The DOI matches its Crossref record; 110 of the 111 references it cites were found in a registry or an index.
Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels
Open accessAbstract
Gelatin methacryloyl (GelMA) hydrogels have been widely used for various biomedical applications due to their suitable biological properties and tunable physical characteristics. Three dimensional (3D) GelMA hydrogels closely resemble some essential properties of native extracellular matrix (ECM) due to the presence of cell-attaching and matrix metalloproteinase responsive peptide motifs, which allow cells to proliferate and spread in GelMA-based scaffolds. GelMA is also versatile from a processing perspective. It crosslinks when exposed to light irradiation to form hydrogels with tunable mechanical properties which mimic the native ECM. It can also be microfabricated using different methodologies including micromolding, photomasking, bioprinting, self-assembly, and microfluidic techniques to generate constructs with controlled architectures. Hybrid hydrogel systems can also be formed by mixing GelMA with nanoparticles such as carbon nanotubes and graphene oxide, and other polymers to form networks with desired combined properties and characteristics for specific biological applications. Recent research has demonstrated the proficiency of GelMA-based hydrogels in a wide range of applications including engineering of bone, cartilage, cardiac, and vascular tissues, among others. Other applications of GelMA hydrogels, besides tissue engineering, include fundamental single-single cell research, cell signaling, drug and gene delivery, and bio-sensing.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“To this end, considerable efforts were made in developing hydrogel-based inks or printing techniques to enhance 3D stability and shape fidelity, such as printing multimaterial inks with combined nozzle system24, 25, photo-crosslinkable hydrogels17, 26, 27, adding viscosifiers28–30, or printing in sacrificial supporting materials31–33.”
From Fibre-infused gel scaffolds guide cardiomyocyte alignment in 3D-printed ventricles (2023) · cites this paper as [17]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cell-laden microengineered gelatin methacrylate hydrogels
Nichol, J. W., Koshy, S. T., Bae, H., Hwang, C. M., Yamanlar, S., & Khademhosseini, A. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.03.064 · Cited by 2,377 · cited 10×
“Specifically, the RGD motifs do not contain groups that will react with MA, which ensures the retention of good cell adhesive properties of the GelMA [6, 19, 29].”
BackgroundMethodInfluentialSelf-citation3D bioprinting of vascularized, heterogeneous cell-laden tissue constructs
Kolesky, D. B., Truby, R. L., Gladman, A. S., Busbee, T. A., Homan, K. A., & Lewis, J. A. (2014) · Advanced Materials · doi:10.1002/adma.201305506 · Cited by 2,102 · cited 3×
“[64] Kolesky DB, Truby RL, Gladman AS, Busbee TA, H oman KA, Lewis JA.”
BackgroundMethodInfluentialStructural and Rheological Properties of Methacrylamide Modified Gelatin Hydrogels
Van Den Bulcke, A. I., Bogdanov, B., De Rooze, N., Schacht, E. H., Cornelissen, M., & Berghmans, H. (2000) · Biomacromolecules · doi:10.1021/bm990017d · Cited by 1,536 · cited 6×
“Co nveniently, introduction of methacryloyl substituent groups confers to gelatin the property of photocrosslinking with the assistance of a photoinitiator and exposure to light, due to the photopolymerization of the methacryloyl substituents [14].”
BackgroundInfluential25th Anniversary Article: Rational Design and Applications of Hydrogels in Regenerative Medicine
Annabi, N., Tamayol, A., Uquillas, J. A., Akbari, M., Bertassoni, L. E., Cha, C., Camci‐Unal, G., Dokmeci, M. R., Peppas, N. A., & Khademhosseini, A. (2014) · Advanced Materials · doi:10.1002/adma.201303233 · Cited by 1,409 · cited 4×
“Hydrogels provide a versatile platform to include desired combinations of properties for designed applications [1].”
BackgroundMethodInfluentialSelf-citationFairbanks, B. D., Schwartz, M. P., Bowman, C. N., & Anseth, K. S. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.08.055 · Cited by 1,206 · cited 5×
“[33] Fairbanks BD, Schwartz MP, Bowman CN, Anseth K S.”
BackgroundInfluentialBilliet, T., Gevaert, E., De Schryver, T., Cornelissen, M., & Dubruel, P. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2013.09.078 · Cited by 1,015 · cited 2×
“gelatin [14], or gelatin methacrylamide [15-18] in literature by different authors.”
