Cited by 886Digital Mental Health InterventionsImpact of Technology on AdolescentsMental Health Research Topics

The efficacy of app-supported smartphone interventions for mental health problems: a meta-analysis of randomized controlled trials

Open access
Linardon, Jake, Cuijpers, Pim, Carlbring, Per, Messer, Mariel, Fuller‐Tyszkiewicz, Matthew·2019·World Psychiatry

Abstract

Although impressive progress has been made toward developing empirically-supported psychological treatments, the reality remains that a significant proportion of people with mental health problems do not receive these treatments. Finding ways to reduce this treatment gap is crucial. Since app-supported smartphone interventions are touted as a possible solution, access to up-to-date guidance around the evidence base and clinical utility of these interventions is needed. We conducted a meta-analysis of 66 randomized controlled trials of app-supported smartphone interventions for mental health problems. Smartphone interventions significantly outperformed control conditions in improving depressive (g=0.28, n=54) and generalized anxiety (g=0.30, n=39) symptoms, stress levels (g=0.35, n=27), quality of life (g=0.35, n=43), general psychiatric distress (g=0.40, n=12), social anxiety symptoms (g=0.58, n=6), and positive affect (g=0.44, n=6), with most effects being robust even after adjusting for various possible biasing factors (type of control condition, risk of bias rating). Smartphone interventions conferred no significant benefit over control conditions on panic symptoms (g=–0.05, n=3), post-traumatic stress symptoms (g=0.18, n=4), and negative affect (g=–0.08, n=5). Studies that delivered a cognitive behavior therapy (CBT)-based app and offered professional guidance and reminders to engage produced larger effects on multiple outcomes. Smartphone interventions did not differ significantly from active interventions (face-to-face, computerized treatment), although the number of studies was low (n≤13). The efficacy of app-supported smartphone interventions for common mental health problems was thus confirmed. Although mental health apps are not intended to replace professional clinical services, the present findings highlight the potential of apps to serve as a cost-effective, easily accessible, and low intensity intervention for those who cannot receive standard psychological treatment. © 2019 World Psychiatric Association

Integrity signals

Registry

Crossref · 10.1002/wps.20673

Cites

85 of 85 references verified0 citation errors · 0 not checkable

Statistics

Nothing to recompute.

Claims the paper makes

12 of 23 cited sources checked · 5 supported · 0 flagged · accuracy not yet measured

  • Findingcitation

    Most effects were robust even after adjusting for various possible biasing factors (type of control condition, risk of bias rating).

    “Crucially, these effects were robust even after performing various sensitivity analyses that adjusted for common biasing factors in RCTs, including the type of control condition, trial risk of bias rating, and publication bias 57,58 .”
    Quote in the paperSubstantial claim2 of 2 sources checked
    • cites [57] 57. Cristea IA. The waiting list is an inadequate benchmark for estimating the effectiveness of psychotherapy for depression. Epidemiol Psychiatr Sci 2019;28:278-9. source

      The opening discussion reports that a meta-analysis found psychotherapy for depression remained effective after sensitivity analyses addressing waiting-list controls, trial risk of bias, and publication bias. It reports one overall effect estimate, reduced by half to Hedges’ g = 0.31; it does not establish that most individual effects were robust. (LLM, conf=0.82)

      Experimental — accuracy not yet measured
    • cites [58] 58. Cuijpers P, Cristea I. How to prove that your therapy is effective, even when it is not: a guideline. Epidemiol Psychiatr Sci 2016;25:428-35. source

      The section “Use the ‘weak spots’ of randomised trials” discusses how control groups and risk of bias can influence apparent treatment effects. Our copy does not report the cited effects or sensitivity analyses adjusting for control condition, risk-of-bias rating, or publication bias; searches for robustness and those adjustments found no such result. Page numbers were not available in our copy. (LLM, conf=0.76)

      Experimental — accuracy not yet measured
  • Premisecitation

    The efficacy of smartphone interventions for common and costly mental health problems, such as depressive and anxiety symptoms, was preliminarily documented in two recent metaanalyses.

