Cited by 208Advanced Sensor and Energy Harvesting MaterialsElectrochemical sensors and biosensorsNon-Invasive Vital Sign Monitoring

Wearable Biosensors for Non-Invasive Sweat Diagnostics

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Xu, Jing, Fang, Yunsheng, Chen, Jun·2021·Biosensors

Abstract

Recent advances in microfluidics, microelectronics, and electrochemical sensing methods have steered the way for the development of novel and potential wearable biosensors for healthcare monitoring. Wearable bioelectronics has received tremendous attention worldwide due to its great a potential for predictive medical modeling and allowing for personalized point-of-care-testing (POCT). They possess many appealing characteristics, for example, lightweight, flexibility, good stretchability, conformability, and low cost. These characteristics make wearable bioelectronics a promising platform for personalized devices. In this paper, we review recent progress in flexible and wearable sensors for non-invasive biomonitoring using sweat as the bio-fluid. Real-time and molecular-level monitoring of personal health states can be achieved with sweat-based or perspiration-based wearable biosensors. The suitability of sweat and its potential in healthcare monitoring, sweat extraction, and the challenges encountered in sweat-based analysis are summarized. The paper also discusses challenges that still hinder the full-fledged development of sweat-based wearables and presents the areas of future research.

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Authors
Xu, J., Fang, Y., & Chen, J.
Affiliations
  • North China Electric Power University (CN)
  • University of California, Los Angeles (US)
Corresponding author
Chen, Jun
Venue
Biosensors
Publisher
MDPI AG
Published
2021-07-23
Volume
11
Issue
8
Pages
245
ISSN
2079-6374 (ISSN-L)
OpenAlex
W3186719133
Cited by
208
References
118
Citations by year
2026: 28 · 2025: 53 · 2024: 48 · 2023: 38 · 2022: 34 · 2021: 7
FWCI
2.69
Type
journal article
Language
en
Open access
Locations
  • Biosensors (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • eScholarship (California Digital Library) (submittedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
Funders
  • Israel Science Foundation
  • University of California, Los Angeles
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Advanced Sensor and Energy Harvesting Materials
  • Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
  • Physical Sciences › Engineering › Biomedical Engineering › Non-Invasive Vital Sign Monitoring
Keywords
wearable biosensors, sweat analysis, non-invasive diagnosis, wearable bioelectronics, flexible sensors, sweating, point-of-care testing, real-time health monitoring, electrochemical sensing, microfluidics
MeSH terms
Wearable Electronic Devices, Sweat, Biosensing Techniques, Microfluidics, Electrochemical Techniques

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