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Pharmacologic Rescue of Impaired Cognitive Flexibility, Social Deficits, Increased Aggression, and Seizure Susceptibility in Oxytocin Receptor Null Mice: A Neurobehavioral Model of Autism
Abstract
Background Oxytocin (OT) has been suggested as a treatment to improve social behavior in autistic patients. Accordingly, the OT (Oxt(-/-)) and the OT receptor null mice (Oxtr(-/-)) display autistic-like deficits in social behavior, increased aggression, and reduced ultrasonic vocalization.Methods Oxtr(-/-) mice were characterized for general health, sociability, social novelty, cognitive flexibility, aggression, and seizure susceptibility. Because vasopressin (AVP) and OT cooperate in controlling social behavior, learning, and aggression, they were tested for possible rescue of the impaired behaviors. Primary hyppocampal cultures from Oxtr(+/+) and Oxtr(-/-) mouse embryos were established to investigate the balance between gamma-aminobutyric acid (GABA) and glutamate synapses and the expression levels of OT and AVP (V1a) receptors were determined by autoradiography.Results Oxtr(-/-) mice display two additional, highly relevant, phenotypic characteristics: 1) a resistance to change in a learned pattern of behavior, comparable to restricted interests and repetitive behavior in autism, and 2) an increased susceptibility to seizures, a frequent and clinically relevant symptom of autism. We also show that intracerebral administration of both OT and AVP lowers aggression and fully reverts social and learning defects by acting on V1a receptors and that seizure susceptibility is antagonized by peripherally administered OT. Finally, we detect a decreased ratio of GABA-ergic versus total presynapses in hippocampal neurons of Oxtr(-/-) mice.Conclusions Autistic-like symptoms are rescued on administration of AVP and OT to young Oxtr(-/-) adult animals. The Oxtr(-/-) mouse is thus instrumental to investigate the neurochemical and synaptic abnormalities underlying autistic-like disturbances and to test new strategies of pharmacologic intervention.
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In the citing paper
“In OTR null mice social exploration and social recognition are reduced, while aggression is increased when compared to wild-type mice.”
From Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery (2018) · cites this paper as [53]
In the citing paper
“While intracerebroventricular (ICV) injection of OT or AVP can restore wild-type levels of these behaviors, the effects of OT and AVP are inhibited by a selective V1aR antagonist.”
From Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery (2018) · cites this paper as [53]
In the citing paper
“There are also studies that have found that OT can act via V1aRs to influence a range of social behaviors [53].”
From Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery (2018) · cites this paper as [53]
In the citing paper
“as discussed above, a V1aR antagonist inhibits the ability of OT to increase social recognition in OTR knock-out mice [53].”
From Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery (2018) · cites this paper as [53]
In the citing paper
“The neuropeptide oxytocin (OXT) has been strongly implicated in social behaviors including social recognition, social approach, pair bonding, paternal care and maternal behavior (Lim et al, 2005;Sala et al, 2011;Winslow and Insel, 2002).”
From Chronic and acute intranasal oxytocin produce divergent social effects in mice (2014) · cites this paper as Sala et al, 2011
In the citing paper
“an acute intracerebroventricular injection of OXT in wild-type male mice reduced the sociability towards a stranger male subject (Sala et al, 2011).”
From Chronic and acute intranasal oxytocin produce divergent social effects in mice (2014) · cites this paper as Sala et al, 2011
In the citing paper
“Therefore, administering oxytocin (for example, in the form of a nasal spray), or other substances that enhance central oxytocin turnover might be effective in ASD even in the presence of a disrupted oxytocin system [164].”
From Social “wanting” dysfunction in autism: neurobiological underpinnings and treatment implications (2012) · cites this paper as [210]
Citations
Cites
Handbook of Chemical Neuroanatomy
Stern, C. D. (1986) · Neurochemistry International · doi:10.1016/0197-0186(86)90021-5 · Cited by 4,160
The establishment of polarity by hippocampal neurons in culture.
Dotti, C., Sullivan, C., & Banker, G. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-04-01454.1988 · Cited by 1,862
Kaech, S., & Banker, G. A. (2006) · Nature Protocols · doi:10.1038/nprot.2006.356 · Cited by 1,766
Oxytocin, vasopressin, and the neurogenetics of sociality
Donaldson, Z. R., & Young, L. J. (2008) · Science · doi:10.1126/science.1158668 · Cited by 1,645
Moy, S. S., Nadler, J. J., Perez, A., Barbaro, R. P., Johns, J. M., Magnuson, T. R., Piven, J., & Crawley, J. N. (2004) · Genes, Brain and Behavior · doi:10.1111/j.1601-1848.2004.00076.x · Cited by 1,522
Autism spectrum disorders: developmental disconnection syndromes
Geschwind, D. H., & Levitt, P. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.01.009 · Cited by 1,411
Culturing hippocampal neurons.
