Immunomodulatory effects of a probiotic drink containing Lactobacillus casei Shirota in healthy older volunteers

Dong, Honglin; Rowland, Ian; Thomas, Linda V.; Yaqoob, Parveen

doi:10.1007/s00394-012-0487-1

Cited by 127Probiotics and Fermented FoodsMicrobial Metabolites in Food BiotechnologyInfant Nutrition and Health

Immunomodulatory effects of a probiotic drink containing Lactobacillus casei Shirota in healthy older volunteers

Dong, Honglin, Rowland, Ian, Thomas, Linda V., Yaqoob, Parveen·2013·European Journal of Nutrition

DOI 10.1007/s00394-012-0487-1

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Abstract

Purpose There is growing evidence that probiotics confer health benefits to the host by modulating immune function, especially in older people, where immunosenescence is a feature even of healthy ageing. The aim of this study was to investigate the effect of a probiotic drink containing Lactobacillus casei Shirota (LcS) on immune function in a healthy non-immunocompromised older population.Methods Thirty healthy old volunteers were recruited into a randomized placebo-controlled, single-blind crossover study. The volunteers were supplemented with the probiotic drink containing 1.3 × 10(10) CFU LcS or skimmed milk per day for 4 weeks, followed by 4 weeks of washout and were crossed over to the other treatment. Peripheral blood and saliva samples were collected at baseline and end of each treatment.Results Probiotic consumption was associated with a significant increase in natural killer (NK) cell activity relative to baseline and a significant decrease in the mean fluorescence intensity of CD25 expression in the resting T cells compared with placebo. Additionally, there was a trend towards an increased ratio of IL-10 to IL-12 relative to baseline after LcS intake.Conclusions Consumption of a probiotic drink containing LcS improved NK cell activity and tended to produce a more anti-inflammatory cytokine profile in an older population.

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Administration of specific strains of Lactobacilli and Bifidobacteria as probiotics, as well as fructooligosaccharides, galactooligosaccharides, and other prebiotics, or the combination of both, might constitute a benefit for immunocompromised people.
“Therefore, the administration of specific strains of Lactobacilli and Bifidobacteria as probiotics as well as fructooligosaccharides, galactooligosaccharides, and other prebiotics, or the combination of both might constitute a benefit for immunocompromised people (118–122).”
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Authors: Dong, H., Rowland, I., Thomas, L. V., & Yaqoob, P.
Affiliations: University of Reading (GB)
Corresponding author: Yaqoob, Parveen
ORCID: Dong, Honglin
Rowland, Ian
Thomas, Linda V.
Yaqoob, Parveen
Venue: European Journal of Nutrition
Publisher: Springer Science and Business Media LLC
Published: 2013-01-10
Volume: 52
Issue: 8
Pages: 1853-1863
ISSN: 1436-6207 (ISSN-L)
1436-6215
DOI: 10.1007/s00394-012-0487-1
OpenAlex: W2057844433
Cited by: 127
References: 50
Citations by year: 2026: 2 · 2025: 9 · 2024: 10 · 2023: 4 · 2022: 6 · 2021: 16 · 2020: 11 · 2019: 18 · 2018: 6 · 2017: 12 · 2016: 13 · 2015: 10 · 2014: 3 · 2013: 7
FWCI: 16.37
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: European Journal of Nutrition (publishedVersion)
PubMed (publishedVersion)
Funders: University of Reading
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Keywords: probiotics, Lactobacillus casei Shirota, immunomodulation, older adults, immunosenescence, NK cell cytotoxicity, anti-inflammatory cytokines, probiotic beverages, healthy aging
MeSH terms: Aged, Beverages, Blood Glucose, Female, Humans, Immunity, Innate, Killer Cells, Natural, Lacticaseibacillus casei, Leukocyte Count, Leukocytes, Mononuclear, Lipids, Male, Middle Aged, Phagocytes, Phenotype, T-Lymphocytes, Biomarkers, Single-Blind Method, Cytokines, Interleukin-10, Cross-Over Studies, Interleukin-12, Probiotics, Cell Proliferation, Interleukin-2 Receptor alpha Subunit, Healthy Volunteers

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Immunomodulatory effects of a probiotic drink containing Lactobacillus casei Shirota in healthy older volunteers

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