    “The efficacy of smartphone interventions for common and costly mental health problems, such as depressive and anxiety symptoms, was preliminarily documented in two recent metaanalyses.”
    Quote in the paperSubstantial claim1 of 2 sources checked
    • cites [7] 7. Firth J, Torous J, Nicholas J et al. The efficacy of smartphone-based men- tal health interventions for depressive symptoms: a meta-analysis of ran- domized controlled trials. World Psychiatry 2017;16:287-98. source
    • cites [8] 8. Firth J, Torous J, Nicholas J et al. Can smartphone mental health interven- tions reduce symptoms of anxiety? A meta-analysis of randomized con- trolled trials. J Affect Disord 2017;218:15-22. source
  • Premisecitation

    Preliminary findings from these meta-analyses suggest that app-supported smartphone interventions have potential in treating and preventing certain common and debilitating mental health problems.

    “Preliminary findings from these meta-analyses suggest that app-supported smartphone interventions have potential in treating and preventing certain common and debilitating mental health problems.”
    Quote in the paperSubstantial claim1 of 2 sources checked
    • cites [7] 7. Firth J, Torous J, Nicholas J et al. The efficacy of smartphone-based men- tal health interventions for depressive symptoms: a meta-analysis of ran- domized controlled trials. World Psychiatry 2017;16:287-98. source
    • cites [8] 8. Firth J, Torous J, Nicholas J et al. Can smartphone mental health interven- tions reduce symptoms of anxiety? A meta-analysis of randomized con- trolled trials. J Affect Disord 2017;218:15-22. source

      The Discussion reports preliminary evidence that smartphone-delivered psychological interventions reduce anxiety symptoms, supporting their potential for treating a common mental health problem. This meta-analysis does not establish that the interventions prevent mental health problems; its measured outcome was symptom reduction. (LLM, conf=0.84)

      Experimental — accuracy not yet measured
  • Findingcitation

    These effects were robust even after performing various sensitivity analyses that adjusted for common biasing factors in RCTs, including the type of control condition, trial risk of bias rating, and publication bias.

    “Crucially, these effects were robust even after performing various sensitivity analyses that adjusted for common biasing factors in RCTs, including the type of control condition, trial risk of bias rating, and publication bias 57,58 .”
    Quote in the paperSubstantial claim2 of 2 sources checked
    • cites [57] 57. Cristea IA. The waiting list is an inadequate benchmark for estimating the effectiveness of psychotherapy for depression. Epidemiol Psychiatr Sci 2019;28:278-9. source
    • cites [58] 58. Cuijpers P, Cristea I. How to prove that your therapy is effective, even when it is not: a guideline. Epidemiol Psychiatr Sci 2016;25:428-35. source

      The sections “Use the ‘weak spots’ of randomised trials,” “Design your trial in the right way,” and “Use the right publication strategy” discuss risk of bias, control-group choice, and nonpublication of negative trials as factors that can distort observed effects (page numbers unavailable). The paper does not report the cited sensitivity analyses or establish that the effects remained robust after them. (LLM, conf=0.84)

      Experimental — accuracy not yet measured
  • Premisecitation

    Automated (and personalized) support has been shown to produce equivalent clinical outcomes to human support in RCTs of computerized treatments.

    “Automated (and personalized) support has been shown to produce equivalent clinical outcomes to human support in RCTs of computerized treatments 67”
    Quote in the paperNot a substantial claim1 of 1 sources checked
    • cites [67] 67. Kelders SM, Bohlmeijer ET, Pots WTM et al. Comparing human and auto- mated support for depression: fractional factorial randomized controlled trial. Behav Res Ther 2015;72:72-80. source

      The Clinical outcomes section reports no significant difference between support conditions at follow-up, and the Implications section suggests automated support can be as effective at six months in this web-based depression intervention. But the Limitations section explicitly says this was not an equivalence trial and that equivalence cannot be stated with certainty; the claim also generalizes from this study to RCTs of computerized treatments. (LLM, conf=0.90)

      Experimental — accuracy not yet measured
  • Classified as probably not a substantial claim. 24
  • May combine two claims. 23
  • The quote only partly states this claim. 2
  • Probably not a substantial claim: may not pass S2 (checkable), S3 (load-bearing).