Tanaka, H. (2002) · Folia Pharmacologica Japonica · doi:10.1254/fpj.119.163 · Cited by 1,141
Social amnesia in mice lacking the oxytocin gene
Ferguson, J. N., Young, L. J., Hearn, E. F., Matzuk, M. M., Insel, T. R., & Winslow, J. T. (2000) · Nature Genetics · doi:10.1038/77040 · Cited by 1,130
Insel, T. R. (2010) · Neuron · doi:10.1016/j.neuron.2010.03.005 · Cited by 1,044
Oxytocin in the Medial Amygdala is Essential for Social Recognition in the Mouse
Ferguson, J. N., Aldag, J. M., Insel, T. R., & Young, L. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-20-08278.2001 · Cited by 1,043
Research works printed but not linked: 1
- Tribollet, 1992, Vasopressin and oxytocin receptors in the rat brain, Vol. 4, 289
Cited by
Sorted by citations
The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999
Neumann, I. D., & Landgraf, R. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.08.004 · Cited by 954
Advancing the understanding of autism disease mechanisms through genetics
de la Torre-Ubieta, L., Won, H., Stein, J. L., & Geschwind, D. H. (2016) · Nature Medicine · doi:10.1038/nm.4071 · Cited by 827
Excitation/Inhibition Imbalance in Animal Models of Autism Spectrum Disorders
Lee, E., Lee, J., & Kim, E. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.05.011 · Cited by 468
Oxytocin and Vasopressin Agonists and Antagonists as Research Tools and Potential Therapeutics
Manning, M., Misicka, A., Olma, A., Bankowski, K., Stoev, S., Chini, B., Durroux, T., Mouillac, B., Corbani, M., & Guillon, G. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02303.x · Cited by 423
Self-citationExogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism
Peñagarikano, O., Lázaro, M. T., Lu, X.-H., Gordon, A., Dong, H., Lam, H. A., Peles, E., Maidment, N. T., Murphy, N. P., Yang, X. W., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.3010257 · Cited by 378
Anagnostou, E., Soorya, L., Chaplin, W., Bartz, J., Halpern, D., Wasserman, S., Wang, A. T., Pepa, L., Tanel, N., Kushki, A., et al. (2012) · Molecular Autism · doi:10.1186/2040-2392-3-16 · Cited by 350
Assembling the puzzle: pathways of oxytocin signaling in the brain
Grinevich, V., Knobloch-Bollmann, H. S., Eliava, M., Busnelli, M., & Chini, B. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.04.013 · Cited by 309
Self-citationThe contributions of oxytocin and vasopressin pathway genes to human behavior
Ebstein, R. P., Knafo, A., Mankuta, D., Chew, S. H., & Lai, P. S. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.014 · Cited by 283
Marotta, R., Risoleo, M. C., Messina, G., Parisi, L., Carotenuto, M., Vetri, L., & Roccella, M. (2020) · Brain Sciences · doi:10.3390/brainsci10030163 · Cited by 279
Breaking the loop: Oxytocin as a potential treatment for drug addiction
McGregor, I. S., & Bowen, M. T. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.001 · Cited by 268
The Emerging Picture of Autism Spectrum Disorder: Genetics and Pathology
Chen, J. A., Peñagarikano, O., Belgard, T. G., Swarup, V., & Geschwind, D. H. (2015) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-012414-040405 · Cited by 254
Neurobiological bases of autism–epilepsy comorbidity: a focus on excitation/inhibition imbalance
Bozzi, Y., Provenzano, G., & Casarosa, S. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.13595 · Cited by 250
Song, Z., & Albers, H. E. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.10.004 · Cited by 244
Uzunova, G., Pallanti, S., & Hollander, E. (2015) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2015.1085597 · Cited by 257
Translational animal models of autism and neurodevelopmental disorders
Crawley, J. N. (2012) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2012.14.3/jcrawley · Cited by 236
The oxytocin system in drug discovery for autism: Animal models and novel therapeutic strategies
Modi, M. E., & Young, L. J. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.010 · Cited by 218
Mouse model of Timothy syndrome recapitulates triad of autistic traits
Bader, P. L., Faizi, M., Kim, L. H., Owen, S. F., Tadross, M. R., Alfa, R. W., Bett, G. C. L., Tsien, R. W., Rasmusson, R. L., & Shamloo, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112667108 · Cited by 220
