Cited by 448Body Composition Measurement TechniquesNutrition and Health in AgingMuscle metabolism and nutrition

Assessing appendicular skeletal muscle mass with bioelectrical impedance analysis in free-living Caucasian older adults

Sergi, Giuseppe, De Rui, Marina, Veronese, Nicola, Bolzetta, Francesco, Berton, Linda, Carraro, Sara, Bano, Giulia, Coin, Alessandra +2 more·2015·Clinical Nutrition

Abstract

Background & aims Aging is characterized by a loss of appendicular skeletal muscle mass (ASMM) leading to physical disability and death. Bioelectrical impedance analysis (BIA) is reliable in estimating ASMM but no prediction equations are available for elderly Caucasian subjects. The aim of the study was to develop and validate an equation derived from bioelectrical impedance analysis (BIA) to predict appendicular skeletal muscle mass (ASMM) in healthy Caucasian elderly subjects, taking dual X-ray absorptiometry (DXA) as the reference method, and comparing the reliability of the new equation with another BIA-based model developed by Kyle et al. (Kyle UG, Genton L, Hans D, Pichard C, 2003).Methods With a cross-sectional design, 296 free-living, healthy Caucasian subjects (117 men, 179 women) over 60 years of age were enrolled. Lean mass of limbs was measured with DXA to ascertain ASMM (ASMMDxA). Whole-body tetrapolar BIA was performed to measure resistance (Rz), resistance normalized for stature (RI), and reactance (Xc). The BIA multiple regression equation for predicting ASMM was developed using a double cross-validation technique. The predicted ASMM values were compared with ASMMKyle, i.e. ASMM estimates derived from the model developed by Kyle et al. (Kyle et al., 2003).Results Cross-validation resulted in a unique equation using the whole sample: ASMM (kg) = -3.964 + (0.227*RI) + (0.095*weight) + (1.384*sex) + (0.064*Xc) [R(2) = 0.92 and SEE = 1.14 kg]. In our sample, ASMMKyle differed significantly from the ASMMDxA (p < 0.0001), with a mean error of -0.97 ± 1.34 kg (5.1 ± 6.9%). Unlike the present BIA prediction equation, the Kyle et al. model showed a correlation between the bias and the mean of ASMMDxA and ASMMKyle (r = -0.406, p < 0.001).Conclusion The new BIA equation provides a valid estimate of ASMM in older Caucasian adults.

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Crossref · 10.1016/j.clnu.2014.07.010

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Authors
Sergi, G., De Rui, M., Veronese, N., Bolzetta, F., Berton, L., Carraro, S., Bano, G., Coin, A., Manzato, E., & Perissinotto, E.
Affiliations
University of Padua (IT)
Venue
Clinical Nutrition
Publisher
Elsevier BV
Published
2015-08
Volume
34
Issue
4
Pages
667-673
ISSN
0261-5614 (ISSN-L)
OpenAlex
W2149295929
Cited by
448
References
27
Citations by year
2026: 50 · 2025: 75 · 2024: 62 · 2023: 54 · 2022: 57 · 2021: 54 · 2020: 36 · 2019: 15 · 2018: 14 · 2017: 7 · 2016: 8 · 2015: 5 · 2012: 1
FWCI
3.91
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion)
  • Padua Research Archive (University of Padova) (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords
appendicular skeletal muscle mass, bioelectrical impedance analysis, prediction equations, older adults, aging, muscle mass assessment, dual-energy X-ray absorptiometry, Caucasian population
MeSH terms
Aged, Aged, 80 and over, Body Composition, Body Weight, Cross-Sectional Studies, Female, Humans, Male, Middle Aged

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