Neuroendocrine dysregulation following early social deprivation in children
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Human and nonhuman animal studies reveal that early experiences with caregivers shape children's ability to regulate their responses to stress. To understand the effects of early deprivation on the regulation of the hypothalamic–pituitary–adrenal axis following social interactions, we examined urinary cortisol levels in a group of internationally adopted children who had experienced institutional care, and thus, species‐atypical attachment relationships, early in life prior to adoption. Cortisol regulation was assessed both basally and following standardized interpersonal interactions between the child and his/her mother and the child and an unfamiliar adult. Postinstitutionalized children showed prolonged elevations in cortisol levels following the mother, but not the stranger, interaction. More severe neglect was associated with the highest basal cortisol levels and the most impaired cortisol regulation following the mother interaction. These results suggest that early social deprivation may contribute to long‐term regulatory problems of the stress‐responsive system, and that these differences are most evident within the context of ongoing, close interpersonal relationships. © 2008 Wiley Periodicals, Inc. Dev Psychobiol 50: 588–599, 2008.
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Significant alterations in cortisol metabolism have been demonstrated in children living in institutions and in children adopted out of institutions.
“Finally, significant alterations in cortisol metabolism in children living in institutions (Carlson and Earls, 1997) and in children adopted out of institutions (Gunnar et al, 2000;Wismer Fries et al, 2008) have been demonstrated.”
From Deviations from the expectable environment in early childhood and emerging psychopathology (2015) · cites this paper as Wismer Fries et al, 2008
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Childhood and adulthood traumatic experiences in patients with psoriasis
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Biological perspectives on the effects of early psychosocial experience
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Gesundheitliche Langzeitfolgen psychosozialer Belastungen in der Kindheit – ein Update
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Affection Deprivation in Romantic Relationships
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‘Me and My Child’: Parenting Experiences of Young Mothers Leaving Care
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Psychoneuroendocrinology of Stress
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IX. RISK, CAUSATION, MEDIATION, AND MODERATION
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Buttner, A. P., Awalt, S. L., & Strasser, R. (2023) · Journal of the Experimental Analysis of Behavior · doi:10.1002/jeab.856 · Cited by 24 · see citing works
- Authors
- Fries, A. B. W., Shirtcliff, E. A., & Pollak, S. D.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Fries, Alison B. Wismer
- Venue
- Developmental Psychobiology
- Publisher
- Wiley
- Published
- 2008-08-05
- Volume
- 50
- Issue
- 6
- Pages
- 588-599
- ISSN
- 0012-1630 (ISSN-L)
- 1098-2302
- PMC
- PMC2673795
- OpenAlex
- W2144807767
- Cited by
- 192
- References
- 84
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 3 · 2023: 4 · 2022: 8 · 2021: 13 · 2020: 9 · 2019: 12 · 2018: 12 · 2017: 7 · 2016: 9 · 2015: 20 · 2014: 12 · 2013: 14 · 2012: 18
- FWCI
- 6.18
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Developmental Psychobiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH61285, MH18931, MH 068858, R01MH068858, T32MH018931, R01MH061285)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Safety Research › Child Welfare and Adoption
- Keywords
- institutional care, internationally adopted children, cortisol regulation, hypothalamic-pituitary-adrenal axis, stress response, attachment, maternal interaction, stranger interaction, child neglect, neuroendocrine dysfunction
- MeSH terms
- Adoption, Body Height, Body Weight, Child Abuse, Child, Institutionalized, Child, Preschool, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Infant, Interpersonal Relations, Male, Mothers, Pituitary-Adrenal System, Romania, Russia, Social Isolation, Stress, Psychological, United States, Caregivers, Orphanages
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