An Allostatic Theory of Oxytocin
Quintana, D. S., & Guastella, A. J. (2020) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2020.03.008 · Cited by 223
Albers, H. E. (2015) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.07.001 · Cited by 200
Chronic and acute intranasal oxytocin produce divergent social effects in mice
Huang, H., Michetti, C., Busnelli, M., Managò, F., Sannino, S., Scheggia, D., Giancardo, L., Sona, D., Murino, V., Chini, B., et al. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.310 · Cited by 199
Self-citationSocial “wanting” dysfunction in autism: neurobiological underpinnings and treatment implications
Kohls, G., Chevallier, C., Troiani, V., & Schultz, R. T. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-10 · Cited by 197
Méziane, H., Schaller, F., Bauer, Š., Villard, C., Matarazzo, V. A., Riet, F., Guillon, G., Lafitte, D., Desarménien, M. G., Tauber, M., et al. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.11.010 · Cited by 194
Leonzino, M., Busnelli, M., Antonucci, F., Verderio, C., Mazzanti, M., & Chini, B. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.03.013 · Cited by 199
Self-citationThe BTBR mouse model of idiopathic autism – Current view on mechanisms
Meyza, K. Z., & Blanchard, D. C. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.12.037 · Cited by 196
MacDonald, K., & Feifel, D. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00035 · Cited by 181
Duque-Wilckens, N., Steinman, M. Q., Busnelli, M., Chini, B., Yokoyama, S., Pham, M., Laredo, S. A., Hao, R., Perkeybile, A. M., Minie, V. A., et al. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.08.024 · Cited by 181
Self-citationPeters, S., Slattery, D. A., Uschold‐Schmidt, N., Reber, S. O., & Neumann, I. D. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.01.021 · Cited by 189
Translational Mouse Models of Autism: Advancing Toward Pharmacological Therapeutics
Kazdoba, T. M., Leach, P. T., Yang, M., Silverman, J. L., Solomon, M., & Crawley, J. N. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_5003 · Cited by 185
Roles of Oxytocin in Stress Responses, Allostasis and Resilience
Takayanagi, Y., & Onaka, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010150 · Cited by 173
The Oxytocin–Vasopressin Pathway in the Context of Love and Fear
Carter, C. S. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00356 · Cited by 170
The extreme male brain revisited: gender coherence in adults with autism spectrum disorder
Bejerot, S., Eriksson, J. M., Bonde, S., Carlström, K., Humble, M. B., & Eriksson, E. (2012) · British Journal of Psychiatry · doi:10.1192/bjp.bp.111.097899 · Cited by 161
Molecular Basis of Oxytocin Receptor Signalling in the Brain: What We Know and What We Need to Know
Busnelli, M., & Chini, B. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_6 · Cited by 168
Self-citationOxytocin transforms firing mode of CA2 hippocampal neurons
Tirko, N. N., Eyring, K. W., Carcea, I., Mitre, M., Chao, M. V., Froemke, R. C., & Tsien, R. W. (2018) · Neuron · doi:10.1016/j.neuron.2018.09.008 · Cited by 157
Miller, J. L., Tamura, R., Butler, M. G., Kimonis, V. E., Sulsona, C. R., Gold, J., & Driscoll, D. J. (2017) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.38160 · Cited by 149
Low CSF oxytocin reflects high intent in suicide attempters
Jokinen, J., Chatzittofis, A., Hellström, C., Nordström, P., Uvnäs-Moberg, K., & Åsberg, M. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.016 · Cited by 143
Buisman‐Pijlman, F. T. A., Sumracki, N. M., Gordon, J. J., Hull, P. R., Carter, C. S., & Tops, M. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.09.005 · Cited by 147
Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice
Vicidomini, C., Ponzoni, L., Lim, D., Schmeißer, M. J., Reim, D., Morello, N., Orellana, D. I., Tozzi, A., Durante, V., Scalmani, P., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.30 · Cited by 147
Self-citationOxytocin receptor knockout mice display deficits in the expression of autism-related behaviors
Pobbe, R. L. H., Pearson, B. L., Defensor, E. B., Bolivar, V. J., Young, W. S., Lee, H., Blanchard, D. C., & Blanchard, R. J. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.10.010 · Cited by 143
