The DOI matches its Crossref record; 151 of the 151 references it cites were found in a registry or an index.
Promoting Health and Longevity through Diet: From Model Organisms to Humans
Open accessAbstract
Reduced food intake, avoiding malnutrition, can ameliorate aging and aging-associated diseases in invertebrate model organisms, rodents, primates, and humans. Recent findings indicate that meal timing is crucial, with both intermittent fasting and adjusted diurnal rhythm of feeding improving health and function, in the absence of changes in overall intake. Lowered intake of particular nutrients rather than of overall calories is also key, with protein and specific amino acids playing prominent roles. Nutritional modulation of the microbiome can also be important, and there are long-term, including inter-generational, effects of diet. The metabolic, molecular, and cellular mechanisms that mediate both improvement in health during aging to diet and genetic variation in the response to diet are being identified. These new findings are opening the way to specific dietary and pharmacological interventions to recapture the full potential benefits of dietary restriction, which humans can find difficult to maintain voluntarily.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Accordingly, long-lived animals, including the naked mole-rat, rodents maintained on calorie restricted (CR) and intermittent fasting (IF) diets, and long-lived daf-2 mutant worms exhibit decreased levels of oxidative damage and are more resistant to oxidative stress (Fontana and Partridge, 2015; Guarente and Kenyon, 2000; Pérez et al., 2009).”
From NAD+ in Brain Aging and Neurodegenerative Disorders (2019) · cites this paper as Fontana and Partridge, 2015
In the citing paper
“Exercise and dietary changes, including caloric restriction and intermittent fasting, can slow and even reverse the progression of aging (Brandhorst et al., 2015; Fontana and Partridge, 2015; Garatachea et al., 2015; Mercken et al., 2012)”
From The Aging Epigenome (2016) · cites this paper as Fontana and Partridge, 2015
In the citing paper
“The effects of caloric restriction can be long lasting and even be passed on to the next generation (Fontana and Partridge, 2015).”
From The Aging Epigenome (2016) · cites this paper as Fontana and Partridge, 2015
In the citing paper
“Changes in diet and exercise impact the activity of various longevity regulatory mechanisms, including insulin/IGF signaling and the nutrient-sensing kinase AMPK, and can alter the expression of many genes (Fontana and Partridge, 2015; Garatachea et al., 2015).”
From The Aging Epigenome (2016) · cites this paper as Fontana and Partridge, 2015
In the citing paper
“the initiation timing and duration of these metabolic interventions (exercise and diet changes) can alter their effect on longevity, suggesting that context is an important factor and that these are not “one size fits all” interventions (Fontana and Partridge, 2015).”
From The Aging Epigenome (2016) · cites this paper as Fontana and Partridge, 2015
In the citing paper
“However, accumulating data from a combination of epidemiological, human clinical trials, animal and molecular studies indicate that diet remains a key factor in the prevention of cardiovascular disease, obesity, type 2 diabetes and some of the most common types of cancer (6).”
From Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms (2018) · cites this paper as [6]
In the citing paper
“Both the quantity and quality of what we eat is essential to promote metabolic and molecular health (6).”
From Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms (2018) · cites this paper as [6]
In the citing paper
“Additionally, CR is considered the most robust intervention to increase longevity in animal model systems and ameliorate age-associated disease in primates and humans (see “Prolonged fasting and caloric/dietary restriction” and “Aging”) (38).”
From Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease (2018) · cites this paper as [38]
In the citing paper
“Dietary restrictions have been shown to increase lifespan and healthspan in all animal models of aging (e.g., yeast, C. elegans, Drosophila, mouse) [239,289,290,291].”
From The mitochondrial permeability transition: Nexus of aging, disease and longevity (2021) · cites this paper as [289]
In the citing paper
“Similar to CR, IF improves multiple markers of health and increases longevity (Fontana and Partridge, 2015).”
