The DOI matches its Crossref record; 151 of the 151 references it cites were found in a registry or an index.
Promoting Health and Longevity through Diet: From Model Organisms to Humans
Open accessAbstract
Reduced food intake, avoiding malnutrition, can ameliorate aging and aging-associated diseases in invertebrate model organisms, rodents, primates, and humans. Recent findings indicate that meal timing is crucial, with both intermittent fasting and adjusted diurnal rhythm of feeding improving health and function, in the absence of changes in overall intake. Lowered intake of particular nutrients rather than of overall calories is also key, with protein and specific amino acids playing prominent roles. Nutritional modulation of the microbiome can also be important, and there are long-term, including inter-generational, effects of diet. The metabolic, molecular, and cellular mechanisms that mediate both improvement in health during aging to diet and genetic variation in the response to diet are being identified. These new findings are opening the way to specific dietary and pharmacological interventions to recapture the full potential benefits of dietary restriction, which humans can find difficult to maintain voluntarily.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Accordingly, long-lived animals, including the naked mole-rat, rodents maintained on calorie restricted (CR) and intermittent fasting (IF) diets, and long-lived daf-2 mutant worms exhibit decreased levels of oxidative damage and are more resistant to oxidative stress (Fontana and Partridge, 2015; Guarente and Kenyon, 2000; Pérez et al., 2009).”
From NAD+ in Brain Aging and Neurodegenerative Disorders (2019) · cites this paper as Fontana and Partridge, 2015
In the citing paper
“Exercise and dietary changes, including caloric restriction and intermittent fasting, can slow and even reverse the progression of aging (Brandhorst et al., 2015; Fontana and Partridge, 2015; Garatachea et al., 2015; Mercken et al., 2012)”
From The Aging Epigenome (2016) · cites this paper as Fontana and Partridge, 2015
In the citing paper
“The effects of caloric restriction can be long lasting and even be passed on to the next generation (Fontana and Partridge, 2015).”
From The Aging Epigenome (2016) · cites this paper as Fontana and Partridge, 2015
In the citing paper
“Changes in diet and exercise impact the activity of various longevity regulatory mechanisms, including insulin/IGF signaling and the nutrient-sensing kinase AMPK, and can alter the expression of many genes (Fontana and Partridge, 2015; Garatachea et al., 2015).”
From The Aging Epigenome (2016) · cites this paper as Fontana and Partridge, 2015
In the citing paper
“the initiation timing and duration of these metabolic interventions (exercise and diet changes) can alter their effect on longevity, suggesting that context is an important factor and that these are not “one size fits all” interventions (Fontana and Partridge, 2015).”
From The Aging Epigenome (2016) · cites this paper as Fontana and Partridge, 2015
In the citing paper
“However, accumulating data from a combination of epidemiological, human clinical trials, animal and molecular studies indicate that diet remains a key factor in the prevention of cardiovascular disease, obesity, type 2 diabetes and some of the most common types of cancer (6).”
From Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms (2018) · cites this paper as [6]
In the citing paper
“Both the quantity and quality of what we eat is essential to promote metabolic and molecular health (6).”
From Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms (2018) · cites this paper as [6]
In the citing paper
“Additionally, CR is considered the most robust intervention to increase longevity in animal model systems and ameliorate age-associated disease in primates and humans (see “Prolonged fasting and caloric/dietary restriction” and “Aging”) (38).”
From Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease (2018) · cites this paper as [38]
In the citing paper
“Dietary restrictions have been shown to increase lifespan and healthspan in all animal models of aging (e.g., yeast, C. elegans, Drosophila, mouse) [239,289,290,291].”
From The mitochondrial permeability transition: Nexus of aging, disease and longevity (2021) · cites this paper as [289]
In the citing paper
“Similar to CR, IF improves multiple markers of health and increases longevity (Fontana and Partridge, 2015).”
