Basolo, A., Pelosini, C., Ricco, I., Magno, S., Querci, G., Ceccarini, G., et al. (2016) · Thyroid · doi:10.1089/thy.2015.0473 · Cited by 51
Levothyroxine absorption in health and disease, and new therapeutic perspectives.
Ianiro, G., Mangiola, F., Rienzo, T. A. D., Bibbò, S., Franceschi, F., Greco, A. V., & Gasbarrini, A. (2014) · PubMed · Cited by 51
A Benefit–Risk Assessment of the Use of Proton Pump Inhibitors in the Elderly
Masclee, G. M. C., Sturkenboom, M., & Kuipers, E. J. (2014) · Drugs & Aging · doi:10.1007/s40266-014-0166-4 · Cited by 52
Diagnosis and Management of Hypothyroidism in Gulf Cooperation Council (GCC) Countries
Alzahrani, A. S., Mourad, M. A., Hafez, K. K., Almaghamsy, A. M., Alamri, F. A., Aljuhani, N. R., Alhazmi, A. S., Saeedi, M. Y., Alsefri, S. S., Alzahrani, M. D. A., et al. (2020) · Advances in Therapy · doi:10.1007/s12325-020-01382-2 · Cited by 53
Relational Stability in the Expression of Normality, Variation, and Control of Thyroid Function
Hoermann, R., Midgley, J. E. M., Larisch, R., & Dietrich, J. W. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00142 · Cited by 48
Advancements in the treatment of hypothyroidism with L-T4 liquid formulation or soft gel capsule: an update
Fallahi, P., Ferrari, S. M., Ruffilli, I., Ragusa, F., Biricotti, M., Materazzi, G., Miccoli, P., & Antonelli, A. (2016) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2016.1227782 · Cited by 48
Reversible normalisation of serum TSH levels in patients with autoimmune atrophic gastritis who received L-T4 in tablet form after switching to an oral liquid formulation: a case series
Fallahi, P., Ferrari, S. M., Ruffilli, I., & Antonelli, A. (2016) · BMC Gastroenterology · doi:10.1186/s12876-016-0439-y · Cited by 46
Hormone Replacement After Thyroid and Parathyroid Surgery
Schäffler, A. (2010) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2010.0827 · Cited by 46
Comparison of TSH Levels with Liquid Formulation Versus Tablet Formulations of Levothyroxine in the Treatment of Adult Hypothyroidism
Brancato, D., Scorsone, A., Saura, G., Ferrara, L., Di Noto, A., Aiello, V., Fleres, M., & Provenzano, V. (2014) · Endocrine Practice · doi:10.4158/ep13418.or · Cited by 44
New levothyroxine formulation meeting 95-105% specification over the whole shelf-life: results from two pharmacokinetic trials
Gottwald-Hostalek, U., Uhl, W., Wolna, P., & Kahaly, G. J. (2017) · Current Medical Research and Opinion · doi:10.1080/03007995.2016.1246434 · Cited by 43
Oral liquid levothyroxine solves the problem of tablet levothyroxine malabsorption due to concomitant intake of multiple drugs
Vita, R., Di Bari, F., & Benvenga, S. (2017) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2017.1290604 · Cited by 43
Hypothyroidism and metabolic cardiovascular disease
Patrizio, A., Ferrari, S. M., Elia, G., Ragusa, F., Balestri, E., Botrini, C., Rugani, L., Mazzi, V., Antonelli, A., Fallahi, P., et al. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1408684 · Cited by 57
Oral liquid levothyroxine treatment at breakfast: a mistake?
Cappelli, C., Pirola, I., Gandossi, E., Formenti, A., & Castellano, M. (2014) · European Journal of Endocrinology · doi:10.1530/eje-13-0693 · Cited by 41
When bioequivalence in healthy volunteers may not translate to bioequivalence in patients: differential effects of increased gastric pH on the pharmacokinetics of levothyroxine capsules and tablets
Seng Yue, C., Benvenga, S., Scarsi, C., Loprete, L., & Ducharme, M. (2015) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.18433/j36p5m · Cited by 41
Prevalence of gastrointestinal disorders having an impact on tablet levothyroxine absorption: should this formulation still be considered as the first-line therapy?