From Mitochondrial (Dys)function and Insulin Resistance: From Pathophysiological Molecular Mechanisms to the Impact of Diet (2019) · cites this paper as Fontana and Partridge, 2015
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Diet rapidly and reproducibly alters the human gut microbiome
David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100
Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80611-x · Cited by 4,139
The impact of the gut microbiota on human health: an integrative view
Clemente, J. C., Ursell, L. K., Parfrey, L. W., & Knight, R. (2012) · Cell · doi:10.1016/j.cell.2012.01.035 · Cited by 3,710
Extending Healthy Life Span—From Yeast to Humans
Fontana, L., Partridge, L., & Longo, V. D. (2010) · Science · doi:10.1126/science.1172539 · Cited by 3,023
Self-citationTreg induction by a rationally selected mixture of Clostridia strains from the human microbiota
Atarashi, K., Tanoue, T., Oshima, K., Suda, W., Nagano, Y., Nishikawa, H., Fukuda, S., Saito, T., Narushima, S., Hase, K., et al. (2013) · Nature · doi:10.1038/nature12331 · Cited by 2,872
Kenyon, C. J. (2010) · Nature · doi:10.1038/nature08980 · Cited by 2,739
The thrifty phenotype hypothesis
Hales, C. N., & Barker, D. J. (2001) · British Medical Bulletin · doi:10.1093/bmb/60.1.5 · Cited by 2,722
Adverse metabolic and cardiovascular consequences of circadian misalignment
Scheer, F. A. J. L., Hilton, M. F., Mantzoros, C. S., & Shea, S. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808180106 · Cited by 2,351
Diet Drives Convergence in Gut Microbiome Functions Across Mammalian Phylogeny and Within Humans
Muegge, B. D., Kuczynski, J., Knights, D., Clemente, J. C., González, A., Fontana, L., Henrissat, B., Knight, R., & Gordon, J. I. (2011) · Science · doi:10.1126/science.1198719 · Cited by 1,988
Self-citationHatori, M., Vollmers, C., Zarrinpar, A., DiTacchio, L., Bushong, E. A., Gill, S., Leblanc, M., Chaix, A., Joens, M., Fitzpatrick, J. A. J., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.019 · Cited by 1,986
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–200 of 1,001
Strategies and Challenges in Clinical Trials Targeting Human Aging
Newman, J. C., Milman, S., Hashmi, S. K., Austad, S. N., Kirkland, J. L., Halter, J. B., & Barzilai, N. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw149 · Cited by 141
Internal states drive nutrient homeostasis by modulating exploration-exploitation trade-off
Corrales-Carvajal, V. M., Faisal, A. A., & Ribeiro, C. (2016) · eLife · doi:10.7554/elife.19920 · Cited by 143
Glycogen controls Caenorhabditis elegans lifespan and resistance to oxidative stress
Gusarov, I., Pani, B., Gautier, L., Смоленцева, О. А., Eremina, S. Y., Shamovsky, I., Katkova-Zhukotskaya, O. A., Mironov, A. S., & Nudler, E. (2017) · Nature Communications · doi:10.1038/ncomms15868 · Cited by 143
Macronutrients and caloric intake in health and longevity
Solon‐Biet, S. M., Mitchell, S. J., de Cabo, R., Raubenheimer, D., Couteur, D. G. L., & Simpson, S. J. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0173 · Cited by 140
Inflammaging as a target for healthy ageing
Dugan, B., Conway, J., & Duggal, N. A. (2023) · Age and Ageing · doi:10.1093/ageing/afac328 · Cited by 154
Choi, I. Y., Lee, C., & Longo, V. D. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.01.042 · Cited by 133
The Role of Immunosenescence in Neurodegenerative Diseases
Costantini, E., D’Angelo, C., & Reale, M. (2018) · Mediators of Inflammation · doi:10.1155/2018/6039171 · Cited by 133