From Mitochondrial (Dys)function and Insulin Resistance: From Pathophysiological Molecular Mechanisms to the Impact of Diet (2019) · cites this paper as Fontana and Partridge, 2015
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Diet rapidly and reproducibly alters the human gut microbiome
David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100
Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80611-x · Cited by 4,139
The impact of the gut microbiota on human health: an integrative view
Clemente, J. C., Ursell, L. K., Parfrey, L. W., & Knight, R. (2012) · Cell · doi:10.1016/j.cell.2012.01.035 · Cited by 3,710
Extending Healthy Life Span—From Yeast to Humans
Fontana, L., Partridge, L., & Longo, V. D. (2010) · Science · doi:10.1126/science.1172539 · Cited by 3,023
Self-citationTreg induction by a rationally selected mixture of Clostridia strains from the human microbiota
Atarashi, K., Tanoue, T., Oshima, K., Suda, W., Nagano, Y., Nishikawa, H., Fukuda, S., Saito, T., Narushima, S., Hase, K., et al. (2013) · Nature · doi:10.1038/nature12331 · Cited by 2,872
Kenyon, C. J. (2010) · Nature · doi:10.1038/nature08980 · Cited by 2,739
The thrifty phenotype hypothesis
Hales, C. N., & Barker, D. J. (2001) · British Medical Bulletin · doi:10.1093/bmb/60.1.5 · Cited by 2,722
Adverse metabolic and cardiovascular consequences of circadian misalignment
Scheer, F. A. J. L., Hilton, M. F., Mantzoros, C. S., & Shea, S. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808180106 · Cited by 2,351
Diet Drives Convergence in Gut Microbiome Functions Across Mammalian Phylogeny and Within Humans
Muegge, B. D., Kuczynski, J., Knights, D., Clemente, J. C., González, A., Fontana, L., Henrissat, B., Knight, R., & Gordon, J. I. (2011) · Science · doi:10.1126/science.1198719 · Cited by 1,988
Self-citationHatori, M., Vollmers, C., Zarrinpar, A., DiTacchio, L., Bushong, E. A., Gill, S., Leblanc, M., Chaix, A., Joens, M., Fitzpatrick, J. A. J., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.019 · Cited by 1,986
Transgenerational epigenetic inheritance: myths and mechanisms
Heard, E., & Martienssen, R. A. (2014) · Cell · doi:10.1016/j.cell.2014.02.045 · Cited by 1,864
Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor
Shimazu, T., Hirschey, M. D., Newman, J., He, W., Shirakawa, K., Le Moan, N., Grueter, C. A., Lim, H., Saunders, L. R., Stevens, R. D., et al. (2013) · Science · doi:10.1126/science.1227166 · Cited by 1,777
mTOR is a key modulator of ageing and age-related disease
Johnson, S. C., Rabinovitch, P. S., & Kaeberlein, M. (2013) · Nature · doi:10.1038/nature11861 · Cited by 1,676
Heat shock factors: integrators of cell stress, development and lifespan
Åkerfelt, M., Morimoto, R. I., & Sistonen, L. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2938 · Cited by 1,516
Fairburn, C. G., & Harrison, P. J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12378-1 · Cited by 1,396
Carone, B. R., Fauquier, L., Habib, N., Shea, J. M., Hart, C. E., Li, R., Bock, C., Li, C., Gu, H., Zamore, P. D., et al. (2010) · Cell · doi:10.1016/j.cell.2010.12.008 · Cited by 1,191
Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
Mattison, J. A., Roth, G. S., Beasley, T. M., Tilmont, E. M., Handy, A. M., Herbert, R. L., Longo, D. L., Allison, D. B., Young, J. E., Bryant, M., et al. (2012) · Nature · doi:10.1038/nature11432 · Cited by 1,145
The insulin and insulin-like growth factor receptor family in neoplasia: an update
Pollak, M. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3215 · Cited by 1,116
Heilbronn, L. K., de Jonge, L., Frisard, M. I., DeLany, J. P., Larson-Meyer, D. E., Rood, J., Nguyen, T., Martin, C. K., Volaufova, J., Most, M. M., et al. (2006) · JAMA · doi:10.1001/jama.295.13.1539 · Cited by 969
Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism
Cabreiro, F., Au, C., Leung, K.-Y., Vergara-Irigaray, N., Cochemé, H. M., Noori, T., Weinkove, D., Schuster, E., Greene, N. D. E., & Gems, D. (2013) · Cell · doi:10.1016/j.cell.2013.02.035 · Cited by 967
Chaix, A., Zarrinpar, A., Miu, P., & Panda, S. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.11.001 · Cited by 956 · cited 2×
“Time-restricted feeding of mice during 8 hours of the dark phase of the daily cycle does not affect overall calorie intake of mice on a high fat diet, but restores normal circadian rhythms of activity in metabolic pathways and protects the mice against weight gain, fat accumulation, inflammation, glucose intolerance,…”
Diet and feeding pattern affect the diurnal dynamics of the gut microbiome
Zarrinpar, A., Chaix, A., Yooseph, S., & Panda, S. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.11.008 · Cited by 926
Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans
Tullet, J. M. A., Hertweck, M., An, J. H., Baker, J., Hwang, J. Y., Liu, S., Oliveira, R. P., Baumeister, R., & Blackwell, T. K. (2008) · Cell · doi:10.1016/j.cell.2008.01.030 · Cited by 923
Solon-Biet, S. M., McMahon, A. C., Ballard, J. W. O., Ruohonen, K., Wu, L. E., Cogger, V. C., Warren, A., Huang, X., Pichaud, N., Melvin, R. G., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.02.009 · Cited by 904
Diet, metabolites, and “western-lifestyle” inflammatory diseases
Thorburn, A. N., Macia, L., & Mackay, C. R. (2014) · Immunity · doi:10.1016/j.immuni.2014.05.014 · Cited by 879 · cited 4×
“G-protein-coupled receptors expressed by enteroendocrine and immune cells may be important mediators of the effects of the microbiome (Thorburn et al., 2014).”
