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Separation of powers: A key feature underlying the neuroprotective role of Retromer in age-related neurodegenerative disease?

Collins, Brett M., Cullen, Peter J.·2025·Current Opinion in Cell Biology
DOI 10.1016/j.ceb.2025.102516PMC PMC7618989
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  • Human Retromer is a stable heterotrimer of VPS35, either VPS26A or VPS26B, and one of three VPS29 isoforms, and regulates endosomal retrieval and trafficking of numerous cargoes away from the degradative pathway.

    “Human Retromer is a stable heterotrimer of vacuolar protein sorting protein 35 (VPS35), either VPS26A or VPS26B [20,21], and one of three VPS29 isoforms [22,23], and regulates the endosomal retrieval and trafficking of numerous cargoes away from the degradative pathway [23].”

    From Global identification of neuronal and astrocytic integral membrane proteins that require Retromer for their endosomal recycling (2026) · cites this paper as [23]

    The Introduction section on the yeast retromer–SNX–BAR pentamer describes a stable human VPS26:VPS35:VPS29 heterotrimer, VPS26A and VPS26B, and endosomal cargo retrieval and recycling. It says there are “at least three VPS29 orthologs,” however, rather than establishing the claim’s exact count of three isoforms. No page number is available in our copy. (LLM, conf=0.84)

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Research works printed but not linked: 69

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Metadata

Authors
Collins, B. M., & Cullen, P. J.
Venue
Current Opinion in Cell Biology
Publisher
Elsevier BV
Published
2025-06
Volume
94
Pages
102516
ISSN
0955-0674
DOI
10.1016/j.ceb.2025.102516
PMC
PMC7618989
Cited by
10
References
6
Language
en
Licence
Funders
  • UK Research and Innovation Medical Research Council (MR/P018807/1, MR/L007363/1)
  • The Royal Society (RSRP/R1/211004)
  • Wellcome Trust (220260/Z/20/Z, 104568/Z/14/Z)
  • Lister Institute of Preventive Medicine
  • National Health and Medical Research Council (APP1136021, APP1156493, APP2016410)

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