Castellana, M., Castellana, C., Giovanella, L., & Trimboli, P. (2020) · Endocrine · doi:10.1007/s12020-019-02185-4 · Cited by 41
Individualised requirements for optimum treatment of hypothyroidism: complex needs, limited options
Hoermann, R., Midgley, J. E. M., Larisch, R., & Dietrich, J. W. (2019) · Drugs in Context · doi:10.7573/dic.212597 · Cited by 41
Drug interactions with levothyroxine therapy in patients with hypothyroidism: observational study in general practice
Trifirò, G., Parrino, F., Sultana, J., Giorgianni, F., Ferrajolo, C., Bianchini, E., Medea, G., Benvenga, S., Cricelli, I., Cricelli, C., et al. (2015) · Clinical Drug Investigation · doi:10.1007/s40261-015-0271-0 · Cited by 40
MANAGEMENT OF ENDOCRINE DISEASE: Pitfalls on the replacement therapy for primary and central hypothyroidism in adults
de Carvalho, G. A., Paz-Filho, G., Mesa, C. O., & Graf, H. (2018) · European Journal of Endocrinology · doi:10.1530/eje-17-0947 · Cited by 41
Levothyroxine absorption test to differentiate pseudomalabsorption from true malabsorption
Ghosh, S., Pramanik, S., Biswas, K., Bhattacharjee, K., Sarkar, R., Chowdhury, S., & Mukhopadhyay, P. (2020) · European Thyroid Journal · doi:10.1159/000504218 · Cited by 39
The influence of lactose intolerance and other gastro-intestinal tract disorders on L-thyroxine absorption.
Ruchała, M., Szczepanek‐Parulska, E., & Zybek, A. (2012) · PubMed · Cited by 38
Treatment-refractory hypothyroidism
Ramadhan, A., & Tamilia, M. (2011) · Canadian Medical Association Journal · doi:10.1503/cmaj.110994 · Cited by 37
Tablet and oral liquid L-thyroxine formulation in the treatment of naive hypothyroid patients with Helicobacter pylori infection
Ribichini, D., Fiorini, G., Repaci, A., Castelli, V., Gatta, L., Vaira, D., & Pasquali, R. (2017) · Endocrine · doi:10.1007/s12020-016-1167-3 · Cited by 35
Concurrent milk ingestion decreases absorption of levothyroxine
Chon, D. A., Reisman, T., Weinreb, J. E., Hershman, J. M., & Leung, A. M. (2018) · Thyroid · doi:10.1089/thy.2017.0428 · Cited by 34
Self-citation
Congenital hypothyroidism: current perspectives
Dayal, D., & Anne, R. P. (2015) · Research and Reports in Endocrine Disorders · doi:10.2147/rred.s56402 · Cited by 34
Thyroid hormone replacement: current status and challenges
Okosieme, O. E. (2011) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2011.600307 · Cited by 33
Effect of timing of levothyroxine administration on the treatment of hypothyroidism: a three-period crossover randomized study
Skelin, M., Lucijanić, T., Liberati-Čizmek, A.-M., Klobučar, S. M., Lucijanić, M., Jakupović, L., Bakula, M., Lončar, J. V., Marušić, S., Matić, T., et al. (2018) · Endocrine · doi:10.1007/s12020-018-1686-1 · Cited by 31
Individually-tailored thyroxine requirement in the same patients before and after thyroidectomy: a longitudinal study
Del Duca, S. C., Santaguida, M. G., Brusca, N., Gatto, I., Cellini, M., Gargano, L., Verga Falzacappa, C., Frattaroli, F. M., Virili, C., & Centanni, M. (2015) · European Journal of Endocrinology · doi:10.1530/eje-15-0314 · Cited by 31
Variation in the biochemical response to l-thyroxine therapy and relationship with peripheral thyroid hormone conversion efficiency
Midgley, J. E. M., Larisch, R., Dietrich, J. W., & Hoermann, R. (2015) · Endocrine Connections · doi:10.1530/ec-15-0056 · Cited by 31
Rapid levothyroxine absorption testing: a case series of nonadherent patients
Balla, M., Jhingan, R. M., & Rubin, D. J. (2015) · International Journal of Endocrinology and Metabolism · doi:10.5812/ijem.31051 · Cited by 30
Timing of breakfast does not influence therapeutic efficacy of liquid levothyroxine formulation
Morelli, S., Reboldi, G., Moretti, S., Menicali, E., Avenia, N., & Puxeddu, E. (2016) · Endocrine · doi:10.1007/s12020-015-0788-2 · Cited by 30
Cabozantinib-Induced Thyroid Dysfunction: A Review of Two Ongoing Trials for Metastatic Bladder Cancer and Sarcoma
Yavuz, S., Apolo, A. B., Kummar, S., Rivero, J. D., Madan, R. A., Shawker, T. H., Reynolds, J. C., & Celi, F. S. (2014) · Thyroid · doi:10.1089/thy.2013.0621 · Cited by 31