InfluentialHarvie, M. N., Pegington, M., Mattson, M. P., Frystyk, J., Dillon, B., Evans, G., Cuzick, J., Jebb, S. A., Martin, B., Cutler, R. G., et al. (2011) · International Journal of Obesity · doi:10.1038/ijo.2010.171 · Cited by 804
Greer, E. L., Dowlatshahi, D., Banko, M. R., Villen, J., Hoang, K., Blanchard, D., Gygi, S. P., & Brunet, A. (2007) · Current Biology · doi:10.1016/j.cub.2007.08.047 · Cited by 801
Autophagy in the Cellular Energetic Balance
Singh, R., & Cuervo, A. M. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.04.004 · Cited by 788
Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila
Grandison, R. C., Piper, M. D. W., & Partridge, L. (2009) · Nature · doi:10.1038/nature08619 · Cited by 785
Self-citationFasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy
Lee, C. D., Raffaghello, L., Brandhorst, S., Safdie, F. M., Bianchi, G., Martín‐Montalvo, A., Pistoia, V., Wei, M., Hwang, S., Merlino, A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003293 · Cited by 734
Reprogramming of the Circadian Clock by Nutritional Challenge
Eckel‐Mahan, K. L., Patel, V. R., de Mateo, S., Orozco-Solís, R., Ceglia, N., Sahar, S., Dilag-Penilla, S. A., Dyar, K. A., Baldi, P., & Sassone‐Corsi, P. (2013) · Cell · doi:10.1016/j.cell.2013.11.034 · Cited by 732
Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys
Colman, R. J., Beasley, T. M., Kemnitz, J. W., Johnson, S. C., Weindruch, R., & Anderson, R. M. (2014) · Nature Communications · doi:10.1038/ncomms4557 · Cited by 711
Metabolic Regulation of Epigenetics
Lu, C., & Thompson, C. B. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.06.001 · Cited by 699
Miller, R. A., Buehner, G., Chang, Y., Harper, J. M., Sigler, R., & Smith‐Wheelock, M. (2005) · Aging Cell · doi:10.1111/j.1474-9726.2005.00152.x · Cited by 681
With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging
Kapahi, P., Chen, D., Rogers, A. N., Katewa, S. D., Li, P. W.-L., Thomas, E., & Kockel, L. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.05.001 · Cited by 678
Shift work and chronic disease: the epidemiological evidence
Wang, X.-S., Armstrong, M. E. G., Cairns, B. J., Key, T. J., & Travis, R. C. (2011) · Occupational Medicine · doi:10.1093/occmed/kqr001 · Cited by 670
FOXO transcription factors: key regulators of cellular quality control
Webb, A. E., & Brunet, A. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.02.003 · Cited by 650
Timing of food intake predicts weight loss effectiveness
Garaulet, M., Gómez-Abellán, P., Alburquerque-Béjar, J. J., Lee, Y.-C., Ordovás, J. M., & Scheer, F. A. J. L. (2013) · International Journal of Obesity · doi:10.1038/ijo.2012.229 · Cited by 639
In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism
Radford, E. J., Ito, M., Shi, H., Corish, J. A., Yamazawa, K., ISGANAITIS, E. M., Seisenberger, S., Hore, T. A., Reik, W., Erkek, S., et al. (2014) · Science · doi:10.1126/science.1255903 · Cited by 627
The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR
Chin, R., Fu, X., Pai, M. Y., Vergnes, L., Hwang, H., Deng, G., Diep, S., Lomenick, B., Meli, V. S., Monsalve, G. C., et al. (2014) · Nature · doi:10.1038/nature13264 · Cited by 624
Aging and Survival: The Genetics of Life Span Extension by Dietary Restriction
Mair, W. B., & Dillin, A. G. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.061206.171059 · Cited by 614
The GH/IGF-1 axis in ageing and longevity
Junnila, R. K., List, E. O., Berryman, D. E., Murrey, J. W., & Kopchick, J. J. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.67 · Cited by 574
Regulation of lifespan by sensory perception in Caenorhabditis elegans
Apfeld, J., & Kenyon, C. (1999) · Nature · doi:10.1038/45544 · Cited by 573
Endogenous hydrogen sulfide production is essential for dietary restriction benefits
