Cited by 348Electrochemical sensors and biosensorsAdvanced Sensor and Energy Harvesting MaterialsAdvanced biosensing and bioanalysis techniques

A stretchable and screen-printed electrochemical sensor for glucose determination in human perspiration

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Abellán-Llobregat, A., Jeerapan, Itthipon, Bandodkar, A., Vidal, L., Canals, A., Wang, J., Morallón, E.·2017·Biosensors and Bioelectronics

Abstract

Here we present two types of all-printable, highly stretchable, and inexpensive devices based on platinum (Pt)-decorated graphite for glucose determination in physiological fluids. Said devices are: a non-enzymatic sensor and an enzymatic biosensor, the latter showing promising results. Glucose has been quantified by measuring hydrogen peroxide (H 2 O 2) reduction by chronoamperometry at -0.35V (vs pseudo-Ag/AgCl) using glucose oxidase immobilized on Pt-decorated graphite. The sensor performs well for the quantification of glucose in phosphate buffer solution (0.25M PBS, pH 7.0), with a linear range between 0 mM and 0.9mM, high sensitivity and selectivity, and a low limit of detection (LOD). Thus, it provides an alternative non-invasive and on-body quantification of glucose levels in human perspiration. This biosensor has been successfully applied on real human perspiration samples and results also show a significant correlation between glucose concentration in perspiration and glucose concentration in blood measured by a commercial glucose meter.

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Crossref · 10.1016/j.bios.2017.01.058

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  • Abellan-Llobregat's printable stretchable Pt-decorated graphite glucose sensor demonstrated a strong correlation between glucose concentration in perspiration and blood glucose measured by a commercial glucose meter.

    “This device was applied on human perspiration samples and demonstrated a strong correlation between glucose concentration in perspiration and glucose concentration in blood, as measured via a commercial glucose meter.”

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Research works printed but not linked: 2

  1. Lodgotra A Verma P Raj SS 2016 J Clin Diagn Res 10 ZC56 ZC61 PMC4963772 27504412
  2. Wang J 2008 CHAPTER 3 - Electrochemical glucose biosensors in electrochemical sensors, biosensors and their biomedical applications Academic Press San Diego 57 69

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Authors
Abellán-Llobregat, A., Jeerapan, I., Bandodkar, A., Vidal, L., Canals, A., Wang, J., & Morallón, E.
Affiliations
  • University of Alicante (ES)
  • University of California San Diego (US)
Corresponding author
Morallón, E.
Venue
Biosensors and Bioelectronics
Publisher
Elsevier BV
Published
2017-05
Volume
91
Pages
885-891
ISSN
0956-5663 (ISSN-L)
OpenAlex
W2580319474
Cited by
348
References
32
Citations by year
2026: 17 · 2025: 31 · 2024: 34 · 2023: 38 · 2022: 46 · 2021: 43 · 2020: 42 · 2019: 54 · 2018: 32 · 2017: 11
FWCI
15.79
Type
journal article
Language
en
Open access
Locations
  • Biosensors and Bioelectronics (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion)
  • Repositorio Institucional de la Universidad de Alicante (Universidad de Alicante) (submittedVersion)
Funders
  • Universidad de Alicante
  • University of San Diego
  • National Institutes of Health (R21EB019698)
  • Ministerio de Economía y Competitividad (MAT2016-76595-R)
  • Generalitat Valenciana (Prometeo2013/038)
  • National Institute of Biomedical Imaging and Bioengineering
Topics
  • Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
  • Physical Sciences › Engineering › Biomedical Engineering › Advanced Sensor and Energy Harvesting Materials
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
Keywords
glucose biosensor, sweating, stretchable sensors, screen-printed electrodes, glucose oxidase, non-enzymatic glucose sensing, hydrogen peroxide reduction, chronoamperometry, non-invasive glucose monitoring, on-body sensing
MeSH terms
Adult, Elasticity, Electrodes, Enzymes, Immobilized, Equipment Design, Female, Glucose, Glucose Oxidase, Graphite, Humans, Hydrogen Peroxide, Male, Platinum, Sweat, Biosensing Techniques, Electrochemical Techniques, Young Adult, Limit of Detection

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