    Premisecitation

    The treatment of mental health problems is expected to change considerably over the next few decades as a result of the widespread availability of Internet and mobile-device applications, and their use to deliver psychological interventions.

    “The treatment of mental health problems is expected to change considerably over the next few decades as a result of the widespread availability of Internet and mobile-device applications, and their use to deliver psychological interventions 1,2 .”
    Quote in the paperNot a substantial claim2 of 2 sources checked
    • cites [1] 1. Fairburn CG, Patel V. The impact of digital technology on psychological treatments and their dissemination. Behav Res Ther 2017;88:19-25. source
    • cites [2] 2. Patel V, Prince M. Global mental health: a new global health field comes of age. JAMA 2010;303:1976-7. source

      The section “Global Mental Health: a new global health field comes of age” discusses psychological treatments and ways to expand care, but does not address Internet or mobile-device applications as a means of delivering them. Searches for Internet, mobile technology, and digital treatment found no passage supporting the predicted change over the next few decades. No page number is available in our copy. (LLM, conf=0.76)

      Experimental — accuracy not yet measured
  • Classified as probably not a substantial claim.

    Premisecitation

    Firth et al identified a small number of randomized controlled trials (RCTs) that examined the efficacy of app-based smartphone interventions on symptoms of anxiety (n=9) and depression (n=18) in both clinical and non-clinical samples.

    “Firth et al 7,8 identified a small number of randomized controlled trials (RCTs) that examined the efficacy of app-based smartphone interventions on symptoms of anxiety (n=9) and depression (n=18) in both clinical and non-clinical samples.”
    Quote in the paperSubstantial claim1 of 2 sources checked
    • cites [7] 7. Firth J, Torous J, Nicholas J et al. The efficacy of smartphone-based men- tal health interventions for depressive symptoms: a meta-analysis of ran- domized controlled trials. World Psychiatry 2017;16:287-98. source
    • cites [8] 8. Firth J, Torous J, Nicholas J et al. Can smartphone mental health interven- tions reduce symptoms of anxiety? A meta-analysis of randomized con- trolled trials. J Affect Disord 2017;218:15-22. source
  • May combine two claims.

    Premisecitation

    Smartphone interventions were found to be significantly more efficacious in reducing symptoms of anxiety and depression than both waitlist (g=0.45 and g=0.56) and active control (mainly attention/placebo-based) groups (g=0.19 and g=0.21).

    “Smartphone interventions were found to be significantly more efficacious in reducing symptoms of anxiety and depression than both waitlist (g=0.45 and g=0.56) and active control (mainly attention/placebo-based) groups (g=0.19 and g=0.21).”
    Quote in the paperSubstantial claim1 of 2 sources checked
    • cites [7] 7. Firth J, Torous J, Nicholas J et al. The efficacy of smartphone-based men- tal health interventions for depressive symptoms: a meta-analysis of ran- domized controlled trials. World Psychiatry 2017;16:287-98. source
    • cites [8] 8. Firth J, Torous J, Nicholas J et al. Can smartphone mental health interven- tions reduce symptoms of anxiety? A meta-analysis of randomized con- trolled trials. J Affect Disord 2017;218:15-22. source

      Section 3.3 reports significant reductions in anxiety symptoms versus waitlist controls (g=0.452) and active controls (g=0.189), matching the claim’s rounded anxiety figures. The paper’s meta-analysis concerns anxiety; our copy does not support the depression figures of g=0.56 and g=0.21. (LLM, conf=0.90)

      Experimental — accuracy not yet measured
  • Probably not a substantial claim: may not pass S4 (based).

