Quiescence Modulates Stem Cell Maintenance and Regenerative Capacity in the Aging Brain

STAR: ultrafast universal RNA-seq aligner

Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709 · see citing works

Model selection and multimodel inference: a practical information-theoretic approach.

Guthery, F. S., Burnham, K. P., & Anderson, D. R. (2003) · The Journal of Wildlife Management · doi:10.2307/3802723 · Cited by 41,495 · see citing works

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

Yu, G., Wang, L.-G., Han, Y., & He, Q.-Y. (2012) · OMICS: A Journal of Integrative Biology · doi:10.1089/omi.2011.0118 · Cited by 36,259 · see citing works

De novo transcript sequence reconstruction from RNA-seq using the Trinity platform for reference generation and analysis

Haas, B. J., Papanicolaou, A., Yassour, M., Grabherr, M., Blood, P. D., Bowden, J., Couger, M. B., Eccles, D., Li, B., Lieber, M., et al. (2013) · Nature Protocols · doi:10.1038/nprot.2013.084 · Cited by 8,464 · see citing works

A scaling normalization method for differential expression analysis of RNA-seq data

Robinson, M. D., & Oshlack, A. (2010) · Genome Biology · doi:10.1186/gb-2010-11-3-r25 · Cited by 7,876 · see citing works

Reversed graph embedding resolves complex single-cell trajectories

Qiu, X., Mao, Q., Tang, Y., Wang, L., Chawla, R., Pliner, H. A., & Trapnell, C. (2017) · Nature Methods · doi:10.1038/nmeth.4402 · Cited by 5,070 · see citing works

Full-length RNA-seq from single cells using Smart-seq2

Picelli, S., Faridani, O. R., Björklund, Å. K., Winberg, G., Sagasser, S., & Sandberg, R. (2014) · Nature Protocols · doi:10.1038/nprot.2014.006 · Cited by 4,137 · see citing works

On the Dependency of Cellular Protein Levels on mRNA Abundance

Liu, Y., Beyer, A., & Aebersold, R. (2016) · Cell · doi:10.1016/j.cell.2016.03.014 · Cited by 3,221 · see citing works

Functional Role of Type I and Type II Interferons in Antiviral Defense

Müller, U., Steinhoff, U., Reis, L. F. L., Hemmi, S., Pavlovic, J., Zinkernagel, R. M., & Aguet, M. (1994) · Science · doi:10.1126/science.8009221 · Cited by 2,453 · see citing works

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

Villeda, S. A., Luo, J., Mosher, K. I., Zou, B., Britschgi, M., Bieri, G., Stan, T. M., Fainberg, N., Ding, Z., Eggel, A., et al. (2011) · Nature · doi:10.1038/nature10357 · Cited by 1,763 · see citing works

Introduction to the Numerical Solution of Markov Chains

Stewart, W. J. (1995) · Princeton University Press eBooks · doi:10.1515/9780691223384 · Cited by 1,757 · see citing works

Immune Response in Mice that Lack the Interferon-γ Receptor

Huang, S., Hendriks, W. J. A. J., Althage, A., Hemmi, S., Bluethmann, H., Kamijo, R., Vilček, J., Zinkernagel, R. M., & Aguet, M. (1993) · Science · doi:10.1126/science.8456301 · Cited by 1,551 · see citing works

InnateDB: systems biology of innate immunity and beyond—recent updates and continuing curation

Breuer, K., Foroushani, A. B. K., Laird, M. R., Chen, C. C. L., Sribnaia, A., Lo, R., Winsor, G. L., Hancock, R. E. W., Brinkman, F. S. L., & Lynn, D. J. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1147 · Cited by 1,224 · see citing works

Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells

Shalek, A. K., Satija, R., Adiconis, X., Gertner, R. S., Gaublomme, J. T., Raychowdhury, R., Schwartz, S., Yosef, N., Malboeuf, C., Lu, D., et al. (2013) · Nature · doi:10.1038/nature12172 · Cited by 1,190 · see citing works

Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors

Katsimpardi, L., Litterman, N. K., Schein, P. A., Miller, C. M., Loffredo, F. S., Wojtkiewicz, G. R., Chen, J. W., Lee, R. T., Wagers, A. J., & Rubin, L. L. (2014) · Science · doi:10.1126/science.1251141 · Cited by 1,037 · see citing works