Hine, C., Harputlugil, E., Zhang, Y., Ruckenstuhl, C., Lee, B. C., Brace, L., Longchamp, A., Treviño-Villarreal, J. H., Mejia, P., Ozaki, C. K., et al. (2015) · Cell · doi:10.1016/j.cell.2014.11.048 · Cited by 558
Starvation-Induced Transgenerational Inheritance of Small RNAs in C. elegans
Rechavi, O., Houri-Ze’evi, L., Anava, S., Goh, W. S. S., Kerk, S. Y., Hannon, G. J., & Hobert, O. (2014) · Cell · doi:10.1016/j.cell.2014.06.020 · Cited by 552
Meal frequency and timing in health and disease
Mattson, M. P., Allison, D. B., Fontana, L., Harvie, M., Longo, V. D., Malaisse, W. J., Mosley, M., Notterpek, L. M., Ravussin, É., Scheer, F. A. J. L., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1413965111 · Cited by 552
Self-citationCalories Do Not Explain Extension of Life Span by Dietary Restriction in Drosophila
Mair, W. B., Piper, M. D. W., & Partridge, L. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030223 · Cited by 528
Self-citationDemography of Dietary Restriction and Death in Drosophila
Mair, W. B., Goymer, P., Pletcher, S. D., & Partridge, L. (2003) · Science · doi:10.1126/science.1086016 · Cited by 526
Self-citationLiao, C., Rikke, B. A., Johnson, T. E., Diaz, V., & Nelson, J. F. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2009.00533.x · Cited by 501
Cheng, C., Adams, G. B., Perin, L., Wei, M., Zhou, X., Lam, B. S., Sacco, S. D., Mirisola, M. G., Quinn, D. I., Dorff, T. B., et al. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.04.014 · Cited by 491
Reduced IGF-1 signaling delays age-associated proteotoxicity in mice
Cohen, E., Paulsson, J. F., Blinder, P., Burstyn-Cohen, T., Du, D., Estepa, G., Adame, A., Pham, H. M., Holzenberger, M., Kelly, J. W., et al. (2009) · Cell · doi:10.1016/j.cell.2009.11.014 · Cited by 488
AMPK at the Nexus of Energetics and Aging
Burkewitz, K., Zhang, Y., & Mair, W. B. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.002 · Cited by 483
Calorie restriction and sirtuins revisited
Guarente, L. (2013) · Genes & Development · doi:10.1101/gad.227439.113 · Cited by 464
PGRP-SC2 Promotes Gut Immune Homeostasis to Limit Commensal Dysbiosis and Extend Lifespan
Guo, L., Karpac, J., Tran, S. L., & Jasper, H. (2014) · Cell · doi:10.1016/j.cell.2013.12.018 · Cited by 464
Structural modulation of gut microbiota in life-long calorie-restricted mice
Zhang, C., Li, S., Yang, L., Huang, P., Li, W., Wang, S., Zhao, G., Zhang, M., Pang, X., Yan, Z., et al. (2013) · Nature Communications · doi:10.1038/ncomms3163 · Cited by 461
Optimal protein intake in the elderly
Wolfe, R. R., Miller, S. L., & Miller, K. B. (2008) · Clinical Nutrition · doi:10.1016/j.clnu.2008.06.008 · Cited by 456
Amino acids and mTORC1: from lysosomes to disease
Efeyan, A., Zoncu, R., & Sabatini, D. M. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.05.007 · Cited by 436 · cited 6×
“Dietary protein intake is an important regulator of the IGF-1/mTOR network (Efeyan et al, 2012).”
InfluentialThe nexus of chromatin regulation and intermediary metabolism
Gut, P., & Verdin, E. M. (2013) · Nature · doi:10.1038/nature12752 · Cited by 431
Yuan, R., Tsaih, S., Petkova, S. B., de Evsikova, C. M., Xing, S., Marion, M. A., Bogue, M. A., Mills, K. D., Peters, L. L., Bult, C. J., et al. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00478.x · Cited by 422
Fasting and cancer treatment in humans: A case series report
Safdie, F. M., Dorff, T. B., Quinn, D. I., Fontana, L., Wei, M., Lee, C. D., Cohen, P., & Longo, V. D. (2009) · Aging · doi:10.18632/aging.100114 · Cited by 410
Self-citationPaternal Diet Defines Offspring Chromatin State and Intergenerational Obesity
Öst, A., Lempradl, A., Casas, E., Weigert, M., Tiko, T., Deniz, M., Pantano, L., Boenisch, U., Itskov, P. M., Stoeckius, M., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.005 · Cited by 406
Sex and Death: What Is the Connection?