    Findingnone given

    Since the publication of those two meta-analyses, which included data from RCTs published until May 2017, nearly 50 RCTs evaluating the efficacy of smartphone apps on various mental health outcomes have been conducted.

    “Since the publication of those two meta-analyses, which included data from RCTs published until May 2017, nearly 50 RCTs evaluating the efficacy of smartphone apps on various mental health outcomes have been conducted.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingown data

    Measures of well-being/quality of life were assessed in 36 studies (54.5%).

    “Measures of well-being/quality of life were assessed in 36 studies (54.5%).”
    Quote in the paperNot a substantial claim
  • The quote only partly states this claim.

    Findingown data

    Smartphone interventions significantly outperformed control conditions in improving general psychiatric distress (g=0.40, n=12).

    “Smartphone interventions were significantly more effective than control conditions in improving general psychological distress (g=0.40)”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Findingown data

    The pooled effect size for the 39 comparisons was g=0.30 (95% CI: 0.20-0.40), with high heterogeneity.

    “The pooled effect size for the 39 comparisons was g=0.30 (95% CI: 0.20-0.40),with high heterogeneity”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Findingown data

    The pooled effect size for the 27 comparisons was g=0.35 (95% CI: 0.21-0.48), with high heterogeneity.

    “The pooled effect size for the 27 comparisons was g=0.35 (95% CI: 0.21-0.48),with high heterogeneity”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Findingown data

    The pooled effect size for the 43 comparisons was g=0.35 (95% CI: 0.29-0.42), with low heterogeneity.

    “The pooled effect size for the 43 comparisons was g=0.35 (95% CI: 0.29-0.42),with low heterogeneity”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Findingown data

    The pooled effect size for the 12 comparisons between smartphone interventions and active comparisons was g=0.13 (95% CI: -0.07 to 0.34), with moderate heterogeneity.

    “The pooled effect size for the 12 comparisons between smartphone interventions and active comparisons was g=0.13 (95% CI: -0.07 to 0.34), with moderate heterogeneity.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Findingown data

    Depressive symptoms were assessed as an outcome in 47 trials (71.2%), and 11 trials (16 comparisons) delivered an app that was specifically designed to target depressive symptoms.

    “Depressive symptoms were assessed as an outcome in 47 trials (71.2%), and 11 trials (16 comparisons) delivered an app that was specifically designed to target depressive symptoms.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S4 (based).

    Findingnone given

    Most RCTs of smartphone apps have been published within the last couple of years.

    “Since most RCTs of smartphone apps have been published within the last couple of years, and interventions delivered through smartphone devices are attracting enormous public, scientific and media attention 9 , we expect that a significant number of additional RCTs will be conducted and published in the near future.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingown data

    Begg and Mazumdar test was non-significant (p=0.217).

    “Begg and Mazumdar test was non-significant (p=0.217).”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Findingown data

    Smartphone interventions did not differ significantly from active interventions (face-to-face, computerized treatment), although the number of studies was low (n≤13).

    “Smartphone interventions did not differ significantly from active interventions (face-to-face, computerized treatment), although the number of studies was low (n≤13).”
    Quote in the paperSubstantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingown data

    Stress levels were assessed in 22 trials (33.3%).

    “Stress levels were assessed in 22 trials (33.3%).”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingown data

    Fifty trials (75.7%) reported an adequate sequence generation.

    “Fifty trials (75.7%) reported an adequate sequence generation”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingown data

    Begg and Mazumdar test was non-significant (p=0.392).

    “Begg and Mazumdar test was non-significant (p=0.392).”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Findingown data

    Out of a total of 3,136 screened abstracts, 66 RCTs with 77 smartphone intervention conditions were included.