Widespread sex dimorphism in aging and age-related diseases
Sampathkumar, N. K., Bravo, J. I., Chen, Y., Danthi, P. S., Donahue, E. K., Lai, R. W., Lu, R. J., Randall, L. T., Vinson, N. M., & Benayoun, B. A. (2019) · Human Genetics · doi:10.1007/s00439-019-02082-w · Cited by 130
Emerging use of senolytics and senomorphics against aging and chronic diseases
Martel, J., Ojcius, D. M., Wu, C., Peng, H., Voisin, L., Perfettini, J., Ko, Y., & Young, J. D. (2020) · Medicinal Research Reviews · doi:10.1002/med.21702 · Cited by 127
Diurnal transcriptome landscape of a multi-tissue response to time-restricted feeding in mammals
Deota, S., Lin, T. C., Chaix, A., Williams, A. E., Le, H. D., Calligaro, H., Ramasamy, R., Huang, L., & Panda, S. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2022.12.006 · Cited by 142
Metabolic Reprogramming in Autosomal Dominant Polycystic Kidney Disease
Nowak, K. L., & Hopp, K. (2020) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.13291019 · Cited by 128
The Multifaceted Role of Nutrient Sensing and mTORC1 Signaling in Physiology and Aging
Fernandes, S., & Demetriades, C. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.707372 · Cited by 131
Carcinogenicity assessment: Addressing the challenges of cancer and chemicals in the environment
Madia, F., Worth, A. P., Whelan, M., & Corvi, R. (2019) · Environment International · doi:10.1016/j.envint.2019.04.067 · Cited by 124
Lv, Y., Yang, Y., Sui, B., Hu, C., Zhao, P., Liao, L., Chen, J., Zhang, L., Yang, T.-T., Zhang, S., et al. (2018) · Theranostics · doi:10.7150/thno.23620 · Cited by 123
A nutritional memory effect counteracts the benefits of dietary restriction in old mice
Hahn, O., Drews, L. F., Nguyen, A., Tatsuta, T., Gkioni, L., Hendrich, O., Zhang, Q., Langer, T., Pletcher, S. D., Wakelam, M. J. O., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0121-0 · Cited by 125
Self-citationUnraveling the metabolic health benefits of fasting related to religious beliefs: A narrative review
Persynaki, A., Karras, S. Ν., & Pichard, C. (2016) · Nutrition · doi:10.1016/j.nut.2016.10.005 · Cited by 126
Capurso, C. A., Bellanti, F., Buglio, A. L., & Vendemiale, G. (2019) · Nutrients · doi:10.3390/nu12010035 · Cited by 124
Stout, M. B., Steyn, F. J., Jurczak, M. J., Camporez, J.-P. G., Zhu, Y., Hawse, J. R., Jurk, D., Palmer, A. K., Xu, M., Pirtskhalava, T., et al. (2017) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glv309 · Cited by 119
The road ahead for health and lifespan interventions
Gonzalez-Freire, M., Diaz-Ruiz, A., Hauser, D., Martinez-Romero, J., Ferrucci, L., Bernier, M., & de Cabo, R. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101037 · Cited by 118
Circadian Metabolism: From Mechanisms to Metabolomics and Medicine
Brown, S. A. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.03.015 · Cited by 122
Autophagy in Human Health and Disease: Novel Therapeutic Opportunities
Giampieri, F., Afrin, S., Forbes-Hernández, T. Y., Gasparrini, M., Cianciosi, D., Reboredo‐Rodríguez, P., Varela‐López, A., Quiles, J. L., & Battino, M. A. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7234 · Cited by 117
Revisiting the Hallmarks of Aging to Identify Markers of Biological Age
Guerville, F., Barreto, P. D. S., Ader, I., Andrieu, S., Casteilla, L., Dray, C., Fazilleau, N., Guyonnet, S., Langin, D., Liblau, R., et al. (2020) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2019.50 · Cited by 122