Partridge, L., Gems, D., & Withers, D. J. (2005) · Cell · doi:10.1016/j.cell.2005.01.026 · Cited by 402
Self-citationFontana, L., Weiss, E. P., Villareal, D. T., Klein, S., & Holloszy, J. O. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00417.x · Cited by 396
Self-citationRegulation of C. elegans Longevity by Specific Gustatory and Olfactory Neurons
Alcedo, J., & Kenyon, C. (2004) · Neuron · doi:10.1016/s0896-6273(03)00816-x · Cited by 388
Early Life Nutrition, Epigenetics and Programming of Later Life Disease
Vickers, M. (2014) · Nutrients · doi:10.3390/nu6062165 · Cited by 366
Nutritional Influences on Aging of Fischer 344 Rats: II. Pathology
Maeda, H., Gleiser, C. A., Masoro, E. J., Murata, I., McMahan, C. A., & Yu, B. (1985) · Journal of Gerontology · doi:10.1093/geronj/40.6.671 · Cited by 362
Lifespan extension in Caenorhabditis elegans by complete removal of food
Kaeberlein, T. L., Smith, E. D., Tsuchiya, M., Welton, K. L., Thomas, J. H., Fields, S., Kennedy, B. K., & Kaeberlein, M. R. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00238.x · Cited by 350
Pembrey, M., Saffery, R., Bygren, L. O., & Network in Epigenetic Epidemiology (2014) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2014-102577 · Cited by 325
Optimization of Dietary Restriction Protocols in Drosophila
Bass, T. M., Grandison, R. C., Wong, R., Martinez, P., Partridge, L., & Piper, M. D. W. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.10.1071 · Cited by 325
Self-citationConnecting threads: epigenetics and metabolism
Katada, S., Imhof, A., & Sassone-Corsi, P. (2012) · Cell · doi:10.1016/j.cell.2012.01.001 · Cited by 315
Gut microbiota dictates the metabolic response ofDrosophilato diet
Wong, A. C.-N., Dobson, A. J., & Douglas, A. E. (2014) · Journal of Experimental Biology · doi:10.1242/jeb.101725 · Cited by 311
Dietary deprivation extends lifespan in Caenorhabditis elegans
Lee, G. D., Wilson, M. A., Zhu, M., Wolkow, C. A., De Cabo, R., Ingram, D. K., & Zou, S. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00241.x · Cited by 307
Transgenerational developmental programming
Aiken, C., & Ozanne, S. E. (2013) · Human Reproduction Update · doi:10.1093/humupd/dmt043 · Cited by 295
Daddy Issues: Paternal Effects on Phenotype
Rando, O. J. (2012) · Cell · doi:10.1016/j.cell.2012.10.020 · Cited by 292
Goodrick, C. L., Ingram, D. K., Reynolds, M. A., Freeman, J. R., & Cider, N. (1990) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(90)90107-q · Cited by 279
Zimmerman, J. A. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00149-3 · Cited by 279
Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans
Honjoh, S., Yamamoto, T., Uno, M., & Nishida, E. (2008) · Nature · doi:10.1038/nature07583 · Cited by 275
Goldman, D. P., Cutler, D., Rowe, J. W., Michaud, P.-C., Sullivan, J., Peneva, D., & Olshansky, S. J. (2013) · Health Affairs · doi:10.1377/hlthaff.2013.0052 · Cited by 274
Medical research: Treat ageing
Fontana, L., Kennedy, B. K., Longo, V. D., Seals, D. R., & Melov, S. (2014) · Nature · doi:10.1038/511405a · Cited by 271
Self-citationWatson, E. V., MacNeil, L. T., Ritter, A. D., Yilmaz, L. S., Rosebrock, A. P., Caudy, A. A., & Walhout, A. J. M. (2014) · Cell · doi:10.1016/j.cell.2014.01.047 · Cited by 269
Mercken, E. M., Crosby, S. D., Lamming, D. W., JeBailey, L., Krzysik‐Walker, S., Villareal, D. T., Capri, M., Franceschi, C., Zhang, Y., Becker, K., et al. (2013) · Aging Cell · doi:10.1111/acel.12088 · Cited by 261
Self-citationMitochondrial oxidative stress, aging and caloric restriction: The protein and methionine connection
Pamplona, R., & Barja, G. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.01.009 · Cited by 256
To Grow or Not to Grow: Nutritional Control of Development DuringCaenorhabditis elegansL1 Arrest
Baugh, L. R. (2013) · Genetics · doi:10.1534/genetics.113.150847 · Cited by 251
Protein and amino acid restriction, aging and disease: from yeast to humans
Mirzaei, H., Suarez, J. A., & Longo, V. D. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.07.002 · Cited by 249
Hydrogen sulfide increases thermotolerance and lifespan in Caenorhabditis elegans
Miller, D. L., & Roth, M. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710191104 · Cited by 222
Comparative and meta‐analytic insights into life extension via dietary restriction
Nakagawa, S., Lagisz, M., Hector, K. L., & Spencer, H. G. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00798.x · Cited by 219
Edrey, Y. H., Hanes, M. A., Pinto, M., Mele, J., & Buffenstein, R. (2011) · ILAR Journal · doi:10.1093/ilar.52.1.41 · Cited by 216
Adult-onset calorie restriction and fasting delay spontaneous tumorigenesis in p53-deficient mice
Berrigan, D. A. (2002) · Carcinogenesis · doi:10.1093/carcin/23.5.817 · Cited by 216
Does caloric restriction extend life in wild mice?
Harper, J. M., Leathers, C. W., & Austad, S. N. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00236.x · Cited by 213
NAD + metabolism: A therapeutic target for age-related metabolic disease
Mouchiroud, L., Houtkooper, R. H., & Auwerx, J. (2013) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2013.789479 · Cited by 193 · cited 4×
“2014), TOR (Kapahi et al., 2010; Johnson et al., 2013), AMPK (Geer et al., 2007; Burkewitz et al. 2014), sirtuins (Mouchiroud et al., 2013; Guarente.”