Ingestion of large amounts of papaya fruit and impaired effectiveness of levothyroxine therapy
Deiana, L., Marini, S., & Mariotti, S. (2012) · Endocrine Practice · doi:10.4158/ep11233.co · Cited by 28
Thyroid hormone profile in patients ingesting soft gel capsule or liquid levothyroxine formulations with breakfast
Cappelli, C., Pirola, I., Gandossi, E., Cristiano, A., Daffini, L., Agosti, B., Casella, C., & Castellano, M. (2016) · International Journal of Endocrinology · doi:10.1155/2016/9043450 · Cited by 29
The thyroid registry: Clinical and hormonal characteristics of adult indian patients with hypothyroidism
Vyas, U., Sethi, B. K., Barua, S., Raghavendra, M., Gotur, J., & Khandelwal, D. (2017) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/ijem.ijem_387_16 · Cited by 29
In Patients With Subclinical Hypothyroidism While in Therapy With Tablet L-T4, the Liquid L-T4 Formulation is More Effective in Restoring Euthyroidism
Fallahi, P., Ferrari, S. M., & Antonelli, A. (2016) · Endocrine Practice · doi:10.4158/ep161545.or · Cited by 28
Drug absorption in celiac disease
Tran, T. H., Smith, C. J., & Mangione, R. A. (2013) · American Journal of Health-System Pharmacy · doi:10.2146/ajhp120689 · Cited by 28
Thyroid Function Alteration in Obesity and the Effect of Bariatric Surgery
Cordido, M., Juiz-Valiña, P., Urones, P., Sangiao‐Alvarellos, S., & Cordido, F. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11051340 · Cited by 29
The Effect of the Bariatric Surgery Type on the Levothyroxine Dose of Morbidly Obese Hypothyroid Patients
Pedro, J. M. P., Cunha, F. M., Souteiro, P., Neves, J. S., Guerreiro, V. A., Magalhães, D. M. D. S., Bettencourt‐Silva, R., Oliveira, S. C., Costa, M. M., Queirós, J. C., et al. (2018) · Obesity Surgery · doi:10.1007/s11695-018-3388-4 · Cited by 25
Increased requirement of replacement doses of levothyroxine caused by liver cirrhosis.
Benvenga, S., Capodicasa, G., Perelli, S., Ferrari, S. M., Fallahi, P., & Antonelli, A. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00150 · Cited by 25
Effect of coffee consumption on thyroid function: NHANES 2007-2012 and Mendelian randomization
Zhao, G., Wang, Z., Ji, J., & Cui, R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1188547 · Cited by 26
Subcutaneous application of levothyroxine as successful treatment option in a patient with malabsorption
Groener, J. B., Lehnhoff, D., Piel, D., Nawroth, P. P., Schanz, J., & Rudofsky, G. (2013) · American Journal of Case Reports · doi:10.12659/ajcr.883788 · Cited by 23
Comparative study between the effects of replacement therapy with liquid and tablet formulations of levothyroxine on mood states, self-perceived psychological well-being and thyroid hormone profile in recently thyroidectomized patients
Lombardi, C. P., Bocale, R., Barini, A., Barini, A., D’Amore, A., Boscherini, M., & Bellantone, R. (2017) · Endocrine · doi:10.1007/s12020-016-1003-9 · Cited by 23
Retrospective study of patients switched from tablet formulations to a gel cap formulation of levothyroxine: results of the control switch study
Ernst, F. R., Sandulli, W., Elmor, R., Welstead, J., Sterman, A. B., & Lavan, M. (2017) · Drugs in R&D · doi:10.1007/s40268-016-0150-z · Cited by 23
Oral L‐thyroxine liquid versus tablet in patients submitted to total thyroidectomy for thyroid cancer (without malabsorption): A prospective study
Fallahi, P., Ferrari, S. M., Materazzi, G., Ragusa, F., Ruffilli, I., Patrizio, A., Miccoli, P., & Antonelli, A. (2018) · Laryngoscope Investigative Otolaryngology · doi:10.1002/lio2.186 · Cited by 23
TSH evaluation in hypothyroid patients assuming liquid levothyroxine at breakfast or 30 min before breakfast
Pirola, I., Gandossi, E., Brancato, D., Marini, F., Cristiano, A., Delbarba, A., Agosti, B., Castellano, M., & Cappelli, C. (2018) · Journal of Endocrinological Investigation · doi:10.1007/s40618-018-0867-3 · Cited by 21
Cumulative release kinetics of levothyroxine-Na pentahydrate from chitosan/arabinogalactane based pH sensitive hydrogel and it's toxicology