Miyauchi, T., Uchida, Y., Kadono, K., Hirao, H., Kawasoe, J., Watanabe, T., Ueda, S., Okajima, H., Terajima, H., & Üemoto, S. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1820282116 · Cited by 120
Effects of dietary restriction on neuroinflammation in neurodegenerative diseases
Fontana, L., Ghezzi, L., Cross, A. H., & Piccio, L. M. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20190086 · Cited by 119
Self-citationThe role of epigenetics in renal ageing
Shiels, P. G., McGuinness, D., Eriksson, M., Kooman, J. P., & Stenvinkel, P. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.78 · Cited by 114
funRiceGenes dataset for comprehensive understanding and application of rice functional genes
Yao, W., Li, G., Yu, Y., & Ouyang, Y. (2017) · GigaScience · doi:10.1093/gigascience/gix119 · Cited by 114
Dorling, J. L., Martin, C. K., & Redman, L. M. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101038 · Cited by 104
Nutritional strategies to optimise cognitive function in the aging brain
Wahl, D., Cogger, V. C., Solon‐Biet, S. M., Waern, R. V. R., Gokarn, R., Pulpitel, T., de Cabo, R., Mattson, M. P., Raubenheimer, D., Simpson, S. J., et al. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.06.006 · Cited by 118
Protein Turnover in Aging and Longevity
Basisty, N., Meyer, J. G., & Schilling, B. (2018) · PROTEOMICS · doi:10.1002/pmic.201700108 · Cited by 111
Exercise preserves physical fitness during aging through AMPK and mitochondrial dynamics
Campos, J. C., Bozi, L. H. M., Krum, B. N., Bechara, L. R. G., Ferreira, N. D., Arini, G. S., Albuquerque, R. P. E., Traa, A., Ogawa, T., van der Bliek, A. M., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2204750120 · Cited by 121
Expansion and Cell-Cycle Arrest: Common Denominators of Cellular Senescence
Ogrodnik, M., Salmonowicz, H., Jurk, D., & Passos, J. F. (2019) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2019.06.011 · Cited by 104
Horita, C. N., Baptista, R. C., Caturla, M. Y. R., Lorenzo, J. M., Barba, F. J., & Sant’Ana, A. S. (2017) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2017.12.003 · Cited by 107
Oxidative stress, aging, antioxidant supplementation and their impact on human health: An overview
Martemucci, G., Portincasa, P., Ciaula, A. D., Mariano, M., Centonze, V., & D‘Alessandro, A. G. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111707 · Cited by 112
Regulation of RNA Polymerase I Transcription in Development, Disease, and Aging
Sharifi, S., & Bierhoff, H. (2018) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-062917-012612 · Cited by 108
The Beneficial and Adverse Effects of Autophagic Response to Caloric Restriction and Fasting
Shabkhizan, R., Haiaty, S., Moslehian, M. S., Bazmani, A., Sadeghsoltani, F., Bagheri, H. S., Rahbarghazi, R., & Sakhinia, E. (2023) · Advances in Nutrition · doi:10.1016/j.advnut.2023.07.006 · Cited by 117
Metabolism and the Epigenome: A Dynamic Relationship
Haws, S. A., Leech, C. M., & Denu, J. M. (2020) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2020.04.002 · Cited by 112
Lifestyle Behavior and Mental Health in Early Adolescence
Loewen, O. K., Maximova, K., Ekwaru, J. P., Faught, E. L., Asbridge, M., Öhinmaa, A., & Veugelers, P. J. (2019) · PEDIATRICS · doi:10.1542/peds.2018-3307 · Cited by 105
Calorie Restriction as a New Treatment of Inflammatory Diseases
Kökten, T., Hansmannel, F., Ndiaye, N. C., Heba, A.-C., Quilliot, D., Dreumont, N., Arnone, D., & Peyrin‐Biroulet, L. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa179 · Cited by 109