BackgroundBiochemistry and Molecular Biology of Gelatinase B or Matrix Metalloproteinase-9 (MMP-9)
den Steen, P. E. V., Dubois, B., Nelissen, I., Rudd, P., Dwek, R., & Opdenakker, G. (2002) · Critical reviews in biochemistry and molecular biology · doi:10.1080/10409230290771546 · Cited by 948 · cited 1×
“[20] Van den Steen PE, Dubois B, Nelissen I, Rudd P M, Dwek RA, Opdenakker G.”
BackgroundCarbon-Nanotube-Embedded Hydrogel Sheets for Engineering Cardiac Constructs and Bioactuators
Shin, S. R., Jung, S. M., Zalabany, M., Kim, K., Zorlutuna, P., Kim, S. B., Nikkhah, M., Khabiry, M., Azize, M., Kong, J., et al. (2013) · ACS Nano · doi:10.1021/nn305559j · Cited by 946 · cited 5×
“Hybrid hydrogels based on GelMA and other biopolymers The fabrication and use of GelMA hybrids with other biopolymers has been explored for diverse purposes, including enhancing mechanical pr operties [85, 86], tuning characteristics such as porosity, swelling ratio and degradability [86], or imparting a particular pr…”
BackgroundMethodInfluentialSelf-citationHydrogel bioprinted microchannel networks for vascularization of tissue engineering constructs
Bertassoni, L. E., Cecconi, M., Manoharan, V., Nikkhah, M., Hjortnaes, J., Cristino, A. L., Barabaschi, G., Demarchi, D., Dokmeci, M. R., Yang, Y., et al. (2014) · Lab Chip · doi:10.1039/c4lc00030g · Cited by 944 · cited 5×
“The sacrificial agarose segments could be eas ily removed from the GelMA matrix by simply pulling of the agarose cords, resulting in a bioprinted GelMA scaffold with internal hollow “vessels” [63].”
BackgroundMethodInfluentialSelf-citationPhotocrosslinkable Gelatin Hydrogel for Epidermal Tissue Engineering
Zhao, X., Lang, Q., Yildirimer, L., Lin, Z. Y., Cui, W., Annabi, N., Ng, K. W., Dokmeci, M. R., Ghaemmaghami, A. M., & Khademhosseini, A. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201500005 · Cited by 839 · cited 2×
“[104] Zhao X, Lang Q, Yildirimer L, Lin ZY, Cui W, Annabi N, et al.”
BackgroundSelf-citation
Flagged first, then by citations
1 of the 111 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 201–300 of 1,004
Ning, L., Sun, H., Lelong, T., Guilloteau, R., Zhu, N., Schreyer, D. J., & Chen, D. (2018) · Biofabrication · doi:10.1088/1758-5090/aacd30 · Cited by 154
Gan, D., Xu, T. K., Xing, W., Wang, M., Fang, J., Wang, K., Ge, X., Chan, C. W., Ren, F., Tan, H., et al. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb01664j · Cited by 154
Dodero, A., Lara, P., Vicini, S., Alloisio, M., Ottonelli, M., & Castellano, M. (2019) · European Polymer Journal · doi:10.1016/j.eurpolymj.2019.06.028 · Cited by 160
3D Bioprinting of Oxygenated Cell‐Laden Gelatin Methacryloyl Constructs
Erdem, A., Darabi, M. A., Nasiri, R., Sangabathuni, S., Ertaş, Y. N., Alem, H., Hosseini, V., Shamloo, A., Nasr, A. S., Ahadian, S., et al. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.201901794 · Cited by 149
Self-citationYoung, A. T., White, O. C., & Daniele, M. A.-A. (2020) · Macromolecular Bioscience · doi:10.1002/mabi.202000183 · Cited by 161
A Novel Strategy to Engineer Pre-Vascularized Full-Length Dental Pulp-like Tissue Constructs
Athirasala, A., Lins, F. F., Tahayeri, A., Hinds, M. T., Smith, A. J., Sedgley, C., Ferracane, J. L., & Bertassoni, L. E. (2017) · Scientific Reports · doi:10.1038/s41598-017-02532-3 · Cited by 154
In vivo printing of growth factor-eluting adhesive scaffolds improves wound healing
Nuutila, K., Samandari, M., Endo, Y., Zhang, Y., Quint, J. P., Schmidt, T. A., Tamayol, A., & Sinha, I. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.06.030 · Cited by 151
Self-citationBioinks and Bioprinting Strategies for Skeletal Muscle Tissue Engineering
Samandari, M., Quint, J. P., Rodríguez‐delaRosa, A., Sinha, I., Pourquié, O., & Tamayol, A. (2021) · Advanced Materials · doi:10.1002/adma.202105883 · Cited by 151
Self-citationAn overview of hydrogel-based intra-articular drug delivery for the treatment of osteoarthritis
He, Z., Wang, B., Hu, C., & Zhao, J. (2017) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2017.03.003 · Cited by 147
Rinoldi, C., Costantini, M., Kijeńska‐Gawrońska, E., Testa, S., Fornetti, E., Heljak, M. K., Ćwiklińska, M., Buda, R., Baldi, J., Cannata, S. M., et al. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201801218 · Cited by 146
Self-citationBioprinting Vasculature: Materials, Cells and Emergent Techniques
Tomasina, C., Bodet, T., Mota, C., Moroni, L., & Camarero‐Espinosa, S. (2019) · Materials · doi:10.3390/ma12172701 · Cited by 151
“GelMA derives from denaturated collagen and it is composed by methacrylamide and methacrylate groups [77].”