Tapdiqov, S. Z., Taghiyev, D., Zeynalov, N. A., Safaraliyeva, S., Fatullayeva, S. S., Hummatov, A. F., Raucci, M. G., Mustafayev, M. M., Jafarova, R., & Shirinova, K. (2022) · Reactive and Functional Polymers · doi:10.1016/j.reactfunctpolym.2022.105334 · Cited by 21
TSH Variability of Patients Affected by Differentiated Thyroid Cancer Treated with Levothyroxine Liquid Solution or Tablet Form
Cappelli, C., Pirola, I., Gandossi, E., Casella, C., Lombardi, D., Agosti, B., Marini, F., Delbarba, A., & Castellano, M. (2017) · International Journal of Endocrinology · doi:10.1155/2017/7053959 · Cited by 21
Stable Isotope Pharmacokinetic Studies Provide Insight into Effects of Age, Sex, and Weight on Levothyroxine Metabolism
Younis, I. R., AHMED, M. A., Burman, K. D., Soldin, O. P., & Jonklaas, J. (2017) · Thyroid · doi:10.1089/thy.2017.0380 · Cited by 21
Ulcerative colitis as a novel cause of increased need for levothyroxine
Virili, C., Stramazzo, I., Santaguida, M. G., Bruno, G., Brusca, N., Capriello, S., Cellini, M., Severi, C., Gargano, L., & Centanni, M. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00233 · Cited by 20
Variation in the biochemical response to l-thyroxine therapy and relationship with peripheral thyroid hormone conversion efficiency
Midgley, J. E. M., Larisch, R., Dietrich, J. W., & Hoermann, R. (2015) · Endocrine Connections · doi:10.1530/ec-150056 · Cited by 31
Drug interactions in users of tablet vs. oral liquid levothyroxine formulations: a real-world evidence study in primary care
Guglielmi, V., Bellia, A., Bianchini, E., Medea, G., Cricelli, I., Sbraccia, P., Lauro, D., Cricelli, C., & Lapi, F. (2018) · Endocrine · doi:10.1007/s12020-017-1412-4 · Cited by 18
Drugs and Other Substances Interfering with Thyroid Function
Montanelli, L., Benvenga, S., Hegedüs, L., Vitti, P., Latrofa, F., & Duntas, L. H. (2018) · Endocrinology · doi:10.1007/978-3-319-45013-1_27 · Cited by 18
Potential drug interactions in drug therapy prescribed for older adults at hospital discharge: cross-sectional study
Dias, B. M., dos Santos, F. S., & Reis, A. M. M. (2019) · Sao Paulo Medical Journal · doi:10.1590/1516-3180.2019.013405072019 · Cited by 21
Levothyroxine dose adjustment in hypothyroid patients following gastric sleeve surgery
Richou, M., Gilly, O., Taillard, V., Brauwere, D. P. D., Donici, I., & Guedj, A. M. (2020) · Annales d Endocrinologie · doi:10.1016/j.ando.2020.04.011 · Cited by 16
Detailed investigation of a γ-cyclodextrin inclusion complex with l-thyroxine for improved pharmaceutical formulations
Lakkakula, J., Krause, R. W. M., Ndinteh, D. T., Vijaylakshmi, S. P., & Raichur, A. M. (2012) · Journal of Inclusion Phenomena and Macrocyclic Chemistry · doi:10.1007/s10847-012-0133-9 · Cited by 16

Authors: Liwanpo, L., & Hershman, J. M.
Affiliations: VA Greater Los Angeles Healthcare System (US)
Corresponding author: Liwanpo, Llanyee
Venue: Best Practice & Research Clinical Endocrinology & Metabolism
Publisher: Elsevier BV
Published: 2009-12
Volume: 23
Issue: 6
Pages: 781-792
ISSN: 1521-690X (ISSN-L)
DOI: 10.1016/j.beem.2009.06.006
OpenAlex: W2073346341
Cited by: 222
References: 45
Citations by year: 2026: 4 · 2025: 9 · 2024: 11 · 2023: 10 · 2022: 12 · 2021: 12 · 2020: 10 · 2019: 10 · 2018: 23 · 2017: 22 · 2016: 20 · 2015: 21 · 2014: 17 · 2013: 16 · 2012: 12
FWCI: 1.09
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Best Practice & Research Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
Keywords: levothyroxine, drug interactions, dietary fiber, espresso, celiac disease, inflammatory bowel disease, lactose intolerance, Helicobacter pylori infection, atrophic gastritis, bile acid sequestrants, ferrous sulfate, sucralfate, calcium carbonate, phosphate binders, raloxifene, proton pump inhibitors
MeSH terms: Aluminum Hydroxide, Animals, Antacids, Biological Availability, Calcium Carbonate, Celiac Disease, Coffee, Dietary Fiber, Drug Interactions, Female, Food, Gastritis, Atrophic, Humans, Intestinal Absorption, Lactose Intolerance, Malabsorption Syndromes, Thyroxine, Helicobacter Infections

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Conditions and drugs interfering with thyroxine absorption

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks