Impact of guidance on intervention adherence in computerised interventions for mental health problems: a meta-analysis

Musiat, Peter; Johnson, Catherine; Atkinson, Melissa; Wilksch, Simon; Wade, Tracey

doi:10.1017/s0033291721004621

Cited by 166Digital Mental Health InterventionsAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesMental Health Treatment and Access

Impact of guidance on intervention adherence in computerised interventions for mental health problems: a meta-analysis

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Musiat, Peter, Johnson, Catherine, Atkinson, Melissa, Wilksch, Simon, Wade, Tracey·2022·Psychological Medicine

DOI 10.1017/s0033291721004621

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Abstract

Web-based interventions are increasingly used for the prevention, treatment and aftercare of mental disorders. A crucial factor to the efficacy of such online programmes is adherence to the intervention content and procedure. It has been frequently suggested that adherence in web-based interventions is low and little is known about which factors influence adherence. To increase intervention uptake and completion, studies increasingly include interventions with some form of guidance. Guided interventions have been shown to have higher efficacy, however, evidence for the impact on adherence is limited and mixed. This meta-analysis explored the impact of human guidance on intervention completion in web-based mental health interventions. A total of 22 studies were included with interventions primarily targeting symptoms of depression and anxiety disorders. Results showed that guidance significantly increases the average amount of intervention completion [ g = 0.29, 95% confidence interval (CI) 0.18–0.40] and the proportion of intervention completers [ log odds ratio (OR) = 0.50, 95% CI 0.34–0.66] with small effects. On average, full completion rates were 12% higher in guided intervention groups. This meta-analysis demonstrated that guidance in web-based mental health interventions does increase adherence, but more research is required to better understand the specific mechanisms between guidance, adherence and outcomes.

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Additional support in other studies (3/22, 14%) was provided to a group of participants; however, this type of support has been excluded from definitions of guidance.
“Additional support in other studies (3/22, 14%) was provided to a group of participants; however, this type of support has been excluded from definitions of guidance [74].”
From Experiences of Using Digital Mindfulness-Based Interventions: Rapid Scoping Review and Thematic Synthesis (2023) · cites this paper as [74]

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Comparative efficacy of onsite, digital, and other settings for cognitive behavioral therapy for insomnia: a systematic review and network meta-analysis
Simon, L., Steinmetz, L., Feige, B., Benz, F., Spiegelhalder, K., & Baumeister, H. (2023) · Scientific Reports · doi:10.1038/s41598-023-28853-0 · Cited by 135 · see citing works
MindfulDiary: Harnessing Large Language Model to Support Psychiatric Patients' Journaling
Kim, T., Bae, S., Kim, H. A., Lee, S. H., Hong, H., Yang, C.-M., & Kim, Y. (2024) · CHI Conference on Human Factors in Computing Systems · doi:10.1145/3613904.3642937 · Cited by 123 · see citing works
Considering the role of human empathy in AI-driven therapy
Rubin, M., Arnon, H., Huppert, J. D., & Perry, A. (2024) · JMIR Mental Health · doi:10.2196/56529 · Cited by 111 · see citing works
A systematic review and meta-analysis of self-guided online acceptance and commitment therapy as a transdiagnostic self-help intervention
Klimczak, K. S., San Miguel, G. G., Mukasa, M. N., Twohig, M. P., & Levin, M. E. (2023) · Cognitive Behaviour Therapy · doi:10.1080/16506073.2023.2178498 · Cited by 88 · see citing works
“Additionally, findings are mixed regarding the impact of these human-supports on adherence and treatment efficacy (Musiat et al., 2021; Shim et al., 2017).”