BackgroundZhang, M., Liu, H., Cui, Q., Han, P., Yang, S., Shi, M., Zhang, T., Zhang, Z., & Li, Z. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01918-x · Cited by 145
Living and Injectable Porous Hydrogel Microsphere with Paracrine Activity for Cartilage Regeneration
Li, X., Li, X., Yang, J., Lin, J., Zhu, Y., Xu, X., & Cui, W. (2023) · Small · doi:10.1002/smll.202207211 · Cited by 145
3D Bioprinting of Neural Tissues
Cadena, M., Ning, L., King, A. T., Hwang, B., Jin, L., Serpooshan, V., & Sloan, S. A. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.202001600 · Cited by 151
Responsive hydrogel-based microneedle dressing for diabetic wound healing
Guo, Z., Liu, H., Shi, Z., Lin, L., Li, Y., Wang, M., Pan, G., Lei, Y., & Xue, L. (2022) · Journal of Materials Chemistry B · doi:10.1039/d2tb00126h · Cited by 144
Hoorick, J. V., Gruber, P., Marković, M., Tromayer, M., Erps, J. V., Hugo Thienpont, A., Liska, R., Ovsianikov, A., Dubruel, P., & Vlierberghe, S. V. (2017) · Biomacromolecules · doi:10.1021/acs.biomac.7b00905 · Cited by 142
Zhuang, P., Ng, W. L., An, J., Chua, C. K., & Tan, L. P. (2019) · PLoS ONE · doi:10.1371/journal.pone.0216776 · Cited by 142
Guan, P., Liu, C., Xie, D., Mao, S., Ji, Y., Lin, Y., Chen, Z., Wang, Q., Fan, L., & Sun, Y. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.09.010 · Cited by 142
Sharifi, R., Sharifi, H., Akbari, A., & Chodosh, J. (2021) · Scientific Reports · doi:10.1038/s41598-021-02830-x · Cited by 142
Biomimetic nanoengineered scaffold for enhanced full-thickness cutaneous wound healing
Zandi, N., Dolatyar, B., Lotfi, R., Shallageh, Y., Shokrgozar, M. A., Tamjid, E., Annabi, N., & Simchi, A. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.01.029 · Cited by 143
Self-citationRecent Advances on Bioprinted Gelatin Methacrylate-Based Hydrogels for Tissue Repair
Rajabi, N., Rezaei, A. A., Kharaziha, M., Bakhsheshi‐Rad, H. R., Luo, H., Ramakrishna, S., & Berto, F. (2021) · Tissue Engineering Part A · doi:10.1089/ten.tea.2020.0350 · Cited by 144
“94,125,127 Another way for bioprinting of GelMA is related to the crosslinking of bioink during the extrusion by exposing the light.”
InfluentialRecent advances in 3D printing with protein-based inks
Mu, X., Agostinacchio, F., Xiang, N., Pei, Y., Khan, Y., Guo, C., Cebe, P., Motta, A., & Kaplan, D. L. (2021) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2021.101375 · Cited by 146
Injectable bottlebrush hydrogels with tissue-mimetic mechanical properties
Vashahi, F., Martinez, M. R., Dashtimoghadam, E., Fahimipour, F., Keith, A. N., Bersenev, E. A., Ivanov, D. A., Zhulina, E. B., Popryadukhin, P. V., Matyjaszewski, K. A., et al. (2022) · Science Advances · doi:10.1126/sciadv.abm2469 · Cited by 144
“The successfully implemented gelation mechanisms carry distinct pros and cons ( 4 , 5 , 8 – 10 ).”