Enhancing and Extending Biological Performance and Resilience
Leak, R. K., Calabrese, E. J., Kozumbo, W. J., Gidday, J. M., Johnson, T. E., Mitchell, J. R., Ozaki, C. K., Wetzker, R., Bast, A., Belz, R. G., et al. (2018) · Dose-Response · doi:10.1177/1559325818784501 · Cited by 107
Cell non-autonomous regulation of health and longevity
Miller, H. A., Dean, E. S., Pletcher, S. D., & Leiser, S. F. (2020) · eLife · doi:10.7554/elife.62659 · Cited by 102
Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle
Ham, D. J., Börsch, A., Chojnowska, K., Lin, S., Leuchtmann, A. B., Ham, A. S., Thürkauf, M., Delezie, J., Furrer, R., Bürri, D., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29714-6 · Cited by 110
Epigenetics and Metabolism in Health and Disease
Tzika, E., Dreker, T., & Imhof, A. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00361 · Cited by 106
Principles of the Molecular and Cellular Mechanisms of Aging
da Silva, P. F. L., & Schumacher, B. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.11.018 · Cited by 106
Extracellular Matrix Dynamics as an Emerging yet Understudied Hallmark of Aging and Longevity
Statzer, C., Park, J. Y. C., & Ewald, C. Y. (2023) · Aging and Disease · doi:10.14336/ad.2022.1116 · Cited by 106
Obesity and Aging in the Drosophila Model
Gáliková, M., & Klepsatel, P. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19071896 · Cited by 97
Amigo, I., Menezes‐Filho, S. L., Luévano‐Martínez, L. A., Chausse, B., & Kowaltowski, A. J. (2017) · Aging Cell · doi:10.1111/acel.12527 · Cited by 95
A fast and accurate way to determine short chain fatty acids in mouse feces based on GC–MS
Han, X., Guo, J., You, Y., Yin, M., Ren, C., Zhan, J., & Huang, W. (2018) · Journal of Chromatography B · doi:10.1016/j.jchromb.2018.09.013 · Cited by 95
Yu, D., Tomasiewicz, J. L., Yang, S. E., Miller, B. R., Wakai, M. H., Sherman, D. S., Cummings, N. E., Baar, E. L., Brinkman, J. A., Syed, F. A., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.08.084 · Cited by 98
Hever, J., & Cronise, R. J. (2017) · Europe PMC (PubMed Central) · doi:10.11909/j.issn.1671-5411.2017.05.012 · Cited by 111
Interventions to promote cardiometabolic health and slow cardiovascular ageing
Fontana, L. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0026-8 · Cited by 96
Self-citationThe mitochondrial permeability transition: Nexus of aging, disease and longevity
Rottenberg, H., & Hoek, J. B. (2021) · Cells · doi:10.3390/cells10010079 · Cited by 94
Regan, J. C., Froy, H., Walling, C. A., Moatt, J. P., & Nussey, D. H. (2019) · Functional Ecology · doi:10.1111/1365-2435.13418 · Cited by 97
Region-Specific Proteome Changes of the Intestinal Epithelium during Aging and Dietary Restriction
Gebert, N., Cheng, C.-W., Kirkpatrick, J. M., Di Fraia, D., Yun, J., Schädel, P., Pace, S., Garside, G. B., Werz, O., Rudolph, K. L., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107565 · Cited by 88
Interventions for age-related diseases: Shifting the paradigm
Figueira, I., Fernandes, A. M. A., Mladenović, A., Lopez-Contreras, A. J., Henriques, C. M., Selman, C., Ferreiro, E. B., Gonos, E. S., Trejo, J. L., Misra, J., et al. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.09.009 · Cited by 92
A Metabolomic Signature of Acute Caloric Restriction
Collet, T., Sonoyama, T., Henning, E., Keogh, J. M., Ingram, B. O., Kelway, S., Guo, L., & Farooqi, I. S. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-01020 · Cited by 88
Guo, K., Su, L., Wang, Y., Liu, H., Lin, J., Peng, C., Yin, X., Liang, M., Wang, Q., & Huang, Z. (2020) · Food & Function · doi:10.1039/d0fo00560f · Cited by 88
Targeting metabolic pathways for extension of lifespan and healthspan across multiple species
Parkhitko, A. A., Filine, E., Mohr, S. E., Moskalev, A., & Perrimon, N. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101188 · Cited by 91
Nutrition and longevity—From mechanisms to uncertainties
Ekmekcioglu, C. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2019.1676698 · Cited by 87
An expanding GSK3 network: implications for aging research
Souder, D. C., & Anderson, R. M. (2019) · GeroScience · doi:10.1007/s11357-019-00085-z · Cited by 89
Chu, C., Yu, L., Qi, G., Mi, Y., Wu, W., Lee, Y. K., Zhai, Q., Tian, F., & Chen, W. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104556 · Cited by 87
The impact of diet upon mitochondrial physiology (Review)
Kyriazis, I. D., Vassi, E., Alvanou, M. V., Angelakis, C., Skaperda, Z., Tekos, F., Garikipati, V. N. S., Spandidos, D. A., & Kouretas, D. (2022) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2022.5191 · Cited by 94
Hou, Q., Huang, J., Zhao, L., Pan, X., Liao, C., Jiang, Q., Lei, J., Guo, F., Cui, J., Guo, Y., et al. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106676 · Cited by 88
Pathological mechanisms of kidney disease in ageing
Yamamoto, T., & Isaka, Y. (2024) · Nature Reviews Nephrology · doi:10.1038/s41581-024-00868-4 · Cited by 96
Wang, Y., Fu, Z., Li, X., Liang, Y., Pei, S., Hao, S., Zhu, Q., Yu, T., Pei, Y., Yuan, J., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.02.003 · Cited by 84
Dietary sugar silences a colonization factor in a mammalian gut symbiont
Townsend, G. E., Han, W., Schwalm, N. D., Raghavan, V., Barry, N. A., Goodman, A. L., & Groisman, E. A. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1813780115 · Cited by 86
Fontana, L., Mitchell, S. E., Wang, B., Tosti, V., van Vliet, T., Veronese, N., Bertozzi, B., Early, D. S., Maissan, P., Speakman, J. R., et al. (2018) · Aging Cell · doi:10.1111/acel.12746 · Cited by 81
“However, the precise mechanisms by which CR improves health are not fully understood (Speakman & Mitchell, 2011; Fontana & Partridge, 2015).”
BackgroundSelf-citationWhy the UK Needs a Social Policy on Ageing
Walker, A. (2017) · Journal of Social Policy · doi:10.1017/s0047279417000320 · Cited by 83
Recent advances in the field of caloric restriction mimetics and anti-aging molecules
Martel, J., Chang, S.-H., Wu, C.-Y., Peng, H., Hwang, T., Ko, Y., Young, J. D., & Ojcius, D. M. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101240 · Cited by 83
Zhang, B., Gong, J., Zhang, W., Xiao, R., Liu, J., & Xu, X. Z. S. (2018) · Genes & Development · doi:10.1101/gad.309625.117 · Cited by 88
Central Amino Acid Sensing in the Control of Feeding Behavior
Heeley, N., & Blouet, C. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00148 · Cited by 85
Caloric Restriction Engages Hepatic RNA Processing Mechanisms in Rhesus Monkeys
Rhoads, T. W., Burhans, M. S., Chen, V. B., Hutchins, P. D., Rush, M. J. P., Clark, J. P., Stark, J. L., McIlwain, S. J., Eghbalnia, H. R., Pavelec, D. M., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.01.014 · Cited by 83
Ali, A. M., & Kunugi, H. (2020) · Antioxidants · doi:10.3390/antiox9100937 · Cited by 88
Caloric Restriction Promotes Immunometabolic Reprogramming Leading to Protection from Tuberculosis