Glendining, K. A., & Jasoni, C. L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020329 · Cited by 140
Lukas, M., & Neumann, I. D. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.08.011 · Cited by 141
Kas, M. J., Glennon, J. C., Buitelaar, J., Ey, E., Biemans, B., Crawley, J., Ring, R. H., Lajonchere, C., Esclassan, F., Talpos, J., et al. (2014) · Psychopharmacology · doi:10.1007/s00213-013-3268-5 · Cited by 132
Ma, Y., Shamay-Tsoory, S., Han, S., & Zink, C. F. (2016) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2015.10.009 · Cited by 131
Oxytocin, vasopressin, and the motivational forces that drive social behaviors
Caldwell, H. K., & Albers, H. E. (2015) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2015_390 · Cited by 129
Ramos, L., Hicks, C., Kevin, R., Caminer, A., Narlawar, R., Kassiou, M., & McGregor, I. S. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.125 · Cited by 128
Neuropeptides as Targets for the Development of Anticonvulsant Drugs
Clynen, E., Swijsen, A., Raijmakers, M., Hoogland, G., & Rigo, J. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8669-x · Cited by 128
Ontogenesis of oxytocin pathways in the mammalian brain: late maturation and psychosocial disorders
Grinevich, V., Desarménien, M. G., Chini, B., Tauber, M., & Muscatelli, F. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00164 · Cited by 133
Self-citationNeurohypophyseal hormones manipulation modulate social and anxiety-related behavior in zebrafish
Braida, D., Donzelli, A., Martucci, R., Capurro, V., Busnelli, M., Chini, B., & Sala, M. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2482-2 · Cited by 125
Self-citationHammock, E. A. D. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00195 · Cited by 115
Carter, C., & Blizard, R. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.10.011 · Cited by 116
Song, Z., McCann, K. E., McNeill, J. K., Larkin, T. E., Huhman, K. L., & Albers, H. E. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.08.005 · Cited by 111
Oxytocin in schizophrenia: a review of evidence for its therapeutic effects
MacDonald, K. S., & Feifel, D. (2011) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2011.00634.x · Cited by 117
A Review of Oxytocin’s Effects on the Positive, Negative, and Cognitive Domains of Schizophrenia
Feifel, D., Shilling, P. D., & MacDonald, K. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.07.025 · Cited by 110
Bertoni, A., Schaller, F., Tyzio, R., Gaillard, S., Santini, F., Xolin, M., Diabira, D., Vaidyanathan, R., Matarazzo, V. A., Medina, I., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01227-6 · Cited by 110
Self-citationPlasma oxytocin concentrations following MDMA or intranasal oxytocin in humans
Kirkpatrick, M. G., Francis, S. M., Lee, R., de Wit, H., & Jacob, S. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.04.006 · Cited by 106
Sabihi, S., Durosko, N. E., Dong, S. M., & Leuner, B. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.03.009 · Cited by 106
Molecular Mechanisms of Oxytocin Signaling at the Synaptic Connection
Bakos, J., Srancikova, A., Havranek, T., & Bacova, Z. (2018) · Neural Plasticity · doi:10.1155/2018/4864107 · Cited by 104
Childhood aggression, callous-unemotional traits and oxytocin genes
Beitchman, J. H., Zai, C. C. H., Muir, K. E., Berall, L. E., Nowrouzi‐Kia, B., Choi, E., & Kennedy, J. L. (2012) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-012-0240-6 · Cited by 103
Selective and potent agonists and antagonists for investigating the role of mouse oxytocin receptors
Busnelli, M., Bulgheroni, E., Manning, M., Kleinau, G., & Chini, B. (2013) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.113.202994 · Cited by 102
Self-citationSong, Z., Borland, J. M., Larkin, T. E., O’Malley, M., & Albers, H. E. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.09.001 · Cited by 101
Oxytocin and vasopressin systems in genetic syndromes and neurodevelopmental disorders
Francis, S. M., Sagar, A., Levin-Decanini, T., Liu, W., Carter, C. S., & Jacob, S. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.021 · Cited by 101
Detection, processing and reinforcement of social cues: regulation by the oxytocin system