Background
Digital Mental Health Interventions for University Students With Mental Health Difficulties: A Systematic Review and Meta‐Analysis
Madrid‐Cagigal, A., Kealy, C., Potts, C., Mulvenna, M. D., Byrne, M., Barry, M. M., & Donohoe, G. (2025) · Early Intervention in Psychiatry · doi:10.1111/eip.70017 · Cited by 78 · see citing works
Psychological and interpersonal dimensions of sexual function and dysfunction: recommendations from the fifth international consultation on sexual medicine (ICSM 2024)
Brotto, L. A., Atallah, S., Carvalho, J., Gordon, E., Pascoal, P. M., Reda, M., Stephenson, K. R., & Tavares, I. M. (2024) · Sexual Medicine Reviews · doi:10.1093/sxmrev/qeae073 · Cited by 52 · see citing works
Digital cognitive–behavioural therapy to reduce suicidal ideation and behaviours: a systematic review and meta-analysis of individual participant data
Büscher, R., Beisemann, M., Doebler, P., Micklitz, H. M., Kerkhof, A. J. F. M., Cuijpers, P. J., Batterham, P. J., Calear, A. L., Christensen, H. M., Jaegere, E. D., et al. (2022) · Evidence-Based Mental Health · doi:10.1136/ebmental-2022-300540 · Cited by 49 · see citing works
Internet- and mobile-based psychological interventions for sexual dysfunctions: a systematic review and meta-analysis
Zarski, A., Velten, J., Knauer, J., Berking, M., & Ebert, D. D. (2022) · npj Digital Medicine · doi:10.1038/s41746-022-00670-1 · Cited by 47 · see citing works
The Advances of Immersive Virtual Reality Interventions for the Enhancement of Stress Management and Relaxation among Healthy Adults: A Systematic Review
Velana, M., Sobieraj, S., Digutsch, J., & Rinkenauer, G. (2022) · Applied Sciences · doi:10.3390/app12147309 · Cited by 42 · see citing works
Improving programme‐led and focused interventions for eating disorders: An experts' consensus statement—A UK perspective
Davey, E., Allen, K. L., Bennett, S. D., Bryant‐Waugh, R., Clarke, T., Cooper, Z., Dixon‐Ward, K., Dudley, J., Eisler, I., Griffiths, J., et al. (2023) · European Eating Disorders Review · doi:10.1002/erv.2981 · Cited by 39 · see citing works
Self-citation
Human contact in internet-based interventions for depression: A pre-registered replication and meta-analysis of randomized trials
Krieger, T., Bur, O. T., Weber, L., Wolf, M., Berger, T., Watzke, B., & Münder, T. (2023) · Internet Interventions · doi:10.1016/j.invent.2023.100617 · Cited by 38 · see citing works
Experiences of Using Digital Mindfulness-Based Interventions: Rapid Scoping Review and Thematic Synthesis
Osborne, E. L., Ainsworth, B., Hooper, N., & Atkinson, M. J. (2023) · Journal of Medical Internet Research · doi:10.2196/44220 · Cited by 37 · see citing works
“%) was provided to a group of participants; however, this type of support has been excluded from definitions of guidance [74].”
Self-citation
Guided versus non‐guided digital psychological interventions for cancer patients: A systematic review and meta‐analysis of engagement and efficacy
Akdemir, A., Smith, A. B., Wu, V. S., Rincones, O., Russell, H., Lyhne, J. D., Kemp, E., David, M., & Bamgboje‐Ayodele, A. (2024) · Psycho-Oncology · doi:10.1002/pon.6290 · Cited by 33 · see citing works
A Group-Facilitated, Internet-Based Intervention to Promote Mental Health and Well-Being in a Vulnerable Population of University Students: Randomized Controlled Trial of the Be Well Plan Program
Fassnacht, D. B., Ali, K., van Agteren, J. E., Iasiello, M. P., Mavrangelos, T., Furber, G., & Kyrios, M. (2022) · JMIR Mental Health · doi:10.2196/37292 · Cited by 31 · see citing works
Internet-delivered cognitive behavior therapy versus treatment as usual for anxiety and depression among Latin American university students: A randomized clinical trial.