Single-cell RNA-seq reveals dynamic paracrine control of cellular variation

Shalek, A. K., Satija, R., Shuga, J., Trombetta, J. J., Gennert, D., Lu, D., Chen, P., Gertner, R. S., Gaublomme, J. T., Yosef, N., et al. (2014) · Nature · doi:10.1038/nature13437 · Cited by 1,000 · see citing works

Neurogenesis in the striatum of the adult human brain

Ernst, A., Alkass, K., Bernard, S., Salehpour, M., Perl, S., Tisdale, J., Possnert, G., Druid, H., & Frisén, J. (2014) · Cell · doi:10.1016/j.cell.2014.01.044 · Cited by 937 · see citing works

Stem cell aging: mechanisms, regulators and therapeutic opportunities

Oh, J., Lee, Y. D., & Wagers, A. J. (2014) · Nature Medicine · doi:10.1038/nm.3651 · Cited by 796 · see citing works

Human Adult Neurogenesis: Evidence and Remaining Questions

Kempermann, G., Gage, F. H., Aigner, L., Song, H., Curtis, M. A., Thuret, S., Kuhn, H. G., Jessberger, S., Frankland, P. W., Cameron, H. A., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.04.004 · Cited by 790 · see citing works

Single-Cell Transcriptomics Reveals a Population of Dormant Neural Stem Cells that Become Activated upon Brain Injury

Llorens-Bobadilla, E., Zhao, S., Baser, A., Saiz-Castro, G., Zwadlo, K., & Martin-Villalba, A. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.07.002 · Cited by 778 · see citing works

Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells

Walter, D., Lier, A., Geiselhart, A., Thalheimer, F. B., Huntscha, S., Sobotta, M. C., Moehrle, B., Brocks, D., Bayindir, I., Kaschutnig, P., et al. (2015) · Nature · doi:10.1038/nature14131 · Cited by 619 · see citing works

Aging-induced type I interferon response at the choroid plexus negatively affects brain function

Baruch, K., Deczkowska, A., David, E., Castellano, J. M., Miller, O., Kertser, A., Berkutzki, T., Barnett-Itzhaki, Z., Bezalel, D., Wyss-Coray, T., et al. (2014) · Science · doi:10.1126/science.1252945 · Cited by 615 · see citing works

Btrim: A fast, lightweight adapter and quality trimming program for next-generation sequencing technologies

Kong, Y. (2011) · Genomics · doi:10.1016/j.ygeno.2011.05.009 · Cited by 580 · see citing works

The Adult Ventricular–Subventricular Zone (V-SVZ) and Olfactory Bulb (OB) Neurogenesis

Lim, D. A., & Alvarez-Buylla, A. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018820 · Cited by 571 · see citing works

Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging

Leeman, D. S., Hebestreit, K., Ruetz, T., Webb, A. E., McKay, A., Pollina, E. A., Dulken, B. W., Zhao, X., Yeo, R. W., Ho, T. T., et al. (2018) · Science · doi:10.1126/science.aag3048 · Cited by 528 · see citing works

Embryonic origin of postnatal neural stem cells

Fuentealba, L. C., Rompani, S. B., Parraguez, J. I., Obernier, K., Romero, R., Cepko, C. L., & Alvarez-Buylla, A. (2015) · Cell · doi:10.1016/j.cell.2015.05.041 · Cited by 488 · see citing works

Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus

Mira, H., Andreu, Z., Suh, H., Lie, D. C., Jessberger, S., Consiglio, A., San Emeterio, J., Hortigüela, R., Marqués-Torrejón, M. Á., Nakashima, K., et al. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.04.016 · Cited by 480 · see citing works

Hematopoietic Cytokines Can Instruct Lineage Choice

Rieger, M. A., Hoppe, P. S., Smejkal, B. M., Eitelhuber, A. C., & Schroeder, T. (2009) · Science · doi:10.1126/science.1171461 · Cited by 404 · see citing works

Single-cell transcriptomic analysis defines heterogeneity and transcriptional dynamics in the adult neural stem cell lineage