    “Out of a total of 3,136 screened abstracts, 66 RCTs with 77 smartphone intervention conditions were included.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Findingown data

    Generalized anxiety symptoms were assessed as an outcome in 29 studies (43.9%), and eight studies (12 comparisons) delivered an app that was specifically designed to target generalized anxiety symptoms.

    “Generalized anxiety symptoms were assessed as an outcome in 29 studies (43.9%), and eight studies (12 comparisons) delivered an app that was specifically designed to target generalized anxiety symptoms.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Findingown data

    Four trials (6.1%) reported blinding of outcome assessors and 62 (93.9%) used self-report questionnaires.

    “four (6.1%) reported blinding of outcome assessors and 62 (93.9%) used self-report questionnaires”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Findingown data

    A variety of smartphone apps were tested, most of which were based on cognitive and/or behavioral principles (n=35) and/or acceptance-or mindfulness-based principles (n=38).

    “A variety of smart-phone apps were tested, most of which were based on cognitive and/or behavioral principles (n=35) and/or acceptance-or mindfulness-based principles (n=38).”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Findingown data

    Seventeen trials (25.7%) met all four criteria, 16 (24.2%) met three criteria, 27 (40.9%) met two criteria, and six trials (9.1%) met one of the criteria.

    “Seventeen trials (25.7%) met all four criteria, 16 (24.2%)met three criteria, 27 (40.9%)met two criteria, and six trials (9.1%) met one of the criteria.”
    Quote in the paperNot a substantial claim
  • The quote only partly states this claim.

    Findingown data

    Smartphone interventions conferred no significant benefit over control conditions on panic symptoms (g=-0.05, n=3).

    “No significant group differences were observed for panic symptoms (g=-0.05)”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingown data

    The majority of RCTs were published in the last two years.

    “Importantly, the majority of RCTs were published in the last two years, highlighting that this area of research is gaining significant momentum and is growing exponentially.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingown data

    Begg and Mazumdar test was non-significant (p=0.622).

    “Begg and Mazumdar test was non-significant (p=0.622).”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Findingown data

    The pooled effect size was small but still statistically significant when attention/placebo control conditions were used (g=0.12), and larger when waitlist (g=0.32) or informational resources (g=0.39) were used as control conditions.

    “The pooled effect size was small but still statistically significant when attention/placebo control conditions were used (g=0.12),and larger when waitlist (g=0.32) or informational resources (g=0.39) were used as control conditions.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Findingown data

    Smartphone interventions significantly outperformed control conditions in improving a range of mental health outcomes, with small to moderate effect sizes.

    “They significantly outperformed (with small to moderate effect sizes) control conditions in improving a range of mental health outcomes”
    Quote in the paperSubstantial claim
  • Probably not a substantial claim: may not pass S2 (checkable), S3 (load-bearing).

    Premisecitation

    This change is predicted to alleviate many barriers that stand in the way of people seeking or receiving treatment under the current model of health care delivery (e.g., insufficient number of trained professionals, geographical constraints, lack of anonymity), thereby vastly increasing the availability of psychological therapies.

    “This change is predicted to alleviate many barriers that stand in the way of people seeking or receiving treatment under the current model of health care delivery (e.g., insufficient number of trained professionals, geographical constraints, lack of anonymity), thereby vastly increasing the availability of psychological therapies 3,4 .”
    Quote in the paperNot a substantial claim0 of 2 sources checked
    • cites [3] 3. Kazdin AE. Addressing the treatment gap: a key challenge for extending evidence-based psychosocial interventions. Behav Res Ther 2017;88:7-18. source
    • cites [4] 4. Kazdin AE. Expanding mental health services through novel models of intervention delivery. J Child Psychol Psychiatry 2019;60:455-72. source
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Study design and conductnone given

    A protocol for this review was registered via PROSPERO (CRD42019122136).

    “A protocol for this review was registered via PROSPERO (CRD42019122136).”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Study design and conductnone given

    There were three small deviations to the original protocol.