Benjet, C. L., Albor, Y., Alvis–Barranco, L., Contreras‐Ibáñez, C. C., Montoya, G. P. C., Cudris–Torres, L., González, N., Morelos, J. C., Gutiérrez–García, R. A., Medina‐Mora, M. E., et al. (2023) · Journal of Consulting and Clinical Psychology · doi:10.1037/ccp0000846 · Cited by 30 · see citing works
Effects of a Chatbot-Based Intervention on Stress and Health-Related Parameters in a Stressed Sample: Randomized Controlled Trial
Schillings, C., Meißner, E., Erb, B., Bendig, E., Schultchen, D., & Pollatos, O. (2024) · JMIR Mental Health · doi:10.2196/50454 · Cited by 44 · see citing works
A randomised controlled trial of clinician supported vs self-help delivery of online cognitive behaviour therapy for Bulimia Nervosa
Barakat, S., Burton, A. L., Cunich, M. M., Hay, P., Hazelton, J. L., Kim, M., Lymer, S. J., Madden, S., Maloney, D., Miskovic‐Wheatley, J., et al. (2023) · Psychiatry Research · doi:10.1016/j.psychres.2023.115534 · Cited by 29 · see citing works
Predictors of dropout in a digital intervention for the prevention and treatment of depression in patients with chronic Back pain: secondary analysis of two randomized controlled trials
Moshe, I., Terhorst, Y., Paganini, S., Schlicker, S., Pulkki-Råback, L., Baumeister, H., Sander, L. B., & Ebert, D. D. (2022) · Journal of Medical Internet Research · doi:10.2196/38261 · Cited by 28 · see citing works
“The same meta-analysis also identified that completing the full intervention was the strongest predictor of outcomes, underscoring the importance of treatment adherence [26].”
The effectiveness of lived experience involvement in eating disorder treatment: A systematic review
Pellizzer, M. L., & Wade, T. D. (2022) · International Journal of Eating Disorders · doi:10.1002/eat.23847 · Cited by 28 · see citing works
Self-citation
Efficacy of an Electronic Cognitive Behavioral Therapy Program Delivered via the Online Psychotherapy Tool for Depression and Anxiety Related to the COVID-19 Pandemic: Pre-Post Pilot Study
Moghimi, E., Stephenson, C., Agarwal, A., Nikjoo, N., Malakouti, N., Layzell, G., O'Riordan, A., Jagayat, J., Shirazi, A., Gutierrez, G., et al. (2023) · JMIR Mental Health · doi:10.2196/51102 · Cited by 28 · see citing works
A pilot study of the perceptions and acceptability of guidance using artificial intelligence in internet cognitive behaviour therapy for perfectionism in young people
Egan, S. J., Johnson, C., Wade, T. D., Carlbring, P., Raghav, S., & Shafran, R. (2024) · Internet Interventions · doi:10.1016/j.invent.2024.100711 · Cited by 28 · see citing works
Self-citation
Using peer-support coaching to improve adherence to online ACT self-help for college mental health: A randomized controlled trial
Klimczak, K. S., Twohig, M. P., Peacock, G. G., & Levin, M. E. (2022) · Behaviour Research and Therapy · doi:10.1016/j.brat.2022.104228 · Cited by 28 · see citing works
Attitudes toward innovative mental health treatment approaches in Germany: E-mental health and home treatment
Lincke, L., Ulbrich, L., Reis, O., Wandinger, E., Brähler, E., Dück, A., & Kölch, M. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.889555 · Cited by 24 · see citing works
Efficacy of an Internet-based self-help intervention with human guidance or automated messages to alleviate loneliness: a three-armed randomized controlled trial
Seewer, N., Skoko, A., Käll, A., Andersson, G., Luhmann, M., Berger, T., & Krieger, T. (2024) · Scientific Reports · doi:10.1038/s41598-024-57254-0 · Cited by 26 · see citing works
Feasibility, adherence, and effectiveness of blended psychotherapy for severe mental illnesses: scoping review
Ehrt-Schäfer, Y., Rusmir, M., Vetter, J., Seifritz, E., Müller, M., & Kleim, B. (2023) · JMIR Mental Health · doi:10.2196/43882 · Cited by 24 · see citing works
“For instance, Musiat et al [64] reported average completion rates of 64% for guided TBIs and 52% for unguided TBIs.”