Dulken, B. W., Leeman, D. S., Boutet, S. C., Hebestreit, K., & Brunet, A. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.060 · Cited by 334 · see citing works

Age-Dependent Niche Signals from the Choroid Plexus Regulate Adult Neural Stem Cells

Silva-Vargas, V., Maldonado-Soto, A. R., Mizrak, D., Codega, P., & Doetsch, F. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.06.013 · Cited by 306 · see citing works

A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing

Florian, M. C., Nattamai, K. J., Dörr, K., Marka, G., Überle, B., Vas, V., Eckl, C., Andrä, I., Schiemann, M., Oostendorp, R. A. J., et al. (2013) · Nature · doi:10.1038/nature12631 · Cited by 303 · see citing works

A sensitive and bright single-cell resolution live imaging reporter of Wnt/ß-catenin signaling in the mouse

Ferrer‐Vaquer, A., Piliszek, A., Tian, G., Aho, R., Dufort, D., & Hadjantonakis, A. (2010) · BMC Developmental Biology · doi:10.1186/1471-213x-10-121 · Cited by 299 · see citing works

Loss of Dickkopf-1 Restores Neurogenesis in Old Age and Counteracts Cognitive Decline

Seib, D. R., Corsini, N. S., Ellwanger, K., Plaas, C., Mateos, Á., Pitzer, C., Niehrs, C., Celikel, T., & Martín-Villalba, A. (2013) · Cell stem cell · doi:10.1016/j.stem.2012.11.010 · Cited by 294 · see citing works

Direct cell–cell contact with the vascular niche maintains quiescent neural stem cells

Ottone, C., Krusche, B., Whitby, A., Clements, M., Quadrato, G., Pitulescu, M. E., Adams, R. H., & Parrinello, S. (2014) · Nature Cell Biology · doi:10.1038/ncb3045 · Cited by 279 · see citing works

FoxJ1-dependent gene expression is required for differentiation of radial glia into ependymal cells and a subset of astrocytes in the postnatal brain

Jacquet, B. V., Salinas-Mondragon, R., Liang, H.-X., Therit, B., Buie, J. D., Dykstra, M., Campbell, K., Ostrowski, L., Brody, S., & Ghashghaei, H. T. (2009) · Development · doi:10.1242/dev.041129 · Cited by 277 · see citing works

Cell cycle and lineage progression of neural progenitors in the ventricular-subventricular zones of adult mice

Ponti, G., Obernier, K., Guinto, C. D., Jose, L., Bonfanti, L., & Álvarez-Buylla, A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219563110 · Cited by 258 · see citing works

Adult Neurogenesis Is Sustained by Symmetric Self-Renewal and Differentiation

Obernier, K., Cebrian-Silla, A., Thomson, M., Parraguez, J. I., Anderson, R., Guinto, C., Rodas Rodriguez, J., Garcia-Verdugo, J.-M., & Alvarez-Buylla, A. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.01.003 · Cited by 250 · see citing works

Oligodendrogliogenic and neurogenic adult subependymal zone neural stem cells constitute distinct lineages and exhibit differential responsiveness to Wnt signalling

Ortega, F., Gascón, S., Masserdotti, G., Deshpande, A., Simon, C., Fischer, J., Dimou, L., Chichung Lie, D., Schroeder, T., & Berninger, B. (2013) · Nature Cell Biology · doi:10.1038/ncb2736 · Cited by 247 · see citing works

Exposure to a youthful circulation rejuvenates bone repair through modulation of β-catenin

Baht, G. S., Silkstone, D., Vi, L., Nadesan, P., Amani, Y., Whetstone, H., Wei, Q., & Alman, B. A. (2015) · Nature Communications · doi:10.1038/ncomms8131 · Cited by 211 · see citing works

Neural Stem and Progenitor Cells Retain Their Potential for Proliferation and Differentiation into Functional Neurons Despite Lower Number in Aged Brain

Ahlenius, H., Visan, V., Kokaia, M., Lindvall, O., & Kokaia, Z. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.6003-08.2009 · Cited by 208 · see citing works

Secreted Frizzled-Related Protein 3 Regulates Activity-Dependent Adult Hippocampal Neurogenesis

