Wearable Biosensors for Non-Invasive Sweat Diagnostics
Open accessAbstract
Recent advances in microfluidics, microelectronics, and electrochemical sensing methods have steered the way for the development of novel and potential wearable biosensors for healthcare monitoring. Wearable bioelectronics has received tremendous attention worldwide due to its great a potential for predictive medical modeling and allowing for personalized point-of-care-testing (POCT). They possess many appealing characteristics, for example, lightweight, flexibility, good stretchability, conformability, and low cost. These characteristics make wearable bioelectronics a promising platform for personalized devices. In this paper, we review recent progress in flexible and wearable sensors for non-invasive biomonitoring using sweat as the bio-fluid. Real-time and molecular-level monitoring of personal health states can be achieved with sweat-based or perspiration-based wearable biosensors. The suitability of sweat and its potential in healthcare monitoring, sweat extraction, and the challenges encountered in sweat-based analysis are summarized. The paper also discusses challenges that still hinder the full-fledged development of sweat-based wearables and presents the areas of future research.
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The same temporal change of cortisol concentration is reported for all biofluids, such as saliva, serum, and sweat.
“The same temporal change of cortisol concentration was also reported for all biofluids, such as saliva, serum, and sweat.[ 8 , 30 ]”
From MicroSweat: A wearable microfluidic patch for noninvasive and reliable sweat collection enables human stress monitoring (2023) · cites this paper as [30]
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- Authors
- Xu, J., Fang, Y., & Chen, J.
- Affiliations
- North China Electric Power University (CN)
- University of California, Los Angeles (US)
- Corresponding author
- Chen, Jun
- Venue
- Biosensors
- Publisher
- MDPI AG
- Published
- 2021-07-23
- Volume
- 11
- Issue
- 8
- Pages
- 245
- ISSN
- 2079-6374 (ISSN-L)
- PMC
- PMC8391966
- OpenAlex
- W3186719133
- Cited by
- 208
- References
- 118
- Citations by year
- 2026: 28 · 2025: 53 · 2024: 48 · 2023: 38 · 2022: 34 · 2021: 7
- FWCI
- 2.69
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Biosensors (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- Israel Science Foundation
- University of California, Los Angeles
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Advanced Sensor and Energy Harvesting Materials
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Physical Sciences › Engineering › Biomedical Engineering › Non-Invasive Vital Sign Monitoring
- Keywords
- wearable biosensors, sweat analysis, non-invasive diagnosis, wearable bioelectronics, flexible sensors, sweating, point-of-care testing, real-time health monitoring, electrochemical sensing, microfluidics
- MeSH terms
- Wearable Electronic Devices, Sweat, Biosensing Techniques, Microfluidics, Electrochemical Techniques
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