Background
Digital Mental Health Interventions for Alleviating Depression and Anxiety During Psychotherapy Waiting Lists: Systematic Review
Huang, S., Wang, Y., Li, G., Hall, B. J., & Nyman, T. J. (2024) · JMIR Mental Health · doi:10.2196/56650 · Cited by 25 · see citing works
Internet-based emotion-regulation training added to CBT in adolescents with depressive and anxiety disorders: A pilot randomized controlled trial to examine feasibility, acceptability, and preliminary effectiveness
Wisman, M. A., Emmelkamp, J., Dekker, J., & Christ, C. (2022) · Internet Interventions · doi:10.1016/j.invent.2022.100596 · Cited by 26 · see citing works
What factors are related to engagement with digital mental health interventions (DMHIs)? A meta-analysis of 117 trials
Zainal, N. H., Wang, V. Y., Garthwaite, B., & Curtiss, J. E. (2025) · Health Psychology Review · doi:10.1080/17437199.2025.2547610 · Cited by 21 · see citing works
StudiCare procrastination - Randomized controlled non-inferiority trial of a persuasive design-optimized internet- and mobile-based intervention with digital coach targeting procrastination in college students
Mutter, A., Küchler, A., Idrees, A. R., Kählke, F., Terhorst, Y., & Baumeister, H. (2023) · BMC Psychology · doi:10.1186/s40359-023-01312-1 · Cited by 22 · see citing works
Effects of a self-guided digital mental health self-help intervention for Syrian refugees in Egypt: A pragmatic randomized controlled trial
Burchert, S., Alkneme, M. S., Alsaod, A., Cuijpers, P., Heim, E., Hessling, J., Hosny, N., Sijbrandij, M., van’t Hof, E., Ventevogel, P., et al. (2024) · PLoS Medicine · doi:10.1371/journal.pmed.1004460 · Cited by 18 · see citing works
Evaluating the Feasibility of a Guided Culturally Adapted Internet-Delivered Mindfulness Intervention for Indonesian University Students Experiencing Psychological Distress
Listiyandini, R. A., Andriani, A., Afsari, N., Krisnamurthi, P. B. U., Moulds, M. L., Mahoney, A., & Newby, J. M. (2024) · Mindfulness · doi:10.1007/s12671-024-02346-1 · Cited by 18 · see citing works
A chatbot-based intervention with ELME to improve stress and health-related parameters in a stressed sample: Study protocol of a randomised controlled trial
Schillings, C., Meißner, E., Erb, B., Schultchen, D., Bendig, E., & Pollatos, O. (2023) · Frontiers in Digital Health · doi:10.3389/fdgth.2023.1046202 · Cited by 17 · see citing works
A randomized controlled feasibility trial of metacognitive training with adolescents receiving treatment for anorexia nervosa
Balzan, R. P., Gilder, M., Thompson, M., & Wade, T. D. (2023) · International Journal of Eating Disorders · doi:10.1002/eat.24009 · Cited by 15 · see citing works
Self-citation
Feasibility and efficacy of a digital resilience training: A pilot study of the strengths-based training RESIST
Behrendt, D., Boß, L., Hannibal, S., Kunzler, A., Wessa, M., & Lehr, D. (2023) · Internet Interventions · doi:10.1016/j.invent.2023.100649 · Cited by 15 · see citing works
The development of a smartphone app to enhance post-traumatic stress disorder treatment in high-risk workers
Deady, M., Collins, D., Gayed, A., Harvey, S. B., & Bryant, R. A. (2023) · Digital Health · doi:10.1177/20552076231155680 · Cited by 14 · see citing works
Reframe-IT+, an indicated preventive school-based intervention, reduces suicidal ideation among adolescents in vulnerable contexts in Chile
Núñez, D. E., Meza, D., Andaur, J., Robinson, J., & Gaete, J. (2024) · BMC Psychology · doi:10.1186/s40359-024-02300-9 · Cited by 13 · see citing works
Efficacy of an Internet- and Mobile-Based Intervention for Subclinical Anxiety and Depression (ICare Prevent) with Two Guidance Formats: Results from a Three-Armed Randomized Controlled Trial