Menon, R., & Neumann, I. D. (2023) · Nature Reviews Neuroscience · doi:10.1038/s41583-023-00759-w · Cited by 100
Sala, M., Braida, D., Donzelli, A., Martucci, R., Busnelli, M., Bulgheroni, E., Rubino, T., Parolaro, D., Nishimori, K., & Chini, B. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02385.x · Cited by 104
Self-citationCD38 and its role in oxytocin secretion and social behavior
Higashida, H., Yokoyama, S., Kikuchi, M., & Munesue, T. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.011 · Cited by 98
Prosocial effects of oxytocin in two mouse models of autism spectrum disorders
Teng, B. L., Nonneman, R. J., Agster, K. L., Nikolova, V. D., Davis, T. T., Riddick, N. V., Baker, L. K., Pedersen, C. A., Jarstfer, M. B., & Moy, S. S. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.04.038 · Cited by 98
Role of oxytocin in the control of stress and food intake
Onaka, T., & Takayanagi, Y. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12700 · Cited by 102
Cataldo, I., Azhari, A., & Esposito, G. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00027 · Cited by 97
Neural Mechanisms Underlying Repetitive Behaviors in Rodent Models of Autism Spectrum Disorders
Gandhi, T., & Lee, C. C. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.592710 · Cited by 97
Sociability Deficits and Altered Amygdala Circuits in Mice Lacking Pcdh10, an Autism Associated Gene
Schoch, H., Kreibich, A. S., Ferri, S. L., White, R. S., Bohorquez, D., Banerjee, A., Port, R. G., Dow, H. C., Cordero, L., Pallathra, A. A., et al. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.06.008 · Cited by 92
Alvares, G. A., Quintana, D. S., & Whitehouse, A. J. O. (2017) · Autism Research · doi:10.1002/aur.1692 · Cited by 91
Antiaggressive activity of central oxytocin in male rats
Calcagnoli, F., de Boer, S. F., Althaus, M., den Boer, J. A., & Koolhaas, J. M. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3124-7 · Cited by 90
Watson, K. K., & Platt, M. L. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-21 · Cited by 91
Anpilov, S., Shemesh, Y., Eren, N., Harony-Nicolas, H., Benjamin, A., Dine, J., Oliveira, V. E. M., Forkosh, O., Karamihalev, S., Hüttl, R.-E., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.05.028 · Cited by 89
Oxytocin and vasopressin in the rodent hippocampus
Cilz, N. I., Cymerblit‐Sabba, A., & Young, W. S. (2018) · Genes Brain & Behavior · doi:10.1111/gbb.12535 · Cited by 92
Learning About Oxytocin: Pharmacologic and Behavioral Issues
Chini, B., Leonzino, M., Braida, D., & Sala, M. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.08.029 · Cited by 91
Self-citationBraida, D., Guerini, F. R., Ponzoni, L., Corradini, I., Astis, S. D., Pattini, L., Bolognesi, E., Benfante, R., Fornasari, D., Chiappedi, M. A., et al. (2015) · Translational Psychiatry · doi:10.1038/tp.2014.136 · Cited by 87
Self-citationSabihi, S., Dong, S. M., Maurer, S., Goodpaster, C. M., & Leuner, B. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.06.024 · Cited by 87
Rebalancing the Addicted Brain: Oxytocin Interference with the Neural Substrates of Addiction
Bowen, M. T., & Neumann, I. D. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.10.003 · Cited by 87
Homberg, J. R., Kyzar, E. J., Nguyen, M., Norton, W., Pittman, J. T., Poudel, M. K., Gaikwad, S., Nakamura, S., Koshiba, M., Yamanouchi, H., et al. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.03.013 · Cited by 86
Myosin IXa Binds AMPAR and Regulates Synaptic Structure, LTP, and Cognitive Function
Folci, A., Murru, L., Vezzoli, E., Ponzoni, L., Gerosa, L., Moretto, E., Longo, F., Zapata, J., Braida, D., Pistillo, F., et al. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00001 · Cited by 83
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Shilling, P. D., & Feifel, D. (2016) · CNS Drugs · doi:10.1007/s40263-016-0315-x · Cited by 84
Transient oxytocin signaling primes the development and function of excitatory hippocampal neurons
Ripamonti, S., Ambrozkiewicz, M. C., Guzzi, F., Gravati, M., Biella, G. R., Bormuth, I., Hammer, M., Tuffy, L. P., Sigler, A., Kawabe, H., et al. (2017) · eLife · doi:10.7554/elife.22466 · Cited by 84