Palma, C., Rocca, C. L., Gigantino, V., Aquino, G., Piccaro, G., Silvestre, D. D., Brambilla, F., Rossi, R., Bonacina, F., Lepore, M. T., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2020.12.016 · Cited by 82
Drug Synergy Slows Aging and Improves Healthspan through IGF and SREBP Lipid Signaling
Admasu, T. D., Batchu, K. C., Barardo, D., Ng, L. F., Lam, V. Y. M., Xiao, L., Cazenave‐Gassiot, A., Wenk, M. R., Tolwinski, N. S., & Gruber, J. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.09.001 · Cited by 87
Preventive Effects and Mechanisms of Garlic on Dyslipidemia and Gut Microbiome Dysbiosis
Chen, K., Xie, K., Liu, Z., Nakasone, Y., Sakao, K., Hossain, M. A., & Hou, D.-X. (2019) · Nutrients · doi:10.3390/nu11061225 · Cited by 79
Wu, Y., Dong, J.-H., Dai, Y.-F., Zhu, M.-Z., Wang, M.-Y., Zhang, Y., Pan, Y.-D., Yuan, X.-R., Guo, Z.-X., Wang, C.-X., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.06.002 · Cited by 84
Hsieh, P. N., Zhou, G., Yuan, Y., Zhang, R., Prosdocimo, D. A., Sangwung, P., Borton, A. H., Boriushkin, E., Hamik, A., Fujioka, H., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00899-5 · Cited by 78
Implications of Oxidative Stress and Cellular Senescence in Age-Related Thymus Involution
Barbouti, A., Vasileiou, P. V. S., Evangelou, K., Vlasis, K. G., Papoudou‐Bai, A., Gorgoulis, V. G., & Kanavaros, P. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/7986071 · Cited by 86
Kumar, A., Joishy, T. K., Das, S., Kalita, M. C., Mukherjee, A. K., & Khan, M. R. (2022) · Antioxidants · doi:10.3390/antiox11020268 · Cited by 80
Human age reversal: Fact or fiction?
Johnson, A. A., English, B. W., Shokhirev, M. N., Sinclair, D. A., & Cuellar, T. L. (2022) · Aging Cell · doi:10.1111/acel.13664 · Cited by 85
Tanca, A., Abbondio, M., Palomba, A., Fraumene, C., Marongiu, F., Serra, M., Pagnozzi, D., Laconi, E., & Uzzau, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-33100-y · Cited by 79
Diet and Chemotherapy: The Effects of Fasting and Ketogenic Diet on Cancer Treatment
Plotti, F., Terranova, C., Luvero, D., Bartolone, M., Messina, G., Feole, L., Cianci, S., Scaletta, G., Marchetti, C., Donato, V. D., et al. (2020) · Chemotherapy · doi:10.1159/000510839 · Cited by 80
New Horizons: Dietary protein, ageing and the Okinawan ratio
Couteur, D. G. L., Solon‐Biet, S. M., Wahl, D., Cogger, V. C., Willcox, B. J., Willcox, D. C., Raubenheimer, D., & Simpson, S. J. (2016) · Age and Ageing · doi:10.1093/ageing/afw069 · Cited by 79
Gao, A. W., Chatzispyrou, I. A., Kamble, R., Liu, Y. J., Herzog, K., Smith, R. L., van Lenthe, H., Vervaart, M. A. T., van Cruchten, A., Luyf, A. C., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-02539-w · Cited by 77
Alpha-ketoglutarate as a potent regulator for lifespan and healthspan: Evidences and perspectives
Naeini, S. H., Mavaddatiyan, L., Kalkhoran, Z. R., Taherkhani, S., & Talkhabi, M. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112154 · Cited by 85
Lv, Y., Kraus, V. B., Gao, X., Yin, Z., Zhou, J., Mao, C., Duan, J., Zeng, Y., Brasher, M. S., Shi, W., et al. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.10.012 · Cited by 77
Magni, P., Bier, D. M., Pecorelli, S., Agostoni, C. V., Astrup, A. V., Brighenti, F., Cook, R., Folco, E., Fontana, L., Gibson, R. A., et al. (2017) · Advances in Nutrition · doi:10.3945/an.116.014738 · Cited by 76
Self-citationAinsworth, T. D., & Gates, R. D. (2016) · Science · doi:10.1126/science.aad9957 · Cited by 76
Regan, J. C., Lu, Y., Ureña, E., Meilenbrock, R. L., Catterson, J. H., Kißler, D., Fröhlich, J., Funk, E., & Partridge, L. (2022) · Nature Aging · doi:10.1038/s43587-022-00308-7 · Cited by 90