Zarski, A.-C., Weisel, K. K., Berger, T., Krieger, T., Schaub, M. P., Berking, M., Görlich, D., Jacobi, C., & Ebert, D. D. (2024) · Psychotherapy and Psychosomatics · doi:10.1159/000536149 · Cited by 13 · see citing works
A randomized controlled trial of online mindfulness and cognitive-behavioral interventions for sexual interest/arousal disorder in women: eSense
Mahar, E. A., Stephenson, K. R., & Brotto, L. A. (2025) · Behaviour Research and Therapy · doi:10.1016/j.brat.2025.104732 · Cited by 12 · see citing works
Internet-delivered therapist-assisted cognitive behavioral therapy for gambling disorder: a randomized controlled trial
Mide, M., Mattiasson, J., Norlin, D., Sehlin, H., Rasmusson, J., Ljung, S., Lindskog, A., Petersson, J., Saavedra, F., & Gordh, A. S. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1243826 · Cited by 12 · see citing works
Technology-based cognitive behavioral therapy interventions
Newby, J. M., Upton, E., Mason, E., & Black, M. (2024) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2024.02.004 · Cited by 11 · see citing works
Feasibility and acceptability of an online mental health intervention for pregnant women and their partners: a mixed method study with a pilot randomized control trial
Canfield, S. M., Canada, K. E., Rolbiecki, A. J., & Petroski, G. F. (2023) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-023-06031-4 · Cited by 11 · see citing works
Digitale Navigatoren zur Akzeptanz- und Kompetenzentwicklung mit Mental Health Apps
Schwarz, J., Heinze, M., Scheunemann, K., Schönbeck, J., Schubert, D., Speck, J., Torous, J. B., Uchtmann, L., Wolff, J., & Meier-Diedrich, E. (2024) · Nervenheilkunde · doi:10.1055/a-2409-4731 · Cited by 10 · see citing works
A systematic review on personalization of treatment components in IBIs for mental disorders
Schaeuffele, C., Zagorscak, P., Langerwisch, V., Wilke, J., Medvedeva, Y., & Knaevelsrud, C. (2025) · Internet Interventions · doi:10.1016/j.invent.2025.100840 · Cited by 11 · see citing works
Piloting Digital Navigators to Promote Acceptance and Engagement With Digital Mental Health Apps in German Outpatient Care: Protocol for a Multicenter, Single-Group, Observational, Mixed Methods Interventional Study (DigiNavi)
Schwarz, J., Chen, K., Dashti, H., Heinze, M., Schönbeck, J., Schubert, D., Senst, B., Speck, J., Torous, J. B., Wolff, J., et al. (2025) · JMIR Research Protocols · doi:10.2196/67655 · Cited by 10 · see citing works
Guided Internet-Delivered Treatment for Depression: Scoping Review
Børtveit, L., Dechsling, A., Sütterlin, S., Nordgreen, T., & Nordahl‐Hansen, A. (2022) · JMIR Mental Health · doi:10.2196/37342 · Cited by 11 · see citing works
Informing nursing policy: An exploration of digital health research by nurses in England
O’Connor, S., Cave, L., & Philips, N. (2024) · International Journal of Medical Informatics · doi:10.1016/j.ijmedinf.2024.105381 · Cited by 10 · see citing works
A Transdiagnostic Video-Based Internet Intervention (Uni Virtual Clinic-Lite) to Improve the Mental Health of University Students: Randomized Controlled Trial
Farrer, L. M., Jackson, H. M., Gulliver, A., Calear, A. L., Leach, L., Hasking, P. A., Katruss, N., & Batterham, P. J. (2024) · Journal of Medical Internet Research · doi:10.2196/53598 · Cited by 9 · see citing works
Artificial intelligence as a virtual coach in a cognitive behavioural intervention for perfectionism in young people: A randomised feasibility trial
Johnson, C., Egan, S. J., Carlbring, P., Shafran, R., & Wade, T. D. (2024) · Internet Interventions · doi:10.1016/j.invent.2024.100795 · Cited by 9 · see citing works
Self-citation