Stem cell-laden injectable hydrogel microspheres for cancellous bone regeneration
Wu, J., Li, G., Ye, T., Lu, G., Li, R., Deng, L., Wang, L., Cai, M., & Cui, W. (2020) · Chemical Engineering Journal · doi:10.1016/j.cej.2020.124715 · Cited by 139
Zheng, Z., Tan, Y., Li, Y., Liu, Y., Yi, G., Yu, C., & Wei, H. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.05.023 · Cited by 139
Exosome-loaded hydrogels: A new cell-free therapeutic approach for skin regeneration
Safari, B., Aghazadeh, M., Davaran, S., & Roshangar, L. (2021) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2021.11.002 · Cited by 153
Zhao, D., Yu, Z., Li, Y., Wang, Y., Li, Q., & Han, D. (2020) · Journal of Molecular Histology · doi:10.1007/s10735-020-09877-6 · Cited by 139
“…sequences of arginine-glycine-aspartic acid (RGD), which is favorable for cells attachment and proliferation on scaffold (Liu and Chan-Park 2010; Hadjizadeh and Doillon 2010), it also contains matrix metalloproteinase (MMP) sequences that help cells migration and remodeling (Yue 2015; Steen 2002).”
BackgroundMethodInfluentialLight‐Guiding Biomaterials for Biomedical Applications
Shabahang, S., Kim, S., & Yun, S. H. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201706635 · Cited by 141
Soft‐Nanoparticle Functionalization of Natural Hydrogels for Tissue Engineering Applications
Elkhoury, K., Russell, C. S., Sánchez‐González, L., Mostafavi, A., Williams, T. J., Kahn, C. J. F., Peppas, N. A., Arab‐Tehrany, E., & Tamayol, A. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900506 · Cited by 138
Self-citationBiology and Models of the Blood–Brain Barrier
Hajal, C., Roi, B. L., Kamm, R. D., & Maoz, B. M. (2021) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-082120-042814 · Cited by 143
Three-Dimensional-Bioprinted Dopamine-Based Matrix for Promoting Neural Regeneration
Zhou, X., Cui, H., Nowicki, M. A., Miao, S., Lee, S., Masood, F., Harris, B. T., & Zhang, L. G. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b18197 · Cited by 139
Chen, J., Huang, D., Wang, L., Hou, J., Zhang, H., Li, Y., Zhong, S., Wang, Y., Wu, Y., & Huang, W. (2020) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2020.04.040 · Cited by 135
ROS‐Catalytic Transition‐Metal‐Based Enzymatic Nanoagents for Tumor and Bacterial Eradication
Li, L., Cao, L., Xiang, X., Wu, X., Ma, L., Chen, F., Cao, S., Cheng, C., Deng, D., & Qiu, L. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202107530 · Cited by 135
Zhu, Y., Haghniaz, R., Hartel, M. C., Guan, S., Bahari, J., Li, Z., Baidya, A., Cao, K., Gao, X., Li, J., et al. (2022) · Advanced Materials · doi:10.1002/adma.202209300 · Cited by 137
Self-citationGellan Fluid Gel as a Versatile Support Bath Material for Fluid Extrusion Bioprinting
Compaan, A. M., Song, K., & Huang, Y. H. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b13792 · Cited by 134
Pahoff, S., Meinert, C., Bas, O., Nguyen, L., Klein, T. J., & Hutmacher, D. W. (2019) · Journal of Materials Chemistry B · doi:10.1039/c8tb02607f · Cited by 137
Hybrid gelatin hydrogels in nanomedicine applications
Salahuddin, B., Wang, S., Sangian, D., Aziz, S., & Gu, Q. (2021) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c01630 · Cited by 134
Liu, H., Korc, M., & Lin, C. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.01.012 · Cited by 134
Permeability mapping of gelatin methacryloyl hydrogels
Miri, A. K., Hosseinabadi, H. G., Çeçen, B., Hassan, S., & Zhang, Y. S. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.07.006 · Cited by 135
Xu, L., Varkey, M., Jorgensen, A. M., Ju, J., Jin, Q., Park, J. H., Fu, Y., Zhang, G., Ke, D., Zhao, W., et al. (2020) · Biofabrication · doi:10.1088/1758-5090/aba2b6 · Cited by 133
Richbourg, N. R., Wancura, M. M., Gilchrist, A. E., Toubbeh, S., Harley, B. A. C., Cosgriff‐Hernandez, E., & Peppas, N. A. (2021) · Science Advances · doi:10.1126/sciadv.abe3245 · Cited by 133
“GelMA hydrogels were selected for their frequent use in biomedical applications (31) and because they are covalently cross-linked via photoinitiated methacrylamide polymerization, which allows control of the degree of polymerization between cross-links by varying the extent of methacrylamide functionalization (14).”