Self-citationMenger, K. E., James, A. M., Cochemé, H. M., Harbour, M. E., Chouchani, E. T., Ding, S., Fearnley, I. M., Partridge, L., & Murphy, M. P. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.05.033 · Cited by 74
Self-citationRasa, S. M. M., Annunziata, F., Křepelová, A., Nunna, S., Omrani, O., Gebert, N., Adam, L., Käppel, S., Hoehn, S., Donati, G., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111017 · Cited by 72
Regulation of metabolic health and aging by nutrient-sensitive signaling pathways
Richardson, N. E., & Lamming, D. W. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.11.014 · Cited by 73
Molecular mechanisms underlying metabolic syndrome: the expanding role of the adipocyte
Armani, A., Berry, A., Cirulli, F., & Caprio, M. (2017) · The FASEB Journal · doi:10.1096/fj.201601125rrr · Cited by 76
Gene expression‐based drug repurposing to target aging
Dönertaş, H. M., Fuentealba, M., Partridge, L., & Thornton, J. M. (2018) · Aging Cell · doi:10.1111/acel.12819 · Cited by 71
Self-citationHormesis in Health and Chronic Diseases
Li, X., Yang, T., & Sun, Z. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.08.007 · Cited by 79
Ferreira‐Marques, M., Aveleira, C. A., Carmo‐Silva, S., Botelho, M., de Almeida, L. P., & Cavadas, C. (2016) · Aging · doi:10.18632/aging.100996 · Cited by 74
Regulation of the Wound Healing Response during Aging
Ding, X., Kakanj, P., Leptin, M., & Eming, S. A. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.11.014 · Cited by 78
Reactive sulfur species and their significance in health and disease
Iciek, M., Bilska‐Wilkosz, A., Kozdrowicki, M., & Górny, M. (2022) · Bioscience Reports · doi:10.1042/bsr20221006 · Cited by 71
Mitochondrial responsibility in ageing process: innocent, suspect or guilty
López‐Lluch, G., Santos‐Ocaña, C., Sánchez-Alcázar, J. A., Fernández‐Ayala, D. J. M., Asencio, C., Rodríguez‐Aguilera, J. C., & Navas, P. (2015) · Biogerontology · doi:10.1007/s10522-015-9585-9 · Cited by 72
Rajpal, A., & Ismail‐Beigi, F. (2020) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14080 · Cited by 74
Metadata
- Authors
- Fontana, L., & Partridge, L.
- Affiliations
- Washington University in St. Louis (US)
- Max Planck Institute for Biology of Ageing (DE)
- Corresponding author
- Fontana, Luigi
- Partridge, Linda
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 161
- Issue
- 1
- Pages
- 106-118
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4547605
- OpenAlex
- W2096935190
- Cited by
- 1,245
- References
- 151
- Citations by year
- 2026: 65 · 2025: 98 · 2024: 99 · 2023: 94 · 2022: 121 · 2021: 158 · 2020: 141 · 2019: 130 · 2018: 121 · 2017: 91 · 2016: 94 · 2015: 33
- FWCI
- 9.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Wellcome Trust (098565)
- Bakewell Foundation
- European Commission
- Max-Planck-Gesellschaft
- National Institute on Aging
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK056341)
- National Center for Research Resources (UL1RR024992)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- dietary restriction, aging, longevity, intermittent fasting, meal timing, circadian feeding rhythm, protein restriction, amino acids, gut microbiota, age-related diseases, pharmacological interventions
- MeSH terms
- Aging, Animals, Diet, Health Promotion, Humans, Longevity, Models, Animal, Caloric Restriction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