    “There were three small deviations to the original protocol.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Study design and conductnone given

    If data from both intention-to-treat and completer analyses were presented, the former were extracted and analyzed.

    “If data from both intention-to-treat and completer analyses were presented, the former were extracted and analyzed.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Premisecitation

    The authors found no evidence that various intervention features (e.g., in-app feedback, mood monitoring features, theoretical orientation) were significantly associated with effect sizes, although larger effects were observed when in-person feedback was not provided.

    “The authors found no evidence that various intervention features (e.g., in-app feedback, mood monitoring features, theoretical orientation) were significantly associated with effect sizes, although larger effects were observed when in-person feedback was not provided 7 .”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [7] 7. Firth J, Torous J, Nicholas J et al. The efficacy of smartphone-based men- tal health interventions for depressive symptoms: a meta-analysis of ran- domized controlled trials. World Psychiatry 2017;16:287-98. source
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Study design and conductnone given

    Two independent assessors (JL and MM) examined the full texts and selected eligible RCTs.

    “Two independent assessors (JL and MM) examined the full texts and selected eligible RCTs.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Study design and conductcitation

    Publication bias was examined through the trim-and-fill procedure, as well as Begg and Mazumdar rank correlation test.

    “Publication bias was examined through the trim-and-fill procedure 15 , as well as Begg and Mazumdar rank correlation test.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [15] 15. Duval S, Tweedie R. Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics 2000; 56:455-63. source
  • May combine two claims.

    Interpretationreasoning

    The present findings highlight the potential of apps to serve as a cost-effective, easily accessible, and low intensity intervention for those who cannot receive standard psychological treatment.

    “Although mental health apps are not intended to replace professional clinical services, the present findings highlight the potential of apps to serve as a cost-effective, easily accessible, and low intensity intervention for those who cannot receive standard psychological treatment.”
    Quote in the paperSubstantial claim
    • Rests on an assumption: A significant proportion of people with mental health problems do not receive empirically-supported psychological treatments.
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Premisecitation

    Smartphone interventions offer many advantages over other digital interventions (e.g., computer-based), including their ability to allow users to engage in exercises and monitor symptoms in situ, in real time, and immediately before and after pivotal events, as well as their capacity to be accessed in private and at a time and location of choice.

    “Smartphone interventions, in particular, offer many advantages over other digital interventions (e.g., computer-based), including their ability to allow users to engage in exercises and monitor symptoms in situ, in real time, and immediately before and after pivotal events, as well as their capacity to be accessed in private and at a time and location of choice 5 .”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [5] 5. Stolz T, Schulz A, Krieger T et al. A mobile app for social anxiety disorder: a three-arm randomized controlled trial comparing mobile and PC-based guided self-help interventions. J Consult Clin Psychol 2018;86:493-504. source
  • May combine two claims.

    Interpretationcitation

    Therapist guidance and engagement reminders bolster the effectiveness of smartphone interventions, consistent with prior meta-analyses of Internet-based and computerized psychological treatments.

    “That therapist guidance and engagement reminders bolster the effectiveness of smartphone interventions is consistent with what has been observed in a series of metaanalyses of Internet-based and computerized psychological treatments [61][62][63][64] .”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [61][62][63][64]

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Study design and conductown data

    JL conducted the quality assessments and MM coded a random 40% of studies, with good agreement observed between raters (kappa = 0.77, 0.69, 1.00 and 0.91, respectively).

    “JL conducted the quality assessments and MM coded a random 40% of studies, with good agreement observed between raters (kappa = 0.77, 0.69, 1.00 and 0.91, respectively).”
    Quote in the paperNot a substantial claim
  • Classified as probably not a substantial claim.

    Study design and conductreasoning

    Since we expected considerable heterogeneity among the studies, random effects models were employed.

    “Since we expected considerable heterogeneity among the studies, random effects models were employed.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Study design and conductown data

    Few studies contributed to the head-to-head comparisons, so these analyses may have been underpowered.

