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Cited by 140Neural and Behavioral Psychology StudiesAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesMemory Processes and Influences

Amygdala Reactivity and Mood-Congruent Memory in Individuals at Risk for Depressive Relapse

Ramel, Wiveka, Goldin, Philippe R., Eyler, Lisa T., Brown, Gregory G., Gotlib, Ian H., McQuaid, John R.·2007·Biological Psychiatry
DOI 10.1016/j.biopsych.2006.05.004
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Abstract

Background According to cognitive diathesis-stress theories, a latent cognitive vulnerability to depression is activated by negative affect in individuals at risk for depressive relapse. This vulnerability can manifest as mood-congruent memory during sad mood and may involve amygdala response, which is implicated in memory for emotionally arousing stimuli. This study examined whether amygdala modulates memory for negatively valenced words before and after a sad mood induction in healthy individuals with and without a history of recurrent major depression. Methods Fourteen unmedicated remitted depressed (RD) and 14 matched never depressed (ND) individuals were scanned using functional magnetic resonance imaging (fMRI) while performing a self-referent encoding/evaluation task (SRET) preceding and following a sad mood challenge. After each SRET, participants' free recall was assessed. Results Following sad mood induction, bilateral amygdala response during encoding of valenced words predicted increased recall of negative self-referent words for a subset of RD participants. This association was not present before the sad mood induction and was not evident in individuals without a history of depression, regardless of mood state. Conclusions These results are consistent with cognitive diathesis-stress theories and suggest a role for the amygdala in modulating mood-congruent memory during transient sad mood in individuals who are vulnerable to depression relapse.

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  • Ramel et al. (2007) found that during sad mood induction, amygdala response to negative self-referential words predicted the subsequent proportion of negative words recalled in remitted participants.

    “Ramel et al. (2007) also used sad mood induction and found that while sad, amygdala response to negative selfreferential words predicted the subsequent proportion of negative words recalled in remitted participants.”

    From Affective Cognition and its Disruption in Mood Disorders (2011) · cites this paper as Ramel et al. (2007)

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Authors
Ramel, W., Goldin, P. R., Eyler, L. T., Brown, G. G., Gotlib, I. H., & McQuaid, J. R.
Affiliations
  • Stanford University (US)
  • University of California San Diego (US)
Corresponding author
Ramel, Wiveka
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2007-01
Volume
61
Issue
2
Pages
231-239
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/j.biopsych.2006.05.004
OpenAlex
W2022272156
Cited by
140
References
61
Citations by year
2026: 2 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 7 · 2020: 1 · 2019: 8 · 2018: 5 · 2017: 6 · 2016: 7 · 2015: 10 · 2014: 11 · 2013: 14 · 2012: 15
FWCI
2.75
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (1f31mh064997-01)
  • National Institute of Mental Health (MH59259, 5 F31-MH064997, R01MH059259)
  • National Center for Research Resources (M-01RR00827, M01RR000827)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
amygdala, mood-congruent memory, depression relapse, recurrent major depressive disorder, negative affect, remitted depression, free recall
MeSH terms
Adult, Affect, Amygdala, Arousal, Brain Mapping, Major Depressive Disorder, Depressive Disorder, Major, Emotions, Female, Humans, Image Enhancement, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Oxygen, Personality Inventory, Mental Recall, Recurrence, Risk Factors, Self Concept, Verbal Learning

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