Chatbot-Delivered Psychotherapy for Adults With Depressive and Anxiety Symptoms: A Systematic Review and Meta-Regression
Abstract
Although psychotherapy is a well-established treatment for depression and anxiety, chatbot-delivered psychotherapy is an emerging field that has yet to be explored in depth. This review aims to (a) examine the effectiveness of chatbot-delivered psychotherapy in improving depressive symptoms among adults with depression or anxiety, and (b) evaluate the preferred features for the design of chatbot-delivered psychotherapy. Eight electronic databases were searched for relevant randomized controlled trials. Meta-analysis and random effects meta-regression was conducted using Comprehensive Meta-Analysis 3.0 software. Overall effect was measured using Hedges's g and determined using z statistics at significance level p < .05. Assessment of heterogeneity was done using χ2 and I2 tests. A meta-analysis of 11 trials revealed that chatbot-delivered psychotherapy significantly improved depressive symptoms (g = 0.54, 95% confidence interval [-0.66, -0.42], p < .001). Although no significant subgroup differences were detected, results revealed larger effect sizes for samples of clinically diagnosed anxiety or depression, chatbots with an embodiment, a combination of types of input and output formats, less than 10 sessions, problem-solving therapy, off-line platforms, and in different regions of the United States than their counterparts. Meta-regression did not identify significant covariates that had an impact on depressive symptoms. Chatbot-delivered psychotherapy can be adopted in health care institutions as an alternative treatment for depression and anxiety. More high-quality trials are warranted to confirm the effectiveness of chatbot-delivered psychotherapy on depressive symptoms. PROSPERO registration number: CRD42020153332.
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Chatbot eHealth meta-analyses to date have focused on specific health conditions, resulting in few studies focusing on comparing primary health effects.
“Chatbot eHealth meta-analyses to-date have focused on specific health conditions resulting in few studies focusing on comparing primary health effects [37, 38].”
From Patient Engagement with Conversational Agents in Health Applications 2016–2022: A Systematic Review and Meta-Analysis (2024) · cites this paper as [38]
Previous reviews limited their focus to a subset of conversational agents based on the embodiment level.
“Third, the previous reviews limited their focus to a subset of CAs based on the embodiment level, such as disembodied CAs13,20, CAs with virtual representation15, or with a physical representation23–25.”
From Use of automated conversational agents in improving young population mental health: a scoping review (2024) · cites this paper as [13]
Most previous reviews did not distinguish fully automated conversational agents from non- or semi-autonomous conversational agents.
“Second, most of the previous reviews did not distinguish fully automated CAs from non- or semi-autonomous CAs13,20.”
From Use of automated conversational agents in improving young population mental health: a scoping review (2024) · cites this paper as [13]
A previous review showed medium to large effects of automated CA interventions when conducted on adults with clinical levels of anxiety or depression.
“Indeed, when conducted on adults with clinical levels of anxiety or depression, a previous review showed medium to large effects of automated CAs interventions13.”
From Use of automated conversational agents in improving young population mental health: a scoping review (2024) · cites this paper as [13]
Rule-based AI chatbots show promise to address some of these limitations, by simulating human conversation using predefined scripts and algorithms such as decision trees, to deliver the benefits of DMHIs in a more dynamic and interactive way.
“Rule-based AI chatbots show promise to address some of these limitations, by simulating human conversation using predefined scripts and algorithms such as decision trees, to deliver the benefits of DMHIs in a more dynamic and interactive way13,14.”
From “It happened to be the perfect thing”: experiences of generative AI chatbots for mental health (2024) · cites this paper as [14]
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- Authors
- Lim, S. M., Shiau, C. W. C., Cheng, L. J., & Lau, Y.
- Affiliations
- Tan Tock Seng Hospital (SG)
- National University of Singapore (SG)
- Corresponding author
- Lau, Ying
- Venue
- Behavior Therapy
- Publisher
- Elsevier BV
- Published
- 2022-03
- Volume
- 53
- Issue
- 2
- Pages
- 334-347
- ISSN
- 0005-7894 (ISSN-L)
- OpenAlex
- W4229082340
- Semantic Scholar
- 339f24a625d39ec71bcddd8f76ee85f9130d123c
- Cited by
- 163
- References
- 84
- Citations by year
- 2026: 35 · 2025: 47 · 2024: 49 · 2023: 26 · 2022: 6
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavior Therapy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Social Psychology › Social Robot Interaction and HRI
- Keywords
- depression, anxiety, depressive symptoms, problem-solving therapy, digital mental health interventions, treatment effectiveness
- MeSH terms
- Adult, Anxiety, Anxiety Disorders, Depression, Humans, Psychotherapy, Software
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