Statistical methods to adjust for the effects on intervention compliance in randomized clinical trials where precision treatment rules are being developed
Zainal, N. H., Benjet, C. L., Albor, Y., Núñez-Delgado, M. J., Cruz, R. Z., Contreras‐Ibáñez, C. C., Cudris–Torres, L., de la Peña, F. R., González, N., Guerrero-López, B., et al. (2025) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.70005 · Cited by 9 · see citing works
The Effectiveness of Lived Experience Involvement in Eating Disorder Treatment: A Systematic Review
Pellizzer, M. L., & Wade, T. D. (2024) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.24022015 · Cited by 8 · see citing works
Self-citation
Hybrid mHealth care: Patient perspectives of blended treatments for psychosis. A systematic review
Greenway, F. T., Weal, M. J., & Palmer-Cooper, E. C. (2024) · Schizophrenia Research · doi:10.1016/j.schres.2024.08.017 · Cited by 7 · see citing works
Barriers and Facilitators of Sleep Restriction Therapy in Internet‐Delivered CBT ‐I: A Qualitative Content Analysis and the Development of a Treatment Path Model
Simon, L., Steinmetz, L., Berghoff, N. M., Rehm, C., Neumann, L., Küchler, A., Riemann, D. W., Ebert, D. D., Spiegelhalder, K., & Baumeister, H. (2025) · Journal of Sleep Research · doi:10.1111/jsr.70018 · Cited by 7 · see citing works
Self-Help to Reduce Body-Focused Repetitive Behaviors via Video or Website? A Randomized Controlled Trial
Schmotz, S., Dilekoglu, E., Hoyer, L. N., Baumeister, A., & Moritz, S. (2024) · Cognitive Therapy and Research · doi:10.1007/s10608-023-10456-8 · Cited by 7 · see citing works
Working alliance and its link to guidance in an internet-based intervention for depressive disorders: a secondary analysis of a randomized controlled trial
Haaf, R., Schefft, C., Krämer, R., Klein, J. P., & Köhler, S. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1448823 · Cited by 6 · see citing works
Acceptability and Feasibility of a Blended School-Based Intervention to Prevent Suicidal Ideation Among Adolescents in Chile: Results from a Randomized Control Pilot Study
Gaete, J., Meza, D., Andaur, J., McKay, S., Robinson, J., & Núñez, D. E. (2025) · Prevention Science · doi:10.1007/s11121-025-01770-6 · Cited by 8 · see citing works
Knowledge, attitudes, and practices survey on postoperative pain management in gastrointestinal surgery patients: A cross-sectional study
Liu, M., Cao, W., Xu, G., He, Y., Du, Z., & Yuan, T. (2025) · Geriatric Nursing · doi:10.1016/j.gerinurse.2025.03.022 · Cited by 6 · see citing works
Web-Based Mind-Body Tactical Resilience Training Program for First Responders: Pre-Post Study Assessing Feasibility, Acceptability, and Usability
Tan, L., Deady, M., Mead, O., Foright, R. M., Brenneman, E. M., Yeager, J. R., Bryant, R. A., & Harvey, S. B. (2022) · JMIR Formative Research · doi:10.2196/40145 · Cited by 7 · see citing works
Positive aging: feasibility and acceptability of an eHealth ACT module for middle-aged and older adults
Verdoodt, K., Batink, T., Simons, M., Janssens, M., Peeters, S., Lataster, J., Jacobs, N., & Reijnders, J. (2023) · Educational Gerontology · doi:10.1080/03601277.2022.2160571 · Cited by 5 · see citing works
Limited effects of phone coaching in an RCT of online self-guided acceptance and commitment therapy for chronic pain
Rabinowitz, E. P., Ripley, G., Levin, M. E., Allen, P. A., & Delahanty, D. L. (2024) · Journal of Contextual Behavioral Science · doi:10.1016/j.jcbs.2024.100828 · Cited by 5 · see citing works
Predicting adherence and clinical response of cognitive behavioral therapy among individuals with chronic low back pain plus depressive symptoms: a secondary analysis of a randomized controlled trial