InfluentialPutting the Balance Back in Diet
Simpson, S. J., Couteur, D. G. L., & Raubenheimer, D. (2015) · Cell · doi:10.1016/j.cell.2015.02.033 · Cited by 188
Partridge, L. (2009) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2009.0222 · Cited by 174
Self-citationNutrient control of Drosophila longevity
Tatar, M., Post, S., & Yu, K. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.02.006 · Cited by 164
Marrero, D. G. (2012) · Springer eBooks · doi:10.1007/978-1-4419-1005-9_1199 · Cited by 163
Ruminations on dietary restriction and aging
Kennedy, B. K., Steffen, K. K., & Kaeberlein, M. R. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6470-y · Cited by 161
Molecular mechanisms underlying genotype‐dependent responses to dietary restriction
Schleit, J., Johnson, S. C., Bennett, C. F., Simko, M., Trongtham, N., Castanza, A., Hsieh, E. J., Moller, R. M., Wasko, B. M., Delaney, J. R., et al. (2013) · Aging Cell · doi:10.1111/acel.12130 · Cited by 159
DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans
Pinkston-Gosse, J., & Kenyon, C. J. (2007) · Nature Genetics · doi:10.1038/ng.2007.1 · Cited by 154
Surgical Stress Resistance Induced by Single Amino Acid Deprivation RequiresGcn2in Mice
Peng, W., Robertson, L. T., Gallinetti, J., Mejia, P., Vose, S. C., Charlip, A., Chu, T., & Mitchell, J. R. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3002629 · Cited by 147
Increased transsulfuration mediates longevity and dietary restriction in Drosophila
Kabil, H., Kabil, Ö., Banerjee, R. V., Harshman, L. G., & Pletcher, S. D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102008108 · Cited by 147
Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice
Killick, R., Scales, G., Leroy, K., Čaušević, M., Hooper, C., Irvine, E. E., Choudhury, A. I., Drinkwater, L., Kerr, F., Al‐Qassab, H., et al. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.06.032 · Cited by 138
Fontana, L., Adelaiye-Ogala, R. M., Rastelli, A. L., Miles, K. M., Ciamporcero, E. S., Longo, V. D., Nguyen, H. M., Vessella, R. L., & Пили, Р. (2013) · Oncotarget · doi:10.18632/oncotarget.1586 · Cited by 132
Self-citationNRF2, cancer and calorie restriction
Martín‐Montalvo, A., Villalba, J. M., Navas, P., & de Cabo, R. (2010) · Oncogene · doi:10.1038/onc.2010.492 · Cited by 129
Will calorie restriction work in humans?
Cava, E., & Fontana, L. (2013) · Aging · doi:10.18632/aging.100581 · Cited by 124
Self-citationRadford, E. J., ISGANAITIS, E. M., Jiménez‐Chillarón, J. C., Schroeder, J., Molla, M. N., Andrews, S., Didier, N., Charalambous, M., McEwen, K. R., Marazzi, G., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002605 · Cited by 120
A Fasting-Responsive Signaling Pathway that Extends Life Span in C. elegans
Uno, M., Honjoh, S., Matsuda, M., Hoshikawa, H., Kishimoto, S., Yamamoto, T., Ebisuya, M., Yamamoto, T., Matsumoto, K., & Nishida, E. (2013) · Cell Reports · doi:10.1016/j.celrep.2012.12.018 · Cited by 118
Ailshire, J., Beltrán‐Sánchez, H., & Crimmins, E. M. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu124 · Cited by 104
Transient adult microbiota, gut homeostasis and longevity: Novel insights from the Drosophila model
Erkoşar, B., & Leulier, F. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.06.041 · Cited by 99
The Architecture of Parent-of-Origin Effects in Mice
Mott, R., Wei, Y., Kaisaki, P. J., Gan, X., Cleak, J., Edwards, A., Baud, A., & Flint, J. (2014) · Cell · doi:10.1016/j.cell.2013.11.043 · Cited by 97
Methionine flux to transsulfuration is enhanced in the long living Ames dwarf mouse
Uthus, E. O., & Brown-Borg, H. M. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.01.001 · Cited by 94
C. elegans Behavior of Preference Choice on Bacterial Food
Abada, E., Sung, H., Dwivedi, M., Park, B.-J., Lee, S.-K., & Ahnn, J. (2009) · Molecules and Cells · doi:10.1007/s10059-009-0124-x · Cited by 94