Jang, M., Bonaguidi, M. A., Kitabatake, Y., Sun, J., Song, J., Kang, E., Jun, H., Zhong, C., Su, Y., Guo, J. U., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2012.11.021 · Cited by 198 · see citing works

Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone

Calzolari, F., Michel, J., Baumgart, E. V., Theis, F. J., Götz, M., & Ninkovic, J. (2015) · Nature Neuroscience · doi:10.1038/nn.3963 · Cited by 186 · see citing works

Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy

Basak, O., Krieger, T. G., Muraro, M. J., Wiebrands, K., Stange, D. E., Frias-Aldeguer, J., Rivron, N. C., van de Wetering, M., van Es, J. H., van Oudenaarden, A., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1715911114 · Cited by 186 · see citing works

Brain Endothelial- and Epithelial-Specific Interferon Receptor Chain 1 Drives Virus-Induced Sickness Behavior and Cognitive Impairment

Blank, T., Detje, C. N., Spieß, A., Hagemeyer, N., Brendecke, S. M., Wolfart, J., Staszewski, O., Zöller, T., Papageorgiou, I. E., Schneider, J., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.04.005 · Cited by 179 · see citing works

Wnt your brain be inflamed? Yes, it Wnt!

Marchetti, B., & Pluchino, S. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.12.001 · Cited by 165 · see citing works

Software tools for single-cell tracking and quantification of cellular and molecular properties

Hilsenbeck, O., Schwarzfischer, M., Skylaki, S., Schauberger, B., Hoppe, P. S., Loeffler, D., Kokkaliaris, K. D., Hastreiter, S., Skylaki, E., Filipczyk, A. A., et al. (2016) · Nature Biotechnology · doi:10.1038/nbt.3626 · Cited by 159 · see citing works

Prospective identification of functionally distinct stem cells and neurosphere-initiating cells in adult mouse forebrain

Mich, J. K., Signer, R. A. J., Nakada, D., Pineda, A., Burgess, R. J., Vue, T. Y., Johnson, J. E. B., & Morrison, S. J. (2014) · eLife · doi:10.7554/elife.02669 · Cited by 151 · see citing works

The nuclear receptor tailless is required for neurogenesis in the adult subventricular zonePreprint

Liu, H., Belz, T., Bock, D., Takacs, A., Wu, H. Q., Lichter, P., Chai, M., & Schütz, G. (2008) · Genes & Development · doi:10.1101/gad.479308 · Cited by 149 · see citing works

Spatiotemporal Changes to the Subventricular Zone Stem Cell Pool through Aging

Shook, B. A., Manz, D. H., Peters, J. J., Kang, S., & Conover, J. C. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5987-11.2012 · Cited by 136 · see citing works

Characterization of stem cells using mathematical models of multistage cell lineages

Stiehl, T., & Marciniak-Czochra, A. K. (2010) · Mathematical and Computer Modelling · doi:10.1016/j.mcm.2010.03.057 · Cited by 123 · see citing works

Age-related changes in astrocytic and ependymal cells of the subventricular zone

Capilla‐González, V., Cebrián‐Silla, A., Guerrero‐Cazares, H., García‐Verdugo, J. M., & Quiñones‐Hinojosa, A. (2014) · Glia · doi:10.1002/glia.22642 · Cited by 108 · see citing works

Neurogenic Niche Microglia Undergo Positional Remodeling and Progressive Activation Contributing to Age-Associated Reductions in Neurogenesis

Fonseca, R. S., Mahesula, S., Apple, D. M., Raghunathan, R., Dugan, A. M., Cardona, A. E., O’Connor, J. C., & Kokovay, E. (2016) · Stem Cells and Development · doi:10.1089/scd.2015.0319 · Cited by 101 · see citing works

Adult Stem Cell Niches

Rezza, A., Sennett, R., & Rendl, M. (2014) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-416022-4.00012-3 · Cited by 95 · see citing works

Age-related neurogenesis decline in the subventricular zone is associated with specific cell cycle regulation changes in activated neural stem cells

Daynac, M., Morizur, L., Chicheportiche, A., Mouthon, M., & Boussin, F. D. (2016) · Scientific Reports · doi:10.1038/srep21505 · Cited by 93 · see citing works

Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging

Zhu, Y., Demidov, O. N., Goh, A. M., Virshup, D. M., Lane, D. P., & Bulavin, D. V. (2014) · Journal of Clinical Investigation · doi:10.1172/jci73015 · Cited by 73 · see citing works

Revealing age-related changes of adult hippocampal neurogenesis using mathematical models

Ziebell, F., Dehler, S., Martín-Villalba, A., & Marciniak-Czochra, A. K. (2018) · Development · doi:10.1242/dev.153544 · Cited by 59 · see citing works

Single-cell transcriptomics reveals gene signatures and alterations associated with aging in distinct neural stem/progenitor cell subpopulations

Shi, Z., Geng, Y., Liu, J., Zhang, H., Zhou, L., Lin, Q., Yu, J., Zhang, K., Liu, J., Gao, X., et al. (2017) · Protein & Cell · doi:10.1007/s13238-017-0450-2 · Cited by 51 · see citing works

Parkinson's disease‐associated receptor GPR37 is an ER chaperone for LRP6

Berger, B. S., Acebrón, S. P., Herbst, J., Koch, S., & Niehrs, C. (2017) · EMBO Reports · doi:10.15252/embr.201643585 · Cited by 44 · see citing works

Mathematical modelling of adult hippocampal neurogenesis: effects of altered stem cell dynamics on cell counts and bromodeoxyuridine-labelled cells

Ziebell, F., Martín-Villalba, A., & Marciniak-Czochra, A. K. (2014) · Journal of The Royal Society Interface · doi:10.1098/rsif.2014.0144 · Cited by 34 · see citing works

Identifying niche‐mediated regulatory factors of stem cell phenotypic state: a systems biology approach

Ravichandran, S., & del Sol, A. (2017) · FEBS Letters · doi:10.1002/1873-3468.12559 · Cited by 5 · see citing works

Single-cell transcriptomic profiling of the aging mouse brain

Ximerakis, M., Lipnick, S. L., Innes, B. T., Simmons, S. K., Adiconis, X., Dionne, D., Mayweather, B. A., Nguyen, L., Niziolek, Z., Ozek, C., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0491-3 · Cited by 736 · see citing works

Single-cell analysis reveals T cell infiltration in old neurogenic niches

Dulken, B. W., Buckley, M. T., Navarro Negredo, P., Saligrama, N., Cayrol, R., Leeman, D. S., George, B. M., Boutet, S. C., Hebestreit, K., Pluvinage, J. V., et al. (2019) · Nature · doi:10.1038/s41586-019-1362-5 · Cited by 521 · see citing works

Ageing and rejuvenation of tissue stem cells and their niches

Brunet, A., Goodell, M. A., & Rando, T. A. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00510-w · Cited by 407 · see citing works

Aging and Rejuvenation of Neural Stem Cells and Their Niches

Navarro Negredo, P., Yeo, R. W., & Brunet, A. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.07.002 · Cited by 246 · see citing works

The aging skin microenvironment dictates stem cell behavior

Ge, Y., Miao, Y., Gur-Cohen, S., Gomez, N., Yang, H., Nikolova, M., Polak, L., Hu, Y., Verma, A., Elemento, O., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1901720117 · Cited by 190 · see citing works

Coordinated changes in cellular behavior ensure the lifelong maintenance of the hippocampal stem cell population

Harris, L., Rigo, P., Stiehl, T., Gaber, Z. B., Austin, S. H. L., Masdeu, M. D. M., Edwards, A., Urbán, N., Marciniak-Czochra, A., & Guillemot, F. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.01.003 · Cited by 173 · see citing works

Defining the Adult Neural Stem Cell Niche Proteome Identifies Key Regulators of Adult Neurogenesis

Kjell, J., Fischer-Sternjak, J., Thompson, A. J., Friess, C., Sticco, M. J., Salinas, F., Cox, J., Martinelli, D. C., Ninkovic, J., Franze, K., et al. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.01.002 · Cited by 163 · see citing works

FoxO maintains a genuine muscle stem-cell quiescent state until geriatric age

García-Prat, L., Perdiguero, E., Alonso-Martín, S., Dell’Orso, S., Ravichandran, S., Brooks, S. R., Juan, A. H., Campanario, S., Jiang, K., Hong, X., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-00593-7 · Cited by 161 · see citing works

