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Single Naive CD4+ T Cells from a Diverse Repertoire Produce Different Effector Cell Types during Infection
Open accessAbstract
SUMMARY A naïve CD4+ T cell population specific for a microbial peptide:major histocompatibility complex II ligand (p:MHCII) typically consists of about 100 cells, each with a different T cell receptor (TCR). Following infection, this population produces a consistent ratio of effector cells that activate microbicidal functions of macrophages or help B cells make antibodies. We studied the mechanism that underlies this division of labor by tracking the progeny of single naïve T cells. Different naïve cells produced distinct ratios of macrophage and B cell helpers but yielded the characteristic ratio when averaged together. The effector cell pattern produced by a given naïve cell correlated with the TCR-p:MHCII dwell time or the amount of p:MHCII. Thus, the consistent production of effector cell subsets by a polyclonal population of naïve cells results from averaging the diverse behaviors of individual clones, which are instructed in part by the strength of TCR signaling.
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Citations
Cites
Differentiation of Effector CD4 T Cell Populations
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Metadata
- Authors
- Tubo, N. J., Pagán, A. J., Taylor, J. J., Nelson, R. W., Linehan, J. L., Ertelt, J. M., Huseby, E. S., Way, S. S., & Jenkins, M. K.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2013-05
- Volume
- 153
- Issue
- 4
- Pages
- 785-796
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2099295104
- Cited by
- 444
- References
- 3
- FWCI
- 24.38
- Type
- journal article
- Language
- en
- Open access
- bronze
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