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Antagonistic Control of Social versus Repetitive Self-Grooming Behaviors by Separable Amygdala Neuronal Subsets
Open accessAbstract
Animals display a range of innate social behaviors that play essential roles in survival and reproduction. While the medial amygdala (MeA) has been implicated in prototypic social behaviors such as aggression, the circuit-level mechanisms controlling such behaviors are not well understood. Using cell-type-specific functional manipulations, we find that distinct neuronal populations in the MeA control different social and asocial behaviors. A GABAergic subpopulation promotes aggression and two other social behaviors, while neighboring glutamatergic neurons promote repetitive self-grooming, an asocial behavior. Moreover, this glutamatergic subpopulation inhibits social interactions independently of its effect to promote self-grooming, while the GABAergic subpopulation inhibits self-grooming, even in a nonsocial context. These data suggest that social versus repetitive asocial behaviors are controlled in an antagonistic manner by inhibitory versus excitatory amygdala subpopulations, respectively. These findings provide a framework for understanding circuit-level mechanisms underlying opponency between innate behaviors, with implications for their perturbation in psychiatric disorders.
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“While advanced circuit mapping tools have recently been effective at identifying specific nodes critical for sex-specific behaviors like mating, parenting, and aggression (Hong et al., 2014; Wu et al., 2009), many of these techniques rely on the use of transgenic mice, which, in contrast to rats, do not engage in tertiary social play.”
From Developmental origins of sex differences in the neural circuitry of play (2020) · cites this paper as Hong et al., 2014
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“previous work has demonstrated that activation of GABAergic rather than glutamatergic neurons in the MeA is associated with onset of male aggression [82].”
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“The MeA has been subdivided into distinct functional regions along the anterior-posterior and dorsal-ventral axes, with the medial amygdala posterodorsal (MeApd) primarily involved in conspecific social behaviors such as mating and aggression (Choi et al., 2005; Hong et al., 2014).”
From Neuronal Representation of Social Information in the Medial Amygdala of Awake Behaving Mice (2017) · cites this paper as Hong et al., 2014
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“The MeApd comprises GABAergic and glutamatergic neurons at an approximate ratio of 2:1, with GABAergic neurons representing the major population of projection neurons driving social responses (Choi et al., 2005; Hong et al., 2014; Keshavarzi et al., 2014).”
From Neuronal Representation of Social Information in the Medial Amygdala of Awake Behaving Mice (2017) · cites this paper as Hong et al., 2014
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Metadata
- Authors
- Hong, W., Kim, D.-W., & Anderson, D. J.
- Affiliations
- California Institute of Technology (US)
- Corresponding author
- Anderson, David J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 158
- Issue
- 6
- Pages
- 1348-1361
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4167378
- OpenAlex
- W2065254519
- Cited by
- 405
- References
- 68
- Citations by year
- 2026: 17 · 2025: 39 · 2024: 32 · 2023: 38 · 2022: 39 · 2021: 45 · 2020: 51 · 2019: 29 · 2018: 30 · 2017: 31 · 2016: 25 · 2015: 25 · 2014: 3
- FWCI
- 15.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- Simons Foundation
- California Institute of Technology
- National Institutes of Health
- National Institute of Mental Health (MH085082, MH070053, R01MH085082, R01MH070053)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- medial amygdala, social behavior, aggression, GABAergic neurons, glutamatergic neurons, neuronal subpopulations, asocial behavior
- MeSH terms
- Aggression, Amygdala, Animals, Female, gamma-Aminobutyric Acid, Grooming, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, Neurons, Social Behavior, Mice, In Vitro Techniques
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