BackgroundSynthetic hydrogels mimicking basement membrane matrices to promote cell-matrix interactions
Cruz‐Acuña, R., & Garcı́a, A. J. (2016) · Matrix Biology · doi:10.1016/j.matbio.2016.06.002 · Cited by 133
Wang, Z., Tian, Z., Menard, F., & Kim, K. (2017) · Biofabrication · doi:10.1088/1758-5090/aa83cf · Cited by 135
Cheng, H., Chabok, R., Guan, X., Chawla, A., Li, Y., Khademhosseini, A., & Jang, H. L. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.01.016 · Cited by 132
“2c), according to our previous protocols [31, 40].”
BackgroundMethodSelf-citation3D Printing and Bioprinting Nerve Conduits for Neural Tissue Engineering
Yu, X., Zhang, T., & Li, Y. (2020) · Polymers · doi:10.3390/polym12081637 · Cited by 132
“To solve this problem, the modified gelatin derivative methacrylic acid gelatin (GelMA) was developed and more widely used, which is cross-linked through photoinduced free radical polymerization [82,83].”
MethodBiomaterials for Bioprinting Microvasculature
Barrs, R. W., Jia, J., Silver, S. E., Yost, M. J., & Mei, Y. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00027 · Cited by 134
Recent trends in gelatin methacryloyl nanocomposite hydrogels for tissue engineering
Sakr, M. A., Sakthivel, K., Hossain, T., Shin, S. R., Siddiqua, S., Kim, J.-H., & Kim, K. (2021) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37310 · Cited by 137
Biodegradable Elastomers and Gels for Elastic Electronics
Chen, S., Wu, Z., Chu, C., Ni, Y., Neisiany, R. E., & You, Z. (2022) · Advanced Science · doi:10.1002/advs.202105146 · Cited by 133
In situ bioprinting: intraoperative implementation of regenerative medicine
Samandari, M., Mostafavi, A., Quint, J. P., Memić, A., & Tamayol, A. (2022) · Trends in biotechnology · doi:10.1016/j.tibtech.2022.03.009 · Cited by 136
Self-citationLiu, S., Jin, M. Y., Chen, Y., Gao, H., Shi, X., Cheng, W., Ren, L., & Wang, Y. (2017) · Journal of Materials Chemistry B · doi:10.1039/c7tb00145b · Cited by 131
Li, F., Wu, Z., Chen, S., Huang, Z., Liang, C., & Lee, S. J. (2021) · International review of cytology · doi:10.1016/bs.ircmb.2025.11.005 · Cited by 130
Luo, Y., Lin, X., Chen, B., & Wei, X. (2019) · Biofabrication · doi:10.1088/1758-5090/ab39c5 · Cited by 131
Bioresorbable Polymers: Advanced Materials and 4D Printing for Tissue Engineering
Saska, S., Pilatti, L., Blay, A., & Shibli, J. A. (2021) · Polymers · doi:10.3390/polym13040563 · Cited by 132
Fan, L., Xiao, C., Guan, P., Zou, Y., Wen, H., Liu, C., Luo, Y., Tan, G., Wang, Q., Li, Y., et al. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202101556 · Cited by 130
Zhu, S., Yu, C., Liu, N., Zhao, M., Chen, Z., Liu, J., Li, G., Huang, H., Guo, H., Sun, T., et al. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.11.011 · Cited by 130
Chen, P., Xia, C., Mei, S., Wang, J., Shan, Z., Lin, X., & Fan, S. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.12.006 · Cited by 129
Fabrication of conductive gelatin methacrylate–polyaniline hydrogels
Wu, Y., Chen, Y. X., Yan, J., Quinn, D., Dong, P. X., Sawyer, S. W., & Soman, P. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.01.036 · Cited by 135
In Situ Printing of Adhesive Hydrogel Scaffolds for the Treatment of Skeletal Muscle Injuries
Russell, C. S., Mostafavi, A., Quint, J. P., Panayi, A. C., Baldino, K., Williams, T. J., Daubendiek, J. G., Sánchez-Rodríguez, V. H., Bonick, Z., Trujillo‐Miranda, M., et al. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.9b01176 · Cited by 130
Self-citationOptimized Photoclick (Bio)Resins for Fast Volumetric Bioprinting