    “However, we note that few studies contributed to these head-to-head comparisons, so these analyses may have been underpowered.”
    Quote in the paperSubstantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Study design and conductreasoning

    Power may have also been an issue for the other outcomes in which smartphone interventions conferred no benefit over control conditions (panic, post-traumatic stress, and negative affect).

    “Power may have also been an issue for the other outcomes in which smartphone interventions conferred no benefit over control conditions (panic, post-traumatic stress, and negative affect).”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S2 (checkable). May combine two claims.

    Interpretationreasoning

    The present findings highlight the potential of apps to serve as a cost-effective, easily accessible, and low intensity intervention for the millions of people worldwide who cannot receive standard psychological treatment.

    “the present findings highlight the potential of apps to serve as a cost-effective, easily accessible, and low intensity intervention for the millions of people worldwide who cannot receive standard psychological treatment.”
    Quote in the paperNot a substantial claim
    • Rests on an assumption: There are millions of people worldwide who need mental health treatment but cannot access standard psychological treatment.
  • May combine two claims.

    Study design and conductreasoning

    The meta-analysis did not analyze the long-term effects of smartphone interventions, due to large differences in follow-up times and inconsistent handling of drop-outs across studies.

    “Second, we did not analyze the long-term effects of smartphone interventions, due to large differences in follow-up times and since drop-outs were dealt with inconsistently across studies.”
    Quote in the paperSubstantial claim
43 of 43
  • The paper relies on this without support.

    A significant proportion of people with mental health problems do not receive empirically-supported psychological treatments.

    “the reality remains that a significant proportion of people with mental health problems do not receive these treatments.”
  • The paper relies on this without support.

    There are millions of people worldwide who need mental health treatment but cannot access standard psychological treatment.

    “the millions of people worldwide who cannot receive standard psychological treatment.”
    “the millions of people around the world in need of (and who cannot gain access to) treatment.”
2 of 2

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Mindfulness-based interventions have gained research interest, showing enhanced well-being in various settings, particularly for coping with chronic conditions such as chronic pain.

    “mindfulness-based interventions have gained research interest, showing enhanced well-being in various settings [32-34], particularly for coping with chronic conditions, such as chronic pain [35-37].”

    From Development and Evaluation of a Smartphone-Based Chatbot Coach to Facilitate a Balanced Lifestyle in Individuals With Headaches (BalanceUP App): Randomized Controlled Trial (2024) · cites this paper as [33]

    The Discussion reports growing research on app-supported smartphone interventions, and the subgroup table shows improved well-being or quality of life for interventions containing mindfulness components. The paper does not establish that mindfulness-based interventions help people cope with chronic pain; its findings concern smartphone interventions for mental health problems. (LLM, conf=0.82)

    Experimental — accuracy not yet measured
  • Technologically enhanced interventions generally result in equivalent outcomes to in-person treatment across disorders.

    “technologically enhanced interventions generally result in equivalent outcomes to in-person treatment across disorders”

    From Treatment histories, barriers, and preferences for individuals with symptoms of generalized anxiety disorder (2024) · cites this paper as Linardon et al., 2019

    The Abstract and Discussion report that app-supported smartphone interventions did not differ significantly from active interventions, which included face-to-face and computerized treatment. The Discussion calls these findings preliminary because few studies made head-to-head comparisons and the analyses may have been underpowered. The paper therefore does not establish equivalent outcomes specifically versus in-person treatment, or for technologically enhanced interventions generally across disorders. (LLM, conf=0.88)

    Experimental — accuracy not yet measured
  • DMHIs are efficacious, with effect sizes comparable to face-to-face therapy in clinical trials.

    “DMHIs are also efficacious, with effect sizes comparable to face-to-face therapy in clinical trials (Linardon et al., 2019).”

