Cited by 183Gut microbiota and healthNutritional Studies and DietAnimal Nutrition and Physiology

Diet-Microbiome Interactions in Health Are Controlled by Intestinal Nitrogen Source Constraints

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Holmes, Andrew J., Chew, Yi Vee, Colakoglu, Feyza, Cliff, John B., Klaassens, Eline, Read, Mark N., Solon-Biet, Samantha M., McMahon, Aisling C. +5 more·2017·Cell Metabolism

Abstract

Diet influences health and patterns of disease in populations. How different diets do this and why outcomes of diets vary between individuals are complex and involve interaction with the gut microbiome. A major challenge for predicting health outcomes of the host-microbiome dynamic is reconciling the effects of different aspects of diet (food composition or intake rate) on the system. Here we show that microbial community assembly is fundamentally shaped by a dichotomy in bacterial strategies to access nitrogen in the gut environment. Consequently, the pattern of dietary protein intake constrains the host-microbiome dynamic in ways that are common to a very broad range of diet manipulation strategies. These insights offer a mechanism for the impact of high protein intake on metabolic health and form the basis for a general theory of the impact of different diet strategies on host-microbiome outcomes.

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Crossref · 10.1016/j.cmet.2016.10.021

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Authors
Holmes, A. J., Chew, Y. V., Colakoglu, F., Cliff, J. B., Klaassens, E., Read, M. N., Solon-Biet, S. M., McMahon, A. C., Cogger, V. C., Ruohonen, K., Raubenheimer, D., Le Couteur, D. G., & Simpson, S. J.
Affiliations
  • The University of Sydney (AU)
  • The University of Western Australia (AU)
  • Ewos Innovation (Norway) (NO)
Corresponding author
  • Holmes, Andrew J.
  • Simpson, Stephen J.
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2017-01
Volume
25
Issue
1
Pages
140-151
ISSN
1550-4131 (ISSN-L)
OpenAlex
W2550352184
Cited by
183
References
44
Citations by year
2026: 10 · 2025: 17 · 2024: 14 · 2023: 15 · 2022: 21 · 2021: 25 · 2020: 25 · 2019: 26 · 2018: 15 · 2017: 13 · 2016: 1
FWCI
9.53
Type
journal article
Language
en
Open access
Locations
  • Cell Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • UWA Profiles and Research Repository (UWA) (submittedVersion)
Funders
  • Australian National Health and Medical Research Council
  • NHMRC (571328, 1026209)
  • Ageing and Alzheimers Research Fund of Concord RG Hospital
  • Sydney Medical School Foundation
  • Australian Research Council Laureate Fellowship
  • National Research Centre for Growth and Development, New Zealand
  • Australian Microscopy and Microanalysis Research Facility (AMMRF)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
Keywords
diet-microbiome interactions, protein intake, metabolic health, food composition, ingestion rate
MeSH terms
Animals, Bacteria, Computer Simulation, Diet, Dietary Carbohydrates, Dietary Proteins, Energy Metabolism, Food, Health, Intestinal Mucosa, Intestines, Mice, Inbred BALB C, Mice, Inbred C57BL, Mucins, Nitrogen, Spectrometry, Mass, Secondary Ion, Biodiversity, Microbiota

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