Rizzo, R., Rütsche, D., Liu, H., & Zenobi‐Wong, M. (2021) · Advanced Materials · doi:10.1002/adma.202102900 · Cited by 129
Chen, C., Zeng, F., Xiao, X., Wang, Z., Li, X., Tan, R.-W., Liu, W., Zhang, Y., She, Z., & Li, S. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b10072 · Cited by 128
Luo, L., He, Y., Jin, L., Zhang, Y., Guastaldi, F. P. S., Albashari, A. A., Hu, F., Wang, X., Wang, L., Xiao, J., et al. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.08.028 · Cited by 128
Malekmohammadi, S., Aminabad, N. S., Sabzi, A., Zarebkohan, A., Razavi, M., Vosough, M., Bodaghi, M., & Maleki, H. H. (2021) · Biomedicines · doi:10.3390/biomedicines9111537 · Cited by 131
“The importance of this FDA-approved protein in regenerative medicine is due to the presence of arginine-glycine-aspartic acid (RGD) peptide sequences, which are vital for cell attachment to the ECM, cell proliferation, and cell differentiation [75,84,85].”
BackgroundAdvances in Gelatin Bioinks to Optimize Bioprinted Cell Functions
Asim, S., Tabish, T. A., Liaqat, U., Ozbolat, I. T., & Rizwan, M. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202203148 · Cited by 141
Assembling Living Building Blocks to Engineer Complex Tissues
Ouyang, L., Armstrong, J. P. K., Manuel, S.-S., & Stevens, M. M. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201909009 · Cited by 131
Zhang, Y., Sheng, R., Chen, J., Wang, H., Zhu, Y. S., Cao, Z., Zhao, X., Wang, Z., Liu, C., Chen, Z., et al. (2023) · Advanced Materials · doi:10.1002/adma.202210517 · Cited by 131
Fang, A., Wang, Y., Guan, N., Zuo, Y., Lin, L., Guo, B., Mo, A., Wu, Y., Lin, X., Cai, W., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39745-2 · Cited by 136
Zhuang, Z., Zhang, Y., Sun, S., Li, Q., Chen, K., An, C., Wang, L., van den Beucken, J. J. J. P., & Wang, H. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c00295 · Cited by 126
Fares, M. M., Sani, E. S., Lara, R. P., Oliveira, R. B., Khademhosseini, A., & Annabi, N. (2018) · Biomaterials Science · doi:10.1039/c8bm00474a · Cited by 127
Self-citationStereolithography 3D Bioprinting
Kumar, H., & Kim, K. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-0520-2_6 · Cited by 136
Injectable “nano-micron” combined gene-hydrogel microspheres for local treatment of osteoarthritis
Li, B., Wang, F., Hu, F., Ding, T., Huang, P., Xu, X. Y., Liang, J., Li, C., Zhou, Q., Lu, M., et al. (2022) · NPG Asia Materials · doi:10.1038/s41427-021-00351-7 · Cited by 125
Advances in Translational 3D Printing for Cartilage, Bone, and Osteochondral Tissue Engineering
Wang, S., Zhao, S., Yu, J., Gu, Z., & Zhang, Y. (2022) · Small · doi:10.1002/smll.202201869 · Cited by 127
Gelatin methacryloyl (GelMA)-based biomaterials for bone regeneration
Dong, Z., Yuan, Q., Huang, K., Xu, W., Liu, G., & Gu, Z. (2019) · RSC Advances · doi:10.1039/c9ra02695a · Cited by 123
Progress of gelatin-based 3D approaches for bone regeneration
Echave, M. C., Sánchez, P., Pedraz, J. L., & Orive, G. (2017) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2017.04.012 · Cited by 123
Laser-assisted 3D bioprinting of exocrine pancreas spheroid models for cancer initiation study
Hakobyan, D., Medina, C. F., Dusserre, N., Stachowicz, M., Handschin, C., Fricain, J., Guillermet‐Guibert, J., & Oliveira, H. (2020) · Biofabrication · doi:10.1088/1758-5090/ab7cb8 · Cited by 129
Chen, Q., Pei, Y., Tang, K., & Albu‐Kaya, M. G. (2023) · Collagen and Leather · doi:10.1186/s42825-023-00127-5 · Cited by 124
“Additionally, collagen-derived gelatin can be used as bioinks for cartilage recovery, such as when bioprinted into chemically modified hydrogels to support cell adhesion and proliferation [158].”
