Agomelatine, a new antidepressant, induces regional changes in hippocampal neurogenesis
Abstract
Background Antidepressant treatments increase neural plasticity and adult neurogenesis, especially in the hippocampus. Here, we determined the effects of agomelatine (S-20098), a new antidepressant, on various phases of neurogenesis in the dentate gyrus of adult rat.Methods Animals were injected with agomelatine for different time periods. Immunostaining for bromodeoxyuridine, neuron specific nuclear protein, and glial fibrillary acid protein, as well as for the highly polysialylated form of neuronal cell adhesion molecule and doublecortin, was used to detect changes in cell proliferation, neurogenesis, and survival. Cell death was estimated by terminal deoxynucleotidyl transferase-mediated biotinylated deoxyuridine triphosphate nick end labeling and cresyl violet staining.Results Chronic (3 weeks) but not acute (4 hours) or subchronic (1 week) administration of agomelatine increased cell proliferation and neurogenesis in the ventral dentate gyrus, a region notably implicated in response to emotion, which is consistent with the antidepressant-anxiolytic properties of the drug. Extending agomelatine treatment over several weeks, however, increases survival of newly formed neurons in the entire dentate gyrus. Finally, agomelatine treatment does not affect mature granule cells.Conclusions This study shows that an antidepressant can affect differentially various stages of neurogenesis in the dorsal and ventral hippocampus. Altogether, these changes lead to a pronounced augmentation in the total number of new granule cells.
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Chronic, but not acute, treatment with agomelatine induces neurogenesis in the hippocampus similar to other antidepressants.
“Furthermore, chronic, but not acute, treatment with agomelatine also induces neurogenesis in the hippocampus similar to other antidepressants (Banasr et al., 2006).”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Banasr et al., 2006
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- Authors
- Banasr, M., Soumier, A., Hery, M., Mocaër, E., & Daszuta, A.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Institut de Recherches Internationales Servier (France) (FR)
- Corresponding author
- Daszuta, Annie
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2006-06
- Volume
- 59
- Issue
- 11
- Pages
- 1087-1096
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W1965355495
- Cited by
- 318
- References
- 95
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 6 · 2023: 8 · 2022: 15 · 2021: 4 · 2020: 10 · 2019: 14 · 2018: 23 · 2017: 12 · 2016: 21 · 2015: 13 · 2014: 27 · 2013: 17 · 2012: 20
- FWCI
- 5.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- agomelatine, antidepressants, adult hippocampal neurogenesis, dentate gyrus, cell proliferation, neuronal survival, granule cells, neuroplasticity, chronic drug administration
- MeSH terms
- Acetamides, Doublecortin Domain Proteins, Doublecortin Protein, Animals, Bromodeoxyuridine, Cell Count, Cell Survival, Fluorescent Antibody Technique, Glial Fibrillary Acidic Protein, Hippocampus, Hypnotics and Sedatives, Male, Microtubule-Associated Proteins, Naphthalenes, Neurons, Neuropeptides, Nuclear Proteins, Time Factors, Cell Death, Rats, Wistar, Dentate Gyrus, Neural Cell Adhesion Molecule L1, Cell Proliferation, Rats
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