Not just a sink: endosomes in control of signal transduction

Functional rafts in cell membranes

Simons, K., & Ikonen, E. (1997) · Nature · doi:10.1038/42408 · Cited by 9,757

Cell Signaling by Receptor Tyrosine Kinases

Lemmon, M. A., & Schlessinger, J. (2010) · Cell · doi:10.1016/j.cell.2010.06.011 · Cited by 7,929

Mammalian Rho GTPases: new insights into their functions from in vivo studies

Heasman, S. J., & Ridley, A. J. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2476 · Cited by 1,871

Cell-signalling dynamics in time and space

Kholodenko, B. N. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1838 · Cited by 1,347

Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1

Um, S. H., D'Alessio, D., & Thomas, G. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.05.003 · Cited by 690

Clathrin-independent pathways of endocytosis

Mayor, S., Parton, R. G., & Donaldson, J. G. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016758 · Cited by 525

Differential Regulation of EGF Receptor Internalization and Degradation by Multiubiquitination within the Kinase Domain

Huang, F., Kirkpatrick, D., Jiang, X., Gygi, S., & Sorkin, A. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.02.018 · Cited by 497

Synaptic Vesicle Endocytosis

Saheki, Y., & De Camilli, P. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005645 · Cited by 457

Rab7 Regulates Late Endocytic Trafficking Downstream of Multivesicular Body Biogenesis and Cargo Sequestration

Vanlandingham, P. A., & Ceresa, B. P. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809277200 · Cited by 441

The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK–ERK pathway to late endosomes

Nada, S., Hondo, A., Kasai, A., Koike, M., Saito, K., Uchiyama, Y., & Okada, M. (2009) · The EMBO Journal · doi:10.1038/emboj.2008.308 · Cited by 341

Intrinsic Tumor Suppression and Epithelial Maintenance by Endocytic Activation of Eiger/TNF Signaling in Drosophila

Igaki, T., Pastor-Pareja, J. C., Aonuma, H., Miura, M., & Xu, T. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.01.002 · Cited by 295

Endosomal and non-endosomal functions of ESCRT proteins

Slagsvold, T., Pattni, K., Malerød, L., & Stenmark, H. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.04.004 · Cited by 238

The insulin secretory granule as a signaling hub

Suckale, J., & Solimena, M. (2010) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2010.06.003 · Cited by 201

Rhbdd3 controls autoimmunity by suppressing the production of IL-6 by dendritic cells via K27-linked ubiquitination of the regulator NEMO

Liu, J., Han, C., Xie, B., Wu, Y., Liu, S., Chen, K., Xia, M., Zhang, Y., Song, L., Li, Z., et al. (2014) · Nature Immunology · doi:10.1038/ni.2898 · Cited by 128

Positioning of AMPA receptor-containing endosomes regulates synapse architecture

Esteves da Silva, M., Adrian, M., Schätzle, P., Lipka, J., Watanabe, T., Cho, S., Futai, K., Wierenga, C. J., Kapitein, L. C., & Hoogenraad, C. C. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.09.062 · Cited by 126

Endocytosis and Cancer: an ‘Insider’ Network with Dangerous Liaisons

Lanzetti, L., & Di Fiore, P. P. (2008) · Traffic · doi:10.1111/j.1600-0854.2008.00816.x · Cited by 119

Vertebrate Membrane Proteins: Structure, Function, and Insights from Biophysical Approaches

Müller, D. J., Wu, N., & Palczewski, K. (2008) · Pharmacological Reviews · doi:10.1124/pr.107.07111 · Cited by 104

Endosomal sorting and trafficking, the retromer complex and neurodegeneration

Vagnozzi, A. N., & Praticò, D. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0221-3 · Cited by 95

NDRG1 functions in LDL receptor trafficking by regulating endosomal recycling and degradation

Pietiäinen, V., Vassilev, B., Blom, T., Wang, W., Nelson, J., Bittman, R., Bäck, N., Zelcer, N., & Ikonen, E. (2013) · Journal of Cell Science · doi:10.1242/jcs.128132 · Cited by 89

Autophosphorylation-dependent degradation of Pak1, triggered by the Rho-family GTPase, Chp

Weisz Hubsman, M., Volinsky, N., Manser, E., Yablonski, D., & Aronheim, A. (2007) · Biochemical Journal · doi:10.1042/bj20061696 · Cited by 56

Role of the endolysosomal pathway and exosome release in tau propagation

Yan, M., & Zheng, T. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.104988 · Cited by 36

Class II phosphatidylinositol 3-kinase isoforms in vesicular trafficking

Yoshioka, K. (2021) · Biochemical Society Transactions · doi:10.1042/bst20200835 · Cited by 31

Spatio-temporal regulation of EGFR signaling by the Eps15 homology domain-containing protein 3 (EHD3)

Amessou, M., Ebrahim, A. S., Dilly, A., Joseph, M., Tabolina, M., Chukkapalli, S., Meroueh, L., Syed, J. T., Liddane, A., Lang, S. L., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.13008 · Cited by 5