BackgroundPhoto-crosslinkable hydrogel and its biological applications
Wang, Y., Zhang, S., & Wang, J. (2020) · Chinese Chemical Letters · doi:10.1016/j.cclet.2020.11.073 · Cited by 122
Natural polymer-derived photocurable bioadhesive hydrogels for sutureless keratoplasty
Zhao, X., Li, S., Du, X., Li, W., Wang, Q., He, D., & Yuan, J. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.07.001 · Cited by 125
Advances in Organ-on-a-Chip Materials and Devices
Nahak, B. K., Mishra, A., Preetam, S., & Tiwari, A. (2022) · ACS Applied Bio Materials · doi:10.1021/acsabm.2c00041 · Cited by 128
Compact holographic sound fields enable rapid one-step assembly of matter in 3D
Melde, K., Kremer, H., Shi, M., Seneca, S., Frey, C., Platzman, I., Degel, C., Schmitt, D., Schölkopf, B., & Fischer, P. (2023) · Science Advances · doi:10.1126/sciadv.adf6182 · Cited by 122
Recent advances in defined hydrogels in organoid research
Gan, Z., Qin, X., Liu, H., Liu, J., & Qin, J. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.06.004 · Cited by 138
3D Cell Printed Tissue Analogues: A New Platform for Theranostics
Choi, Y., Yi, H., Kim, S.-W., & Cho, D. (2017) · Theranostics · doi:10.7150/thno.19396 · Cited by 121
“In contrast, other studies aim to maintain the gelatin-printed structure by methacrylation of the gelatin with irreversible UV photopolymerization [53, 54].”
MethodMulti-material 3D bioprinting of porous constructs for cartilage regeneration
Ruiz‐Cantu, L., Gleadall, A., Faris, C., Segal, J. I., Shakesheff, K. M., & Yang, J. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.110578 · Cited by 122
Gu, L., Li, T., Song, X., Yang, X., Li, S., Chen, L., Liu, P., Gong, X., Chen, C., & Sun, L. J. (2019) · Regenerative Biomaterials · doi:10.1093/rb/rbz050 · Cited by 121
Solid Organ Bioprinting: Strategies to Achieve Organ Function
Jorgensen, A. M., Yoo, J. J., & Atala, A. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00145 · Cited by 125
Hydrogels: The Next Generation Body Materials for Microfluidic Chips?
Nie, J., Fu, J., & He, Y. (2020) · Small · doi:10.1002/smll.202003797 · Cited by 126
Stimuli-responsive peptide hydrogels for biomedical applications
Zhou, H., Zhu, Y., Yang, B., Huo, Y., Yin, Y., Jiang, X., & Ji, W. (2024) · Journal of Materials Chemistry B · doi:10.1039/d3tb02610h · Cited by 127
Madonna, R., Laake, L. W. V., Bøtker, H. E., Davidson, S. M., Caterina, R. D., Engel, F. B., Eschenhagen, T., Fernandez-Aviles, F., Hausenloy, D. J., Hulot, J., et al. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz010 · Cited by 123
3D printing in biomedical engineering: Processes, materials, and applications
Lai, J., Wang, C., & Wang, M. (2021) · Applied Physics Reviews · doi:10.1063/5.0024177 · Cited by 127
Bioink Formulation and Machine Learning-Empowered Bioprinting Optimization
Freeman, S. R., Calabro, S., Williams, R., Jin, S., & Ye, K. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.913579 · Cited by 133
“The reaction induces the presence of methacryloyl substitution groups on the reactive amine and hydroxyl groups of the gelatin amino acid chain (Yue et al., 2015) and makes GelMA amenable to photo-induced chemical crosslinking.”