Self-citationDai, Y., Zhang, H., Schön, M., Böckers, T. M., Han, S., Han, J., & Zhang, R. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00355 · Cited by 84
He, Z., Young, L., Ma, X.-M., Guo, Q., Wang, L., Yang, Y., Luo, L., Yuan, W., Li, L., Zhang, J., et al. (2019) · eLife · doi:10.7554/elife.44026 · Cited by 81
Bürkner, P., Williams, D. R., Simmons, T. C., & Woolley, J. D. (2017) · Schizophrenia Bulletin · doi:10.1093/schbul/sbx053 · Cited by 82
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Hammock, E. A. D., Veenstra-VanderWeele, J. M., Yan, Z., Kerr, T. M., Morris, M., Anderson, G. M., Carter, C. S., Cook, E. H., & Jacob, S. (2012) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2012.04.010 · Cited by 80
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Goh, K. K., Chen, C.-H., & Lane, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042146 · Cited by 84
Horie, K., Inoue, K., Suzuki, S., Adachi, S., Yada, S., Hirayama, T., Hidema, S., Young, L. J., & Nishimori, K. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.10.011 · Cited by 77
Self-citationHicks, C., Ramos, L., Reekie, T., Misagh, G. H., Narlawar, R., Kassiou, M., & McGregor, I. S. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12613 · Cited by 76
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Higashida, H., Yokoyama, S., Huang, J., Liu, L., Ma, W., Akther, S., Higashida, C., Kikuchi, M., Minabe, Y., & Munesue, T. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.01.030 · Cited by 74
A, T. R. D. J., & Neumann, I. D. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_13 · Cited by 76
Hicks, C., Jorgensen, W., Brown, C., Fardell, J., Koehbach, J., Gruber, C. W., Kassiou, M., Hunt, G. E., & McGregor, I. S. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02311.x · Cited by 73
Häring, M., Kaiser, N., Monory, K., & Lutz, B. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026617 · Cited by 73
Bowen, M. T., Peters, S. T., Absalom, N. L., Chebib, M., Neumann, I. D., & McGregor, I. S. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1416900112 · Cited by 75
Dumais, K. M., Alonso, A. G., Immormino, M. A., Bredewold, R., & Veenema, A. H. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.11.007 · Cited by 79
Dougnon, G., & Matsui, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147550 · Cited by 76
Prenatal chlorpyrifos leads to autism-like deficits in C57Bl6/J mice
Lan, A., Kalimian, M., Amram, B., & Kofman, O. (2017) · Environmental Health · doi:10.1186/s12940-017-0251-3 · Cited by 75
Metadata
- Authors
- Sala, M., Braida, D., Lentini, D., Busnelli, M., Bulgheroni, E., Capurro, V., Finardi, A., Donzelli, A., Pattini, L., Rubino, T., Parolaro, D., Nishimori, K., Parenti, M., & Chini, B.
- Affiliations
- University of Milan (IT)
- University of Milano-Bicocca (IT)
- National Research Council (IT)
- Politecnico di Milano (IT)
- University of Insubria (IT)
- Tohoku University (JP)
- Corresponding author
- Chini, Bice
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2011-05
- Volume
- 69
- Issue
- 9
- Pages
- 875-882
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2116573486
- Cited by
- 375
- References
- 61
- Citations by year
- 2026: 13 · 2025: 17 · 2024: 15 · 2023: 18 · 2022: 19 · 2021: 24 · 2020: 23 · 2019: 19 · 2018: 33 · 2017: 31 · 2016: 33 · 2015: 32 · 2014: 26 · 2013: 21 · 2012: 35
- FWCI
- 42.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- BOA (University of Milano-Bicocca) (submittedVersion)
- IrInSubria (University of Insubria) (submittedVersion)
- Virtual Community of Pathological Anatomy (University of Castilla La Mancha) (submittedVersion)
- Funders
- Fondazione Cariplo
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, oxytocin, oxytocin receptor, vasopressin, vasopressin V1a receptor, social behavior, aggression, seizure susceptibility, cognitive flexibility, social novelty, GABAergic synapses, glutamatergic synapses, hippocampus
- MeSH terms
- Aggression, Analysis of Variance, Animals, Arginine Vasopressin, Autistic Disorder, Autoradiography, Cells, Cultured, Cognition, Disease Models, Animal, Hippocampus, Immunohistochemistry, Male, Neurons, Oxytocin, Seizures, Social Behavior, Receptors, Oxytocin, Mice, Knockout, Mice
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