Lowered Insulin Signalling Ameliorates Age-Related Sleep Fragmentation in Drosophila
Metaxakis, A., Tain, L. S., Grönke, S., Hendrich, O., Hinze, Y., Birras, U., & Partridge, L. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001824 · Cited by 94
Self-citationPromoting longevity by maintaining metabolic and proliferative homeostasis
Wang, L., Karpac, J., & Jasper, H. (2013) · Journal of Experimental Biology · doi:10.1242/jeb.089920 · Cited by 91
Water sensor ppk28 modulates Drosophila lifespan and physiology through AKH signaling
Waterson, M. J., Chung, B. Y., Harvanek, Z. M., Ostojic, I., Alcedo, J., & Pletcher, S. D. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1315461111 · Cited by 89
Independent and Additive Effects of Glutamic Acid and Methionine on Yeast Longevity
Wu, Z., Song, L., Liu, S., & Huang, D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079319 · Cited by 89
The impact of early nutrition on the ageing trajectory
Tarry-Adkins, J. L., & Ozanne, S. E. (2014) · Proceedings of The Nutrition Society · doi:10.1017/s002966511300387x · Cited by 88
Dang, W., Sutphin, G. L., Dorsey, J. A., Otte, G. L., Cao, K., Perry, R. M., Wanat, J. J., Saviolaki, D., Murakami, C. J., Tsuchiyama, S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.04.004 · Cited by 83
Thondamal, M., Witting, M. A., Schmitt‐Kopplin, P., & Aguilaniu, H. (2014) · Nature Communications · doi:10.1038/ncomms5879 · Cited by 82
Jakubowicz, D., Barnea, M., Wainstein, J., & Froy, O. (2013) · Clinical Science · doi:10.1042/cs20130071 · Cited by 81
Calorie restriction and the nutrient sensing signaling pathways
Dilova, I., Easlon, E. J., & Lin, S.-J. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6381-y · Cited by 77
Interpreting interactions between treatments that slow aging
Gems, D., Pletcher, S. D., & Partridge, L. (2002) · Aging Cell · doi:10.1046/j.1474-9728.2002.00003.x · Cited by 77
Self-citationCalorie restriction and susceptibility to intact pathogens
Kristan, D. M. (2008) · AGE · doi:10.1007/s11357-008-9056-1 · Cited by 76
ATF 4 activity: a common feature shared by many kinds of slow‐aging mice
Li, W., Li, X., & Miller, R. A. (2014) · Aging Cell · doi:10.1111/acel.12264 · Cited by 74
PER1 Phosphorylation Specifies Feeding Rhythm in Mice
Liu, Z., Huang, M., Wu, X., Shi, G., Xing, L., Dong, Z., Qu, Z., Yan, J., Yang, L., Panda, S., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.04.032 · Cited by 73
Stöhr, O., Schilbach, K., Moll, L., Hettich, M. M., Freude, S., Wunderlich, F. T., Ernst, M. B., Zemva, J., Brüning, J. C., Krone, W., et al. (2011) · AGE · doi:10.1007/s11357-011-9333-2 · Cited by 73
Simons, M. J. P., Koch, W., & Verhulst, S. (2013) · Aging Cell · doi:10.1111/acel.12061 · Cited by 72
Yeast replicative aging: a paradigm for defining conserved longevity interventions
Wasko, B. M., & Kaeberlein, M. R. (2013) · FEMS Yeast Research · doi:10.1111/1567-1364.12104 · Cited by 67
Effect of calorie restriction and refeeding on skin wound healing in the rat
Hunt, N. D., Li, G. D., Zhu, M., Levette, A., Chachich, M. E., Spangler, E. L., Allard, J. S., Hyun, D., Ingram, D. K., & de Cabo, R. (2011) · AGE · doi:10.1007/s11357-011-9321-6 · Cited by 64
Cameron, K., Miwa, S., Walker, C., & von Zglinicki, T. (2012) · Longevity & Healthspan · doi:10.1186/2046-2395-1-3 · Cited by 58
Dietary switch reveals fast coordinated gene expression changes in Drosophila melanogaster
Whitaker, R., Gil, M. P., Ding, F., Tatar, M., Helfand, S. L., & Neretti, N. (2014) · Aging · doi:10.18632/aging.100662 · Cited by 58
The Intersection of Aging, Longevity Pathways, and Learning and Memory in C. elegans
Stein, G. M., & Murphy, C. T. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2012.00259 · Cited by 56
Impact of weight regain on metabolic disease risk: a review of human trials.
