Cited by 368Stress Responses and CortisolAdrenal Hormones and DisordersNeuroendocrine regulation and behavior

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Long-term adaptations in glucocorticoid receptor and mineralocorticoid receptor mrna and negative feedback on the hypothalamo-pituitary-adrenal axis following neonatal maternal separation

Ladd, Charlotte O, Huot, Rebecca L, Thrivikraman, K.V, Nemeroff, Charles B, Plotsky, Paul M·2004·Biological Psychiatry

DOI 10.1016/j.biopsych.2003.10.007

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Abstract

Background Maternally separated rats exhibit exaggerated hypothalamic-pituitary-adrenal responses to an acute stressor but normal diurnal trough functioning. We hypothesized that maternally separated rats experience adequate proactive glucocorticoid negative feedback but deficient "reactive" negative feedback, contributing to prolonged hypothalamic-pituitary-adrenal stress responses.Methods We measured plasma adrenocorticotropic hormone and corticosterone concentrations following an acute stressor or 6 to 8 hours after dexamethasone administration in adult rats previously exposed to daily handling-maternal separation for 15 minutes (HMS15) or 180 minutes (HMS180) during postnatal days 2 to 14. We also examined regional mineralocorticoid receptor and glucocorticoid receptor messenger RNA density in these two groups.Results HMS180 rats appeared to escape dexamethasone suppression of plasma adrenocorticotropic hormone and corticosterone faster than their HMS15 counterparts (p <.01). In situ hybridization analysis revealed increased hippocampal mineralocorticoid receptor messenger RNA density (p <.05) with decreased cortical (p <.05) and hippocampal (p <.05) glucocorticoid receptor messenger RNA density in HMS180 versus HMS15 animals.Conclusions These results are consistent with the hypothesis that in rats exposed to moderate neonatal handling-maternal separation, enhanced proactive feedback maintains the hypothalamic-pituitary-adrenal axis during the diurnal trough, while decreased reactive feedback contributes to prolonged responsiveness of the hypothalamic-pituitary-adrenal axis following an acute stressor.

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Authors: Ladd, C. O., Huot, R. L., Thrivikraman, K. V., Nemeroff, C. B., & Plotsky, P. M.
Affiliations: Emory University (US)
Corresponding author: Plotsky, Paul M
ORCID: Ladd, Charlotte O
Nemeroff, Charles B
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2004-02
Volume: 55
Issue: 4
Pages: 367-375
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2003.10.007
OpenAlex: W2140973156
Cited by: 368
References: 94
Citations by year: 2026: 3 · 2025: 6 · 2024: 6 · 2023: 7 · 2022: 6 · 2021: 7 · 2020: 22 · 2019: 12 · 2018: 22 · 2017: 18 · 2016: 17 · 2015: 25 · 2014: 21 · 2013: 18 · 2012: 20
FWCI: 8.21
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5f30mh012163-02)
National Institute of Mental Health (P50MH058922, MH58922, MH12163, MH-50113, R01MH050113)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords: neonatal maternal separation, hypothalamic-pituitary-adrenal axis, glucocorticoid receptor, mineralocorticoid receptor, negative feedback, ACTH, corticosterone, dexamethasone suppression, acute stress response, hippocampus, cortex, diurnal cycle
MeSH terms: Adaptation, Physiological, Adrenocorticotropic Hormone, Animals, Animals, Newborn, Corticosterone, Densitometry, Dexamethasone, Female, Glucocorticoids, Hippocampus, Hypothalamo-Hypophyseal System, Male, Maternal Deprivation, Pituitary-Adrenal System, Pregnancy, Radioimmunoassay, Receptors, Glucocorticoid, RNA, Messenger, Time Factors, In Situ Hybridization, Receptors, Mineralocorticoid, Rats, Long-Evans, Feedback, Physiological, Rats

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Long-term adaptations in glucocorticoid receptor and mineralocorticoid receptor mrna and negative feedback on the hypothalamo-pituitary-adrenal axis following neonatal maternal separation

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