    From A text messaging intervention to support the mental health of young adults: User engagement and feedback from a field trial of an intervention prototype (2023) · cites this paper as Linardon et al., 2019

    The Abstract reports that app-supported smartphone interventions were efficacious and did not differ significantly from active interventions, including face-to-face therapy. But the comparison pooled different active treatments and involved few studies (n≤13); it does not establish that effect sizes were specifically comparable to face-to-face therapy. (LLM, conf=0.85)

    Experimental — accuracy not yet measured
  • There is convincing evidence for the effectiveness of digital interventions when delivered in health and community settings.

    “There is now convincing evidence for the effectiveness of digital interventions when delivered in health and community settings [10]”

    From Feasibility and Preliminary Efficacy of Web-Based and Mobile Interventions for Common Mental Health Problems in Working Adults: Multi-Arm Randomized Pilot Trial (2022) · cites this paper as [10]

    The Discussion reports that app-supported smartphone interventions improved several mental-health outcomes across clinical and non-clinical populations, including general-population samples. It does not establish effectiveness for digital interventions broadly or specifically assess delivery in both health and community settings. (LLM, conf=0.86)

    Experimental — accuracy not yet measured
  • EMA/EMI have shown good results in other psychological disorders, such as substance use, anxiety, and major depressive disorders.

    “EMA/EMI have shown good results in other psychological disorders, such as substance use disorders (e.g., smoking cessation), anxiety disorders (e.g., social anxiety disorder, generalized anxiety disorder), and major depressive disorders (LaFreniere and Newman, 2016; Colombo et al., 2019; Linardon et al., 2019; Miralles et al., 2020).”

    From Efficacy of an internet-based psychological intervention for problem gambling and gambling disorder: Study protocol for a randomized controlled trial (2021) · cites this paper as Linardon et al., 2019

    The Discussion reports that app-supported smartphone interventions improved depressive symptoms and generalized and social anxiety symptoms compared with controls. It does not establish efficacy for EMA/EMI specifically or report a result for substance use disorders or smoking cessation. Its findings concern symptoms across clinical and non-clinical populations, not necessarily diagnosed major depressive disorder. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

  • Stress-effect confidence interval excludes its own estimate

    Minor

    The reported low-risk-of-bias stress effect is 0.78, but its stated 95% confidence interval runs from 0.63 to 0.04. The estimate cannot lie outside its own confidence interval; the midpoint of the printed bounds is 0.335.

    Reported 0.78 · recomputed 0.335

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Authors
Linardon, J., Cuijpers, P., Carlbring, P., Messer, M., & Fuller‐Tyszkiewicz, M.
Affiliations
  • Deakin University (AU)
  • Amsterdam Public Health (NL)
  • Stockholm University (SE)
Venue
World Psychiatry
Publisher
Wiley
Published
2019-09-09
Volume
18
Issue
3
Pages
325-336
ISSN
  • 1723-8617 (ISSN-L)
  • 2051-5545
OpenAlex
W2972598474
Cited by
886
References
81
Citations by year
2026: 127 · 2025: 135 · 2024: 110 · 2023: 123 · 2022: 114 · 2021: 115 · 2020: 75 · 2019: 4 · 2018: 1
FWCI
53.36
Type
journal article
Language
en
Open access
Locations
  • World Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • VU Research Portal (submittedVersion, other-oa)
  • PubMed Central (submittedVersion)
  • Own your potential (DEAKIN) (submittedVersion)
  • Figshare (submittedVersion, cc-by)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Topics
  • Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
  • Social Sciences › Sociology and Political Science › Impact of Technology on Adolescents
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
Keywords
smartphone-based intervention, mental health apps, digital mental health, depression, generalized anxiety disorder, stress, quality of life, social anxiety

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Claims read by deepseek-v4.1-flash under definition version 3 (extract-v3) on 2026-10-11.

Classified by jev-1.13-20260917 (gold-guideline-v0.2) on 2026-10-11.

Cited sources are checked by gpt-6-sol.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

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