Kroeger, C. M., Hoddy, K. K., & Varady, K. A. (2014) · Journal of Obesity · doi:10.1155/2014/614519 · Cited by 55
Wu, Z., Liu, S., & Huang, D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064448 · Cited by 55
Growth hormone signaling is necessary for lifespan extension by dietary methionine
Brown‐Borg, H. M., Rakoczy, S. G., Wonderlich, J. A., Rojanathammanee, L., Kopchick, J. J., Armstrong, V., & Raasakka, D. (2014) · Aging Cell · doi:10.1111/acel.12269 · Cited by 54
Saiki, R., Lunceford, A. L., Bixler, T., Dang, P., Lee, W., Furukawa, S., Larsen, P. L., & Clarke, C. F. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00378.x · Cited by 54
Handbook of the Biology of Aging
(2011) · Elsevier eBooks · doi:10.1016/c2009-0-01967-9 · Cited by 53
Ostojic, I., Boll, W., Waterson, M. J., Chan, T. P., Chandra, R., Pletcher, S. D., & Alcedo, J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1315466111 · Cited by 44
Dietary restriction in C. elegans: Recent advances
Cypser, J. R., Kitzenberg, D., & Park, S.-K. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.02.018 · Cited by 41
Role of the hypothalamus in mediating protective effects of dietary restriction during aging
Dacks, P. A., Moreno, C. L., Kim, E. S., Marcellino, B. K., & Mobbs, C. V. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2012.12.001 · Cited by 38
Sensory systems: their impact on C. elegans survival
Allen, E., Ren, J. H., Zhang, Y., & Alcedo, J. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.06.054 · Cited by 37
Pollin, T. I., Isakova, T., Jablonski, K. A., de Bakker, P. I. W., Taylor, A., McAteer, J. B., Pan, Q., Horton, E. S., Delahanty, L. M., Altshuler, D., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002895 · Cited by 35
Evidence of a metabolic memory to early-life dietary restriction in male C57BL/6 mice
Selman, C., & Hempenstall, S. (2012) · Longevity & Healthspan · doi:10.1186/2046-2395-1-2 · Cited by 32
Withers, S. S., Kass, P. H., Rodriguez, C. O., Skorupski, K. A., O’Brien, D., Guerrero, T. A., Sein, K. D., & Rebhun, R. B. (2014) · Translational Oncology · doi:10.1016/j.tranon.2014.04.014 · Cited by 29
Broadening the therapeutic scope for rapamycin treatment
Menzies, F. M., & Rubinsztein, D. C. (2010) · Autophagy · doi:10.4161/auto.6.2.11078 · Cited by 27
Mortality shifts in Caenorhabditis elegans: remembrance of conditions past
Wu, D., Rea, S. L., Cypser, J. R., & Johnson, T. E. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00523.x · Cited by 24
The First International Mini-Symposium on Methionine Restriction and Lifespan
Ables, G. P., Brown‐Borg, H. M., Buffenstein, R., CHURCH, C. D., Elshorbagy, A. K., Gladyshev, V. N., Huang, T.-H., Miller, R. A., Mitchell, J. R., Richie, J. P., et al. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00122 · Cited by 22
Colaneri, A., Wang, T., Pagadala, V., Kittur, J., Staffa, N. G., Peddada, S. D., ISGANAITIS, E. M., Patti, M., & Birnbaumer, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072670 · Cited by 21
Ikeno, Y., Lew, C. M., Cortez, L. A., Webb, C. R., Lee, S., & Hubbard, G. B. (2006) · AGE · doi:10.1007/s11357-006-9007-7 · Cited by 21
Tessitore, L., & Bollito, E. (2006) · Cell Proliferation · doi:10.1111/j.1365-2184.2006.00371.x · Cited by 13
Metabolic adaptations to short-term every-other-day feeding in long-living Ames dwarf mice
Brown‐Borg, H. M., & Rakoczy, S. G. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.06.009 · Cited by 13
Feeding Mistiming Decreases Reproductive Fitness in Flies
Gill, S., & Panda, S. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.05.003 · Cited by 9
Calorie Restriction in Nonhuman and Human Primates
Fontana, L., Colman, R. J., Holloszy, J. O., & Weindruch, R. H. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-378638-8.00021-x · Cited by 4
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
You are what you eat: Diet, health and the gut microbiota
Zmora, N., Suez, J., & Elinav, E. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0061-2 · Cited by 1,792
Facing up to the global challenges of ageing
Partridge, L., Deelen, J., & Slagboom, P. E. (2018) · Nature · doi:10.1038/s41586-018-0457-8 · Cited by 1,475
Self-citationO’Toole, P. W., & Jeffery, I. B. (2015) · Science · doi:10.1126/science.aac8469 · Cited by 1,202
Metformin as a tool to target aging
Barzilai, N., Crandall, J. P., Kritchevsky, S. B., & Espeland, M. A. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.011 · Cited by 1,096
ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age‐Related Diseases
Davalli, P., Mitic, T., Caporali, A., Lauriola, A., & D’Arca, D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3565127 · Cited by 1,059
Metadata
- Authors
- Fontana, L., & Partridge, L.
- Affiliations
- Washington University in St. Louis (US)
- Max Planck Institute for Biology of Ageing (DE)
- Corresponding author
- Fontana, Luigi
- Partridge, Linda
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 161
- Issue
- 1
- Pages
- 106-118
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4547605
- OpenAlex
- W2096935190
- Cited by
- 1,245
- References
- 151
- Citations by year
- 2026: 65 · 2025: 98 · 2024: 99 · 2023: 94 · 2022: 121 · 2021: 158 · 2020: 141 · 2019: 130 · 2018: 121 · 2017: 91 · 2016: 94 · 2015: 33
- FWCI
- 9.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Wellcome Trust (098565)
- Bakewell Foundation
- European Commission
- Max-Planck-Gesellschaft
- National Institute on Aging
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK056341)
- National Center for Research Resources (UL1RR024992)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- dietary restriction, aging, longevity, intermittent fasting, meal timing, circadian feeding rhythm, protein restriction, amino acids, gut microbiota, age-related diseases, pharmacological interventions
- MeSH terms
- Aging, Animals, Diet, Health Promotion, Humans, Longevity, Models, Animal, Caloric Restriction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