Sanabria‐Mazo, J. P., Royuela-Colomer, E., Navarrete, J., Rodríguez‐Freire, C., Robles, B., McCracken, L. M., Feliu‐Soler, A., & Luciano, J. V. (2025) · Pain Medicine · doi:10.1093/pm/pnaf020 · Cited by 5 · see citing works
Mediators and Predictors of Treatment Response in a Brief Online Intervention for Rumination and Worry
Upton, E., Venkatesha, V., Joubert, A., Mahoney, A. E. J., Moulds, M. L., Werner-Seidler, A., & Newby, J. M. (2025) · Cognitive Therapy and Research · doi:10.1007/s10608-025-10593-2 · Cited by 5 · see citing works
A randomized controlled trial comparing mindfulness to escitalopram for anxiety: In-person and remote, synchronous delivery pre and post COVID-19 pandemic
Hoge, E. A., Mete, M., Baker, A. W., Szuhany, K. L., Armstrong, C. H., Steinberg, M. H., Dutton, M. A., Bui, É., & Simon, N. M. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.04.145 · Cited by 5 · see citing works
Patient-centered development ofEmbrace Pain: an online acceptance and commitment therapy intervention for cancer survivors with chronic painful chemotherapy-induced peripheral neuropathy
van de Graaf, D. L., Smeets, T., van der Lee, M. L., Trompetter, H. R., Baars-Seebregts, A., Børøsund, E., Nes, L. S., Schreurs, K. M. G., & Mols, F. (2023) · Acta Oncologica · doi:10.1080/0284186x.2023.2187260 · Cited by 5 · see citing works
Examining the potential of an internet-based emotion regulation intervention added to acute psychiatric inpatient care: results from a randomized controlled pilot trial
Wälchli, G., Berger, T., Nissen, C., Moggi, F., & Bielinski, L. L. (2024) · Psychiatry Research · doi:10.1016/j.psychres.2024.116326 · Cited by 5 · see citing works
Breaking the cycle: a pilot study on autonomous Digital CBTe for recurrent binge eating
Murphy, R., Khera, C. K., & Osborne, E. L. (2025) · Frontiers in Digital Health · doi:10.3389/fdgth.2024.1499350 · Cited by 5 · see citing works
Mediating Role of Treatment Perceptions in the Relationship Between Individual Characteristics and Engagement With a Digital Psychological Intervention for Pediatric Chronic Pain: Secondary Data Analysis
de la Vega, R., & Palermo, T. M. (2023) · JMIR Pediatrics and Parenting · doi:10.2196/42399 · Cited by 5 · see citing works
Remote blended treatment for individuals with suicidal ideation: A single‐arm proof‐of‐concept trial
Büscher, R., Teismann, T., Hartleitner, P., Klein, J. P., Baumeister, H., & Sander, L. (2023) · Clinical Psychology & Psychotherapy · doi:10.1002/cpp.2905 · Cited by 5 · see citing works
Acceptability and effectiveness study of therapist-assisted internet-delivered cognitive behaviour therapy for agriculture producers
Beck, C. D., Peynenburg, V. A., Patterson, T., Titov, N., Dear, B. F., & Hadjistavropoulos, H. D. (2024) · Internet Interventions · doi:10.1016/j.invent.2024.100709 · Cited by 5 · see citing works
Tailoring Guidance in Internet-Based Interventions With Motive-Oriented Therapeutic Relationship
Debrot, A., Berthoud, L., Caspar, F., Berger, T., & Pomini, V. (2022) · Frontiers in Digital Health · doi:10.3389/fdgth.2022.842487 · Cited by 5 · see citing works
The Effect of Predicted Compliance With a Web-Based Intervention for Anxiety and Depression Among Latin American University Students: Randomized Controlled Trial
Benjet, C. L., Zainal, N. H., Albor, Y., Alvis–Barranco, L., Tapias, N. E. C., Contreras‐Ibáñez, C. C., Morelos, J. C., Cudris–Torres, L., de la Peña, F. R., González, N., et al. (2025) · JMIR Mental Health · doi:10.2196/64251 · Cited by 4 · see citing works
Assessing the effectiveness of emotion-focused online intervention in mitigating compassion fatigue and enhancing compassion satisfaction among helping professionals.