Early stem cell aging in the mature brain

Ibrayeva, A., Bay, M., Pu, E., Jörg, D. J., Peng, L., Jun, H., Zhang, N., Aaron, D., Lin, C., Resler, G., et al. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.03.018 · Cited by 137 · see citing works

Age-related loss of neural stem cell O-GlcNAc promotes a glial fate switch through STAT3 activation

White, C. W., Fan, X., Maynard, J. C., Wheatley, E. G., Bieri, G., Couthouis, J., Burlingame, A. L., & Villeda, S. A. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2007439117 · Cited by 98 · see citing works

Differentiation Drives Widespread Rewiring of the Neural Stem Cell Chaperone Network

Vonk, W. I. M., Rainbolt, T. K., Dolan, P. T., Webb, A. E., Brunet, A., & Frydman, J. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.03.009 · Cited by 84 · see citing works

Declining lamin B1 expression mediates age-dependent decreases of hippocampal stem cell activity

bin Imtiaz, M. K., Jaeger, B. N., Bottes, S., Machado, R. A. C., Vidmar, M., Moore, D. L., & Jessberger, S. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.01.015 · Cited by 83 · see citing works

Restoration of hippocampal neural precursor function by ablation of senescent cells in the aging stem cell niche

Fatt, M. P., Tran, L. M., Vetere, G., Storer, M. A., Simonetta, J. V., Miller, F. D., Frankland, P. W., & Kaplan, D. R. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.12.010 · Cited by 58 · see citing works

Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification

Hwang, I., Uchida, H., Dai, Z., Li, F., Sanchez, T., Locasale, J. W., Cantley, L. C., Zheng, H., & Paik, J. (2021) · Nature Communications · doi:10.1038/s41467-020-20839-0 · Cited by 61 · see citing works

DNA damage in aging, the stem cell perspective

McNeely, T., Leone, M., Yanai, H., & Beerman, I. (2020) · Human Genetics · doi:10.1007/s00439-019-02047-z · Cited by 52 · see citing works

ATM modulates subventricular zone neural stem cell maintenance and senescence through Notch signaling pathway

Dong, C., Wang, X., Sun, L., Zhu, L., Yang, D., Gao, S., Zhang, W., Ling, B., Liang, A., Gao, Z., et al. (2022) · Stem Cell Research · doi:10.1016/j.scr.2021.102618 · Cited by 16 · see citing works

Vascular Senescence: A Potential Bridge Between Physiological Aging and Neurogenic Decline

Rojas-Vázquez, S., Blasco-Chamarro, L., López-Fabuel, I., Martínez-Máñez, R., & Fariñas, I. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.666881 · Cited by 15 · see citing works

4D imaging analysis of the aging mouse neural stem cell niche reveals a dramatic loss of progenitor cell dynamism regulated by the RHO-ROCK pathway

Zhao, X., Fisher, E. S., Wang, Y., Zuloaga, K., Manley, L., & Temple, S. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.12.007 · Cited by 10 · see citing works

Multiple roles of Ulk4 in neurogenesis and brain function

Liu, M., Xu, P., O’Brien, T., & Shen, S. (2017) · Neurogenesis · doi:10.1080/23262133.2017.1313646 · Cited by 18 · see citing works

The proliferation of amplifying neural progenitor cells is impaired in the aging brain and restored by the mTOR pathway activation

Romine, J., Gao, X., Xu, X., So, K., & Chen, J. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.01.003 · Cited by 62 · see citing works

Mouse Models for Studying Hippocampal Adult Neural Stem Cell Biology

Semerci, F., Parkitny, L., & Maletić‐Savatić, M. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1008-4_4 · Cited by 4 · see citing works

Ganglioside GD3 Is Required for Neurogenesis and Long-Term Maintenance of Neural Stem Cells in the Postnatal Mouse Brain

Wang, J., Cheng, A., Wakade, C. G., & Yu, R. K. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2275-14.2014 · Cited by 73 · see citing works

Adult Brain Neurogenesis, Neural Stem Cells and Neurogenic Niches

Delgado‐García, L. M. (2016) · International Journal of Stem cell Research & Therapy · doi:10.23937/2469-570x/1410039 · Cited by 3 · see citing works