BackgroundClassification, processing, and applications of bioink and 3D bioprinting: A detailed review
Raees, S., Ullah, F., Javed, F. T., Akil, H. M., Khan, M. J., Safdar, M. M., Din, I. U., Alotaibi, M. A., Alharthi, A. I., Bakht, M. A., et al. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.123476 · Cited by 136
Spencer, A., Primbetova, A., Koppes, A. N., Koppes, R. A., Fenniri, H., & Annabi, N. (2018) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.8b00135 · Cited by 123
Self-citationZhou, L., Zhou, L., Wei, C., & Guo, R. (2022) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2022.119558 · Cited by 119
RetractedCells Cultured on Core–Shell Photonic Crystal Barcodes for Drug Screening
Fu, F., Shang, L., Zheng, F., Chen, Z., Wang, H., Wang, J., Gu, Z., & Zhao, Y. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b04966 · Cited by 118
Modaresifar, K., Hadjizadeh, A., & Niknejad, H. (2017) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2017.1392970 · Cited by 117
“carbon nanotubes, gold nanorods and graphene oxide are incorporated in GelMA to enhance its electrical conductivity for using in cardiac tissue engineering [12,27,28] and GelMA/ hydroxyapatite hybrids have been proposed as a suitable coating for bone implants made of titanium [29].”
BackgroundInfluentialShin, M., Galarraga, J. H., Kwon, M. Y., Lee, H., & Burdick, J. A. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.10.028 · Cited by 118
Chasing the Paradigm: Clinical Translation of 25 Years of Tissue Engineering
Hoffman, T., Khademhosseini, A., & Langer, R. (2019) · Tissue Engineering Part A · doi:10.1089/ten.tea.2019.0032 · Cited by 122
Self-citationClasky, A. J., Watchorn, J., Chen, P., & Gu, F. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.12.030 · Cited by 118
Interaction chemistry of functional groups for natural biopolymer-based hydrogel design
Hoque, M., Alam, M. M., Wang, S., Zaman, J. U., Rahman, M. S., Johir, M., Tian, L., Choi, J., Ahmed, M. B., & Yoon, M. (2023) · Materials Science and Engineering R Reports · doi:10.1016/j.mser.2023.100758 · Cited by 124
Abdulsalam, L., Abubakar, S., Permatasari, I., Lawal, A. A., Uddin, S., Ullah, S., & Ahmad, I. (2025) · Polymers · doi:10.3390/polym17212901 · Cited by 133
Evaluating CAR‐T Cell Therapy in a Hypoxic 3D Tumor Model
Ando, Y., Siegler, E. L., Ta, H. P., Cinay, G. E., Zhou, H., Gorrell, K. A., Au, H., Jarvis, B. M., Wang, P., & Shen, K. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900001 · Cited by 115
Metadata
- Authors
- Yue, K., Trujillo-de Santiago, G., Alvarez, M. M., Tamayol, A., Annabi, N., & Khademhosseini, A.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Annabi, Nasim
- Khademhosseini, Ali
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 73
- Pages
- 254-271
- ISSN
- 0142-9612 (ISSN-L)
- PMC
- PMC4610009
- OpenAlex
- W1120477740
- Semantic Scholar
- db0131b27b7eaf183c929a73ccd69d06de5cc188
- Cited by
- 3,146
- References
- 111
- Citations by year
- 2026: 433 · 2025: 464 · 2024: 394 · 2023: 430 · 2022: 347 · 2021: 314 · 2020: 243 · 2019: 213 · 2018: 137 · 2017: 106 · 2016: 60 · 2015: 3
- FWCI
- 7.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biomaterials (acceptedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Health and Medical Research Council
- National Science Foundation (EFRI-1240443)
- IMMODGEL (602694)
- National Institutes of Health (EB012597, AR057837, DE021468, HL099073, AI105024, AR063745)
- Tecnológico de Monterrey
- Consejo Nacional de Ciencia y Tecnología, México-CONACyT (262130)
- CONACyT-Sistema Nacional de Investigadores (26048)
- MIT International Science and Technology Initiatives (MISTI)
- Fundación México en Harvard
- CONACYT (234713)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Keywords
- gelatin methacryloyl, GelMA hydrogel, hydrogel synthesis, photopolymerization, extracellular matrix mimics, cell adhesion, tissue engineering scaffolds, bone tissue engineering, cartilage tissue engineering, cardiac tissue engineering, vascular tissue engineering, bioprinting, microfabrication, hybrid hydrogels, carbon nanotubes, graphene oxide, drug delivery, gene delivery, biosensing
- MeSH terms
- Animals, Biocompatible Materials, Extracellular Matrix, Gelatin, Graphite, Humans, Methacrylates, Oxides, Polymers, Hydrogels, Amino Acid Motifs, Tissue Engineering, Nanotubes, Carbon, Microfluidics, Cell Proliferation, Mice, Tissue Scaffolds
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