Halamová, J., Kanovský, M., Greškovičová, K., Krizova, K., & Šoková, B. (2025) · Applied Psychology: Health and Well-Being · doi:10.1111/aphw.70032 · Cited by 8 · see citing works
Effects of an Online Meditation Program on Sleep Quality, Depression, Anxiety, and Perceived Stress in Liver Transplant Recipients: A Randomized Controlled Trial
Pacheco, A., Figueiredo, T. R., ARTIFON, J. P. M., Ribeiro, J. L. D. C., Santos, L. C., Soares, L. A., Valentim, M. E. Z., Gambaroto, R. L., Silva, M. E. D. S. E., & Magno, L. A. V. (2025) · Mindfulness · doi:10.1007/s12671-025-02639-z · Cited by 4 · see citing works
How digital therapeutic alliances influence the perceived helpfulness of online mental health Q&A: An explainable machine learning approach
Huang, Y., Liu, H., Chi, M., Meng, S., & Wang, W. (2025) · Digital Health · doi:10.1177/20552076251333480 · Cited by 7 · see citing works
A Digital Psychosocial Service (Sui App) for Arabic-Speaking Refugees in Switzerland: Development and Cultural-Contextual Adaptation Using a User-Centered and Participatory Approach
Stoeckli, R. T., Berger, T., Aebersold, M., Zoellner, V., Haji, F., Hunziker, M., Ferreira, B. J., Hosmann, M., Burchert, S., Wabiszczewicz, J., et al. (2025) · JMIR Formative Research · doi:10.2196/59905 · Cited by 5 · see citing works
Überblick über Digitale Gesundheitsanwendungen mit Fokus Depression
Haaf, R., Machleid, F., & Köhler, S. (2023) · Nervenheilkunde · doi:10.1055/a-2103-4557 · Cited by 4 · see citing works
Experiences with a guided trauma-focused internet- and mobile-based intervention: a qualitative study of youth’s perspectives
Schulte, C. E., Sachser, C., Rosner, R., Ebert, D. D., & Zarski, A. (2025) · European Journal of Psychotraumatology · doi:10.1080/20008066.2025.2480040 · Cited by 4 · see citing works
Clinician guidance in digital therapeutics for panic disorder: Meta-analytic dissection and implications for regulatory framing and scalable deployment
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Authors: Musiat, P., Johnson, C., Atkinson, M., Wilksch, S., & Wade, T.
Affiliations: Flinders University (AU)
University of Bath (GB)
Corresponding author: Musiat, Peter
ORCID: Musiat, Peter
Johnson, Catherine
Atkinson, Melissa
Wilksch, Simon
Wade, Tracey
Venue: Psychological Medicine
Publisher: Cambridge University Press (CUP)
Published: 2021-11-22
Volume: 52
Issue: 2
Pages: 229-240
ISSN: 0033-2917 (ISSN-L)
1469-8978
DOI: 10.1017/s0033291721004621
OpenAlex: W3215127018
Cited by: 166
References: 70
Citations by year: 2026: 34 · 2025: 55 · 2024: 37 · 2023: 26 · 2022: 14
FWCI: 3.09
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.cambridge.org/core/terms (unspecified)
Locations: Psychological Medicine (publishedVersion)
PubMed (publishedVersion)
Pure (University of Bath) (publishedVersion, other-oa)
Funders: Australian Research Council (DP170100237)
Topics: Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
Keywords: intervention adherence, online intervention, guided intervention, human guidance, intervention completion, mental health, depression, anxiety disorders
MeSH terms: Internet-Based Intervention, Humans, Mental Health, Internet

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Impact of guidance on intervention adherence in computerised interventions for mental health problems: a meta-analysis

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